Trachea Treatment

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Jun 15, 2018 - Cell division cycle 34 (ubiquitin-conjugating ligase). 43327. 4 ...... Pan-specific. Protein-serine phosphatase 4 - regulatory subunit (PPX/A'2).
Supplemental Table 1-KinexTM KAM-1.1 800 Antibody

Microarray analysis of pooled trachea tissue lysates from smoke exposed rats.

Averages are from duplicate measurements with the ranges shown as a percentage of the measured signal intensities of the antibody-captured captured dye-labeled proteins in the microarray spots.

%CFC ≥ 200

500 %CFC ≥ -50

%CFC ≥ 100 %CFC ≥ 50

200 %CFC ≥ -75 100

%CFC ≥ -50

Seri al Antibody Codes No.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116

NN001 PN001 PN114 PN128 NK001 PN002 NN135-1 NN135-2 NK002 PN003-PN004 NN002 NN003 NK003 NK004 PK002 NK006 NN004 NN122 NN121 PN133 NK007 NK007-2 PK118 NN160 PN006-3 PN006-1 NK008-1 NK008-2 NK193 NK009 NK010 PK045-PN007 PN008 PN008-2 PN009 PN010 PN012-1 NN000 NN005 NN006 NN007 NN008 NN009 NK011 PN013 NK012 PK003 PN014 NK013 NK014 PK004 NK015 PN015 NN136-1 NN136-2 NN-136-4 NN137-1 NK211 NK016-1 NK016-2 PK005-1 PK005-2 NK018-1 NK018-2 NK019-1 NK019-2 NK020 NK021 NK021-2 NK021-3 NK022 NN010 NK023 NN020 NN011-NN125 NN012 NN013 NN014 NN015 NN016 NN017 NN019 NN021 NN022-1 PN018 NP001 NP002 NP003 PP005 NK024 NN023 NN024 NK025-1 NK025-2 NK025-3 NK025-4 NK025-5 NK025-6 PK006 PK007-1 PK007-2 PK007-3 PK008 NK033 NK026-7 NK026-2 NK026-3 NK026-4 NK026-5 NK026-6 NK027 NK027-2 NK028-1 NK028-2 NK028-5 NK028-4

Target Protein Name

14-3-3 z 4E-BP1 4E-BP1 4E-BP1 Abl AcCoA carboxylase Acetylated Lysine Acetylated Lysine ACK1 Adducin a, g AIF AK2 ALK ALS2CR7 (PFTAIRE2) AMPKa1/2 ANKRD3 APG1 APG2 Arrestin b1 Arrestin b1 ASK1 (MAP3K5) ASK1 (MAP3K5) ASK1 (MAP3K5) ATF2 ATF2 ATF2 Aurora A (AIK) Aurora A (AIK) Aurora B (AIM-1) Aurora C (AIK3) Axl MEK1/2+B23 (NPM) B23 (NPM) B23 (NPM) B23 (NPM) Bad Bad Bak Bax Bcl2 Bcl-xL Bcl-xS/L Bid BLK BLNK BMX (Etk) BMX (Etk) BRCA1 BRD2 Btk Btk BUB1A Caldesmon Calnexin Calnexin Calnexin Calreticulin CAMK1a CaMK1d CaMK1d CaMK2a CaMK2a CAMK2b CAMK2b CAMK2d CAMK2d CAMK2g CaMK4 CaMK4 CaMK4 CaMKK (CaMKK2) CAS CASK/Lin2 CASP12 CASP1ab CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP9 Catenin b1 Caveolin 2 Caveolin 2 CD45 Cdc25B Cdc25C Cdc25C CDC2L5 (CHED) Cdc34 Cdc42 CDK1 (CDC2) CDK1 (CDC2) CDK1 (CDC2) CDK1 (CDC2) CDK1 (CDC2) CDK1 (CDC2) CDK1/2 CDK1/2 CDK1/2 CDK1/2 CDK1/2 CDK10 CDK2 CDK2 CDK2 CDK2 CDK2 CDK2 CDK4 CDK4 CDK5 CDK5 CDK5 CDK5

Phospho Site (Human)

Pan-specific S64 T45 T69 Pan-specific S80 Pan-specific Pan-specific Pan-specific S726, S693 Pan-specific Pan-specific Pan-specific Pan-specific T183 Pan-specific Pan-specific Pan-specific Pan-specific S412 Pan-specific Pan-specific S1046 Pan-specific T69/T71 T69/T71 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S217+S221, S4 T199 T199 T234/T237 S75 S99 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y84 Pan-specific Y40 S1497 Pan-specific Pan-specific Y223 Pan-specific S789 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T286 T286 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S36 Pan-specific Pan-specific Pan-specific S216 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T14+Y15 Y15 Y15 Y15 T161 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific

