SUPPLEMENTARY DATA Supplementary dataset S1: Serovar ...

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Jan 16, 2018 - S. Mississippi. 2,249. 3.8%. S. Virchow. 1,755. 3.0%. S. Infantis. 1,461 ... S. Chester. 388. 0.7%. S. Weltevreden. 358. 0.6%. S. Havana. 351.
SUPPLEMENTARY DATA Supplementary dataset S1: Serovar distribution All serovars where n>100 isolates

Salmonella enterica Serovar S. Typhimurium S. Enteritidis S. Mississippi S. Virchow S. Infantis S. Bovismorbificans S. Saintpaul S. Stanley Salmonella 1,4,[5],12:i:S. Newport S. Agona S. Singapore S. Hadar S. Anatum S. Derby S. Heidelberg S. Chester S. Weltevreden S. Havana S. Mbandaka S. Muenchen S. Birkenhead S. Senftenberg S. Montevideo S. Corvallis S. Oranienburg S. Give S. Hvittingfoss S. Ohio S. subsp II ser Sofia S. Cerro S. Kottbus S. Potsdam S. Zanzibar S. Hessarek S. Blockley S. Victoria S. Bareilly S. Panama S. London S. Kiambu S. Schwarzengrund

Number 33,081 2,554 2,249 1,755 1,461 1,309 1,066 858 801 798 611 535 496 460 406 391 388 358 351 336 329 265 258 252 240 230 209 208 205 205 194 189 177 177 170 168 160 158 149 147 146 146

% of total isolates 56.2% 4.3% 3.8% 3.0% 2.5% 2.2% 1.8% 1.5% 1.4% 1.4% 1.0% 0.9% 0.8% 0.8% 0.7% 0.7% 0.7% 0.6% 0.6% 0.6% 0.6% 0.5% 0.4% 0.4% 0.4% 0.4% 0.4% 0.4% 0.3% 0.3% 0.3% 0.3% 0.3% 0.3% 0.3% 0.3% 0.3% 0.3% 0.3% 0.2% 0.2% 0.2%

S. Braenderup S. Adelaide S. Javiana S. Tennessee S. Oslo S. Aberdeen S. Kentucky S. Thompson S. Reading S. Rissen S. Bredeney S. Orientalis Salmonella 16:l,v:S. Dublin Other serovars Total

139 131 129 127 124 118 110 110 108 107 106 105 105 102 2,563 58,830

0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 0.2% 4.4%

Supplementary dataset S2: Serovars associated with critical resistances, 1984-2015 Non-susceptible Salmonella serovar (n) Total (n) Multidrug resistance (non-susceptible to three or more classes of antimicrobials S. Blockley 111 168

Adjusted ORa

% 66.1

51.3

Salmonella 1,4,[5],12:i:-

588

801

73.4

48.9

S. Panama

114

149

76.5

46.9

S. Kentucky

79

110

71.8

33.5

S. Rissen

68

107

63.6

23.7

S. Schwarzengrund

72

146

49.3

21.8

S. Corvallis

101

240

42.1

9.2

146 496 858 406 209 147 611 460 798 58,830

27.4 23.8 24.0 11.1 10.5 11.6 10.8 10.9 8.6 6.4

5.6 5.3 4.7 2.6 2.4 2.2 2.0 1.9 1.6

S. Kiambu 40 S. Hadar 118 S. Stanley 206 S. Derby 45 S. Give 22 S. London 17 S. Agona 66 S. Anatum 50 S. Newport 69 Overall 3,783 a logistic regression, adjusted for year (reference serovar, S. Typhimurium)

95% CI (34.8, 75.7) (41.1, 58.2) (31.7, 69.5) (21.8, 51.5) (15.9, 35.4) (14.8, 32.2) (7.1, 12.0) (3.8, 8.1) (4.3, 6.6) (4.0, 5.6) (1.8, 3.6) (1.5, 3.8) (1.3, 3.6) (1.5, 2.6) (1.4, 2.7) (1.2, 2.1)

P-value