Table S1 Proteins with predicted extracellular ...

Table S1 Proteins with predicted extracellular localization produced by soil bacterial community during growth in minimal medium supplemented with suberin, from 5 to 60 days UniProt or UniRef accession number

Bacterial species

Amino acid metabolism A3KZ66 a,b Pseudomonas spp.

Abundance (NSpC)

Putative function

Pvds-regulated endoprotease

5d

10 d

20 d

30 d

60 d

-c

0.67

0.80

0.73

-

0.03

-

-

-

-

0.15

-

-

-

-

b

Pseudomonas spp.

dihydroxy-acid dehydratase

C3K6V7 b

Pseudomonas spp.

protease

C3K907

Pseudomonas fluorescens

protease

0.08

-

-

-

-

E1T7C4

Burkholderia sp.

ArgE, acetylornithine deacetylase

-

0.04

-

-

-

F2LE35

Burkholderia gladioli

protease

-

0.12

-

-

-

J2YKE9

Pseudomonas sp.

dipeptidase

0.06

-

-

-

-

P34816

Pseudomonas syringae

tryptophan synthase

0.11

-

-

-

-

-

0.11

-

-

-

0.03

-

-

-

-

-

-

0.08

-

-

0.29

0.09

-

-

-

0.22

-

-

-

-

-

-

-

0.11

0.33

-

-

-

-

0.03

0.19

-

-

-

-

-

0.53

-

-

-

0.13

0.61 0.04

-

-

-

0.20

-

-

-

-

0.05

-

-

-

-

0.33

-

-

-

-

0.06

-

-

-

-

0.06

-

-

-

-

-

0.16

-

-

-

2.11

1.11

-

-

-

0.10

-

-

-

-

0.10

-

-

-

-

-

-

-

0.56

-

0.78

-

-

-

-

C3K3P0

Carbohydrate metabolism A3ML77 a,b Burkholderia spp.

enolase

C3K5I7


malate:quinone oxidoreductase

C9ZE95

Streptomyces scabiei

xylanase A

UPI000289064F

Pseudomonas sp.

malic enzyme

Cell wall, membrane and envelope biogenesis A6BTB9 a,b Yersinia spp. A8F2R2 b

Rickettsia spp.

A9W4H1 b

Methylobacterium spp.

peptidoglycan-associated lipoprotein peptidoglycan-associated lipoprotein BamA

A9Z1A5

Acinetobacter baumannii

outer membrane protein A

B1FWC4 b

Burkholderia spp.

B2JGA1 b

Burkholderia spp.

C3JYS2 b C3K1L1

Pseudomonas spp. Pseudomonas fluorescens

peptidoglycan-associated lipoprotein peptidoglycan-associated lipoprotein TolB BamB

C3K324


LptD

C3KBX8 b

Pseudomonas spp.

OmpA family-lipoprotein

C3KDM6 b

Pseudomonas spp.

phosphatidylserine decarboxylase

E2XZ64


SurA

G8M7G2

Burkholderia sp.

TolB

J0YEJ9 b

Pseudomonas spp.

J2M1D5 b

Pseudomonas spp.

peptidoglycan-associated lipoprotein outer membrane protein H1

L7HFX4 b

Pseudomonas spp.

BamD

O85417

Pseudomonas caricapapayae

outer membrane lipoprotein I

UPI00028991C8

Pseudomonas extremaustralis

flagellin

Energy production and conversion B1FT18 b Burkholderia spp. B1FV46

b

PQQ-dependent dehydrogenase

Burkholderia spp.

malate dehydrogenase

C3K121 b

Pseudomonas spp.

phosphoenolpyruvate synthase

C3K1E7 b

Pseudomonas spp.

ATP synthase, gamma chain

C3K6M5 b

Pseudomonas spp.

C3KBL8


C3KCP3


succinate dehydrogenase flavoprotein subunit aerobic glycerol-3-phosphate dehydrogenase acetyltransferase

C3KE78


azurin

I2BM47 b

Pseudomonas spp.

J1IL09 b

Pseudomonas spp.

electron transfer flavoprotein, beta subunit UDP-glucose 6-dehydrogenase

Lipid metabolism and ketogenesis A9IIX3 a,b Bordetella spp.

acetoacetyl-CoA reductase

b

Pseudomonas spp.

C3K743 b

Pseudomonas spp.

I4WGM2

Rhodanobacter thiooxydans

glycerophosphoryl diester phosphodiesterase 3-hydroxydecanoyl-[acyl-carrierprotein] dehydratase lipase

J0YBC2 b

Pseudomonas spp.

Yce1-like protein

Q1CWS1

Myxococcus xanthus

lipase

C3JZ29

Replication, transcription, translation and DNA repair A2W9A3 a,b Burkholderia spp. elongation factor Ts

-

0.12

-

-

-

-

0.34

-

-

-

0.11

-

-

-

-

0.13

-

-

-

-

0.09

-

-

-

-

0.17

-

-

-

-

0.30

0.18

-

-

-

0.31

-

-

-

-

0.46

0.08

-

-

-

0.08

-

-

-

-

-

0.19

-

-

-

0.07

-

-

-

-

0.16

-

-

-

-

-

-

-

-

0.11

-

0.14

-

-

-

-

-

0.02

-

-

-

0.10

-

-

-

-

0.35

-

-

-

0.27

-

-

-

-

0.15

-

-

-

-

0.61

0.17

-

-

-

-

0.27

-

-

-

-

0.17

-

-

-

-

0.13

-

-

-

-

0.17

-

-

-

0.43

-

-

-

-

0.06

-

-

-

-

0.33

-

-

-

-

A4SUU7 a,b

Polynucleobacter necessarius

elongation factor Tu

A4VHN7 a,b

Pseudomonas spp.

50S ribosomal protein L16

A4VHP0 a,b

Pseudomonas spp.


A5VXR4 b

Pseudomonas spp.

30S ribosomal protein S5

A9ADK4 a,b

Burkholderia spp.


B2JHS8 b

Burkholderia spp.

LacI, transcriptional regulator

B2T724 b

Burkholderia spp.


B2T750 b

Burkholderia spp.


C1DKN6 b

Pseudomonas spp.


C3JXX2 b

Pseudomonas spp.

ATP-dependent RNA helicase

C3K2V7 b

Pseudomonas spp.


C3K3H0 b

Pseudomonas spp.

RNA helicase

0.03

-

-

-

-

C3KC10


LemA, virulence regulator

0.22

-

-

-

-

C3KCS0



0.18

-

-

-

-

C3KE70 b

Pseudomonas spp.


0.27

0.20

-

-

-

C5A9H1

Burkholderia glumae


-

0.50

-

-

-

E2XL76 b

Pseudomonas spp.

GTP-binding protein

0.08

-

-

-

-

E7PK79

Pseudomonas syringae


0.27

-

-

-

-

I2BR39


ribosomal protein L25

0.33

-

-

-

-

K8R288

Burkholderia sp.

transcription accessory protein

-

0.08

-

-

-

-

0.04

-

-

-

0.21

-

-

-

-

0.20

0.07

-

-

-

0.08

-

-

-

-

Stress and defense mechanisms A0K6C2 a,b Burkholderia spp. C3K1W9

b

FtsH, metalloprotease

Pseudomonas spp.

thioredoxin reductase

C3K275


DnaK

C3KB07 b

Pseudomonas spp.

peroxidase

C3KDG0 b

Pseudomonas spp.

RecA

0.21

-

-

-

-

E2XRC5


thiol peroxidase

0.22

-

-

-

-

E2XY77


0.71

-

-

-

-

E2XY89 b

Pseudomonas spp.

hyperosmotically inducible periplasmic protein FtsH, metalloprotease

0.05

-

-

-

-

I2BQB7 b

Pseudomonas spp.

cold-shock DEAD box protein A

0.07

-

-

-

-

I4L9S5

Pseudomonas synxantha

DnaK

-

0.13

-

-

-

-

0.14

-

-

-

-

0.15

-

-

-

-

-

-

0.17

0.25

-

0.02

-

-

-

-

-

-

-

0.02

0.16

-

-

-

-

0.09

-

-

-

-

0.34

-

-

-

-

0.11

-

-

-

-

-

-

-

-

0.05

0.24

-

-

-

-

Transport, secretion and efflux A0K2W2 a,b Burkholderia spp. A1TUU8 a,b

Acidovorax spp.

amino acid/amide ABC transporter monosaccharide ABC transporter

A1WC85 a,b

Acidovorax spp.

porin

A2VY88 a,b

Burkholderia spp.

cation/multidrug efflux pump

A5V8N4 a

Sphingomonas wittichii

TonB-dependent receptor

A8GAT7 a

Serratia proteamaculans

metal ABC transporter

A8GB28 a,b

Serratia spp.

amino acid transporter

A8GCJ4 a

Serratia proteamaculans

porin

A8GH34 b

Serratia spp.

A9VYY1 b


cationic amino acid ABC transporter porin

B0KQ05 b

Pseudomonas spp.

sulfate ABC transporter

B1FY32 b

Burkholderia spp.

OmpC family porin

-

0.18

-

-

0.15

B1G0N8

Burkholderia graminis

porin

-

-

-

-

0.19

B1GB98

Burkholderia graminis

porin

-

-

-

0.20

0.48

B1LV39

Methylobacterium radiotolerans

porin

-

-

-

-

0.10

B1ZFK7 b


porin

-

-

0.30

-

-

B2JH03 b

Burkholderia spp.

-

0.26

-

-

-

B2JK19 b

Burkholderia spp.

-

1.50

-

-

-

B2JM60

Burkholderia spp.

monosaccharide-transporting ATPase extracellular amino acid-binding receptor porin

-

-

-

-

0.08

B2T4D9

Burkholderia phytofirmans

-

0.07

-

-

-

extracellular amino acid-binding protein

B2T6X5

Burkholderia phytofirmans

dipeptide-binding protein

-

0.07

-

-

-

B2U879

Ralstonia pickettii

OmpA/MotB domain protein

-

-

-

0.65

0.70

Ralstonia pickettii

porin

-

0.08

0.11

1.08

1.03

Ralstonia spp.

porin

-

-

-

0.27

0.23

B5WCV4 b

Burkholderia spp.

-

0.10

-

-

-

B5WIR3

Burkholderia sp.

-

0.29

-

-

-

B7S235 C3JXZ7 b

unclassified Gammaproteobacteria Pseudomonas spp.

amino acid ligand-binding receptor cationic amino acid ABC transporter TonB-dependent receptor

C3JYK8


C3JYX7 b

Pseudomonas spp.

C3JZ77 b

B2UDU1 B2UFC4

b

-

-

-

-

0.02

histidine-binding periplasmic protein RND efflux transporter

0.11

-

-

-

-

-

0.17

-

-

-

0.07

-

-

-

-

Pseudomonas spp.

branched-chain amino acid ABC transporter maltose-binding protein

0.07

-

-

-

-

C3JZG0


ferric siderophore receptor

0.03

-

-

-

-

C3K0T0


porin A

3.14

0.14

-

-

-

C3K187 b

Pseudomonas spp.

imelysin

0.13

-

-

-

-

C3K1B9


metal ABC transporter

0.28

-

-

-

-

C3K1N2 b

Pseudomonas spp.

SecD

0.04

-

-

-

-

C3K3C7 b

Pseudomonas spp.

0.12

-

-

-

-

C3K3T8 b

Pseudomonas spp.

glycine betaine/L-proline ABC transporter putrescine ABC transporter

0.23

-

-

-

-

C3K3Z3 b

Pseudomonas spp.

ABC transporter

0.07

-

-

-

-

C3K5B7


porin

0.14

-

-

-

-

C3K5V1


OprE3

0.40

-

-

-

-

C3K717 b

Pseudomonas spp.

amino acid transporter

0.44

-

-

-

-

C3K7C1 b

Pseudomonas spp.

SecB

0.22

-

-

-

-

C3K7I2



0.25

-

-

-

-

C3K8P0 b

Pseudomonas spp.

nucleoside-binding protein

0.13

-

-

-

-

C3K8Z6


0.60

-

-

-

-

C3K914


branched amino acid ABC transporter ABC transporter

0.31

-

-

-

-

C3KB06


iron transporter

0.53

-

-

-

-

C3KBL7 b

Pseudomonas spp.

0.27

0.15

-

-

-

C3KBT7 b

Pseudomonas spp.

glutamate/aspartate ABC transporter sulfate ABC transporter

0.16

-

-

-

-

C3KDU7 b

Pseudomonas spp.

ABC transporter

0.38

-

-

-

-

C3KEB0


amino acid ABC transporter

1.08

-

-

-

-

C3KEC2


OmpA-like

0.62

-

-

-

-

D0S6Y6

Acinetobacter calcoaceticus

DcaP-like

0.53

0.53

0.43

0.17

-

D5H5Q2

Salinibacter ruber


-

-

-

-

0.02

D8D960

Comamonas testosteroni

OmpA/MotB

-

-

0.61

0.43

-

D8G164

Oscillatoria sp.

TonB receptor

-

-

-

-

0.06

D8JEE3 b

Acinetobacter spp.

porin

-

0.11

0.11

-

-

D8JLF9

Acinetobacter sp.

porin

0.39

0.43

0.43

-

-

D8NXA2

Ralstonia solanacearum

porin

-

-

-

0.72

0.74

E2T0T6

Ralstonia sp.

porin

-

-

0.05

0.44

0.51

E2XKC2


0.07

-

-

-

-

E2XKL7 b

Pseudomonas spp.