Full Target Protein Name

14-3-3 protein zeta (cross-reacts with other isoforms) Eukaryotic translation initiation factor 4E binding protein 1 (PHAS1) Eukaryotic translation initiation factor 4E binding protein 1 (PHAS1) Eukaryotic translation initiation factor 4E binding protein 1 (PHAS1) Abelson proto-oncogene-encoded protein-tyrosine kinase Acetyl coenzyme A carboxylase Acetylated Lysine Acetylated Lysine Activated p21cdc42Hs protein-serine kinase Adducin alpha (ADD1)/gamma (ADD3) Apoptosis inducing factor (programed cell death protein 8 (PDCD8)) Adenylate kinase 2 Anaplastic lymphoma kinase Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein-serine kinase 7 5'-AMP-activated protein kinase subunit alpha 1/2 Ankyrin repeat domain protein-serine kinase 3 (RIPK4, DIK) Hsp 70-related heat shock protein 1 (osmotic stress protein 94 (OSP94)) Hsp 70-related heat shock protein 4 (HSP70RY) Arrestin beta 1 Arrestin beta 1 Apoptosis signal regulating protein-serine kinase Apoptosis signal regulating protein-serine kinase Apoptosis signal regulating protein-serine kinase Activating transcription factor 2 (CRE-BP1) Activating transcription factor 2 (CRE-BP1) Activating transcription factor 2 (CRE-BP1) Aurora Kinase A (serine/threonine protein kinase 6) Aurora Kinase A (serine/threonine protein kinase 6) Aurora Kinase B (serine/threonine protein kinase 12) Aurora Kinase C (serine/threonine-protein kinase 13) Axl proto-oncogene-encoded protein-tyrosine kinase MAPK/ERK protein-serine kinase 1/2 (MKK1/2) + B23 (nucleophosmin, numatrin, nucleolar protein NO38) B23 (nucleophosmin, numatrin, nucleolar protein NO38) B23 (nucleophosmin, numatrin, nucleolar protein NO38) B23 (nucleophosmin, numatrin, nucleolar protein NO38) Bcl2-antagonist of cell death protein Bcl2-antagonist of cell death protein Bcl2 homologous antagonist/killer (BCK2L7) Apoptosis regulator Bcl2-associated X protein B-cell lymphoma protein 2 alpha Bcl2-like protein 1 Bcl-xS/L BH3 interacting domain death agonist B lymphoid tyrosine kinase B-cell linker protein Bone marrow X protein-tyrosine kinase Bone marrow X protein-tyrosine kinase Breast cancer type 1 susceptibility protein Bromodomain-containing protein-serine kinase 2 Bruton's agammaglobulinemia tyrosine kinase Bruton's agammaglobulinemia tyrosine kinase BUB1 mitotic checkpoint protein-serine kinase Caldesmon Calnexin Calnexin Calnexin Calreticulin Calcium/calmodulin-dependent protein-serine kinase 1 alpha Calcium/calmodulin-dependent protein-serine kinase 1 delta Calcium/calmodulin-dependent protein-serine kinase 1 delta Calcium/calmodulin-dependent protein-serine kinase 2 alpha Calcium/calmodulin-dependent protein-serine kinase 2 alpha Calcium/calmodulin-dependent protein-serine kinase 2 beta Calcium/calmodulin-dependent protein-serine kinase 2 beta Calcium/calmodulin-dependent protein-serine kinase 2 delta Calcium/calmodulin-dependent protein-serine kinase 2 delta Calcium/calmodulin-dependent protein-serine kinase 2 gamma Calcium/calmodulin-dependent protein-serine kinase 4 Calcium/calmodulin-dependent protein-serine kinase 4 Calcium/calmodulin-dependent protein-serine kinase 4 Calcium/calmodulin-dependent protein-serine kinase kinase Cellular apoptosis susceptibility protein (CSE1L) Calcium/calmodulin-dependent protein-serine kinase (Lin2 homolog) Pro-caspase 12 (mouse) Pro-caspase 1 (Interleukin-1 beta convertase) alpha/beta isoform Pro-caspase 2 (ICH1 protease) Pro-caspase 3 (apopain, cysteine protease CPP32) Pro-caspase 4 (ICH2 protease, ICE(rel)-II) Caspase 5 (ICH3 protease, ICE(rel)-III) Pro-caspase 6 (apoptotic protease Mch2) Pro-caspase 7 (ICE-like apoptotic protease 3 (ICE-LAP3), Mch3) Pro-caspase 9 (ICE-like apoptotic protease 6 (ICE-LAP6), Mch6, APAF3) Catenin (cadherin-associated protein) beta 1 Caveolin 2 Caveolin 2 Leukocyte common antigen CD45 receptor-tyrosine phosphatase (LCA, T200) Cell division cycle 25B phosphatase Cell division cycle 25C phosphatase Cell division cycle 25C phosphatase Cell division cycle 2-like protein-serine kinase 5 Cell division cycle 34 (ubiquitin-conjugating ligase) Cell division control protein 42 homolog Cyclin-dependent protein-serine kinase 1 Cyclin-dependent protein-serine kinase 1 Cyclin-dependent protein-serine kinase 1 Cyclin-dependent protein-serine kinase 1 Cyclin-dependent protein-serine kinase 1 Cyclin-dependent protein-serine kinase 1 Cyclin-dependent protein-serine kinase 1/2 Cyclin-dependent protein-serine kinase 1/2 Cyclin-dependent protein-serine kinase 1/2 Cyclin-dependent protein-serine kinase 1/2 Cyclin-dependent protein-serine kinase 1/2 Cyclin-dependent protein-serine kinase 10 [PISSLRE] Cyclin-dependent protein-serine kinase 2 Cyclin-dependent protein-serine kinase 2 Cyclin-dependent protein-serine kinase 2 Cyclin-dependent protein-serine kinase 2 Cyclin-dependent protein-serine kinase 2 Cyclin-dependent protein-serine kinase 2 Cyclin-dependent protein-serine kinase 4 Cyclin-dependent protein-serine kinase 4 Cyclin-dependent protein-serine kinase 5 Cyclin-dependent protein-serine kinase 5 Cyclin-dependent protein-serine kinase 5 Cyclin-dependent protein-serine kinase 5

