SUPPLEMENTARY DATA Supplementary Table 1. Genes ... - Diabetes

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secreted frizzled-related protein 4. NM_003014 ... eyes absent homolog 4 .... GEM. GTP binding protein overexpressed in skeletal muscle. NM_005261. -0.7.

SUPPLEMENTARY DATA  

Supplementary Table 1. Genes differentially expressed in microarray in the dorsocervical vs. the abdominal s.c. adipose tissue in the cART+LD+ group. Abbreviation Gene name

Accession no.

MDF

NM_003014

-1.9

Cell proliferation SFRP4

secreted frizzled-related protein 4

Organogenesis and regulation of transcription ZIC1

zic family member 1

NM_003412

3.6

ZIC4

zic family member 4

NM_032153

2.2

EYA4

eyes absent homolog 4

NM_004100

1.7

SHOX2

short stature homeobox 2

NM_006884

1.4

HOXB5

homeobox B5

NM_002147

1.0

HOXA4

homeobox A4

NM_002141

0.8

TCF21

transcription factor 21

NM_003206

-0.8

FOXF2

forkhead box F2

NM_001452

-0.9

OSR1

odd-skipped related 1

NM_145260

-0.9

PITX2

paired-like homeodomain 2

NM_153426

-1.0

PRRX1

paired related homeobox 1

NM_006902

-1.0

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

CYR61

cysteine-rich, angiogenic inducer 61

NM_001554

-1.1

NKX2-1

NK2 homeobox 1

NM_003317

-1.1

HAND2

heart and neural crest derivatives expressed 2

NM_021973

-1.5

HOXA7

homeobox A7

NM_006896

-1.7

HOXC8

homeobox C8

NM_022658

-1.8

HOXC9

homeobox C9

NM_006897

-1.9

DMRT3

doublesex and mab-3 related transcription factor 3

NM_021240

-2.1

HOXA9

homeobox A9

NM_152739

-2.2

HOXA10

homeobox A10

NM_018951

-2.4

CDH23

cadherin-like 23

NM_022124

0.6

PGM5

phophoglucomutase 5

NM_021965

-0.7

CPXM2

carboxypeptidase X (M14 family), member 2

NM_198148

-0.9

FN1

fibronectin 1

NM_212482

-0.9

CLDN11

claudin 11

AF085871

-1.0

stathmin-like 2

NM_007029

1.5

Cell adhesion

Cytoskeleton STMN2

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

PDLIM5

PDZ and LIM domain 5

NM_006457

-0.5

CALD1

caldesmon 1

AK022222

-0.6

STMN3

stathmin-like 3

NM_015894

-0.6

ANK2

ankyrin 2, neuronal

NM_001148

-0.7

DPYSL3

dihydropyrimidinase-like 3

NM_001387

-1.0

SPAG17

sperm associated antigen 17

NM_206996

-1.1

PDLIM3

PDZ and LIM domain 3

BC001017

-1.3

Extracellular matrix ADAMTS3

ADAM metallopeptidase with thrombospondin type 1 motif 3

NM_014243

-1.0

ELN

elastin

NM_000501

-1.1

MGP

matrix Gla protein

NM_000900

-1.3

ASPN

asporin

NM_017680

-1.6

CTGF

connective tissue growth factor

NM_001901

-1.6

Energy metabolism PPP1R3B

protein phosphatase 1, regulatory (inhibitor) subunit 3B

NM_024607

-0.6

ENTPD1

ectonucleoside triphosphate diphosphohydrolase 1

NM_001776

-0.6

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

ATP8B4

ATPase, class I, type 8B, member 4

NM_024837

-1.0

Immune response and inflammation PIK3AP1

phosphoinositide-3-kinase adaptor protein 1

NM_152309

-0.6

TNFAIP8L3

tumor necrosis factor, alpha-induced protein 8-like 3 NM_207381

-0.6

SAMHD1

SAM domain and HD domain 1

NM_015474

-0.7

TAGAP

T-cell activation RhoGTPase activating protein

NM_054114

-0.7

CD55

CD55 molecule

NM_000574

-0.8

C1QTNFF7

C1q and tumor necrosis factor related protein 7

NM_031911

-0.9

MRC1L1

mannose receptor, C type 1-like 1

NM_001009567 -1.0