0.13

-

-

-

-

E2XLH2 b

Pseudomonas spp.

type I secretion outer membrane protein branched-chain amino acid ABC transporter dipeptide ABC transporterer

0.05

-

-

-

-

E2XMS6 b

Pseudomonas spp.

OmpH

0.37

-

-

-

-

E2XN23


0.12

-

-

-

-

E2XW23


type I secretion membrane fusion protein long-chain fatty acid transporter

0.04

-

-

-

-

E2Y0H8


porin

0.29

-

-

-

-

E5C8U6 b

Bacteroides spp.

-

-

-

-

0.02

F0KK22

Acinetobacter calcoaceticus

TonB-linked outer membrane protein porin D

0.13

0.15

0.06

-

-

F6KQ92

Pseudomonas costantinii

OprF

0.35

-

-

-

-

G3A5T6

Ralstonia syzygii

OmpA

-

-

-

0.54

0.63

G7Z7T4

Azospirillum lipoferum

OmaA

-

-

-

0.10

-

G8M678 b

Burkholderia spp.

-

0.43

-

-

-

G8M683 b

Burkholderia spp.

extracellular solute-binding protein OmpC

-

0.13

-

-

-

G8M6G8

Burkholderia sp.

OmpA/MotB family protein

-

0.6

-

-

-

G8M893

Burkholderia sp.

porin

-

-

-

0.17

0.56

G8MAY7

Burkholderia sp.

porin

-

-

-

0.11

0.36

G8MB24 b

Burkholderia spp.

-

0.07

-

-

-

G8TGU8

Niastella koreensis

branched chain amino acid ABC transporter TonB-dependent receptor G

-

-

-

-

0.02

H0E3A2 a,b

Patulibacter spp.

phosphate binding protein

-

1.49

1.08

0.08

-

H1KP99

Methylobacterium extorquens

porin

-

-

0.22

-

-

H1S518

Cupriavidus basilensis

HlyD

-

0.07

-

-

-

H1SI50

Cupriavidus basilensis

porin

-

-

-

-

0.18

H1Y2T7

Mucilaginibacter paludis

OmpA/MotB domain protein

-

-

-

0.06

0.10

I0KRP1

Stenotrophomonas maltophilia


-

-

-

-

0.06

I2BKL0 b

Pseudomonas spp.

OprD

0.10

-

-

-

-

I2BLJ9


porin

-

0.45

-

-

-

I2BPB1


FpvA

0.09

-

-

-

-

I2BVR7


OprD

0.38

-

-

-

-

I2BWR7


TagQ

0.34

-

-

-

-

I2BWZ9


NLPA family lipoprotein

0.39

-

-

-

-

I2IFR8 b

Burkholderia spp.

porin

-

-

-

-

0.48

I3AHW1

Serratia plymuthica


0.29

-

-

-

-

I4K2Q7 b

Pseudomonas spp.

OprB

0.20

-

-

-

-

I4KG72 b

Pseudomonas spp.

amino acid ABC transporter

0.29

-

-

-

-

I4KV15

Pseudomonas synxantha


0.15

-

-

-

-

I4MZT9

Pseudomonas sp.

LivK

0.43

-

-

-

-

I4VVL8 b

Rhodanobacter spp.


-

-

-

0.03

0.06

I4W1F0

Rhodanobacter spathiphylli


-

-

-

-

0.07

I4W299 b

Rhodanobacter spp.

PilQ

-

-

-

-

0.12

I5D4U3

Burkholderia terrae

-

0.43

-

-

0.52

J2SD86

Flavobacterium sp.

-

-

-

-

0.02

J2T7G6

Variovorax sp.

OmpA/MotB domain-containing protein TonB-linked outer membrane protein, porin

-

-

0.20

0.24

0.24

J2TZX3 b

Pseudomonas spp.

OprD family porin

-

-

0.06

-

-

J2Z2M0 b

Pseudomonas spp.

0.24

0.19

0.08

-

-

J3CB80

Variovorax sp.

peptidoglycan-associated lipoprotein porin

-

0.10

0.05

0.20

0.25

J3CWR3

Bradyrhizobium sp.

porin

-

0.05

0.16

0.29

0.44

J3DTD1

Pseudomonas putida

OprD family porin

-

0.15

0.10

0.04

0.06

J3GVG6

Pseudomonas sp.

OprD family porin

-

0.13

0.04

-

-

K0HTW4

Acidovorax sp.

OmpA/MotB

-

-

-

0.32

-

K8P9Z0

Afipia broomeae

porin

-

-

-

-

0.24

K8R697

Burkholderia sp.

porin

-

-

-

-

0.15

K8R8N3

Burkholderia sp.

OmpC family porin

-

-

-

0.05

0.32

K8RAU9

Burkholderia sp.

OmpC family porin

-

0.13

0.10

0.15

0.53

K8RQJ6

Burkholderia sp.

porin

-

-

-

-

0.46

K9AC78


Omp38

0.39

0.58

0.45

0.08

-

K9ACC8


DcaP-like

0.15

0.38

0.21

-

-

K9CQK5


-

0.09

0.06

-

-

L2EK35 b

Cupriavidus spp.

transporter, Ompp1/FadL/TodX family porin

-

-

-

0.43

0.96

L7H9X2


0.35

-

-

-

-

L7HLG1


branched-chain amino acid ABC transporter porin

0.76

-

-

-

-

Q213J7

Rhodopseudomonas palustris

Omp2b

-

-

0.13

-

0.36

Q46WM6

Ralstonia eutropha

porin

-

-

-

-

0.33

Q4FCM8

Acinetobacter sp.


0.16

-

-

-

-

Q5QQ59


OprE3

0.49

-

-

-

-

Q6FE98

Acinetobacter sp.

porin

0.10

-

-

-

-

Q985C3

Rhizobium loti

porin

-

-

0.05

0.10

0.10

UPI0002885851

Pseudomonas sp.

LivK

0.63

-

-

-

-

UPI00028A1D9E

Sphingomonas sp.


-

-

-

-

0.03

UPI00029AA93B

Pseudomonas geniculata


-

-

-

-

0.05

Burkholderia spp.

cell division factor

-

0.10

-

-

-

Pseudomonas spp.

adenylosuccinate lyase

0.06

-

-

-

-

Other functions A0KAZ1 a,b A4VLW4

a,b

A6VCJ6 a

Pseudomonas aeruginosa

B2KBE7

Elusimicrobium minutum

polyribonucleotide nucleotidyltransferase Smc

C3K1M9 b

Pseudomonas spp.

inositol monophosphatase

C3K1U2


aminotransferase

C3K5Y0 b

Pseudomonas spp.

C3KD06


NADP(H)-dependent aldo-keto reductase amidase

C3KEC6 b

Pseudomonas spp.

adenylate kinase

E2XPE0 b

Pseudomonas spp.

E2XX99


peptidyl-prolyl cis-trans isomerase iron-regulated protein

I2BTN8 b

Pseudomonas spp.

chromosome partitioning protein

I2BZ33 b

Pseudomonas spp.

YeaG

UPI00028A32F2


VacJ family lipoprotein

Function unknown A6UXA9 a,b A2VTE3

a,b

Pseudomonas spp. Burkholderia spp.

0.14

-

-

-

-

-

-

-

0.03

-

0.13

-

-

-

-

0.10

-

-

-

-

0.08

-

-

-

-

0.04

-

-

-

-

0.22

-

-

-

-

0.58

0.38

-

-

-

0.21

-

-

-

-

0.20

-

-

-

-

0.24

-

-

-

-

0.31

-

-

-

-

0.08

-

-

-

-

-

0.14

-

-

-

B7L1B2 b


-

-

0.12

0.09

-

C3JYK6


-

0.87

-

-

-

C3K3H1


0.29

-

-

-

-

C3K3V2


0.53

-

-

-

-

C3KBL3 b

Pseudomonas spp.

0.22

-

-

-

-

C3KED5


0.35

-

-

-

-

C6WZ97

Methylotenera mobilis

0.19

0.14

0.17

0.12

0.10

D7DNB6

Methylotenera sp.

0.16

0.07

0.07

0.07

-

D8JLH9 b

Acinetobacter spp.

-

0.13

0.09

-

-

D8JYJ3

Hyphomicrobium denitrificans

-

-

-

-

0.06

E2XJW5


0.10

-

-

-

-

E2XLQ8


0.38

0.29

-

-

-

E2XUK8


-

0.47

-

-

-

G4MGY8 b

Burkholderia spp.

-

0.59

-

-

-

I2BNE9 b

Pseudomonas spp.

0.11

-

-

-

-

I2BVK9


-

0.60

-

-

-

I2BWV2 b

Pseudomonas spp.

0.44

0.13

-

-

-

J8V5Q9

Pseudomonas putida

-

0.11

0.33

-

-

UPI000288EA66


0.13

-

-

-

-

UPI000289F004


0.10 This protein could be assigned to more than one bacterial genus. The genus mentioned was arbitrarily chosen as it represented the most abundant genus at the sampling date. b This protein could be assigned to more than one species of the genus mentioned. c Protein not detected or protein identification not considered valid. a

Table S2 Proteins produced by Rhodanobacter thiooxidans LCS2 during growth in minimal medium supplemented with suberin at day 5 and day 30 Uniprot accession Putative function number Amino acid metabolism I4VHY4b methylisocitrate lyase cysteine synthase I4VI38 I4VNT3 isovaleryl-CoA dehydrogenase glutamine synthetase I4VP75 I4VUT5 pyrroline-5-carboxylate reductase I4VWA7 Xaa-Pro aminopeptidase I4W1V5 anthranilate phosphoribosyltransferase I4W2U0 asparaginase I4W3N8 HtpX, protease I4W5U6 N-acetylornithine carbamoyltransferase I4W668 aspartate-semialdehyde dehydrogenase I4W6F3 histidine ammonia-lyase I4W6N2 peptidyl-prolyl cis-trans isomerase I4W9W4 cysteine synthase I4WAC2 peptidyl-prolyl cis-trans isomerase I4WAU6 3-dehydroquinate dehydratase I4WAZ4 methylcrotonoyl-CoA carboxylase I4WB23 4-hydroxy-tetrahydrodipicolinate synthase I4WB48 methionine aminotransferase I4WBE2 peptidase M28 I4WBP2 glycyl aminopeptidase I4WBY8 arginine decarboxylase I4WBY9 polyamine aminopropyl transferase I4WC22 glutamine synthetase I4WC30 Zn-dependent oligopeptidase I4WC93 shikimate dehydrogenase I4WCE3 branched-chain amino acid aminotransferase I4WCR0 aminopeptidase N I4WCU6 aromatic amino acid aminotransferase I4WD72 peptidase M28 I4WD80 protease I4WDN0 alanine dehydrogenase I4WDQ1 leucine dehydrogenase I4WDT5 ArgD, acetylornithine aminotransferase I4WE81 arginase I4WEE3 cysteine desulfurase

Abundance (NSpCa) 5 days

30 days

0.16 -c 0.07 0.04 0.26 0.08 3.41 0.20 0.03 0.08 0.04 0.04 0.07 0.03 0.24 0.13 0.11 0.10 0.34 0.12 0.17 0.36 0.22 0.03 0.04

0.23 1.23 0.07 0.07 0.04 0.14 0.05 0.04 0.09 7.35 0.08 0.34 0.13 0.40 0.06 0.04 0.48 0.14 0.33 0.09 0.58 0.08 0.63 0.07 0.24 0.40 0.10

I4WEG3 I4WEG6 I4WEG8 I4WEP6 I4WEZ1 I4WFS5 I4WFS8 I4WG51 I4WG78 I4WG79 I4WGE0 I4WGE5 I4WGQ3 I4WH07 I4WH24 I4WHD2 I4WHD9 I4WI88 I4WI91 I4WI92 I4WIP0 I4WIP2 I4WIR5 I4WIT5 I4WIU0 I4WIU1 I4WIU5 I4WIU6 I4WIU8 I4WIV0 I4WIW2 I4WIW4 I4WJA2 I4WJL2 I4WJL5 I4WJU9 I4WKD9 I4WKJ1 I4WL26 I4WLF3 I4WLH1 I4WLV4

ornithine/acetylornithine aminotransferase proline iminopeptidase D-3-phosphoglycerate dehydrogenase dipeptidyl aminopeptidase/acylaminoacyl peptidase nitrogen regulatory protein P-II protease leucine aminopeptidase cystathionine beta-lyase/cystathionine gamma-synthase GcvT, aminomethyltransferase glycine cleavage system H protein maleylacetoacetate isomerase cysteine synthase peptidase M28 peptidase S10 serine carboxypeptidase peptidyl-dipeptidase bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase peptidyl-dipeptidase 4-hydroxy-tetrahydrodipicolinate reductase carbamoyl-phosphate synthase carbamoyl phosphate synthase 3-phosphoshikimate 1-carboxyvinyltransferase phosphoserine aminotransferase glycine dehydrogenase D-amino acid dehydrogenase HflC protease peptidase peptidase S46 L-threonine 3-dehydrogenase 2-amino-3-ketobutyrate coenzyme A ligase aspartate aminotransferase peptidyl-prolyl cis-trans isomerase serine hydroxymethyltransferase protease X-Pro dipeptidyl-peptidase ProC, pyrroline-5-carboxylate reductase methylthioribose-1-phosphate isomerase histidine ammonia-lyase protease tryptophan synthase beta chain imidazoleglycerol-phosphate dehydratase aminotransferase