Globally Normalize dTrachea Ctrl (M)

%Error Range Trachea Ctrl (M)

10193 22392 3657 7590 8191 8955 30949 3939 13302 5619 10377 3077 47313 7074 1854 11447 8138 10070 44935 44920 9005 6942 2130 1089 31640 43405 10188 15721 5487 2732 2180 1263 40668 1145 39608 45508 2207 15071 12791 2430 31957 15900 18713 3764 12026 39347 1092 3274 4650 6068 756 2706 3662 23145 20703 21158 17978 14415 2646 17397 10996 34593 23425 1662 24892 5780 11692 1571 1265 3522 5822 40638 1401 6882 10973 4094 32372 7158 4230 2065 5424 962 18100 40249 33553 36838 45860 10290 1731 15630 43327 45789 49707 42604 12756 1534 9854 6792 22196 4038 1108 9434 11559 1787 9294 2083 43531 1878 12979 7564 2985 10337 1660 2499 15742 9157

31 7 39 1222 1 117 4 44 58 12 14 95 2 176 33 11 25 7 10 4 6 8 46 11 8 1 82 252 61 6 2 18 12 56 1 6 3 6 34 16 18 2 65 97 8 1 46 53 169 20 34 28 74 23 32 13 0 15 23 17 29 7 2 12 6 30 36 3 41 57 8 5 24 62 4 47 6 6 39 1 31 29 17 15 1 12 4 0 41 20 4 2 2 5 6 50 16 41 9 30 26 20 15 19 85 2 5 36 36 57 91 3 50 33 59 7

Globally %Error Globally %Error Globally %Error Globally Normalized Range Normalize Range Normalized Range Normalized Trachea dTrachea Trachea Trachea Treatmen Trachea Treatmen Trachea Treatment Trachea Ctrl Treatment t (M) 75 Treatment t (M) 200 Treatment (M) 400 (F) (M) 75 (M) 200 (M) 400 7137 19210 3906 2047 6752 14175 21768 8162 10638 7630 7956 13390 16812 6065 1605 16846 6028 6824 31720 16027 9286 14190 3566 2913 29950 17640 20281 6993 27435 3181 2508 1192 21784 1811 30667 21316 3140 10985 12062 2619 37766 17643 10000 2406 9648 42242 1651 5183 3381 8299 1207 4235 3428 41963 14716 10831 44629 7155 5752 6844 8383 14855 17068 1751 14839 10589 15112 1858 1599 3196 4743 27334 1994 8033 6649 6087 26610 6641 5958 2169 2879 1628 10664 29101 16920 26286 33143 7464 2066 15088 30799 31685 25723 40342 18814 1981 7375 5854 35276 6751 1932 6082 8484 3361 5414 3726 14128 3503 7093 8605 2912 3658 2324 3971 5050 2644

8 74 66 38 5 30 2 3 7 35 9 11 1 55 23 28 10 33 22 10 21 10 19 59 4 4 42 20 37 1 45 30 25 10 6 1 11 4 14 4 6 3 6 41 54 5 21 23 17 61 1 43 14 5 29 11 33 26 42 22 4 116 3 33 4 27 7 3 10 2 30 4 10 30 62 26 3 18 53 20 10 49 12 3 18 8 8 2 17 59 1 1 4 17 9 33 13 5 17 41 8 3 22 33 20 59 11 115 16 24 31 5 19 3 27 4

11201 8765 4267 1466 8132 11290 29625 2697 8725 3924 7111 3820 20207 3015 1364 8670 4306 7605 36222 13111 6664 6618 3777 1075 19200 17428 4936 6729 7284 2329 2074 998 32817 974 26422 16379 2597 10273 16899 2293 19297 15652 5305 3116 3552 36385 1427 3229 3168 2736 1102 3286 2437 51966 53350 28238 55942 7077 3836 10017 12034 17972 16503 2351 19312 6890 12605 1113 1021 3672 7956 20229 1400 6822 7431 6466 24012 5703 3285 2353 3163 1305 11959 31867 12853 23623 29786 20386 1461 15047 32681 21741 23612 33627 14286 2484 6953 6794 29606 9884 1133 14781 16929 1462 7289 1452 16499 2140 6504 6767 2163 4694 1228 2451 4293 6304

