Supplementary Information Epigenetic regulation of the circadian gene Per1 in the hippocampus contributes to agerelated changes in memory and synaptic plasticity Kwapis et al.
Supplementary Figure 1. Genetic deletion or activity-specific disruption of HDAC3 in the dorsal hippocampus of aging mice. (a) Representative immunofluorescence images of HDAC3 (green) expression in HDAC3+/+ and HDAC3flox/flox mice injected with AAV2.1-CaMKII-Cre. Cell bodies were counterstained with a fluorescent Nissl stain (NeuroTrace, red). Right: mean intensity of HDAC3 immunofluorescence sampled from CA1 (normalized to background). HDAC3 expression was significantly reduced in HDAC3flox/flox mice compared to HDAC3+/+ controls (t(30)=8.45, ***p