0.10 0.43 0.50 0.11 0.04 0.10 0.40 0.86 0.17 0.03 0.14 0.07 0.08 0.08 0.08 0.11 0.10 0.08 0.07 0.17 0.15 0.09 0.13 0.24 0.12 0.06 0.18 0.04 0.20 0.01 0.11

0.45 0.13 0.16 0.03 0.38 0.03 0.10 0.14 0.46 0.08 0.46 0.09 0.02 0.21 0.11 0.52 0.04 0.04 0.12 0.15 0.14 0.23 0.21 0.15 0.03 0.23 1.49 0.17 0.38 0.07 0.03 0.03 0.16 0.03 0.34

I4WM29 acetylornithine deacetylase I4WM35 metalloendopeptidase I4WM64 prepilin-type N-terminal cleavage I4WM81 NAD-glutamate dehydrogenase I4WM86 glutaryl-CoA dehydrogenase I4WMC6 peptidyl-prolyl cis-trans isomerase I4WMK5 kynureninase I4WMM4 carbamoyl phosphate synthase I4WN39 Xaa-Pro dipeptidase I4WN55 peptidase S8/S53 I4WN66 Indole-3-glycerol phosphate synthase I4WN78 dipeptidase I4WPB8 HutI, imidazolonepropionase I4WPC0 N-formimino-L-glutamate deiminase I4WPD1 urocanate hydratase I4WPH1 Xaa-Pro aminopeptidase I4WPJ5 peptidyl-prolyl cis-trans isomerase I4WPK6 peptidyl-prolyl cis-trans isomerase I4WQ39 argininosuccinate synthase I4WQ41 acetylornithine deacetylase I4WQ42 acetylglutamate kinase I4WQ44 argininosuccinate lyase I4WQ91 metallopeptidase I4WQ99 peptidyl-prolyl cis-trans isomerase I4WQQ8 gamma-glutamyltranspeptidase I4WRE3 TrpA, tryptophan synthase I4WRG1 histidinol dehydrogenase I4WRG9 enolase-phosphatase I4WRS1 aminopeptidase I4WRX3 gamma-glutamyltranspeptidase I4WSM1 aminopeptidase I4WSM4 threonine aldolase I4WSY4 branched-chain amino acid aminotransferase I4WSY6 methylenetetrahydrofolate reductase I4WT46 peptidase M28 I4WTB2 metallopeptidase I4WU28 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase I4WVA0 peptidyl-prolyl cis-trans isomerase I4WZ73 X-Pro dipeptidyl-peptidase M4NC29 Zn-dependent peptidase M4NEI4 ornithine carbamoyltransferase Carbohydrate metabolism

0.06 0.47 0.14 0.08 0.27 0.06 0.03 0.05 0.02 0.21 0.03 0.06 0.06 0.18 0.85 0.17 0.03 0.11 0.02 0.26 0.17 0.05 0.10 0.14 0.08 0.23 0.28 0.05 0.31 0.36 0.04 -

0.04 0.76 0.10 0.36 0.15 0.22 0.17 0.29 0.03 0.03 0.31 0.02 0.20 0.44 0.10 0.04 0.23 0.07 0.98 0.03 0.11 0.25 0.91 0.08 0.22 0.07 0.45 0.02 0.14

I4VKM3 inositol monophosphatase/fructose-1,6-bisphosphatase family protein I4WAH6 phosphoglucomutase I4WAH7 glucose-6-phosphate isomerase I4WAH8 transaldolase I4WBW6 ribokinase I4WBX9 phosphomannomutase I4WCH0 GDP-L-fucose synthase I4WCI9 Fpb, fructose-1,6-bisphosphatase I4WCL1 L-sorbosone dehydrogenase I4WCP3 Glk PE, glucokinase I4WDU0 6-phosphofructokinase I4WEL7 2-dehydro-3-deoxy-6-phosphogalactonate aldolase I4WEN5 6-phosphogluconate dehydrogenase-like protein I4WEQ2 Entner-Doudoroff aldolase I4WEQ3 phosphogluconate dehydratase I4WEQ4 6-phosphogluconolactonase I4WEQ5 glucose-6-phosphate 1-dehydrogenase I4WF95 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase I4WGD0 glyceraldehyde-3-phosphate dehydrogenase I4WGD2 Pyruvate kinase I4WGD4 fructose-bisphosphate aldolase I4WGD7 transketolase I4WGD9 Pgk, phosphoglycerate kinase I4WGM3 xylanase deacetylase I4WH34 alpha,alpha-trehalase I4WHZ0 phosphoketolase I4WI35 propanediol utilization protein I4WIU7 glycogen debranching enzyme I4WM90 transketolase domain-containing protein I4WN50 ribose-5-phosphate isomerase I4WN86 glycoside hydrolase clan GH-D I4WN98 ribulose-phosphate 3-epimerase I4WPH4 enolase I4WPK2 phosphoenolpyruvate synthase I4WQC6 N-ethylammeline chlorohydrolase I4WRP0 fructose-1,6-bisphosphatase I4WRR0 cyclomaltodextrin glucanotransferase I4WRR9 alpha-glucosidase I4WU59 PEP phosphonomutase-like protein M4NMT8 transaldolase Cell wall, membrane and envelope biogenesis I4VNC9 glycosyl transferase family protein

0.08 0.04 0.12 0.02 0.07 0.09 0.08 0.03 0.45 0.10 0.44 0.30 0.25 0.42 0.48 0.33 0.11 0.13 0.42 0.05 0.29 0.20 0.02 0.35 0.13 0.33 0.13 0.09 0.09 0.20 0.08 0.06

0.05 0.10 0.16 0.63 0.18 0.09 0.11 0.13 0.03 0.11 0.20 0.75 0.24 0.42 0.92 0.09 0.62 0.49 0.75 0.21 0.82 0.06 0.11 0.52 0.01 0.15 1.17 0.08 0.25 0.38 0.08 0.07 0.15

-

0.09

I4VVG1 I4VX44 I4VZT9 I4W030 I4W2A0 I4W2P0 I4W6X0 I4WAP1 I4WAZ3 I4WB89 I4WC49 I4WCG1 I4WCH4 I4WDT8 I4WDV8 I4WEJ0 I4WEJ4 I4WEQ7 I4WER7 I4WF26 I4WFA3 I4WFN8 I4WFT7 I4WG42 I4WG67 I4WGE3 I4WGE6 I4WGM9 I4WGP0 I4WGU3 I4WGU4 I4WH26 I4WI78 I4WIC8 I4WID1 I4WIN9 I4WIT4 I4WIV2 I4WJ11 I4WJS2 I4WJT4

D-alanine--D-alanine ligase LysM domain-containing protein C-terminal processing peptidase lipoprotein releasing system transmembrane protein LolC/E family pilus assembly protein membrane fusion protein UTP-glucose-1-phosphate uridylyltransferase BamD, outer membrane protein assembly factor outer membrane protein type 4 fimbrial biogenesis protein pily1-related protein glycosyl transferase family protein glycosyl transferase family protein Class II pilin PilE UDP-N-acetylmuramate--L-alanine ligase glycosyltransferase BamA .outer membrane protein assembly factor lipid-A-disaccharide synthase glucosamine-fructose-6-phosphate aminotransferase lipid A 3-O-deacylase Rhs family protein membrane fusion protein GlmU, bifunctional acetyl transferase/uridyl transferase D-alanyl-D-alanine carboxypeptidase glucosamine--fructose-6-phosphate aminotransferase aminotransferase OmpA/MotB domain-containing protein glucosamine--fructose-6-phosphate aminotransferase LysM domain-containing protein glycosyl/glycerophosphate transferase peptidoglycan-associated lipoprotein Tol-pal system protein hemaglutitin BamE, outer membrane protein assembly factor type IV pilus biogenesis/stability protein BamB, outer membrane protein assembly factor 3-deoxy-manno-octulosonate cytidylyltransferase alanine racemase peptidoglycan-associated protein capsular polysaccharide biosynthesis protein filamentous hemaglutin-like two-component system sensor histidine kinase-response regulator hybrid protein pill

0.08 0.18 0.05 0.30 0.09 0.14 0.29 1.31 0.03 0.22 0.06 3.60 0.06 0.09 0.03 0.11 0.19 0.14 0.04 0.18 0.15 0.79 3.39 0.20 0.08 0.05 0.31 0.07 0.05 2.18 0.04 0.77 0.05

0.03 0.35 0.14 0.31 0.13 0.05 3.90 0.04 0.23 0.01 0.08 0.08 0.13 0.24 0.07 0.51 0.09 6.24 0.13 0.15 0.12 0.29 0.09 2.38 0.04 0.29 0.05

I4WJT5 I4WM62 I4WM66 I4WM67 I4WMA3 I4WNG6 I4WNG7 I4WNG8 I4WNG9 I4WNH8 I4WPA0 I4WPA1 I4WPB6 I4WPH3 I4WPK7 I4WQ35 I4WRC8 I4WRD8 I4WRZ3 I4WSL0 I4WT16

pilus biogenesis protein Tfp pilus assembly protein FimT-like protein PilY1, type 4 fimbrial biogenesis protein PilE OmpA-like fimbrial assembly membrane protein fimbrial assembly membrane protein fimbrial assembly membrane protein penicillin-binding protein surface lipoprotein outer membrane lipoprotein outer membrane protein MsbA, lipid A export ATP-binding/permease protein 2-dehydro-3-deoxyphosphooctonate aldolase UDP-glucose dehydrogenase outer membrane lipoprotein lytic murein transglycosylase FimV N-terminal domain-containing protein flagellin domain-containing protein LPS-assembly protein LptD UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase I4WTB1 C-terminal processing peptidase I4WUZ6 lytic murein transglycosylase Energy production and conversion I4VKE0 isocitrate dehydrogenase I4VM16 alcohol dehydrogenase I4VXG5 succinyl-CoA ligase [ADP-forming] subunit alpha I4W1D3 glyceraldehyde-3-phosphate dehydrogenase I4W1F4 NADH:flavin oxidoreductase/NADH oxidase I4W1R0 bifunctional malic enzyme oxidoreductase/phosphotransacetylase I4W332 cytochrome c4 I4W6A9 high potential iron-sulfur protein I4W788 isocitrate lyase I4W7P8 rubrerythrin I4W977 NADPH:quinone oxidoreductase I4W9P0 fumarate hydratase class II I4WAP4 succinyl-CoA ligase [ADP-forming] subunit beta I4WB45 short-chain dehydrogenase I4WB57 aconitate hydratase I4WBN1 ubiquinol-cytochrome c reductase iron-sulfur subunit I4WBN2 cytochrome b I4WBN3 ubiquinol-cytochrome c reductase

0.22 0.03 0.65 0.29 0.34 0.03 1.55 1.06 0.02 0.25 0.03 1.21 0.43 0.08 0.12

0.17 0.08 0.03 0.09 0.54 0.54 0.40 0.22 0.02 0.13 0.93 0.24 0.03 0.28 0.15 0.61 0.02 0.13 0.29 0.05 0.05

0.03

0.01 -

0.10 0.28 0.29 0.27 0.12 0.07 0.04 0.22 0.52 0.39

0.09 0.19 0.02 0.02 0.29 0.09 0.35 0.33 0.19 0.03 0.17 0.61 0.34 0.04 0.26

I4WBP6 I4WBR2 I4WD44 I4WD61 I4WDW2 I4WDY5 I4WDY6 I4WE11 I4WE12 I4WE63 I4WE70 I4WE71 I4WEG7 I4WEU1 I4WFA2 I4WFB8 I4WFD5 I4WFN1 I4WFN2 I4WFN3 I4WFN4 I4WFN5 I4WG68 I4WG69 I4WG74 I4WG85 I4WGC7 I4WH70 I4WH92 I4WHD0 I4WHD3 I4WI10 I4WIV5 I4WIW1 I4WJ90 I4WJ91 I4WJC7 I4WKC6 I4WKC7 I4WKC8 I4WKE9 I4WKF6

sulfur oxidation protein, flavocytochrome C DsrE/DsrF-like family protein aldehyde dehydrogenase oxydoreductase NADH dehydrogenase/NAD(P)H nitroreductase dihydrolipoamide dehydrogenase dihydrolipoamide acetyltransferase pyruvate dehydrogenase E1 component bifunctional malic enzyme oxidoreductase/phosphotransacetylase aconitate hydratase pyruvate dehydrogenase E1 alpha subunit pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit FAD/FMN-dependent dehydrogenase sulfide-quinone reductase cytochrome c isocitrate dehydrogenase NADPH:quinone reductase ATP synthase subunit b AtpH, ATP synthase subunit delta ATP synthase subunit alpha ATP synthase gamma chain ATP synthase subunit beta electron transfer flavoprotein alpha subunit electron transfer flavoprotein subunit beta electron transfer flavoprotein-ubiquinone oxidoreductase glucose-methanol-choline oxidoreductase azurin NAD(P) transhydrogenase FAD-dependent pyridine nucleotide-disulfide oxidoreductase cytochrome c oxidase subunit 2 aldehyde dehydrogenase short chain dehydrogenase/reductase f citrate synthase malate dehydrogenase voltage-gated potassium channel beta subunit alcohol dehydrogenase superfamily protein rubrerythrin 2-oxoglutarate dehydrogenase 2-oxoglutarate dehydrogenase dihydrolipoyl dehydrogenase NADH-quinone oxidoreductase subunit N NADH dehydrogenase subunit G

