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S7 Determination of the generation of singlet oxygen of [email protected] through the absorption of DPBF upon irradiation by laser at 633 nm for 0 min, ...

Supporting Information Construction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles

Jia Wen 1, Kui Yang 1, Yongqian Xu 1, Hongjuan Li 1, Fengyu Liu2,* and Shiguo Sun1,* 1

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest

A&F University, Yangling, Shaanxi 712100, People’s Republic of China 2

State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology,

No.2 linggong Road, Ganjingzi, District, Dalian 116023, People’s Republic of China

*Corresponding author: Fengyu Liu ([email protected]) Shiguo Sun ([email protected])

Table of contents

Fig. S1 ....................................................................................................................................... 2 Fig. S2 ....................................................................................................................................... 2 Fig. S3 ....................................................................................................................................... 3 Fig. S4 ....................................................................................................................................... 3 Fig. S5 ....................................................................................................................................... 4 Fig. S6 ....................................................................................................................................... 5 Fig. S7 ....................................................................................................................................... 5

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Fig. S1

Fig. S1 SEM micrographs of (a) MSN-HP and (b) MSN-HP-DOX.

Fig. S2

Fig. S2 HRTEM micrographs of (a) MSN-HP and (b) MSN-HP-DOX.

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Fig. S3

Fig. S3 EDX spectrum of (a) MSN; (b) MSN-HP ; (c) MSN-HP-DOX; (d) [email protected]

Transmittance (%)

Fig. S4

MSN [email protected]

4000

3500

3000

2500

2000

1500

1000

500

Wavenumber (cm-1)

Fig. S4 FTIR spectra of MSN and [email protected]

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Fig. S5

0.5

b) 0.5

0.4

0.4

Absorbance

Absorbance

a)

0.3 0.2 0.1

0.3 0.2 0.1

0.0 300

400

500

600

0.0 300

700

400

c) 0.5

d)

Absorbance

Absorbance

0.4 0.3 0.2

700

0.5 0.4 0.3 0.2

0.0

0.0 300

400

500

600

300

700

400

0.5

f)

600

700

1.5 1.2

Absorbance

0.4 0.3 0.2 0.1

0.9 0.6 0.3

0.0 300

500

Wavelength (nm)

Wavelength (nm)

Absorbance

600

0.1

0.1

e)

500

Wavelength (nm)

Wavelength (nm)

400

500

600

0.0 200

700

Wavelength (nm)

300

400

500

600

700

Wavelength (nm)

Fig. S5 Absorbance spectrum of MSN (a), MSN-HP (b), MSN-HP-DOX (c), [email protected] (d), HP (e) and DOX (f).

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Fig. S6 400

300

200

100

0 550

600

650

800

b)

A B C D E

Fluorescence Intensity (a.u.)

Fluorescence Intensity (a.u.)

a)

A B

600

400

200

700

0 500

550

Wavelength (nm)

Fig. S6

600

650

700

Wavelength (nm)

(a) Emission spectra of MSN-HP (A), MSN-HP-DOX (B), MSN-HP -DOX with the addition of GSH (C),

[email protected] without the addition of GSH and irradiation (D), [email protected] with the addition of GSH and irradiation (E) λex = 480 nm. (b) Emission spectra of HP (A) and DOX (B) λex = 480 nm.

Fig. S7

Absorption

0.3

0.2 laser

0.1

0.0 300

400

500

600

700

800

Wavelength (nm) Fig. S7 Determination of the generation of singlet oxygen of [email protected] through the absorption of DPBF upon irradiation by laser at 633 nm for 0 min, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 35 min, 40 min, 45 min, 50 min, 55 min, 60 min, 70 min, 80 min, 90 min and 120 min).

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