26 6 8 24 23 34 2 1 4 41 23 31 1 22 37 47 41 10 21 12 31 40 22 17 11 3 191 44 24 6 43 45 23 34 15 9 37 3 2 58 3 8 115 6 31 3 1 5 16 24 119 8 36 5 3 8 1 22 25 2 1 7 17 11 16 18 5 269 59 9 9 9 12 63 39 39 27 18 28 18 20 33 27 3 7 16 55 73 31 31 3 6 2 17 14 40 22 27 6 176 10 68 0 7 4 34 1 8 31 52 10 40 9 9 23 7

4090 22039 3823 1467 5496 10550 24747 4179 7384 7308 5845 11603 16613 3178 1216 7048 6417 6589 42956 11674 6326 9135 2695 922 38934 18416 11315 4437 12912 1839 2226 901 40205 1222 39849 19060 2200 9182 9769 2300 31160 12732 7842 2091 7761 48650 898 4151 1975 3851 919 2110 1633 43102 38424 10592 45837 6091 6179 7921 11452 36589 17057 1364 20257 11707 12360 1058 885 2515 3487 36971 965 4571 8694 7041 42090 3373 5377 1766 3856 1020 9985 42802 32168 36305 43790 6824 1810 14494 46644 41107 30889 44540 15853 1546 6229 4388 35113 5514 1037 20631 21990 2158 3923 1262 20455 2633 6006 6436 2264 2320 1874 12828 3848 2311

72 7 10 62 0 27 3 52 5 27 19 7 4 53 15 65 9 9 9 16 25 73 24 18 5 2 17 79 21 1 14 37 2 12 2 1 23 8 1 3 4 2 9 5 144 3 18 45 11 153 34 6 13 0 19 4 0 1 97 11 17 3 47 36 1 24 23 22 14 37 48 1 8 37 22 40 4 11 55 38 23 71 20 4 12 1 5 8 32 48 6 14 5 7 9 9 148 21 12 40 34 23 20 37 14 5 12 1 17 22 20 15 28 11 100 18

18738 21101 14255 1752 6764 19771 32277 11968 9623 9838 11077 6796 39234 3797 2009 17119 11564 10372 41690 25244 10400 14322 5765 1445 31031 35865 7515 6505 5432 3805 2363 1062 34185 1894 36198 38196 4044 11503 10180 3621 33983 16722 13150 3460 19822 39358 1870 11577 5716 4805 1526 5163 6698 25395 23771 19426 24570 12152 7293 20127 9769 34512 23094 2366 22390 15151 23858 1607 1666 4729 8195 40446 2640 10248 10662 7750 33214 13118 7204 5601 6728 1708 22419 35478 31202 36866 42522 6532 2249 17652 38906 41857 38438 39741 20047 2259 11256 8569 23431 4220 1175 9090 4273 2291 9457 2547 37423 2751 12986 5881 2471 10806 1654 3559 10116 7863

50

%Error %Error Globally %Error %Error %CFC %CFC Globally Globally Range Range Normalized Range Range (Trachea (Trachea Normalized Normalized Trache Trachea Trachea Trachea Treatment (M) Treatment (M) Trachea Trachea a Ctrl Treatmen Trachea Treatment Treatmen 75 from 200 from Treatment Treatment (F) t (F) 75 Treatment (F) 200 t (F) 400 Trachea Ctrl Trachea Ctrl (F) 75 (F) 400 (F) 200 (M)) (M)) 85 9 10 45 14 109 1 61 5 53 22 46 3 84 0 90 130 10 0 8 34 138 40 53 1 25 73 14 30 42 23 6 1 24 6 12 50 0 12 20 10 9 43 26 27 7 15 7 33 139 272 55 51 9 4 7 1 27 10 5 126 2 1 7 10 5 4 1 17 73 48 10 3 45 60 6 0 49 55 103 136 8 16 8 3 13 1 5 33 23 4 2 24 2 5 21 13 2 7 4 50 45 9 42 1 48 2 26 19 66 4 29 6 3 18 18

9958 22754 3352 1609 5226 9724 36716 6049 4550 6498 7164 16764 12079 2744 1375 10897 6624 3324 28410 10698 5117 20594 2193 1715 25718 13043 24792 5075 7352 2893 1650 1213 28223 1816 26321 13936 4042 8842 7464 2512 24341 10236 7474 1599 5351 42578 1793 7079 3226 4198 12811 3726 5804 42024 37346 9707 45926 4433 5034 5973 6934 20439 11218 1404 36574 28689 15703 1243 11515 2114 4061 30319 1334 7603 5934 5393 30138 4948 6419 2149 2247 1365 10819 34807 25276 31647 40759 6306 1782 7717 34366 34245 18661 31418 11292 1675 10810 5299 35517 5033 871 8210 3440 1854 7935 2932 19516 2500 5707 11637 2169 2372 1974 3931 4992 3562

72 27 40 21 18 51 23 5 43 34 16 43 3 1 14 14 79 189 37 2 27 70 28 34 1 19 35 21 42 22 9 32 26 8 8 9 262 9 18 10 51 24 19 29 54 34 6 69 10 160 94 79 96 18 11 13 2 38 40 8 34 12 8 43 11 5 69 37 1289 20 91 3 10 13 57 60 1 46 9 13 8 21 20 7 0 10 7 16 8 30 5 17 40 10 2 36 9 31 3 12 8 23 52 11 258 58 2 6 128 304 21 14 9 34 134 58

