Atypical glandular cells. AGC. M69720. Low-grade squamous intraepithelial lesion. LSIL. Atypical squamous cells of undetermined significance ASCUS ... event counts, incidence rates and incidence rate ratios for incident cervical cancer (all ...
Appendix 1: Supplementary tables [as supplied by author] Table A: SNOMED codes for cytological diagnoses in the study, defined by Swedish Association for Clinical Cytology Cytological diagnosis
Abbreviation
SNOMED code
Normal cytology
--
M00110
Atypical glandular cells
AGC
M69720
Low-grade squamous intraepithelial lesion
LSIL
Atypical squamous cells of undetermined significance
ASCUS
M69710
Mild squamous dysplasia
LSIL
M74006
High-grade squamous intraepithelial lesion
HSIL
Suspected high-grade squamous dysplasia
ASC-H
M69719
Moderate squamous dysplasia
HSIL
M74007
Severe squamous dysplasia
HSIL
M80702
Squamous cell cancer
SCC
M80703
Table B: Age-specific event counts, incidence rates and incidence rate ratios for incident cervical cancer (all histopathologies) following HSIL and LSIL, by follow-up time Age at abnormality HSIL vs Normal Age 23-29 Age 30-39 Age 40-49 Age 50-59 LSIL vs Normal Age 23-29 Age 30-39 Age 40-49 Age 50-59 a. b. c.
0.5 to 3.5 years Na IRb
IRR (95%CI) c
3.5 to 6.5 years N IR IRR (95%CI)
6.5 to 10.5 years N IR IRR (95%CI)
10.5 to 15.5 years N IR IRR (95%CI)
38 76 45 19
58.2 123.6 145.4 139.3
7.1 (5.5 to 9.2) 14.0 (11.5 to 17.2) 18.3 (14.5 to 23.2) 24.1 (17.9 to 32.4)
9 19 18 12
16.4 36.6 69.0 103.5
2.8 (2.0 to 3.9) 5.5 (4.1 to 7.4) 7.2 (5.2 to 9.9) 9.4 (6.5 to 13.6)
19 27 16 10
31.4 47.9 55.3 78.1
3.2 (2.4 to 4.3) 6.3 (4.8 to 8.2) 8.2 (6.1 to 11.1) 10.8 (7.6 to 15.3)
16 23 13 11
29.0 45.0 48.3 97.8
3.1 (2.3 to 4.3) 6.1 (4.6 to 8.1) 8.0 (5.9 to 10.9) 10.5 (7.3 to 15.1)
82 141 85 39
32.4 78.1 60.8 47.4
4.6 (3.9 to 5.4) 9.6 (8.3 to 11.0) 6.7 (5.7 to 8.0) 5.9 (4.7 to 7.4)
43 87 41 22
21.0 57.8 35.0 31.3
3.1 (2.6 to 3.8) 6.5 (5.5 to 7.7) 4.6 (3.8 to 5.6) 4.0 (3.2 to 5.1)
61 79 36 16
28.4 49.4 28.4 21.0
2.9 (2.4 to 3.5) 6.1 (5.2 to 7.2) 4.3 (3.5 to 5.3) 3.8 (3.0 to 4.8)
61 55 31 21
32.8 39.1 27.2 33.7
3.0 (2.5 to 3.6) 6.2 (5.2 to 7.4) 4.4 (3.6 to 5.4) 3.8 (3.0 to 4.9)
Number of cervical cancer cases Observed incidence rate, per 100 000 person-years Incidence rate ratio and 95% confidence interval, relative to women with normal cytology, adjusted for attained age
Table C: Percentage of histology assessment, prevalent and incident cervical cancer (all histopathologies) by abnormality and calendar period N of abnormality
AGC 1980-1992 1993-1997 1998-2002 2003-2007 2008-2011 HSIL 1980-1992 1993-1997 1998-2002 2003-2007 2008-2011 LSIL 1980-1992 1993-1997 1998-2002 2003-2007 2008-2011 a. b. c.
Histology assessment in six months % p-value for trend
