Supplementary information - Stanford University

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EPM score in light-off epoch: p
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doi:10.1038/nature12018

Statistical Analysis Fig 1a. n = 5 for each group. p 0.05), (b) inhibiting BNST somata (n = 10 for exp; n = 11 for controls; p > 0.05), (c) stimulating BNST somata (n = 6 for exp; n = 6 for controls; p > 0.05), (d) inhibiting the ovBNST (n = 8 for exp; n = 8 for controls; p > 0.05), (e) stimulating ovBNST (n = 7 for exp; n = 7 for controls; p > 0.05), (f) inhibiting BLA fibers in the adBNST (n = 11 for exp; n = 11 for controls; p > 0.05), (g) stimulating BLA fibers in the adBNST (n = 8 for exp; n = 8 for controls; p > 0.05), (h) stimulating adBNST fibers in the LH (n = 11 for exp; n = 8 for controls; p > 0.05), (i) stimulating BNST fibers in the PB (n = 8 for exp; n = 7 for controls; p > 0.05) or (j) stimulating adBNST fibers in the VTA (n = 8 for exp; n = 7 for controls; p > 0.05) had no detectable effect on mean locomotion speed. Values are mean ± s.e.m. WWW.NATURE.COM/NATURE | 28

RESEARCH SUPPLEMENTARY INFORMATION

doi:10.1038/nature12018



Supplementary Figure 5. Functional heterogeneity in the BNST in anxiety paradigms. Yellow light in eNpHR3.0:BNST somata mice increased center time in the OFT (a) and open-arm entry probability in the EPM (b). Yellow light in eNpHR3.0:ovBNST mice increased center time in the OFT (c) and open-arm entry probability in the EPM (d). Yellow light in eNpHR3.0:BLA-adBNST mice reduced center time in the OFT (e) and open-arm entry probability in the EPM (f). Values are mean ± s.e.m. *, ** and *** indicate p