Supplementation with carnitine reduces the

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Mar 1, 2017 - the Society for Free Radical Research Japan. Kyoto ... correlation between level of free carnitine and severity of consti ..... Cerebral palsy. 36.
Original Article Journal JCBN the 1880-5086 0912-0009 Kyoto, Original 10.3164/jcbn.16-52 jcbn16-52 Society Japan ofArticle Clinical for FreeBiochemistry Radical Research and Nutrition Japan Supplementation with carnitine reduces the severity of constipation: a retrospective study of patients with severe motor and intellectual disabilities Shinya Murata,1,* Keisuke Inoue,1 Tomoki Aomatsu,2 Atsushi Yoden2 and Hiroshi Tamai2 1 2

Department of Pediatrics, Hirakata City Hospital, 2141 Kinyahonmachi, Hirakata, Osaka 5731013, Japan Department of Pediatrics, Osaka Medical College, 27 Daigakumachi, Takatsuki, Osaka 5698686, Japan

(Received 10 June, 2016; Accepted 21 July, 2016; Published online 1 March, 2017) 3

Carnitine is an for the mitochondrial transport vided Creative stricted Copyright This 2017 the isuse, original an Commons open distribution, © essential 2017 work access JCBN Attribution isnutrient article and properly reproduction distributed License, cited. under which in anythe permits medium, terms of unreprothe of fatty acids. Carnitine deficiency causes a variety of symptoms in multiple organs. Patients with severe motor and intellectual disabilities often have carnitine deficiency. This study aimed to determine the correlation between constipation and carnitine deficiency in them. Patients with severe motor and intellectual disabilities at our hospital were retrospectively reviewed. The correlation between level of free carnitine and severity of consti pation was examined. Constipation and nonconstipation groups were compared for age; sex; body mass index; bed rest period; use of antiepileptic drugs, valproate sodium, or enteral nutrition; and serum levels of albumin, prealbumin, totalcholesterol, free carnitine, folic acid, and trace elements. Moreover, severity of constipation before and after carnitine supplementation was assessed. Twentyseven patients were enrolled. Of these, 14 were assigned to the constipation group and 13 to the nonconstipation group. The free carnitine level was significantly correlated with severity of constipation (R = 0.7604, p