0.03 0.40 0.08 0.21 0.38 0.78 0.39 0.15 0.09 0.46

0.06 0.24 0.12 0.12 0.13 0.24 0.30 0.04 1.25 1.82

0.19 0.45 0.53 0.34 0.18 0.62 0.18 0.54 0.15 0.56 0.36 0.65 0.05 0.09 0.75 0.26 0.34 0.05 0.15 0.09 0.29 0.30 0.16 0.83 0.15 0.43 0.54 0.08

0.68 0.41 0.22 1.24 0.35 0.66 0.13 0.55 0.69 0.44 0.03 0.34 0.30 0.83 0.05 0.07 0.07 0.56 0.11 0.26 0.22 0.34 0.33 0.05 0.04

I4WKF7 NADH-quinone oxidoreductase I4WKG0 NADH-quinone oxidoreductase I4WLR8 NADH-quinone oxidoreductase subunit C I4WMA7 cytochrome c family protein I4WML0 short-chain dehydrogenase I4WNH1 citrate synthase I4WP39 cytochrome c biogenesis protein I4WPA7 succinate dehydrogenase I4WPA8 succinate dehydrogenase I4WQ25 FAD linked oxidase domain-containing protein I4WRH2 high potential iron-sulfur protein I4WSC0 NADP oxidoreductase I4WSY9 phosphoenolpyruvate carboxylase I4WU19 short-chain dehydrogenase I4WU37 nitrous-oxide reductase I4WUC8 NADPH dehydrogenase I4WW98 pyruvate dehydrogenase M4NS93 citrate synthase M4NTL5 ATP synthase subunit delta Lipid metabolism and ketogenesis acyl carrier protein I4VIC2 I4VRU7 3-hydroxyacyl-CoA dehydrogenase YdiF, acetate-CoA transferase I4VV45 3-oxoacyl-ACP reductase I4VY74 I4VZY3 acetoacetyl-CoA reductase I4W091 acyl-CoA dehydrogenase domain-containing protein I4WAL3 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase I4WAL4 beta-ketoacyl-[ACP] synthase I I4WAZ2 acetoacetyl-CoA thiolase I4WB09 3-hydroxybutyryl-CoA dehydratase I4WB55 long-chain fatty acyl-CoA ligase I4WBU8 acetyl-coenzyme A synthetase I4WBY7 3-hydroxybutyrate dehydrogenase I4WBZ6 acetyl-CoA acetyltransferase I4WCN8 GpsA, glycerol-3-phosphate dehydrogenase I4WDA0 acyl-CoA dehydrogenase I4WE25 fatty acid binding protein I4WE72 branched-chain alpha-keto acid dehydrogenase subunit E2 I4WEJ2 FabZ, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase I4WEK0 acetyl-coenzyme A carboxylase carboxyl transferase I4WFP4 fatty acyl-CoA synthetase I4WGM2 lipase

0.07 0.13 0.05 0.19 0.48 0.05 0.09 0.14 0.33 0.14 0.18 0.12 0.11 0.29 -

0.15 0.08 0.19 0.45 0.05 0.17 0.07 0.21 0.12 0.37 0.08 0.24 0.47 0.03

0.04 0.12 0.66 0.13 0.11 0.13 0.13 0.04 0.15 0.38 0.16 0.14

1.44 0.28 0.13 0.07 0.06 0.08 0.43 0.66 0.07 0.12 0.09 0.07 0.07 0.25 0.09 0.22 0.29 0.04 0.05 0.09

I4WIC3 acetyl-CoA acetyltransferase I4WIC4 3-hydroxyacyl-CoA dehydrogenase I4WJC3 polyhydroxyalkanoate depolymerase I4WKE0 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit I4WKE1 poly(R)-hydroxyalkanoic acid synthase subunit I4WKH0 3-oxoacyl-[acyl-carrier-protein] synthase I4WKH1 acyl carrier protein I4WKH2 3-ketoacyl-[acyl-carrier-protein] reductase I4WKH3 malonyl-CoA-acyl carrier protein transacylase I4WKH4 3-oxoacyl-[acyl-carrier-protein] synthase I4WKP8 acyl-CoA dehydrogenase I4WM78 acyl-CoA dehydrogenase domain-containing protein I4WM94 acyl-CoA dehydrogenase I4WM95 acyl-CoA dehydrogenase I4WM96 acetoacetate decarboxylase I4WMY1 phasin I4WP46 trans-2-enoyl-CoA reductase I4WPL0 enoyl-CoA hydratase I4WPU1 acyl-CoA dehydrogenase I4WR42 acyl carrier protein I4WR77 enoyl-CoA hydratase I4WSC3 lipase I4WSG8 acyl-CoA dehydrogenase I4WU86 acyl-CoA thiolesterase I4WUC2 lipase I4WUD4 acetoacetyl-CoA reductase I4WZ09 YdiF, acetate CoA-transferase M4NHA9 acyl-CoA dehydrogenase Replication, transcription, translation and DNA repair G4FZ48 elongation factor Tu NusG, transcription termination/antitermination protein I4VIS9 50S ribosomal protein L11 I4VIT0 50S ribosomal protein L10 I4VIT2 I4VIT3 50S ribosomal protein L7/L12 I4VK78 methionine--tRNA ligase I4VLN4 RNA polymerase sigma factor RpoD I4VM70 30S ribosomal protein S10 I4VM75 30S ribosomal protein S19 I4VM80 30S ribosomal protein S17 I4VM82 50S ribosomal protein L24 I4VM90 50S ribosomal protein L15 I4VM95 DNA-directed RNA polymerase subunit alpha

0.23 0.20 0.07 0.14 0.05 0.12 0.11 0.20 0.14 0.16 0.20 1.86 0.11 0.19 0.10 0.08 0.08 0.37 0.17 0.13 -

0.62 0.94 0.05 0.21 0.04 0.31 0.13 0.04 0.12 0.06 0.03 0.13 5.43 0.25 0.20 0.05 0.35 0.20 1.02 0.16 0.07 0.36

1.83 0.43 0.42 0.04 0.04 0.42 0.45 0.59 -

1.03 0.10 0.43 0.08 0.03 0.25 0.30 0.50 0.13 0.42

I4VN96 I4VQ72 I4VS93 I4VWM0 I4VXT9 I4VZ43 I4VZ44 I4VZ46 I4VZ51 I4VZ55 I4VZ56 I4VZ58 I4VZ59 I4VZC9 I4W0F8 I4W1I1 I4W447 I4W664 I4W6N1 I4WA42 I4WAQ1 I4WB47 I4WBV8 I4WBW0 I4WBX1 I4WBY3 I4WC48 I4WC56 I4WCN6 I4WCP9 I4WCU7 I4WD05 I4WDR8 I4WEH2 I4WEH6 I4WEI2 I4WEI3 I4WF04 I4WFK0 I4WG27 I4WGB3 I4WGB4

30S ribosomal protein S6 30S ribosomal protein S21 50S ribosomal protein L7/L12 chromosome partition protein DNA topoisomerase 1 30S ribosomal protein S11 30S ribosomal protein S13 50S ribosomal protein L15 30S ribosomal protein S8 50S ribosomal protein L14 30S ribosomal protein S17 50S ribosomal protein L16 30S ribosomal protein S3 30S ribosomal protein S2 Crp/Fnr family transcriptional regulator amidase RecA N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase nucleoid DNA-binding protein serine--tRNA ligase Fis family transcriptional regulator transcriptional regulator DNA gyrase subunit B DNA polymerase III subunit beta tyrosine--tRNA ligase ArgS, arginine--tRNA ligase chromosome partitioning protein transcriptional regulator 50S ribosomal protein L28 Rho, transcription termination factor RdgC, recombination-associated protein RhlB, ATP-dependent RNA helicase 50S ribosomal protein L23 phenylalanine--tRNA ligase beta subunit translation initiation factor IF-3 30S ribosomal protein S2 elongation factor Ts NADPH-dependent 7-cyano-7-deazaguanine reductase Glycine--tRNA ligase beta subunit 50S ribosomal protein L25 50S ribosomal protein L1 50S ribosomal protein L10

0.39 0.31 0.64 0.37 1.18 0.50 0.17 0.13 0.07 0.09 0.24 0.04 7.00 0.07 0.18 0.03 0.66 0.09 0.02 0.08 0.12 0.28 0.17 0.04 0.02 0.08 0.31 0.66 0.24 0.04 0.15 0.48 0.34

0.22 0.01 0.03 0.14 0.38 0.77 0.30 0.25 0.40 0.11 2.85 0.17 0.05 0.10 0.03 0.32 0.04 0.08 0.11 0.23 0.15 0.17 0.02 0.27 0.26

I4WGF0 I4WGM7 I4WGT1 I4WHZ5 I4WI04 I4WI69 I4WI93 I4WI99 I4WIK9 I4WIR1 I4WIT6 I4WIU3 I4WJD2 I4WJK2 I4WJK8 I4WJK9 I4WKB9 I4WKC4 I4WKD8 I4WKE2 I4WKE6 I4WKE7 I4WKH5 I4WKI6 I4WKJ2 I4WKR3 I4WKR6 I4WKR7 I4WKT0 I4WKT6 I4WKT7 I4WKT8 I4WKU7 I4WL10 I4WL11 I4WL13 I4WL14 I4WL19 I4WL23 I4WL41 I4WL46 I4WL48

Mg-dependent DNase DNA topoisomerase 1 aspartate--tRNA ligase GreA/GreB family elongation factor exodeoxyribonuclease I ribonuclease E GreA, transcription elongation factor 30S ribosomal protein S1 lysine--tRNA ligase ribonuclease R regulatory protein Hfq, RNA-binding protein glutamine--tRNA ligase ValS, valine-tRNA ligase proline--tRNA ligase DNA-binding protein H-NS transcriptional regulator transcription factor DNA gyrase polyribonucleotide nucleotidyltransferase translation initiation factor IF-2 NusA, transcription elongation factor 50S ribosomal protein L32 DNA polymerase III histidine--tRNA ligase 50S ribosomal protein L3 50S ribosomal protein L2 30S ribosomal protein S19 30S ribosomal protein S5 30S ribosomal protein S4 DNA-directed RNA polymerase subunit alpha 50S ribosomal protein L17 ribonuclease G elongation factor G 30S ribosomal protein S7 DNA-directed RNA polymerase subunit beta DNA-directed RNA polymerase subunit beta NusG, transcription termination/antitermination protein elongation factor Tu amidase 30S ribosomal protein S4 30S ribosomal protein S13

0.07 0.06 0.16 0.20 0.12 0.29 0.46 0.10 0.01 0.41 0.04 0.06 0.06 3.21 0.73 0.07 0.05 0.45 0.12 0.09 0.43 0.02 0.45 0.58 0.92 0.68 0.02 0.25 1.41 0.40 0.17 0.52 0.04 0.31 0.88

0.25 0.12 0.20 0.03 0.04 0.24 0.12 0.05 0.16 0.71 0.27 0.04 0.03 1.07 0.07 0.18 0.06 0.05 0.52 0.20 0.31 0.54 0.22 0.56 0.18 0.14 0.91 0.02 -

I4WL53 I4WL54 I4WL55 I4WL57 I4WL64 I4WL66 I4WL67 I4WL68 I4WL69 I4WM58 I4WMK9 I4WN52 I4WN53 I4WN63 I4WNH2 I4WNH5 I4WNL3 I4WNP6 I4WP50 I4WP94 I4WPI7 I4WPL6 I4WPU8 I4WPX4 I4WQ37 I4WQA4 I4WQB0 I4WQB2 I4WQB3 I4WQB4 I4WQB9 I4WQC2 I4WQD3 I4WQM0 I4WRF0 I4WT09 I4WT42 I4WTM6 I4WTZ3 I4WU00 I4WU53 I4WUG6

50S ribosomal protein L18 50S ribosomal protein L6 30S ribosomal protein S8 50S ribosomal protein L5 50S ribosomal protein L22 50S ribosomal protein L2 50S ribosomal protein L23 50S ribosomal protein L4 50S ribosomal protein L3 isoleucine--tRNA ligase elongation factor P 30S ribosomal protein S9 50S ribosomal protein L13 Crp, transcriptional regulator 50S ribosomal protein L31 type B endoribonuclease 50S ribosomal protein L17 ribosome-recycling factor MarR family transcriptional regulator polyhydroxyalkonate synthesis repressor RNA-binding protein LepA, elongation factor single-stranded DNA-binding protein FusA, elongation factor G transcriptional regulator endoribonuclease asparagine--tRNA ligase 30S ribosomal protein S6 30S ribosomal protein S18 50S ribosomal protein L9 30S ribosomal protein S16 50S ribosomal protein L19 DksA, RNA polymerase-binding transcription factor leucine--tRNA ligase glutamate--tRNA ligase ribosomal RNA small subunit methyltransferase MarR family transcriptional regulator cysteine--tRNA ligase Crp/Fnr family transcriptional regulator metallo-beta-lactamase family protein, RNA-specific regulatory protein alanine--tRNA ligase

