Research Article
The Role of Systemic Inflammation in Pathogenesis of Diabetic Maculopathy Sonja Cekic1*, Predrag Jovanovic1,2, Ivan Jovanovic3, Gordana Stankovic Babic1,2 and Tatjana Cvetkovic4 1
Clinic for Eye Diseases, Clinical Centre Niš, Serbia Faculty of Medicine University of Niš, Clinic for Eye Diseases, Clinical Centre Niš, Serbia 3 Department for Anatomy, Faculty of Medicine University of Niš, Serbia 4 Department for Biohemistry, Clinical Center, Faculty of Medicine University, Niš, Serbia 2
*Corresponding Author: Sonja Cekić, Radoja Dakića, Niš, Serbia; E-mail:
[email protected] Published: September 30, 2015
Abstract: Introduction The aim of our study was to assess basic inflammatory markers in patients with type 2 diabetes mellitus and diabetic maculopathy, ischemic (DMI) and exudative (DME) forms. Method Prospective case control study carried on 90 patients with diabetic maculopathy, grouped in two groups: 45 patients with DME and 45 patients with DMI. Diabetic maculopathy has been proved by indirect ophthalmoscopy, fluorescein angiography and OCT. Blood laboratory examination obtain erythrocytes sedimentation rate (ESR), WBC, plasma fibrinogen level (PF), C reactive protein-(CRP), glucose in blood, HbA1C, cholesterol, low density cholesterol LDL-C and high density cholesterol HDL-C, triglycerides. Systolic and diastolic blood pressure was measured. The Atherogenic Index of Plasma (AIP) has been calculated. Results The statistical significance was noted in levels of HbA1C (7.45 ± 0.95%, 8.46 ± 1.68% vs. DMI p