6993 17554 4524 1158 8190 13667 28513 4165 5600 4242 4647 2826 55113 2587 1407 6717 3565 6241 51641 41861 5053 4220 3180 1236 38504 51189 6354 4072 7818 1930 1635 919 46272 1478 46778 53470 2134 9820 11074 2404 40699 14045 4589 2646 8965 47868 1025 3719 4118 3748 1233 2840 1781 15704 10657 18109 11934 9180 3396 10388 7279 42242 17621 2236 20114 5245 14059 1628 862 3158 9529 51619 1611 4114 6133 5272 38163 7513 5696 2744 5913 1323 13461 51240 38253 47408 53371 7263 1411 9295 49810 52499 42977 49696 13236 1260 7885 7604 27333 2944 1046 4513 6963 1686 5849 1257 55210 1566 4591 3513 1787 7644 1370 1828 3350 2830

13 43 10 28 6 61 4 8 6 26 29 71 2 5 42 14 66 7 1 12 140 12 16 22 6 1 15 53 78 36 53 45 0 75 4 1 20 24 5 1 6 5 63 1 5 3 27 11 77 65 37 29 61 5 11 1 1 18 1 16 52 6 12 40 3 63 14 81 20 41 5 8 2 15 50 75 3 23 97 42 356 26 8 7 1 3 6 15 41 0 5 2 9 1 47 17 18 6 8 9 44 9 24 37 28 28 1 8 4 34 11 65 40 66 122 68

6786 16449 4700 1569 6820 17766 23309 10149 5655 5811 5367 9678 16667 4810 1364 14360 2848 3453 28344 13734 6054 12449 3179 1850 28777 15730 17534 4770 15749 3614 2437 1139 26160 1297 32041 16019 3057 9458 10480 2778 31874 14213 4345 2276 2327 45096 1391 5899 2978 2816 1444 2519 3376 52832 50293 11466 59942 4621 3902 8208 6223 27681 12805 1460 17289 8485 14560 994 1284 2743 6158 32425 1602 4891 5093 6555 26989 8080 6974 3227 2192 1731 9687 39403 16482 29438 41502 4413 1790 12499 39083 41864 16923 43901 11045 2070 3081 2882 43090 3393 1175 7507 6015 3189 5569 2965 22880 2436 4120 4338 2091 1345 1932 5502 4188 2445

52 10 23 18 2 11 21 75 4 8 5 101 2 95 25 11 26 59 28 2 5 23 36 46 4 4 9 55 24 52 2 32 7 1 7 2 15 12 10 1 39 2 10 23 33 11 27 72 47 14 4 24 36 0 10 7 6 1 6 7 21 5 31 25 10 2 32 47 143 13 4 8 8 26 47 16 40 28 3 9 20 77 9 10 13 2 10 34 24 27 12 35 11 30 0 26 42 1 0 31 29 8 39 28 34 43 1 44 11 35 8 8 2 2 49 2

-30 -14 7 -73 -18 58 -30 107 -20 36 -23 335 -64 -14 -13 47 -26 -32 -29 -64 3 104 67 168 -5 -59 99 -56 400 16 15 -6 -46 58 -23 -53 42 -27 -6 8 18 11 -47 -36 -20 7 51 58 -27 37 60 57 -6 81 -29 -49 148 -50 117 -61 -24 -57 -27 5 -40 83 29 18 26 -9 -19 -33 42 17 -39 49 -18 -7 41 5 -47 69 -41 -28 -50 -29 -28 -27 19 -3 -29 -31 -48 -5 47 29 -25 -14 59 67 74 -36 -27 88 -42 79 -68 86 -45 14 -2 -65 40 59 -68 -71

10 -61 17 -81 -1 26 -4 -32 -34 -30 -31 24 -57 -57 -26 -24 -47 -24 -19 -71 -26 -5 77 -1 -39 -60 -52 -57 33 -15 -5 -21 -19 -15 -33 -64 18 -32 32 -6 -40 -2 -72 -17 -70 -8 31 -1 -32 -55 46 21 -33 125 158 33 211 -51 45 -42 9 -48 -30 41 -22 19 8 -29 -19 4 37 -50 0 -1 -32 58 -26 -20 -22 14 -42 36 -34 -21 -62 -36 -35 98 -16 -4 -25 -53 -52 -21 12 62 -29 0 33 145 2 57 46 -18 -22 -30 -62 14 -50 -11 -28 -55 -26 -2 -73 -31