0.79 0.22 0.45 0.33 0.35 0.64 0.64 0.28 0.06 0.02 0.43 0.19 0.11 0.15 0.88 0.21 0.23 0.03 0.19 0.13 0.56 0.61 1.16 0.67 0.75 0.13 0.05 0.16 0.15 0.32 0.04 0.02 0.07

0.58 0.75 0.95 0.17 0.66 0.25 0.05 0.46 0.81 1.73 0.53 0.02 0.06 1.42 0.07 0.07 0.07 0.13 0.56 0.32 0.05 0.05 0.06 0.04 0.04 0.07 0.04

I4WYD0 poly(A) polymerase I M4NEI0 DksA, RNA polymerase-binding protein Stress and defense mechanisms I4VQY6 hemolysin D I4VYT9 anaerobically induced outer membrane transmembrane protein I4VZV3 thioredoxin I4W2P1 ariflavin resistance protein D I4W6N0 Lon protease I4W949 cold shock protein I4WAB5 AhpD, alkyl hydroperoxide reductaseS I4WAV1 10 kDa chaperonin I4WAV2 60 kDa chaperonin I4WB26 PhoH family protein, phosphate starvation inducible protein I4WB63 GTP-binding protein TypA/BipA I4WBN4 stringent starvation protein I4WBS7 ATP-dependent protease ATPase subunit HslU I4WC57 salt-induced outer membrane protein I4WDA1 OsmC-like protein I4WDM9 thioredoxin reductase I4WE54 anaerobically induced outer membrane protein I4WEF2 aminoglycoside phosphotransferase I4WEG4 PsiF repeat family protein I4WEU5 acriflavin resistance protein I4WEZ6 CRISPR-associated protein Csd2 family I4WFB4 CRISPR-associated protein I4WG36 thiol-disulfide isomerase-like thioredoxin I4WG89 chaperonin I4WGC1 anaerobically induced outer membrane protein I4WGS4 chaperone GrpE, chaperone I4WI84 DnaK, chaperone I4WI86 I4WIA8 beta-lactamase I4WIQ0 HflD, high frequency lysogenization protein I4WIV8 alkyl hydroperoxide reductase I4WJB1 carbon starvation protein I4WJR0 superoxide dismutase I4WKI2 starvation-inducible outer membrane lipoprotein I4WMA1 starvation-inducible lipoprotein I4WPF1 activator of Hsp90 ATPase 1 family protein I4WQL5 thioredoxin I4WRQ8 AhpD, alkyl hydroperoxide reductase I4WSK9 SurA, chaperone

0.13

0.10 0.02

0.02 1.63 0.04 3.60 3.14 0.11 0.04 0.17 0.46 0.38 0.13 0.63 0.33 0.03 0.24 0.04 0.12 0.21 0.54 0.11 0.11 1.55 0.76 1.05 0.19 0.19 0.23 0.41

0.02 0.38 0.42 0.02 1.25 0.54 16.30 2.01 0.07 0.26 0.48 0.07 0.07 1.69 0.01 0.05 0.06 0.12 0.18 0.08 0.52 0.06 0.79 0.88 2.60 0.02 5.60 1.02 0.44 0.27 1.25

I4WUA1 thioredoxin I4WUC5 cold shock protein I4WUC6 cold shock protein I4WUD7 HtpG, chaperone protein I4WUF3 catalase I4WYA6 competence/damage-inducible protein CinA-like Transport, secretion and efflux I4VLQ8 bacterioferritin I4VNB1 YajC, preprotein translocase subunit I4VRS1 sortase system response regulator I4VUA8 ExbB, biopolymer transport protein I4VUA9 TonB family protein I4VVG8 translocase subunit SecA I4VYG3 FtsY, signal recognition particle receptor I4VYN0 TolQ protein I4VYN5 YbgF, Tol-pal system protein I4W0B9 FtsY, signal recognition particle receptor I4W1W5 Oar protein I4W345 outer membrane receptor protein I4W9D2 twin arginine-targeting protein translocase I4WAP8 TonB-dependent receptor I4WBA3 bacterioferritin I4WBV4 ExbD1, biopolymer transport protein I4WBV5 ExbB, biopolymer transport protein I4WBW4 YidC, insertase I4WBX8 ABC transporter I4WC41 TonB dependent receptor protein I4WDN2 LolA, outer-membrane lipoprotein carrier protein I4WDU8 bacterioferritin I4WDV1 TolC family type I secretion outer membrane protein I4WDW0 Na+/proline symporter I4WE23 TonB-dependent outer membrane receptor protein I4WEF4 SecF, protein-export membrane protein I4WEF5 SecD, translocase I4WEQ9 TonB-dependent receptor I4WEU4 RND family efflux transporter I4WEX9 TonB-dependent receptor I4WFK2 ferrienterochelin and colicin receptor I4WFT1 cobalamin receptor protein I4WG81 TonB protein I4WGD3 TonB family protein I4WGD5 OmpB-like

0.22 0.38 2.69 0.31 0.31 -

0.13 0.22 0.82 0.12

0.19 0.08 0.65 0.05 0.14 0.07 0.03 0.03 0.03 1.25 0.04 0.19 0.31 0.14 0.63 0.06 0.67 0.04 0.33 0.29 0.35 1.44 0.19 0.30 0.06 2.90

0.38 0.10 0.31 0.03 0.06 0.16 0.05 0.02 0.36 0.15 0.36 0.30 0.02 0.52 0.81 0.05 1.61 0.06 0.09 0.34 0.18 0.33 1.75 0.29 0.14 0.13 3.24

I4WGD6 I4WGS8 I4WGU0 I4WGU2 I4WH55 I4WH99 I4WHB0 I4WHD4 I4WIQ1 I4WIQ3 I4WIQ6 I4WIQ7 I4WIX0 I4WJ71 I4WJJ4 I4WJQ5 I4WJU6 I4WL02 I4WM79 I4WM80 I4WNG4 I4WNI0 I4WNI1 I4WNI3 I4WP57 I4WP96 I4WPE6 I4WPJ0 I4WPL7 I4WPX5 I4WQ75 I4WR37 I4WRP8 I4WRR8 I4WSA6 I4WSX0 I4WSX8 I4WT49 I4WTY3 I4WU14 I4WU70 I4WUB7 I4WUE7

autotransorter ferric enterobactin receptor TolR protein TolB TonB-dependent siderophore receptor sodium ABC transporter ATP-binding protein ABC transporter ATP-binding protein long chain fatty acid transport protein porin PstS, phosphate-binding protein PstB, phosphate import ATP-binding protein PhoU, phosphate-specific transport system accessory protein TonB-dependent receptor TonB-dependent receptor preprotein translocase TonB-dependent outer membrane receptor TonB dependent receptor protein outer membrane efflux protein hydrophobe/amphiphile efflux-1 (HAE1) family transporter multidrug resistance protein type IV pilus secretin ABC transporter auxiliary protein ABC transporter periplasmic protein ABC transporter ABC transporter permease efflux pump membrane protein RNA signal recognition particle 4.5S RNA trigger factor signal peptidase TonB-dependent receptor TonB-dependent receptor protein hemolysin D sugar transporter outer membrane protein ferritin ABC-type transporter Fe2+-dicitrate sensor RND family efflux transporter TonB-dependent outer membrane receptor efflux pump membrane fusion protein polyketide cyclase/dehydrase and lipid transport metal ion ABC transporter substrate-binding protein TonB-dependent siderophore receptor

0.04 0.36 0.11 0.12 0.13 0.74 0.54 0.07 0.14 0.21 0.13 0.23 0.05 0.23 0.34 0.76 0.10 0.03 0.05 0.03 0.08 0.32 0.20 0.50 0.11 0.08 0.07 0.12 0.09 0.73 0.90 0.08

0.13 0.14 0.09 0.26 0.17 0.07 0.06 0.25 0.26 0.76 0,05 0.04 0.20 0.24 0.34 0.04 0.05 0.12 0.05 0.70 0.05 0.12 0.02 0.05 0.19 0.05 0.05 0.04 0.08 0.11 0.07 0.26 0.21 0.08 0.11 0.07 0.04 1.13 0.66 0.12

I4WWB0 outer membrane cobalamin receptor protein I4WZB9 ABC transporter ATP-binding protein Other functions I4VJ32 serine/threonine phosphatase with Cache sensor I4VJL1 dTDP-glucose 4.6-dehydratase I4VKW0 Cell division protein MoxR-like ATPase I4VP03 I4VPB8 modulator of FtsH protease I4VPN3 cell division protein I4VPP0 partition protein I4VQ36 FtsE, cell division ATP-binding protein I4VQR5 MreB, rod shape-determining protein I4VTQ2 AMP nucleosidase response regulator consisting of a CheY-like receiver domain and a FisI4VV38 type HTH domain protein PilH, two-component system response regulatory protein I4VV66 response regulator receiver protein I4VV67 I4VXH1 two-component system response regulator protein response regulator receiver domain-containing protein I4VZJ1 I4W0C6 NTP pyrophosphohydrolase I4W2S6 ribose-phosphate pyrophosphokinase I4W459 sulfate adenylyltransferase subunit 2 I4W782 protein kinase I4W8Y5 amidohydrolase I4W9N8 glutathione S-transferase I4W9N9 adenylosuccinate lyase I4W9T6 methyltransferase I4WAH3 HemC, porphobilinogen deaminase I4WAT9 PurH, bifunctional purine biosynthesis protein I4WAZ7 ObgE, GTPase I4WB46 metal-dependent amidohydrolase I4WB49 amidohydrolase I4WBQ6 5'-nucleotidase domain-containing protein I4WBV2 PdxJ, pyridoxine 5'-phosphate synthase I4WBZ2 partition protein I4WCC3 alkaline phosphatase I4WCC6 5'-nucleotidase domain-containing protein I4WCF1 thymidylate synthase I4WCF2 dihydrofolate reductase I4WCL9 Amidohydrolase I4WCM6 thymidine kinase I4WCP1 haloacid dehalogenase-like hydrolase

0.33 0.09

-

0.10 0.29 0.04 0.18

0.01 0.05 0.06 0.04 0.11 0.11 0.09 -

0.18 0.42 0.12 0.12 0.16 0.09 0.04 0.10 0.03 0.15 0.17 0.08 0.08 0.28 -

0.06 0.27 0.07 0.04 0.02 0.11 0.02 0.21 0.16 0.04 0.11 0.08 0.03 0.04 0.23 0.04 0.09 0.20

I4WCP5 I4WCP7 I4WCP8 I4WD04 I4WD67 I4WD71 I4WDN1 I4WDT2 I4WDT3 I4WDT9 I4WDU5 I4WDV0 I4WDW1 I4WE19 I4WE39 I4WE90 I4WEG5 I4WEI4 I4WF02 I4WF09 I4WF36 I4WF93 I4WF97 I4WFD4 I4WG63 I4WG75 I4WG76 I4WG77 I4WG87 I4WGC2 I4WGC3 I4WGC5 I4WGP6 I4WGV1 I4WH93 I4WH94 I4WHH6 I4WIB5 I4WIC6 I4WID0 I4WID4 I4WID5

delta-aminolevulinic acid dehydratase dihydroorotase glutamate--cysteine ligase thioredoxin methyltransferase metallo carboxipeptidase FtsK, DNA segregation ATPase thiamine-phosphate synthase HemL, glutamate-1-semialdehyde 2.1-aminomutase Adk, adenylate kinase inorganic pyrophosphatase L-isoaspartate carboxylmethyltransferase lipid/polyisoprenoid binding protein aspartyl/asparaginyl beta-hydroxylase NAD-dependent epimerase/dehydratase response regulator with CheY-like receiver domain uracil phosphoribosyltransferase uridylate kinase glutathione S-transferase MreB, rod shape-determining protein UbiB, kinase oxygen-dependent coproporphyrinogen-III oxidase N-acyl-L-amino acid amidohydrolase amidohydrolase acetyl transferase amidase sulfate adenylyltransferase bifunctional sulfate adenylyltransferase /adenylylsulfate kinase protein signal transduction protein formylglycine-generating sulfatase family protein SCO1 /SenC family protein thiol peroxidase glutamine cyclotransferase laccase-domain protein RmuC domain-containing protein GTP cyclohydrolase uroporphyrin-III C-methyltransferase pirin nucleoside diphosphate kinase GTP binding protein inosine-5'-monophosphate dehydrogenase GMP synthase

0.06 0.12 0.04 0.17 0.09 0.04 0.11 0.10 1.53 0.08 2.76 0.02 0.11 0.69 0.09 0.08 0.21 0.25 0.02 0.02 0.17 0.24 0.20 0.39 0.36 0.21 0.14 0.36 0.05 0.33 0.28 0.10 0.63 0.19 0.05

0.49 0.39 0.17 0.02 0.12 1.18 0.50 0.13 1.19 0.48 0.29 0.12 0.22 0.04 0.02 0.03 0.03 0.10 0.10 0.29 0.29 0.24 0.03 0.04 0.34 1.53 0.13 0.10 -

I4WIK5 I4WIM0 I4WIN6 I4WIT8 I4WIV3 I4WJ80 I4WJ85 I4WJ96 I4WJ97 I4WJ98 I4WJA5 I4WJB8 I4WJQ4 I4WJR1 I4WJR2 I4WJS9 I4WJT2 I4WJT6 I4WJT9 I4WJU3 I4WJU7 I4WJU8 I4WKD1 I4WKD2 I4WKH9 I4WKI3 I4WMK7 I4WNA1 I4WNG3 I4WNH3 I4WNV0 I4WP91 I4WPE1 I4WPF7 I4WPG0 I4WPG1 I4WPG2 I4WPH2 I4WPJ1 I4WPM8 I4WPM9 I4WPV1

