Up-regulated Genes in Intestinal Epithelial Crypts in Aged H2bâIEC Micea. aSignificantly (P < .05) up-regulated genes from isolated epithelial crypts of H2bÎIEC ...
Supplementary Tables Legends Supplementary Table 1. Up-regulated Genes in Intestinal Epithelial Crypts in Aged H2b∆IEC Micea Significantly (P < .05) up-regulated genes from isolated epithelial crypts of H2bΔIEC were compared with
a
epithelial crypts from H2bfl/fl mice; “padj” is the P value adjusted using the Benjamini-Hochberg method.
Supplementary Table 2. Down-regulated Genes in Intestinal Epithelial Crypts in Aged H2b∆IEC Micea Significantly (P < .05) down-regulated genes from isolated epithelial crypts of H2bΔIEC were compared
a
with those from epithelial crypts from H2bfl/fl mice; “padj” is the P value adjusted using the BenjaminiHochberg method.
Supplementary Table 3. Up-regulated Genes in Small Intestinal Organoids From H2b/p53∆IEC Compared With H2b∆IEC Micea Significantly (P < .05) up-regulated genes in H2b/p53ΔIEC small intestinal organoids were compared with
a
those from H2bΔIEC small intestinal organoids; “padj” is the P value adjusted using the BenjaminiHochberg method.
Supplementary Table 4. Down-regulated Genes in Small Intestinal Organoids From H2b/p53∆IEC Compared With H2b∆IEC Micea Significantly (P < .05) down-regulated genes in H2b/p53ΔIEC small intestinal organoids were compared
a
with those from H2bΔIEC small intestinal organoids; “padj” is the P value adjusted using the BenjaminiHochberg method.
Supplementary Table 5. Up-regulated Genes in Small Intestinal Tumors From H2b/p53∆IEC Compared With Adjacent Nontumor Tissuea a
Significantly (P < .05) up-regulated genes from small intestinal tissue (tumor vs nontumor) were isolated
from H2b/p53ΔIEC mice; “padj” is the P value adjusted using the Benjamini-Hochberg method.
Supplementary Table 6. Down-regulated Genes in Small Intestinal Tumors From H2B/p53∆IEC Compared With Adjacent Nontumor Tissuea a
Significantly (P < .05) down-regulated genes from small intestinal tissue (tumor vs nontumor) were
isolated from H2b/p53ΔIEC mice; “padj” is the P value adjusted using the Benjamini-Hochberg method.
Supplementary Table 7. List of Exonic, Somatic InDelsa a
Table includes all exonic, somatic InDels that were called in the tumor sample but not in the
corresponding liver or nontumor samples.
Supplementary Table 8. List of Exonic, Somatic SNVsa a
Table includes all exonic, somatic SNVs that were called in the tumor sample but were supported by
fewer than 5% of the reads at this position in the corresponding liver and nontumor samples.
Supplementary Table 9. Tumor Mutations From COSMIC Databasea a
Somatic RNase H2 tumor variants in all 3 subunits were extracted from the COSMIC database based on
sample frequency (with 4 being the highest number of affected tumor samples), tumor site (mutations in gastrointestinal tract tumors were favored), or structural reasons (eg, the RNASEH2A R280G variant was chosen because the mutation is located within the RNASEH2A C-terminus, which is crucial for RNase H2 complex formation).
Supplementary Table 10. Clinical Characteristics of 122 Tumor Samplesa a
Clinical characteristics of 122 CRC paired tumor samples were assessed and correlated with the
expression of RNASEH2A expression in tumor samples.