%CFC %CFC %CFC (Trachea %CFC (Trachea (Trachea Treatmen (Trachea Ctrl Treatment Treatment t (M) 400 (F) from (F) 200 (F) 400 from Trachea Ctrl from from Trachea (M)) Trachea Trachea Ctrl (M)) Ctrl (F)) Ctrl (F) -60 -2 5 -81 -33 18 -20 6 -44 30 -44 277 -65 -55 -34 -38 -21 -35 -4 -74 -30 32 27 -15 23 -58 11 -72 135 -33 2 -29 -1 7 1 -58 0 -39 -24 -5 -2 -20 -58 -44 -35 24 -18 27 -58 -37 22 -22 -55 86 86 -50 155 -58 134 -54 4 6 -27 -18 -19 103 6 -33 -30 -29 -40 -9 -31 -34 -21 72 30 -53 27 -14 -29 6 -45 6 -4 -1 -5 -34 5 -7 8 -10 -38 5 24 1 -37 -35 58 37 -6 119 90 21 -58 -39 -53 40 -54 -15 -24 -78 13 413 -76 -75

-47 8 -76 -8 -23 -51 14 -49 -53 -34 -35 147 -69 -28 -32 -36 -43 -68 -32 -58 -51 44 -62 19 -17 -64 230 -22 35 -24 -30 14 -17 -4 -27 -64 0 -23 -27 -31 -28 -39 -43 -54 -73 8 -4 -39 -44 -13 740 -28 -13 65 57 -50 87 -64 -31 -70 -29 -41 -51 -41 63 89 -34 -23 591 -55 -50 -25 -49 -26 -44 -30 -9 -62 -11 -62 -67 -20 -52 -2 -19 -14 -4 -3 -21 -56 -12 -18 -51 -21 -44 -26 -4 -38 52 19 -26 -10 -19 -19 -16 15 -48 -9 -56 98 -12 -78 19 10 -51 -55

-63 -17 -68 -34 21 -31 -12 -65 -42 -57 -58 -58 40 -32 -30 -61 -69 -40 24 66 -51 -71 -45 -14 24 43 -15 -37 44 -49 -31 -13 35 -22 29 40 -47 -15 9 -34 20 -16 -65 -24 -55 22 -45 -68 -28 -22 -19 -45 -73 -38 -55 -7 -51 -24 -53 -48 -25 22 -24 -6 -10 -65 -41 1 -48 -33 16 28 -39 -60 -42 -32 15 -43 -21 -51 -12 -23 -40 44 23 29 26 11 -37 -47 28 25 12 25 -34 -44 -30 -11 17 -30 -11 -50 63 -26 -38 -51 48 -43 -65 -40 -28 -29 -17 -49 -67 -64

-64 -22 -67 -10 1 -10 -28 -15 -41 -41 -52 42 -58 27 -32 -16 -75 -67 -32 -46 -42 -13 -45 28 -7 -56 133 -27 190 -5 3 7 -23 -32 -11 -58 -24 -18 3 -23 -6 -15 -67 -34 -88 15 -26 -49 -48 -41 -5 -51 -50 108 112 -41 144 -62 -47 -59 -36 -20 -45 -38 -23 -44 -39 -38 -23 -42 -25 -20 -39 -52 -52 -15 -19 -38 -3 -42 -67 1 -57 11 -47 -20 -2 -32 -20 -29 0 0 -56 10 -45 -8 -73 -66 84 -20 0 -17 41 39 -41 16 -39 -11 -68 -26 -15 -88 17 55 -59 -69

Uniprot Link

P63104 Q13541 Q13541 Q13541 P00519 Q13085 NA NA Q07912 P35611 O95831 P54819 Q9UM73 Q96Q40 Q13131 P57078 O95757 P34932 P49407 P49407 Q99683 Q99683 Q99683 P15336 P15336 P15336 O14965 O14965 Q96GD4 Q9UQB9 P30530 P06748 P06748 P06748 P06748 Q92934 Q92934 Q16611 Q07812 P10415 Q07817 Q07817 P55957 P51451 O75498 P51813 P51813 P38398 P25440 Q06187 Q06187 O43683 Q05682 P27824 P27824 P27824 P27797 Q14012 Q8IU85 Q8IU85 Q9UQM7 Q9UQM7 Q13554 Q13554 Q13557 Q13557 Q13555 Q16566 Q16566 Q16566 Q8N5S9 P55060 O14936 O08736 P29466 P42575 P42574 P49662 P51878 P55212 P55210 P55211 P35222 P51636 P51636 P08575 P30305 P30307 Q13972 Q14004 P49427 P60953 P06493 P06493 P06493 P06493 P06493 P06493 P06493 P06493 P06493 P06493 P06493 Q15131 P24941 P24941 P24941 P24941 P24941 P24941 P11802 P11802 Q00535 Q00535 Q00535 Q00535

