0.36. 0.35. 0.34. 0.49. 0.42. 0.78. 0.80. 0.51. 0.27. 0.41. 0.29. 0.27. 0.42. 0.32 rs4836493. Chr 5,. 129,499,621. CSS3. GWAS. A/G. 0.11/0.07. Allelic. Additive.
Supporting Information Table S2. Validation study results: SNP associations with ventricular dysfunction after primary coronary artery bypass graft surgery in 786 European ancestry men from the CABG Genomics Study Cohort. (63 SNPs were selected from 34 genetic loci identified to be associated with ventricular dysfunction in the GWAS) SNP
Chr #, Location NCBI hg36
Gene
GWAS or Additional SNP
Minor Allele/ Major Allele
rs7549755
Chr 1, 91,930,396
TGFBR3
GWAS
C/T
MAF VnD Cases (n=71)*/ Controls (n=715) 0.32/0.21
T/C
GWAS 0.33/0.19 0.08/0.11
rs2765888
rs6690388
rs6426944
rs1702176
rs2798601
rs1013219
rs12744134
rs10752878
Chr 1, 91,934,880
Additional
Chr 1, 153,041,071
KCNN3
Chr 1, 153,043,036
KCNN3
Chr 1, 153,043,781
KCNN3
Chr 1, 153,046,309
KCNN3
Chr 1, 175,479,499
FAM5B
Chr 1, 175,490,296
FAM5B
Chr 1, 180,848,998
RGS16
Additional
Additional
Additional
GWAS
Additional
GWAS
GWAS
C/T
A/G
T/C
0.30/0.20
0.37/0.25
0.25/0.27
A/G
0.30/0.18
A/G
GWAS 0.29/0.16 0.36/0.40
A/G
0.11/0.23
G/T
GWAS 0.11/0.25 0.25/0.14 GWAS 0.27/0.13
1
Genetic Model
Unadjusted Odds Ratio
Univariate Asymptotic P value
Univariate Permuted Point-wise P value
Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive
1.78 1.81 2.23 1.67 0.68 0.68 0.63 1.25 1.78 1.75 2.16 1.62 1.76 1.77 2.35 1.56 0.94 0.94 1.03 0.54 1.94 1.92 2.16 2.66 0.85 0.85 1.10 0.38 0.42 0.42 0.43 2.09 1.98 2.16 3.38
0.002 0.002 0.002 0.30 0.24 0.24 0.19 0.83 0.003 0.004 0.002 0.33 0.002 0.002 0.001 0.30 0.74 0.74 0.90 0.31 0.0006 0.0009 0.002 0.04 0.38 0.38 0.72 0.04 0.001 0.002 0.004 1.00 0.0003 0.0007 0.003 0.01
0.003 0.003 0.002 0.31 0.26 0.26 0.17 0.37 0.002 0.003 0.001 0.31 0.002 0.002 0.001 0.26 0.78 0.71 0.98 0.23 0.001 0.001 0.002 0.04 0.43 0.42 0.73 0.03 0.001 0.0008 0.003 0.98 0.0006 0.0008 0.002 0.01
MV Adjusted Odds Ratio
MV Adjusted Asymptotic P value
MV Adjusted Point-wise P value
1.65 2.14 1.16
0.02 0.005 0.78
0.02 0.005 0.75
0.84 0.77 1.96
0.61 0.48 0.54
0.61 0.50 0.20
1.70 2.24 1.20
0.01 0.003 0.74
0.008 0.002 0.62
1.81 2.12 2.00
0.005 0.007 0.15
0.006 0.007 0.12
0.83 0.87 0.53
0.41 0.61 0.32
0.41 0.62 0.33
1.95 2.11 2.92
0.003 0.006 0.05
0.002 0.004 0.04
0.81 1.01 0.36
0.28 0.97 0.04
0.27 1.00 0.04
0.39 0.39 -
0.002 0.003 1.00
0.001 0.002 0.98
2.10 2.29 3.86
0.001 0.003 0.02
0.0008 0.004 0.01
rs1287820
rs7646796
rs7430827
rs17691914
Chr 1, 180,855,954
GWAS
Chr 3, 6,615,547
Additional
Chr 3, 6,617,993
GWAS
Chr 3, 34,937,807
GWAS
G/C
0.32/0.20
T/C
GWAS 0.34/0.20 0.45/0.43
C/A
0.42/0.36
G/A
GWAS 0.42/0.34 0.19/0.08 GWAS 0.21/0.07
rs9835451
rs17358517
rs17061085
rs6774674
rs6766797
rs9863767
rs9831754
rs9837024
2
Chr 3, 34,946,568
Chr 3, 59,660,772
GWAS
GWAS
Chr 3, 59,666,765
Additional
Chr 3, 67,263,367
Additional
Chr 3, 67,266,318
GWAS
Chr 3, 75,164,647
Chr 3, 78,436,281
Chr 3,
GWAS
GWAS
GWAS
G/A
0.22/0.11
T/C
GWAS 0.23/0.11 0.38/0.23
A/G
GWAS 0.38/0.22 0.26/0.13
C/T
0.32/0.39
A/T
0.27/0.36
A/C
GWAS 0.24/0.41 0.33/0.22
G/T
GWAS 0.34/0.20 0.29/0.20
G/A
GWAS 0.30/0.18 0.36/0.22
Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive
1.96 2.00 2.19 3.02 1.08 1.07 0.79 1.66 1.29 1.28 0.86 2.76 2.74 2.74 3.53 -
Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic Additive Dominant Recessive Allelic
2.17 2.14 2.76 0.77 2.07 2.07 2.57 2.52 2.42 2.04 2.69 2.59 0.71 0.71 0.62 0.72 0.64 0.63 0.51 0.75 1.72 1.79 1.88 2.68 1.65 1.67 1.53 3.82 1.99
0.0004 0.0004 0.002 0.01 0.68 0.69 0.36 0.07 0.16 0.17 0.53 0.0004 -6 9.3X10 -5 2.7X10 6 2.2X101.00 0.0003 0.0005 -5 8.1X10 0.80 -5 5.8X10 -5 9.6X10 0.0003 0.02 1.2X10-5 0.0001 0.0001 0.03 0.07 0.07 0.05 0.39 0.02 0.02 0.007 0.49 0.004 0.003 0.01 0.03 0.01 0.01 0.09 0.002 0.0002
0.001 0.0004 0.001 0.02 0.72 0.71 0.36 0.07 0.17 0.16 0.62 0.001