by the Singapore-MIT Alliance. T.A. Hatton is ..... and G. Storm, â Comparitive transfection studied of human ovarian ... from the University of Wisconsin, Madison. He has ... in gene and oligonucleotide therapy against cancerâ, Adv. Drug Deliv.
Synthesis and Properties of Novel Cationic, Temperature-Sensitive Block-Copolymers Smeet Deshmukh, Lev Bromberg, and T. Alan Hatton Department of Chemical Engineering Massachusetts Institute of Technology, Cambridge, MA 02139
Abstract—Facile, one-step synthesis of self-assembling, cationic block copolymers of poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and PEO-PPO-PEO (Pluronic®) is developed. The copolymers are obtained via free-radical polymerization of DMAEMA initiated by Pluronic-radicals generated by cerium (IV). The copolymers possess surface activity, are polycationic at pH