117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247

NK029 NK029-2 NK029-3 NK030-1 NK030-2 NK030-3 NK031-2 NK031-3 NK031-5 NK031-4 NK032 NK199 NK034 NK034-2 NK035 PK119 NN025 NK036 NK037 NK198 NK040 NK041 PN130 NN026 PN019 PN020 PN022-2 NK042 NK042-2 NN027 NK043 PN023 PN024 PN024-2 NN149 NN149-2 NN149-3 NN149-1 PN025 PN110 NK044 NK044-2 NN028 NN029 NN030-1 NN030-2 NN031 NN032 NN033 PN026 NK210 NK046 NN034 NN035-NN126 NK219 NK048 NK048-2 PN027 PN027-2 NK050 NK051 NK052-1 PK009 PK010-2 PK010 PK011 PK121 PN028-1 PN028-2 NN039-1 PN030-1 PN030-2 PN031 NK053 NK054-1 NK054-2 PK013-1 PK013-2 PK134 PK135 NK055-NK056 NK055-NK056-2 NK055-NK056-4 NK055-NK056-5 NK055-NK056-6 NK055-NK056-8 NK056 PK014-PK015-2 PK014-PK015-3 PK014-PK015-4 NK057-2 NK058 NK206-1 NK206-2 NK206-3 PK016 PK016-3 NN040 NN041 NK060 PK017 PK018-1 PK018-2 PK020-3 PK021 PK022-2 PK024 NN042 NN043 NK061 NK062 NK063 NN127 PN032 NK064 NN044 PN033 NK065 PN098 NK066 PN034 NN045 NK067 PK025 NK068 NN046 NN047 NN048 NN048-2 NN049 NN049-2

CDK6 CDK6 CDK6 CDK7 CDK7 CDK7 CDK8 CDK8 CDK8 CDK8 CDK9 CDKL1 Chk1 Chk1 Chk2 Chk2 c-IAP1 CK1d CK1e CK1g CK1g2 CK2a c-Myc Cofilin 1 Cofilin 1 Cofilin 2 Cortactin COT COT COX2 CPG16/CaMKinase VI CREB1 CREB1 CREB1 Crystallin aB Crystallin aB Crystallin aB Crystallin aB Crystallin aB Crystallin aB Csk Csk Cyclin A Cyclin B1 Cyclin D1 Cyclin D1 Cyclin E Cyclin G1 CytoC Dab1 DAPK1 DAPK2 DAXX DFF35, DFF45 DGKz DNAPK DNAPK Dok2 Dok2 DRAK2 eEF2K EGFR EGFR EGFR EGFR EGFR EGFR eIF2a eIF2a eIF4E eIF4E eIF4E eIF4G EphA1 ErbB2 (HER2) ErbB2 (HER2) ErbB2 (HER2) ErbB2 (HER2) ErbB2 (HER2) ErbB2 (HER2) Erk1/2 Erk1/2 Erk1/2 Erk1/2 Erk1/2 Erk1/2 Erk2 Erk1/2 Erk1/2 Erk1/2 Erk3 Erk4 Erk5 Erk5 Erk5 Erk5 Erk5 ERP57 ERP72 FAK FAK FAK FAK FAK FAK FAK FAK FAS FasL Fes FGFR1 FGFR2 FKBP52 FKHRL1 FLT4 Fos Fos Fyn GAP-43 GCK GFAP GNB2L1 GRK2 (BARK1) GRK2 (BARK1) GRK3 (BARK2) GroEL Grp75 Grp78 Grp78 Grp94 Grp94

Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T68 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T58/S62 Pan-specific S3 S3 Y466 Pan-specific Pan-specific Pan-specific Pan-specific S129+S133 S133 S133 Pan-specific Pan-specific Pan-specific Pan-specific S19 S45 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y198 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y142 Y142 Pan-specific Pan-specific Pan-specific Y1092 Y1172 Y1172 Y1197 T693 S51 S51 Pan-specific S209 S209 S1107 Pan-specific Pan-specific Pan-specific Y1248 Y1248 T686 Y1112 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T202+Y204; T184/Y186 T202+Y204; T184/Y186 T202+Y204; T184/Y186 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T218+Y220 T218+Y220 Pan-specific Pan-specific Pan-specific Y397 Y576 Y576 S722 S732 S843 S910 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T32 Pan-specific Pan-specific T232 Pan-specific S41 Pan-specific S8 Pan-specific Pan-specific S670 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific

