Accepted Manuscript Title: Swelling and deswelling kinetics of polyvinyl alcohol and lactic acid hydrogel films Author: Natawat Chankana, Chitradee Luprasong, Chaowalit Monton, Jirapornchai Suksaeree PII: DOI: Reference:
S1818-0876(15)00267-6 http://dx.doi.org/doi: 10.1016/j.ajps.2015.11.104 AJPS 329
To appear in:
Asian Journal of Pharmaceutical Sciences
Please cite this article as: Natawat Chankana, Chitradee Luprasong, Chaowalit Monton, Jirapornchai Suksaeree, Swelling and deswelling kinetics of polyvinyl alcohol and lactic acid hydrogel films, Asian Journal of Pharmaceutical Sciences (2015), http://dx.doi.org/doi: 10.1016/j.ajps.2015.11.104. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Swelling and deswelling kinetics of polyvinyl alcohol and lactic acid hydrogel films Natawat Chankana *, a, b, Chitradee Luprasongb, Chaowalit Monton a, and Jirapornchai Suksaeree a, c a
The Herbal Medicinal Products Research and Development Center (Cooperation between
Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine) b c
Sun Herb Thai Chinese Manufacturing Plant
Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani 12000, Thailand *E-mail:
[email protected] In this study, we studied the swelling and deswelling kinetics of polyvinyl alcohol (PVA) and lactic acid (LA) hydrogel films between distilled water and acetone phase. The hydrogel films were prepared by dissolve 5.0 g of PVA in hot water. Then, 7.5 g LA solution was slowly added into the clearly PVA solution at room temperature. After that, the mixture solution was subsequently cured in an oven for different curing times at 100ºC. The swelling and deswelling kinetics of hydrogel films were determined by immerse the hydrogel films in distilled water and acetone at room temperature. The hydrogel films were weighted at different time (Wt). The swelling and deswelling were calculated in terms of the relative hydrogel volume (Vrel) using this equation when W was its equilibrated swollen weight of hydrogel films in distilled water [1].
V rel
W t W
3
Fig. 1 shows the swelling and deswelling kinetics of hydrogel films, the initial swollen hydrogel films volume began at 1 value of Vrel. They could be recovered after collapsing the hydrogel films in acetone within 20-30 min (Vrel = 0). However, all hydrogel films quickly swell within 50 min, but they could not attain to its initial volume (Vrel = 1) after transferring to distilled water again. Second cycle, this process required much shorter times (not more than 20 min) than those of the corresponding hydrogel films. The surface of hydrogel films would be initially large by start to relax formation after immersed in distilled water, water absorption of the hydrogel films occured easily. However, the mixing time and curing time not significantly affected on swelling and deswelling process. The swelling and deswelling kinetics were very important. They would be used to prepare the pharmaceutical formulation and controlled drug release. Keywords: Hydrogel films, swelling, deswelling
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Acknowledgements The authors acknowledge the financial support received from Council for the Research Institute of Rangsit University (Grant no.07/2557).
Reference [1] Ceylan D, Ozmen MM, Okay O. Swelling–deswelling kinetics of ionic poly(acrylamide) hydrogels and cryogels. J Appl Polym Sci 2006;99 (1):319-25.
Fig. 1.Swelling and deswelling kinetics of hydrogel films (PM1, 2, 3 mixed for 30 min, PM4, 5, 6 mixed time for 60 min, and PM7, 8, 9 mixed for 90 min with curing time for 120, 150, and 180 min, respectively at 100C)
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