ZipA, cell division protein TraB, pheromone shutdown-related protein histone-like protein adenylosuccinate synthetase 2-methylcitrate dehydratase acetylornithine aminotransferase Parathion hydrolase 6,7-dimethyl-8-ribityllumazine synthase L.D-carboxypeptidase A 3,4-dihydroxy-2-butanone 4-phosphate synthase orotidine 5'-phosphate decarboxylase phosphoribosylformylglycinamidine synthase Rossmann fold nucleotide-binding protein N5-carboxyaminoimidazole ribonucleotide synthase N5-carboxyaminoimidazole ribonucleotide mutase adenosylmethionine-8-amino-7-oxononanoate aminotransferase chemotaxis-related protein chemotaxis signal transduction protein pili glutathione synthetase aspartate carbamoyltransferase twitching motility protein twitching motility protein response regulator receiver protein DnaJ-class molecular chaperone MoxR-like ATPase diadenosine tetraphosphate hydrolase 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase phosphoribosylaminoimidazole-succinocarboxamide synthase MoxR-like ATPase inosine-uridine nucleoside N-ribohydrolase sulfatase-modifying factor protein 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase 3-demethylubiquinone-9 3-methyltransferase glutathione S-transferase penicillin acylase succinate-CoA transferase 3-demethylubiquinone-9 3-methyltransferase PyrG, CTP synthase ATP-dependent Clp protease hypoxanthine-guanine phosphoribosyltransferase S-methyl-5'-thioinosine phosphorylase geranylgeranyl pyrophosphate synthase

0.08 0.03 3.65 0.24 0.16 0.03 0.22 0.06 0.06 0.11 0.28 0.25 0.08 0.13 0.28 0.54 0.11 0.04 0.14 0.11 0.05 0.04 0.04 0.10 0.24 0.12 0.06

1.50 0.21 0.32 0.19 0.21 0.10 0.05 0.02 0.07 0.04 0.03 0.10 0.01 0.02 0.09 0.12 0.38 0.05 0.03 0.12 0.26 0.10 0.02 0.04 0.33 0.87 0.10 0.11 0.15

I4WPV4 I4WPW4 I4WQ95 I4WQC3 I4WQC8 I4WQL8 I4WRC2 I4WRC7 I4WRK0 I4WRN4 I4WSD6 I4WSL8 I4WSY2 I4WSY8 I4WSZ6 I4WT06 I4WT08 I4WU93 I4WUC9 I4WV01

polyisoprenoid-binding protein polyisoprenoid-binding protein S-formylglutathione hydrolase PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase UbiG, ubiquinone biosynthesis O-methyltransferase PqiB family protein carboxymethylenebutenolidase ATPase bifunctional folylpolyglutamate synthase/dihydrofolate synthase isoprenoid biosynthesis protein nucleotide-binding protein GTP binding protein response regulator with CheY-like receiver domain adenosylhomocysteinase S-adenosylmethionine synthase LppC family lipoprotein MraZ, transcriptional regulator acetyl transferase pirin phosphoglycerol transferase family protein, alkaline phosphatase superfamily I4WV06 pteridine reductase I4WVE3 disulfide isomerase I4WVE4 thiol:disulfide interchange protein I4WVX6 (p)ppGpp synthetase I4WXN8 inosine-5'-monophosphate dehydrogenase I4WYH0 N5-carboxyaminoimidazole ribonucleotide synthase M4NDJ5 heme biosynthesis enzyme Function unknown I4VQ20 I4VSJ4 I4VV34 I4W9G3 I4W9L9 I4WAA1 I4WB04 I4WB10 I4WB40 I4WBM4 I4WBS3 I4WBT2 I4WBV7

0.05 0.07 0.08 0.05 0.25 0.05 0.03 0.18 0.03 0.04 0.36 0.14 0.13 0.24 0.23 0.23 -

0.08 0.05 0.07 0.07 0.03 0.04 0.14 0.26 0.03 0.28 0.16 0.12 0.11 0.04

0.24 0.17 0.07 -

0.11 0.53 0.19 0.01 0.04 0.05

0.04 0.21 0.81 0.08 0.21 0.10 0.25 0.06 0.72

0.19 0.35 0.06 0.23 0.05 0.44 0.02 0.32 0.06 0.44

I4WC23 I4WC53 I4WCF0 I4WD84 I4WDU6 I4WDZ3 I4WDZ5 I4WE01 I4WE02 I4WE09 I4WE16 I4WEN9 I4WEU3 I4WEX6 I4WF92 I4WF94 I4WFK9 I4WFL9 I4WFM7 I4WG57 I4WG83 I4WG92 I4WGK8 I4WGK9 I4WH42 I4WH59 I4WHT8 I4WJA7 I4WJS3 I4WJU4 I4WM37 I4WMC4 I4WMK6 I4WN45 I4WN49 I4WNI6 I4WNX0 I4WPE8 I4WPL8 I4WPM4 I4WQL9 I4WQS0 I4WRB7

0.09 0.11 0.28 0.11 0.09 0.09 0.15 0.15 0.17 0.57 0.01 0.45 0.14 0.02 5.89 0.26 0.13 0.05 1.02 0.08 0.06 0.28 0.15 0.10 0.50 0.15 0.21 0.15 0.21 0.25 0.08 0.08 0.59

0.50 0.07 0.13 0.20 0.19 0.12 0.14 2.33 0.01 0.09 0.02 0.01 9.61 0.03 0.03 0.45 0.17 0.16 0.03 0.16 0.06 0.36 0.10 0.14 0.67 0.14 0.01 0.14 0.13 0.35

I4WRC0 I4WRF9 I4WRK1 I4WRN7 I4WRW1 I4WRX1 I4WSB0 I4WSB4 I4WSM6 I4WSW9 I4WU94 I4WUA7 I4WUC4 I4WUE0 I4WYZ8 a Data are the mean of two replicates. b Proteins in bold characters have a predicted intracellular localization. c Protein not detected or protein identification not considered valid.

0.38 0.64 0.69 0.14 0.01 0.07 0.19 0.28 0.44 0.28 0.39

0.26 0.14 0.06 0.02 0.04 1.28 0.08 0.11 0.01 0.16 -

Table S3 Proteins produced by Myxococcus xanthus DK 1622 during growth in minimal medium supplemented with suberin at day 5 and day 25 Uniprot accession Putative function number Amino acid metabolism Q1D8A6 penicillin acylase Q1D5W7 peptidase b Q1D4C2 Glu/Leu/Phe/Val dehydrogenase Q1D7P1 peptidase Glu/Leu/Phe/Val dehydrogenase PNP Q1D9F6 peptidase Q1DBU7 peptidase aminotransferase Q1D215 prolyl endopeptidase Q1DAS8 Xaa-Pro aminopeptidase Q1DAR8 peptidase Q1CXD4 Cys/Met metabolism PLP-dependent enzyme Q1DAQ9 Q1DBU8 peptidase glycine dehydrogenase Q1D7X2 peptidase Q1CY03 Q!CZK0 pptidase Q1DD17 peptidase cysteine synthase Q1DC00 4-hydroxy-tetrahydrodipicolinate synthase Q1CZV8 aspartate aminotransferase Q1D6Z0 Q1D7L0 peptidase urocanate hydratase Q1D4A7 branched-chain amino acid aminotransferase Q1D827 Q1CWK6 peptidase Q1CZV3 peptidase serine hydroxymethyltransferase GLYA 2-oxoisovalerate dehydrogenase Q1D3P1 Q1D9S1 aminopeptidase Q1DER8 serine protease S-adenosylmethionine synthase METK Q1D5T1 peptidase peptidase Q1DEW1 2-oxoisovalerate dehydrogenase Q1D3P0 histidine ammonia-lyase HUTH Q1CWF2 peptidase Q1D6F2 peptidyl-dipeptidase glutamine synthetase Q1DDV0 peptidase Q1DAV7 peptidase Q1DFN7

Abundance (NSpCa) 5 days

25 days

0.18 0.27 0.36 0.24 0.28 0.30 0.29 0.22 0.22 0.19 0.18 0.19 0.22 0.16 0.15 0.13 0.27 0.29 0.21 0.12 0.15 0.24 0.13 0.26 0.19 0.18 0.19 0.10 0.16 0.11 0.11 0.18 0.10 0.08 0.09 0.14 0.10 0.13 0.15

0.11 0.03 0.04 -c 0.14 0.22 0.04 0.04 0.23 0.11 0.08 0.05 0.20 0.39 0.07 0.24 0.10 0.05 0.07 0.02 0.21

SAHH Q1DDP8 Q1CZZ5 Q1D2E3 Q1D4V2 Q1D2K4 Q1CZD2 Q1CYE6 CARB HSLU Q1CYQ0 Q1DBS1 F8CLH1 Q1D9N1 Q1DEY9 Q1DAK3 ASTB Q1DA13 Q1DAQ3 Q1D625 Q1D624 Q1DG40 Q1D459 Q1DD72 Q1D4R7 Q1D6K7 Q1CY62 Q1D3A8 Q1CW90 Q1CY13 Q1CYP7 Q1DCI3 Q1DBP3 Q1DDS8 Q1D013 A0A0H4W WS1 Q1DA16 Q1D3D3 DAPB Q1DDD9 Q1D1D4 Q1DCD4 HGD Q1D188 Q1D6G9

adenosylhomocysteinase peptidase. 1-pyrroline-5-carboxylate dehydrogenase peptidase alanine dehydrogenase aminopeptidase zinc metalloprotease arginine N-succinyltransferase carbamoyl-phosphate synthase ATP-dependent protease fumarylacetoacetate hydrolase chymotrypsin aspartate-semialdehyde dehydrogenase peptidase dipeptidyl peptidase peptidase N-succinylarginine dihydrolase peptidase cystathionine beta-synthase peptidase peptidase peptidase L-erytro-3,5-diaminohexanoate dehydrogenase peptidase peptidase chorismate synthase protease L-lysine 2,3-aminomutase metallopeptidase peptidase serine protease gamma-glutamyltranspeptidase deoxyhypusine synthase family protein protease glutamate dehydrogenase

0.12 0.11 0.12 0.13 0.11 0.07 0.10 0.05 0.09 0.10 0.13 0.10 0.03 0.05 0.05 0.08 0.06 0.06 0.06 0.05 0.05 0.06 0.02 0.02 0.07 0.15 0.04 0.04 0.04 0.03 0.02 0.05 0.03 0.03 0.03

0.17 0.13 0.09 -

sarcosine oxidase peptidyl-dipeptidase dihydrodipicolinate reductase 4-hydroxy-tetrahydrodipicolinate reductase Glu/Leu/Phe/Val dehydrogenase peptidase L-allo-threonine aldolase homogentisate 1,2-dioxygenase peptidase peptidase

0.02 0.03 0.05 0.04 0.02 0.03 0.02 -

0.10 0.13 0.04 0.09

Q1D7W5 aspartate-semialdehyde dehydrogenase serine protease Q1CYR4 aminotransferase Q1DFN6 Q1D8P6 peptidase Q1DE55 peptidase Q1CZR8 peptidase Q1D8L5 protease aspartate 1-decarboxylase PAND phosphoserine aminotransferase SERC Q1DEW6 peptidase Carbohydrate metabolism phosphoenolpyruvate carboxykinase Q1DCV2 fructose-bisphosphate aldolase Q1D5Z8 glyceraldehyde-3-phosphate dehydrogenase Q1D8J1 transketolase Q1CVV7 ENO enolase transaldolase TAL glucose-6-phosphate 1-dehydrogenase Q1DDQ9 triosephosphate isomerase TPIS Q1CY18 gluconolaconase GDP-mannose 4,6-dehydratase Q1D1J6 Q1DDR1 6-phosphogluconate dehydrogenase glucose-6-phosphate isomerase G6PI phosphoglucomutase/phosphomannomutase Q1D0G8 Q1CXL1 glucose/sorbosone dydrogenase UDP-glucose 4-epimerase Q1D6M2 phosphoglycerate kinase Q1D8J0 pyruvate kinase Q1D6L5 pyruvate kinase Q1CYU9 UTP-glucose-1-phosphate uridylyltransferase Q1DCE1 Q1D3S1 chitinase 6-phosphogluconolactonase Q1DDR0 glycogen synthase GLGA Cell wall, membrane and envelope biogenesis Q1DDQ0 lipoprotein Q1CVX7 lipoprotein Q1CZE8 outer membrane protein MLPA lipoprotein MlpA Q1D8U6 lipoprotein Q1D0K1 lipoprotein Q1DD51 lipoprotein Q1D8L4 lipoprotein Q1CXU8 lipoprotein Kelch motif/HYR domain protein Q1CYZ9 Q1CWA7 outer membrane protein Q1DFL0 cell surface protein

-

0.03 0.06 0.03 0.03 0.02 0.04 0.07 0.08 0.11

0.22 0.34 0.28 0.13 0.23 0.29 0.17 0.26 0.12 0.11 0.10 0.09 0.04 0.08 0.07 0.06 0.05 0.03 0.05 0.05 0.04 0.02

