Supporting Information Table S2 - PLOS

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0.36. 0.35. 0.34. 0.49. 0.42. 0.78. 0.80. 0.51. 0.27. 0.41. 0.29. 0.27. 0.42. 0.32 rs4836493. Chr 5,. 129,499,621. CSS3. GWAS. A/G. 0.11/0.07. Allelic. Additive.
Supporting Information Table S2. Validation study results: SNP associations with ventricular dysfunction after primary coronary artery bypass graft surgery in 786 European ancestry men from the CABG Genomics Study Cohort. (63 SNPs were selected from 34 genetic loci identified to be associated with ventricular dysfunction in the GWAS) SNP

Chr #, Location NCBI hg36

Gene

GWAS or Additional SNP

Minor Allele/ Major Allele

rs7549755

Chr 1, 91,930,396

TGFBR3

GWAS

C/T

MAF VnD Cases (n=71)*/ Controls (n=715) 0.32/0.21

T/C

GWAS 0.33/0.19 0.08/0.11

rs2765888

rs6690388

rs6426944

rs1702176

rs2798601

rs1013219

rs12744134

rs10752878

Chr 1, 91,934,880

Additional

Chr 1, 153,041,071

KCNN3

Chr 1, 153,043,036

KCNN3

Chr 1, 153,043,781

KCNN3

Chr 1, 153,046,309

KCNN3

Chr 1, 175,479,499

FAM5B

Chr 1, 175,490,296

FAM5B

Chr 1, 180,848,998

RGS16

Additional

Additional

Additional

GWAS

Additional

GWAS

GWAS

C/T

A/G

T/C

0.30/0.20

0.37/0.25

0.25/0.27

A/G

0.30/0.18

A/G

GWAS 0.29/0.16 0.36/0.40

A/G

0.11/0.23

G/T

GWAS 0.11/0.25 0.25/0.14 GWAS 0.27/0.13

1

Genetic Model

Unadjusted Odds Ratio

Univariate Asymptotic P value

Univariate Permuted Point-wise P value

Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive

1.78 1.81 2.23 1.67 0.68 0.68 0.63 1.25 1.78 1.75 2.16 1.62 1.76 1.77 2.35 1.56 0.94 0.94 1.03 0.54 1.94 1.92 2.16 2.66 0.85 0.85 1.10 0.38 0.42 0.42 0.43 2.09 1.98 2.16 3.38

0.002 0.002 0.002 0.30 0.24 0.24 0.19 0.83 0.003 0.004 0.002 0.33 0.002 0.002 0.001 0.30 0.74 0.74 0.90 0.31 0.0006 0.0009 0.002 0.04 0.38 0.38 0.72 0.04 0.001 0.002 0.004 1.00 0.0003 0.0007 0.003 0.01

0.003 0.003 0.002 0.31 0.26 0.26 0.17 0.37 0.002 0.003 0.001 0.31 0.002 0.002 0.001 0.26 0.78 0.71 0.98 0.23 0.001 0.001 0.002 0.04 0.43 0.42 0.73 0.03 0.001 0.0008 0.003 0.98 0.0006 0.0008 0.002 0.01

MV Adjusted Odds Ratio

MV Adjusted Asymptotic P value

MV Adjusted Point-wise P value

1.65 2.14 1.16

0.02 0.005 0.78

0.02 0.005 0.75

0.84 0.77 1.96

0.61 0.48 0.54

0.61 0.50 0.20

1.70 2.24 1.20

0.01 0.003 0.74

0.008 0.002 0.62

1.81 2.12 2.00

0.005 0.007 0.15

0.006 0.007 0.12

0.83 0.87 0.53

0.41 0.61 0.32

0.41 0.62 0.33

1.95 2.11 2.92

0.003 0.006 0.05

0.002 0.004 0.04

0.81 1.01 0.36

0.28 0.97 0.04

0.27 1.00 0.04

0.39 0.39 -

0.002 0.003 1.00

0.001 0.002 0.98

2.10 2.29 3.86

0.001 0.003 0.02

0.0008 0.004 0.01

rs1287820

rs7646796

rs7430827

rs17691914

Chr 1, 180,855,954

GWAS

Chr 3, 6,615,547

Additional

Chr 3, 6,617,993

GWAS

Chr 3, 34,937,807

GWAS

G/C

0.32/0.20

T/C

GWAS 0.34/0.20 0.45/0.43

C/A

0.42/0.36

G/A

GWAS 0.42/0.34 0.19/0.08 GWAS 0.21/0.07

rs9835451

rs17358517

rs17061085

rs6774674

rs6766797

rs9863767

rs9831754

rs9837024

2

Chr 3, 34,946,568

Chr 3, 59,660,772

GWAS

GWAS

Chr 3, 59,666,765

Additional

Chr 3, 67,263,367

Additional

Chr 3, 67,266,318

GWAS

Chr 3, 75,164,647

Chr 3, 78,436,281

Chr 3,

GWAS

GWAS

GWAS

G/A

0.22/0.11

T/C

GWAS 0.23/0.11 0.38/0.23

A/G

GWAS 0.38/0.22 0.26/0.13

C/T

0.32/0.39

A/T

0.27/0.36

A/C

GWAS 0.24/0.41 0.33/0.22

G/T

GWAS 0.34/0.20 0.29/0.20

G/A

GWAS 0.30/0.18 0.36/0.22

Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive

1.96 2.00 2.19 3.02 1.08 1.07 0.79 1.66 1.29 1.28 0.86 2.76 2.74 2.74 3.53 -

Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic

2.17 2.14 2.76 0.77 2.07 2.07 2.57 2.52 2.42 2.04 2.69 2.59 0.71 0.71 0.62 0.72 0.64 0.63 0.51 0.75 1.72 1.79 1.88 2.68 1.65 1.67 1.53 3.82 1.99

0.0004 0.0004 0.002 0.01 0.68 0.69 0.36 0.07 0.16 0.17 0.53 0.0004 -6 9.3X10 -5 2.7X10 6 2.2X101.00 0.0003 0.0005 -5 8.1X10 0.80 -5 5.8X10 -5 9.6X10 0.0003 0.02 1.2X10-5 0.0001 0.0001 0.03 0.07 0.07 0.05 0.39 0.02 0.02 0.007 0.49 0.004 0.003 0.01 0.03 0.01 0.01 0.09 0.002 0.0002

0.001 0.0004 0.001 0.02 0.72 0.71 0.36 0.07 0.17 0.16 0.62 0.001