CD163

CD163 molecule

NM_004244

-1.1

CYBB

cytochrome b-245, beta polypeptide

NM_000397

-1.1

C1QTNF3

C1q and tumor necrosis factor related protein 3

NM_181435

-1.3

PON3

paraoxonase 3

NM_000940

0.7

DIO3

deiodinase, iodothyronine, type III

NM_001362

-0.8

ALDH1A1

aldehyde dehydrogenase 1 family member A1

NM_000689

-1.1

ALDH1A3

aldehyde dehydrogenase 1 family member A3

NM_000693

-1.2

Metabolism

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

Molecular transport SLCO2B1

solute carrier organic anion transporter family, member 2B1

NM_007256

-0.9

CP

ceruloplasmin

NM_000096

-1.0

LYVE1

lymphatic vessel endothelial hyaluronan receptor 1

NM_006691

-1.4

Signal transduction ALPK2

alpha-kinase 2

NM_052947

1.1

RET

ret proto-oncogene

NM_020975

1.1

AKAP13

A kinase (PRKA) anchor protein 13

NM_006738

-0.6

PIK3CG

phosphoinositide-3-kinase, catalytic, gamma polypeptide

NM_002649

-0.6

PLK3

polo-like kinase 3

NM_004073

-0.6

GEM

GTP binding protein overexpressed in skeletal muscle

NM_005261

-0.7

MERTK

c-mer proto-oncogene tyrosine kinase

U080823

-0.7

DACT2

dapper, antagonist of beta-catenin, homolog 2

NM_214462

-1.4

MUM1L1

melanoma associated antigen (mutated) 1-like 1

NM_152423

1.3

LSDP5

lipid storage droplet protein 5

NM_001013706 1.1

Miscellaneous

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

LOC404266

hypothetical LOC404266

BC010732

1.0

ART4

ADP-ribosyltransferase 4

NM_021071

-0.7

C5orf13

chromosome 5 open reading frame 13

NM_004772

-0.7

PLEKHA6

pleckstrin homology domain containing, family A member 6

NM_014935

-1.0

TMEM200A

transmembrane protein 200A

NM_052913

-1.0

ITM2A

intergal memebrane protein 2A

NM_004867

-1.1

The differentially expressed genes are classified into functional categories (given in alphabetical order) and listed according to their mean fold difference (MFD) within each category.

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

Supplementary Table 2. Genes differentially expressed in microarray in the dorsocervical vs. the abdominal s.c. adipose tissue in the cART+LD- group. Abbreviation Gene name

Accession no.

MDF

NM_206996

-1.3

Cytoskeleton SPAG17

sperm associated antigen 17

Organogenesis and regulation of transcription ZIC1

zic family member 1

NM_003412

3.8

ZIC4

zic family member 4

NM_032153

2.2

SHOX2

short stature homeobox 2

NM_006884

1.4

HAND2

heart and neural crest derivatives expressed 2

NM_021973

-1.4

HOXC9

homeobox C9

NM_006897

-2.0

HOXC8

homeobox C8

NM_022658

-2.1

HOXA10

homeobox A10

NM_018951

-2.2

macrophage scavenger reseptor 1

NM_138715

-1.3

flavin containing monooxygenase

NM_001002294 -0.9

Immune respons and inflammation MSR1

Metabolism FMO

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1

SUPPLEMENTARY DATA  

ALDH1A1

aldehyde dehydrogenase 1 family member A1

NM_000689

-1.3

alpha-kinase 2

NM_052947

1.4

chromosome 18 open reading frame 34

NM_001105528 -1.1

Signal transduction ALPK2

Miscellaneous C18orf34

The differentially expressed genes are classified into functional categories (given in alphabetical order) and listed according to their mean fold difference (MFD) within each category.

©2011 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-0075/-/DC1