0.06 0.43 0.05 0.09 0.11 0.16 0.04 -

0.17 0.23 0.23 0.20 0.15 0.50 0.10 0.26 0.12 0.09 0.26 0.23

0.17 0.03 0.13 0.20 0.14 0.28 0.17 0.08 0.06 0.20

Q1CZ46 Q1CY27 Q1CY79 Q1D364 Q1D6V9 Q1CXU6 Q1D9N0 Q1CWM1 Q1D0H4 Q1DCM4 Q1DE07 Q1D8J2 Q1CY59 Q1D5A9 Q1D813 Q1D9B4 Q1CWS3 Q1CWB1 Q1D1K7 Q1D3C1 Q1DDE9 Q1CXN6 Q1D049 Q1D805 Q1CVX8 Q1DEJ6 Q1D227 Q1D729 Q1DC33 Q1D638 Q1D917 Q1D3F5 Q1D122 Q1DE38 Q1D139 Q1DDT8 Q1CYN2 Q1DDJ2 Q1DA87 Q1DCK1 Q1D0G9 Q1DAK4 Q306N4 Q1DFQ7 Q1D1X6 Q1D218

secretion system protein cell surface protein lipoprotein outer membrane lipoprotein lipoprotein lipoprotein cell surface protein lipoprotein lipoprotein lipoprotein lipoprotein chemotaxis protein MotB N-acetylmuramoyl-L-alanine amidase stomatin-like domain-containing protein stomatin-like domain-containing protein LysM domain protein outer membrane protein chemotaxis protein MotB lipoprotein outer membrane protein outer membrane protein lipoprotein lipoprotein Ig-like domain protein membrane protein lipoprotein lipoprotein Tol-pal system protein YbgF L-seryl-tRNA(Sec) selenium transferase lipoprotein lipoprotein outer membrane protein pilus assembly protein lipoprotein lipoprotein outer membrane protein outer membrane protein lipoprotein type IV pilus assembly protein lipoprotein pilus assembly protein outer membrane protein OmpA domain protein type IV secretion protein PilO lipoprotein OmpA domain protein OmpA family protein

0.32 0.08 0.32 0.12 0.18 0.14 0.18 0.18 0.17 0.11 0.22 0.05 0.14 0.16 0.12 0.13 0.16 0.03 0.15 0.13 0.12 0.18 0.02 0.05 0.13 0.05 0.11 0.07 0.13 0.11 0.13 0.14 0.18 0.06 0.09 0.09 0.13 0.02 0.05 0.02 0.06 0.03 0.07 0.16 0.05 0.12

0.06 0.08 0.04 0.10 0.08 0.11 0.02 0.05 0.03 0.07 0.18 0.01 0.02 0.11 0.16 0.07 0.11 0.08 0.01 -

Q1D811 MotA/TolQ/ExbB proton channel protein BamA Q1D383 UDP-N-acetylmuramyl-tripeptide synthetase Q1D0S5 pilus assembly protein PilM Q1DD080 Q1D427 outermmebrane protein Q1CYZ8 OmpA domain protein Q1D314 surface cell protein Q1D991 lipoprotein OmpA domain protein Q1D2C6 Q1D1M7 collagen triple helix repeat protein Q1CWC6 lipoprotein Q1D3M7 membrane protein Q1D1J2 lipoprotein Q1D8L3 lipoprotein Q1DAX3 lipoprotein lipoprotein Q1DAE0 Q1D6F4 lipoprotein lipoprotein Q1DE67 Q1D0I5 lipoprotein Q1D191 cell surface protein Q1CVK5 Ig domain protein Q1D8Z4 outer membrane lipoprotein Q1D0T6 OmpA domain protein Q1D9T7 lipoprotein Q1DE25 lipoprotein Q1D271 Ig domain protein Q1D7R7 lipoprotein Q1D646 lipoprotein Q1D7R8 lipoprotein type IV secretion system protein Q1D303 Q1CXP7 lipoprotein lipoprotein Q1CXB9 A0A0H4W XC7 outer membrane protein assembly factor Q1D9P7 Omp A domain protein Energy production and conversion ATP synthase ATPB dihydrolipoyl dehydrogenase Q1D4M9 molybdopterin oxidoreductase Q1CZF9 ATP synthase ATPA citrate synthase Q1D6L0 pyruvate dehydrogenase Q1D8Y7 pyruvate dehydrogenase Q1D8Y8 MDH malate dehydrogenase Q1D6J1 succinate dehydrogenase Q1DCK3 aconitate hydratase

0.05 0.02 0.05 0.04 0.09 0.04 0.01 0.03 0.03 0.05 0.06 0.07 0.08 0.04 0.05 0.01 0.05 0.02 0.02 -

0.02 0.10 0.09 0.04 0.04 0.02 0.03 0.21 0.04 0.06 0.01 0.04 0.07 0.02 0.01 0.03 0.02 0.06 0.02 0.07

-

0.02 0.06

0.43 0.38 0.20 0.38 0.27 0.34 0.26 0.32 0.22 0.14

0.11 0.09 0.07 0.11 0.14 0.04 0.09 0.04 0.02

isocitrate dehydrogenase Q1CYR1 2-oxoglutarate dehydrogenase Q1CZK3 adventurous gliding motility protein Q846U1 SUCC succinyl-CoA ligase pyruvate dehydrogenase Q1D8Y6 alpha keto acid dehydrogenase Q1D4N1 ATP synthase ATPG Q1D1C4 cytochrome c 2-oxoglutarate dehydrogenase Q1CZK2 pyruvate dehydrogenase Q1CZX3 Q1D4Q0 CyaE Q1CZF6 cytochrome c family protein succinyl-CoA ligase Q1D6I8 Q1D6J0 succinate dehydrogenase ATP synthase ATPD NADH-quinone oxidoreductase NUOD aldehyde dehydrogenase Q1D2C8 Q1D856 NADH-quinone oxidoreductase NADH-quinone oxidoreductase NUOI NADH dehydrogenase I Q1D8S8 aldehyde dehydrogenase Q1CWX3 2-nitropropane dioxygenase Q1DA35 NADH-quinone oxidoreductase NUOB Q1CZG0 cytochrome c NADH dehydrogenase Q1DDC7 Q1D5X3 PQQ enzyme repeat domain protein Q1CW00 short chain dehydrogenase NADH dehydrogenase Q1DDC8 ATP synthase ATPF succinate dehydrogenase Q1DDE1 cytochrome c Q1CZF2 oxidoreductase Q1D6Y7 Lipid metabolism and ketogenesis Q1CWS1 lipase patatin-like phospholipase Q1D4F3 Q1CYB4 acetyl co-enzyme A carboxylase carboxyltransferase acetyl-coenzyme A synthetase Q1D030 acetyl-CoA acetyltransferase Q1D5V0 long-chain-fatty-acid--CoA ligase Q1D9B8 Q1D233 3-hydroxyacyl-CoA dehydrogenase carboxyl transferase domain protein Q1D5Y2 Q1D009 YceI-like family protein acyl-CoA dehydrogenase Q1D3D6 beta-ketothiolase BKT acyl-CoA dehydrogenase Q1D5U4 acetyl-coenzyme A synthetase Q1D984

0.31 0.10 0.21 0.29 0.16 0.26 0.26 0.12 0.15 0.14 0.12 0.20 0.18 0.16 0.25 0.10 0.06 0.16 0.12 0.06 0.04 0.07 0.05 0.12 0.14 0.07 0.05 0.05 0.12 0.06 0.03 -

0.08 0.01 0.07 0.12 0.04

0.31 0.35 0.37 0.19 0.33 0.20 0.17 0.19 0.27 0.13 0.17 0.10 0.06

0.21 0.13 0.16 0.06 0.10 0.14 0.12 -

propionyl-CoA carboxylase Q1DDA0 3-oxoacyl-[acyl-carrier protein] reductase Q1DFT0 acetyl-CoA carboxylase. biotin carboxylase Q1D0B9 malonyl CoA-acyl carrier protein transacylase Q1D340 3-hydroxyacyl-CoA dehydrogenase Q1D5U1 enoyl CoA dehydratase Q1D5U2 acyl-CoA dehydrogenase Q1D4E4 acetyl CoA carboxylase Q1D0T9 acetyl-coenzyme A carboxylase carboxyl transferase Q1D555 acetyl-CoA acetyltransferase Q1D234 Q1CZK4 enoyl-[acyl-carrier-protein] propionyl-CoA carboxylase Q1DDA2 Q1D343 3-oxoacyl-[acyl-carrier-protein] synthase acyl-CoA hydrolase Q1D964 Q1CYM5 medium-chain fatty acid-CoA ligase A0A0H4W acyl-CoA dehydrogenase WQ8 3-hydroxybutyryl-CoA dehydratase Q1D5Y4 acetyl-coenzyme A carboxylase carboxyl transferase Q1D8V2 acyl-CoA dehydrogenase Q1D5Y1 patatin-like phospholipase family protein Q1D5W1 3-oxoacid CoA-transferase family Q1D5V2 long-chain-fatty-acid--CoA ligase Q1D855 acyltransferase Q1D566 acyl-CoA dehydrogenase Q1CZW5 beta-ketothiolase Q1D003 Replication, transcription, translation and DNA repair elongation factor Tu EFTU1 DNA-directed RNA polymerase RPOB Q1CYZ6 cyclic nucleotide-binding domain protein transcription termination/antitermination protein NusA Q1DAM8 DNA-directed RNA polymerase RPOC DNA-directed RNA polymerase RPOA Q1DC39 DNA topoisomerase Q1CYZ5 cyclic nucleotide-binding domain protein ATP-dependent helicase Q1D015 adventurous-gliding motility protein AGLZ development-specific protein TPS elongation factor EFTS glutamine--tRNA ligase Q1D9U0 OB-fold nucleic acid binding domain protein Q1D8J8 response regulator receiver domain protein (CheY-like) Q1DDC0 proline--tRNA ligase SYP ribonuclease L7UF14 methionine--tRNA ligase SYM SYT threonine--tRNA ligase

0.07 0.21 0.10 0.11 0.18 0.13 0.07 0.03 0.06 0.05 0.07 0.04 0.07 0.08 0.03

0.02 -

0.02 0.05 0.05 0.04 0.01 0.07 0.02 0.02 0.02 -

0.02 0.13

0.62 0.14 0.26 0.27 0.10 0.22 0.36 0.15 0.10 0.06 0.21 0.25 0.12 0.11 0.11 0.10 0.03 0.06 0.07

-

5'-nucleotidase Q1CWL9 SSU ribosomal protein S1p Q1D5U8 translation initiation factor IF-2 IF2 exodeoxyribonuclease III Q1D1Z2 30S ribosomal protein RS2 Q1D0I2 PspA/IM30 family protein elongation factor G 1 EFG1 transcriptional regulator Q1DCG4 signal transduction protein Q1DEC3 Q1DFW6 methyl-accepting chemotaxis protein serine--tRNA ligase SYS DNA-binding protein FruA Q1D7Q3 isoleucine--tRNA ligase Q1CZ22 alanine--tRNA ligase SYA 50S ribosomal protein L9 RL9 asparagine--tRNA ligase SYN trigger factor TIG Q1D293 50S ribosomal protein L25 tRNA pseudouridine synthase Q1D5D5 glycine--tRNA ligase SYGB IF3 translation initiation factor IF-3 phosphohistidine phosphatase SixA Q1D1I5 DNA polymerase I Q1D7R1 50S ribosomal protein L10 RL10 exoribonuclease Q1DGB6 ribosome-recycling factor RRF gliding motility regulatory protein Q1D4V8 transcriptional regulator Q1DFR3 valine--tRNA ligase Q1D3Z2 tryptophanyl-tRNA synthetase Q1D5P9 response regulator Q1D3Z1 aspartyl-tRNA synthetase Q1D3C3 50S ribosomal protein L2 RL2 histidine kinase/response regulator Q1DEC4 Q1DAU4 30S ribosomal protein S9 histidine kinase/response regulator Q1D3G7 Q1D8Z3 5'-nucleotidase family protein Q1D668 methyl accepting chemotaxis protein Q1D087 translation elongation factor transcription termination factor Rho Q1D0P8 elongation factor Tu 2 EFTU2 single-stranded DNA-binding protein Q1DDE2 Stress and defense mechanisms chaperonin CH602 DSBA-like thioredoxin domain protein Q1D7G6 chaperonin CH601

0.06 0.07 0.04 0.10 0.12 0.14 0.04 0.08 0.04 0.06 0.02 0.12 0.03 0.04 0.13 0.05 0.05 0.13 0.03 0.03 0.07 0.14 0.02 0.08 0.04 0.10 0.02 0.19 0.01 0.05 0.04 0.01 0.05 0.01 0.10 0.02 0.02 0.03 0.05 0.02 -

