SUPPLEMENTARY DATA Supplementary Table 1 ... - Diabetes

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Characteristics of 18 SNPs at the JAZF1 type 2 diabetes locus. SNP. Chromosome position (hg19). Overlaps islet open chromatin*. LD with rs849134. (D'/r2) †.
SUPPLEMENTARY DATA  

Supplementary Table 1. Characteristics of 18 SNPs at the JAZF1 type 2 diabetes locus SNP

Chromosome position (hg19)

Overlaps islet open chromatin*

LD with rs849134 (D’/r2) †

Transcriptional activity evaluated

rs1635852 rs849133 rs860262 rs849142 rs702814

chr7:28189411 chr7:28192280 chr7:28194397 chr7:28185891 chr7:28172732

Yes Yes Yes Yes Yes

.99/.95 high 1.0/1.0 high 1.0/1.0 high .98/.93 high .97/.91 high

Yes Yes Yes Yes Yes

rs849135 rs849134 rs864745

chr7:28196413 chr7:28196222 chr7:28180556

No No No

1.0/.95 high 1.0/1.0 high .99/.97 high

Yes Yes Yes

rs881850 rs1109483 rs1109484 rs757729

chr7:28152675 chr7:28145031 chr7:28144801 chr7:28146305

No No No No

.83/.47_low .68/.31_low .68/.31_low .69/.32_low

Yes Yes Yes Yes

rs849138 rs1708302 rs1513272 rs12531540 -

chr7:28177338 chr7:28198677 chr7:28200097 chr7:28162674 chr7:28186775:I chr7:28178625:D chr7:28174263:D

No No No No No No No

.97/.91 high 1.0/.95 high 1.0/.95 high .94/.81 high .97/.91 high .97/.91 high .96/.90 high

No No No No No No No

*Islet open chromatin data from the ENCODE consortium (see Methods). † High LD refers to variants with r2≥.8 (1000G March 2012 release) with GWAS index SNP rs849134, low LD refers to variants with r2