Synthesis and characterization of high catalytic

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Synthesis and characterization of high catalytic activity magnetic Fe3O4 supported. Pd (II), as a green ... heterogeneous catalysis. ... Conclusion: In the present paper, we summarized the application of a nanomagnetic catalyst of ... addition due to its function in the water, it adheres to the principles of green chemistry, and,.
Synthesis and characterization of high catalytic activity magnetic Fe3O4 supported Pd (II), as a green and efficient nanocatalyst for the Suzuki-Miyaura cross-coupling reaction in water Firouz Matloubi Moghaddama*, Ashkan Karimia, Seyed Ebrahim Ayatia a

Laboratory of organic synthesis and natural products, Chemistry department, Sharif University, Tehran, Iran

[email protected]

Introduction: Transition metals play an essential roles in cross-coupling reactions [1]. The Suzuki reaction between aryl halides and aryl bronic acid is one of the important and widely used procedures for the synthesis of molecules containing biphenyl moiety, which is found in many fine chemicals and biologically active compounds [2], [3]. This work reports a green and high yield protocol for the Suzuki reaction. Here, a nanomagnetic catalyst based on Palladium with 2-amino pyridine ligand has been used for the Suzuki reaction at room temperature and in water. Also, a very promising result was observed for oxidation and Sonogashira reaction. Experimental: The overall fabrication strategy is shown in Scheme 1. The silica-coated magnetic nanoparticles were synthesized according to the procedure reported elsewhere in the literature [4]. The silica-coated magnetic nanoparticles were used to synthesize [MNPs@2-aminopy][Cl] nanoparticles. The catalyst was fully characterized by FT-IR, TGA, CHN, SEM, EDX, and atomic absorption spectroscopy. Also DFT method was employed for electronic and structural studies. The synthesized catalyst was used in the synthesis of different derivatives of biphenyl systems. The optimized condition was identified by GC.

Scheme 1 Results and discussion: The surface morphology of the synthesized nanoparticles was observed by SEM. Fig. 1 shows uniform sized spherical particles with slight aggregation and a mean particle size of 20–25 nm. Atomic absorption spectroscopy (AAS) analysis of the catalyst showed the amount of palladium loaded on the magnetic nanoparticles was about 0.80 mmol g-1. In addition to its recyclability, its air and moisture-stable properties other important aspects of this new heterogeneous catalysis. We evaluated optimized reaction condition at room temperature and in

water. The reaction of phenyl bronic acid and para bromo toluene was fully converted after 4 hours. In general, the yields of the reactions in all cases were excellent and were completed in moderately low reaction times.

Fig. 1

Conclusion: In the present paper, we summarized the application of a nanomagnetic catalyst of Pd in the Suzuki reaction. This catalyst can not only catalyze the reaction with high yields, in addition due to its function in the water, it adheres to the principles of green chemistry, and, furthermore, because of its magnetic property it can easily be separated from the reaction medium by using an external magnet. References [1] T. Hayashi, M. Konishi, Y. Kobori, M. Kumada, T. Higuchi, K. Hirotsu, J. Am. Chem. Soc.1984, 106, 158 – 163. [2] R. Chinchilla, C.Miyaura, Norio; Yamada, Kinji; A. Suzuki, Tetrahedron Lett. 1979, 20, 3437– 3440. [3] A. Chatterjee, T. R. Ward, Catalysis Lett, 2016, 146, 820–840 [4] A. Pourjavadi, S. H. Hosseini, S. T. Hosseini, S. A. Aghayee Meibody, Catal. Commun. 2012, 28, 86-89