0.02 0.23 0.11

0.49 0.47 0.47

0.11 0.16 0.19

alkyl hydroperoxide reductase Q1DC07 Q1D2K1 thioredoxin domain-containing protein chaperone protein DnaK Q1D7I0 encapsulating protein for peroxidase Q1D6H4 Q1D2Y6 superoxide dismutase Q1D024 superoxide dismutase Lon protease Q1D5A0 chaperone HtpG B8QZT3 F8CP79 DSBA-like thioredoxin A0A0F7E2 chaperonin A3 chaperone ClpB Q1D2Z9 thioredoxin Q1D902 chaperone Q1D0R6 Dps family protein Q1DC09 Q1CWM0 glutathione peroxidase thioredoxin domain-containing protein Q1D1X3 Q1CWQ0 peptide methionine sulfoxide reductase OsmC/Ohr family protein Q1D8R6 Q1D819 HtrA protease/chaperone protein S-formylglutathione hydrolase Q1CWL7 Transport, secretion and efflux Q1DCB6 TonB-dependent receptor TonB-dependent receptor Q1CX48 Q1CWS0 long fatty acid chain transporter Q1D031 porin TonB-dependent receptor Q1D365 Q1DBN3 TonB family protein Q1D2E5 TonB dependent receptor Q1D9E0 secretion pathway protein Q1D2D8 efflux transporter type V1 secretion protein Q1D304 Q1DCQ0 TonB dependent receptor MotA/TolQ/ExbB proton channel family protein Q1CYB8 Q1DCG9 PBS lyase HEAT-like repeat protein Q1D4S2 outer membrane efflux protein MotA/TolQ/ExbB proton channel protein Q1CX94 Q1DE39 TonB family protein Q1CVN2 efflux protein MotA/TolQ/ExbB proton channel protein Q1DCB8 A176_0055 Oar protein 31 Q1CXU1 branched chain amino acid ABC transporter Q1DDZ2 apolipoprotein-containing domain Q1D4F4 arsenical pump-driving ATPase iron-chelator utilization protein Q1D697

0.62 0.41 0.21 0.23 0.23 0.20 0.05 0.03 0.03

0.14 0.08 0.03 0.20 0.16 -

0.18 0.02 0.25 0.09 0.11 0.10 0.04 0.06 0.07 0.02 -

0.13 0.10

0.40 0.45 0.35 0.24 0.22 0.18 0.23 0.18 0.30 0.22 0.16 0.22 0.13 0.17 0.23 0.10 0.18 0.21

0.27 0.20 0.14 0.18 0.05 0.04 0.27 0.08 0.16 0.13 0.12 0.03 0.05 -

0.01 0.19 0.10 0.13 0.17

0.21 0.13

Q1DB13 Q1D3P6 Q1CVZ3 Q1DEY6 SECA Q1D9H3 Q1DFV8 Q1DEU2 Q1DCV4 Q1DE87 Q1DEU5 Q1D5I8 Q1D099 Q1D2U8 Q1DD62 Q1DFZ8 Q1DEV0 Q1CWK2 TOLB Q1DEG8 Q1D696 Q1DCP7 Q1DCC0 Q1D7R4 Q1CZ64 Q1CYB7 Q1D3B5 Q1D521 Q1DCB7 Q1D8I1 Q1CVG1 Q1D3Z8 Q1CY23 Q1D5Z6 Q1D1X8 A0A0H4W T21 Q1D9M3 Q1CVX9 Q1D0D3 Other functions Q1CWK0 Q1D9I3 Q1D3W0 Q1DF51

porin TonB dependent receptor porin TonB-dependent receptor translocase SecA signal peptide peptidase SppA efflux pump phosphate-selective porin ABC transporter iron ABC transporter ABC transporter efflux transporter twitching motility protein TonB domain protein amino acid transporter WD domain G-beta repeat/PBS lyase HEAT-like repeat protein ABC transporter cysteine-rich secretory protein TolB ferric siderophore ABC transporter siderophore biosynthesis aminotransferase hemin ABC transporter ExbD/TolR transport protein protein transporter efflux transporter transport energizing protein preprotein translocase YajC ABC transporter TonB Nit/TauT transport system insertase YidC polyketide cyclase/dehydrase and lipid transport TonB-dependent receptor phospholipid transport system PBS lyase HEAT repeat-like domain protein

0.11 0.05 0.12 0.05 0.04 0.06 0.05 0.08 0.08 0.09 0.04 0.08 0.09 0.05 0.07 0.01

0.08 0.10 0.02 0.08 0.02 0.04

0.03 0.14 0.07 0.06 0.05 0.05 0.11 0.04 0.05 0.17 0.17 0.05 0.08 0.05 0.02 0.09 0.02 0.07 0.03

0.03 -

arsenical pump-driving ATPase ABC transporter TonB-dependent receptor MotA/TolQ/ExbB proton channel protein

0.01 0.04 0.01 0.04

-

peptidyl-prolyl cis-trans isomerase 5'-nucleotidase family protein phage tail sheath protein myo-inositol-1-phosphate synthase

0.52 0.31 0.20 0.28

0.31 0.12 0.30 -

Q1DCH7 Q1D0E3 Q1DEX1 Q1CVJ5 NDK Q1D4V7 Q1DD37 Q1D4E5 Q1DCD9 Q1DC52 GLPK Q1D458 Q1D5W4 CGLB PURA Q1DA41 Q1D440 Q1CVR5 Q1D1J7 Y1394 Q1CYB9 Q1D6F6 Q1DDZ8 Q1D5X7 Q1DFJ0 Q1D7G7 Q1D3H2 Q1DG65 Q1D4E8 L7U7N0 PYRF Q1CWR7 Q1DCF0 PYRG Q1D418 PYRB Q1D2U6 Q1DG46 DEOD PUR4 Q1CYZ7 Q1CVY7 Q1D4M7 Q1CXA7

alkaline phosphatase aspartyl beta-hydroxylase NAD dependent epimerase/dehydratase bactofilin nucleoside diphosphate kinase frizzy aggregation protein peptidyl-prolyl cis-trans isomerase phosphodiesterase/nucleotide pyrophosphatase family protein glutathione S-transferase adenosine deaminase glycerol kinase feruloyl esterase iInosine-5'-monophosphate dehydrogenase CglB adenylosuccinate synthetase B12 binding domain/ArgK/methylmalonyl-CoA mutase family protein methyl transferase vegetative protein phytase beta lactamase oxidoreductase metallophosphoesterase glutathione S-transferase peptidyl-prolyl cis-trans isomerase oxidoreductase dihydrofolate reductase bactofilin amidohydrolase polyketide synthase serine-threonine protein kinase orotidine 5'-phosphate decarboxylase oxidoreductase NAD-dependent epimerase/dehydratase CTP synthase serine/threonine protein kinase aspartate carbamoyltransferase adventurous gliding motility protein AglT amidohydrolase purine nucleoside phosphorylase phosphoribosylformylglycinamidine synthase terpene synthase oxidoreductase DofB peptidyl-prolyl cis-trans isomerase

0.17 0.22 0.18 0.63 0.66 0.24 0.23

0.14 0.08 0.07 -

0.19 0.28 0.19 0.17 0.15 0.11 0.11 0.12

0.09 0.19 0.05 0.05 -

0.05 0.09 0.21 0.11 0.14 0.14 0.12 0.22 0.19 0.14 0.21 0.16 0.01 0.02 0.05 0.10 0.07 0.13 0.05 0.03 0.09 0.06 0.04 0.13 0.03 0.04 0.07 0.15 0.23

0.03 0.29 0.06 0.13 -

Q1D3V9 Q1D025 Q1CVM7 Q1DA70 Q1D2V2 Q1D0H5 Q1D669 Q1D7X4 Q1D3H8 Q1CXJ4 Q1DDY8 Q1D806 Q1D689 Q1CZT4 Q1D4E6 A0A0H4X GT4 Q1D4A1 Q1D9Y5 A0A0H4W UN0 Q1D6L8 Q1D2F6 PSD Q1CWP9 Q1D1B9 Q1D965 Q1CYQ7 Q1DEX3 Q1D0V7 Q1D4F6 Q1CXC7 Q1CVW0 Q1D5D1 Q1D7W4 F8CEV8 Q1D910 MGLA Q1DDR3 Q1D7M7 Q1D559 Q1D161 Q1D7K0 Q1DFD3 DESS Q1DDX6

phage tail protein methyl transferase glycosyl transferase pirin family protein adventurous gliding motility protein AgmX pyrimidine-nucleoside phosphorylase biotin synthase aminomethyltransferase L-aspartate oxidase coproporphyrinogen oxidase glutathione S transferase adventurous gliding motility protein AglU 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase acetyltransferase FAD-binding domain protein

0.16 0.03 0.04 0.05 0.04 0.07 0.10 0.06 0.04 0.06 0.06 0.04 0.06 0.15 0.03

0.38 -

quorum sensing signal AsgA bifunctional NAD(P)H-hydrate repair enzyme glutathione-disulfide reductase

0.05 0.03 0.03

0.05

peptidyl-prolyl cis-trans isomerase PpiA dihydroorotase decarboxylase family protein phosphatidylserine decarboxylase myxobacterial hemagglutinin choloylglycine hydrolase family protein HesB/YadR/YfhF family protein glycine cleavage system T protein aminotransferase Inorganic pyrophosphatase polyketide synthase late embryogenesis abundant-like protein vegetative protein pyridine nucleotide-disulphide oxidoreductase ferrodoxin pseudouridine synthase peptidylprolyl isomerase gliding motility protein MglA AMP-binding protein xanthine dehydrogenase glutathione S-transferase male sterility protein-like protein oxidoreductase endonuclease/exonuclease/phosphatase family protein development-specific protein S amidohydrolase

0.02 0.03 0.03 0.06 0.04 0.05 0.18 0.04 0.03 0.06 0.01 0.07 0.05 0.03 0.17 0.02 0.03 0.07 0.02 0.01 0.04 0.03 0.03 -

0.08 0.05 0.03 0.12 0.16 0.01

S-(hydroxymethyl)glutathione dehydrogenase phage tail protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II polyribonucleotide nucleotidyltransferase PNP Function unknown Q1DBN2 Q1D2V4 Q1D5E0 Q1D8Z5 Q1D2R6 Q1D2U5 Q1CVR0 Q1D1M5 Q1CZV5 Q1D2E4 Q1D9N6 Q1CXK5 Q1CZI8 Q1CXW5 Q1D077 Q1D9B3 Q1D840 Q1D6H7 Q1D5W5 Q1D3G6 Q1D2V0 Q1D7L1 Q1D2U9 Q1D4F5 Q1D959 Q1DEA6 Q1D0J9 Q1D5R1 Q1D9C8 Q1CX67 Q1CW98 Q1D0K0 Q1D4U1 Q1DBT9 Q1DDR7 Q1DEJ3 Q1D4F9 Q1V0D2 Q1CYL8 Q1CX74 Q1CWL6 Q1D3U9 Q1D6W6

-

0.04 0.02

-

0.02 0.03

0.28 0.18 0.23 0.27 0.33 0.17 0.18 0.22 0.13 0.23 0.09 0.29 0.22 0.14 0.33 0.13 0.05 0.19 0.35 0.15 0.14 0.06 0.18 0.38 0.13 0.10 0.29 0.13 0.23 0.10 0.23 0.16 0.15 0.07 0.04 0.29 0.05 0.13 0.08 0.24

0.21 0.28 0.12 0.14 0.19 0.03 0.16 0.06 0.13 0.27 0.21 0.04 0.05 0.09 0.19 0.08 0.21 0.10 0.13 0.18 0.02 0.03 0.29 -

Q1D3V0 Q1DFZ6 Q1DC42 Q1D6G2 Q1D9T8 Q1DEJ8 Q1D9B5 Q1CWJ8 Q1D4R8 Q1DA21 Q1DFS2 Q1D9J1 Q1D1K3 Q1D904 Q1D0U7 Q1D3U7 Q1D8D6 Q1DET2 Q1DCJ4 Q1DBX9 Q1DDY7 Q1DEJ9 Q1D9M7 Q1D5D6 Q1D3A5 Q1DF90 Q1D0E8 Q1D450 Q1D2W3 Q1D9I8 Q1CVW3 Q1CYX4 Q1CZ57 Q1CWY2 Q1DCE2 Q1CXT3 Q1D1Q5 Q1D3U8 Q1DDX9 Q1CZ58 Q1CZF4 Q1D615 Q1DEF2 Q1D2J1 Q1D100 Q1DCA5

0.07 0.05 0.07 0.08 0.08 0.08 0.07 0.05 0.06 0.24 0.08 0.10 0.05 0.25 0.08 0.06 0.02 0.09 0.13 0.07 0.12 0.04 0.05 0.06 0.09 0.13 0.08 0.14 0.05 0.06 0.12 0.02 0.05 0.07 0.08 0.07 0.06 0.06 0.11 0.04 0.12 0.08 0.11 0.06 0.06 0.12

0.08 0.01 0.09 0.03 0.07 0.11 0.04 0.11 0.08 0.09 0.08 0.05 0.06 -

Q1D417 Q1DBU4 Q1CZ63 Q1D4R1 Q1DFH8 Q1D4H9 Q1DD93 Q1CYW3 Q1D1C2 Q1DB38 Q1D4U3 Q1CVK8 Q1D2D5 Q1D6J5 Q1D992 Q1DAD6 Q1CZF7 Q1D8H6 Q1D8C0 Q1CZ50 Q1D1D7 Q1D680 Q1D3V8 Q1CXB7 Q1DA09 Q1DDQ6 Q1CX13 Q1CVF7 a Data are the mean of two replicates. b Proteins in bold characters have a predicted intracellular localization. c Protein not detected or protein identification not considered valid.

0.03 0.08 0.02 0.02 0.06 0.08 0.02 0.03 0.03 0.08 0.02 0.14 0.09 0.05 0.05 0.05 0.05 0.08 0.02 0.01 0.02 -

0.23 0.12 0.06 0.11 0.07 0.03 0.06 0.01