Cyclin-dependent protein-serine kinase 6 Cyclin-dependent protein-serine kinase 6 Cyclin-dependent protein-serine kinase 6 Cyclin-dependent protein-serine kinase 7 Cyclin-dependent protein-serine kinase 7 Cyclin-dependent protein-serine kinase 7 Cyclin-dependent protein-serine kinase 8 Cyclin-dependent protein-serine kinase 8 Cyclin-dependent protein-serine kinase 8 Cyclin-dependent protein-serine kinase 8 Cyclin-dependent protein-serine kinase 9 Cyclin-dependent kinase-like 1 Checkpoint protein-serine kinase 1 Checkpoint protein-serine kinase 1 Checkpoint protein-serine kinase 2 Checkpoint protein-serine kinase 2 Cellular inhibitor of apoptosis protein 1 (baculoviral IAP repeat-containing protein 3, apoptosis inhibitor 2 (API2)) Casein protein-serine kinase 1 delta Casein protein-serine kinase 1 epsilon Casein kinase I gamma 1 isoform Casein protein-serine kinase 1 gamma 2 Casein protein-serine kinase 2 alpha/ alpha prime Myc proto-oncogene protein Cofilin 1 Cofilin 1 Cofilin 2 Cortactin (amplaxin) (mouse) Osaka thyroid oncogene protein-serine kinase (Tpl2) Osaka thyroid oncogene protein-serine kinase (Tpl2) Cyclo-oxygenase 2 (prostaglandin G/H synthase 2 precursor) Serine/threonine-protein kinase DCAMKL1 cAMP response element binding protein 1 cAMP response element binding protein 1 cAMP response element binding protein 1 Crystallin alpha B (heat-shock 20 kDa like-protein) Crystallin alpha B (heat-shock 20 kDa like-protein) Crystallin alpha B (heat-shock 20 kDa like-protein) Crystallin alpha B (heat-shock 20 kDa like-protein) Crystallin alpha B (heat-shock 20 kDa like-protein) Crystallin alpha B (heat-shock 20 kDa like-protein) C-terminus of Src tyrosine kinase C-terminus of Src tyrosine kinase Cyclin A1 Cyclin B1 Cyclin D1 (PRAD1) Cyclin D1 (PRAD1) Cyclin E1 Cyclin G1 Cytochrome C Disabled homolog 1 Death-associated protein kinase 1 Death-associated protein kinase 2 Death-associated protein 6 (BING2) DNA fragmentation factor alpha (ICAD) 35-kDa, 45-kDa subunit Diacylglycerol kinase zeta DNA-activated protein-serine kinase DNA-dependent protein kinase catalytic subunit Docking protein 2 (mouse) Docking protein 2 DAP kinase-related apoptosis-inducing protein-serine kinase 2 (STK17B) Elongation factor-2 protein-serine kinase Epidermal growth factor receptor-tyrosine kinase Epidermal growth factor receptor-tyrosine kinase Epidermal growth factor receptor-tyrosine kinase Epidermal growth factor receptor-tyrosine kinase Epidermal growth factor receptor-tyrosine kinase Epidermal growth factor receptor-tyrosine kinase Eukaryotic translation initiation factor 2 alpha Eukaryotic translation initiation factor 2 alpha Eukaryotic translation initiation factor 4 (mRNA cap binding protein) Eukaryotic translation initiation factor 4 (mRNA cap binding protein) Eukaryotic translation initiation factor 4 (mRNA cap binding protein) Eukaryotic translation initiation factor 4 gamma 1 Ephrin type-A receptor 1 protein-tyrosine kinase ErbB2 (Neu) receptor-tyrosine kinase ErbB2 (Neu) receptor-tyrosine kinase ErbB2 (Neu) receptor-tyrosine kinase ErbB2 (Neu) receptor-tyrosine kinase ErbB2 (Neu) receptor-tyrosine kinase ErbB2 (Neu) receptor-tyrosine kinase Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 2 (p42 MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 1 (p44 MAP kinase), 2 (p42MAP kinase) Extracellular regulated protein-serine kinase 3 Extracellular regulated protein-serine kinase 4 Extracellular regulated protein-serine kinase 5 (Big MAP kinase 1 (BMK1)) Extracellular regulated protein-serine kinase 5 (Big MAP kinase 1 (BMK1)) Extracellular regulated protein-serine kinase 5 (Big MAP kinase 1 (BMK1)) Extracellular regulated protein-serine kinase 5 (Big MAP kinase 1 (BMK1)) Extracellular regulated protein-serine kinase 5 (Big MAP kinase 1 (BMK1)) ER protein 57 kDa (protein disulfide isomerase-associated 3; 58 kDa glucose regulated protein) ER protein 72 kDa (protein disulfide isomerase-associated 4) Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Focal adhesion protein-tyrosine kinase Tumor necrosis factor superfamily member 6 (Apo1, CD95) Tumor necrosis factor ligand, member 6 Fes/Fps protein-tyrosine kinase Fibroblast growth factor receptor-tyrosine kinase 1 Fibroblast growth factor receptor-tyrosine kinase 2 (BEK) FK506-binding protein 4 Forkhead-like transcription factor 1 (FOXO3A) Vascular endothelial growth factor receptor-protein-tyrosine kinase 3 (VEGFR3) Fos-c FBJ murine osteosarcoma oncoprotein-related transcription factor Fos-c FBJ murine osteosarcoma oncoprotein-related transcription factor Fyn proto-oncogene-encoded protein-tyrosine kinase Growth associated protein 43 (Neuromodulin) Germinal centre protein-serine kinase Glial fibrillary acidic protein Guanine nucleotide-binding protein beta (receptor for activated C kinase 1 (RACK1)) G protein-coupled receptor-serine kinase 2 G protein-coupled receptor-serine kinase 2 G protein-coupled receptor-serine kinase 3 GroEL homolog (may correspond to Hsp60) Glucose regulated protein 75 Glucose regulated protein 78 Glucose regulated protein 78 Glucose regulated protein 94 (endoplasmin) Glucose regulated protein 94 (endoplasmin)

5636 2257 9627 1041 11243 1111 4637 2187 10854 2145 14604 824 13022 10919 9592 1355 7958 11523 43461 1244 1692 1587 3090 42449 15000 3706 41415 1003 1753 40150 39075 36515 5189 1033 13315 3920 5041 21496 34704 31140 40544 13308 19295 10597 18985 915 9749 8402 8358 37404 1018 3672 20714 1457 16879 4362 31971 41323 47652 1645 1898 25014 4589 6774 5062 896 1943 8944 21054 41718 46949 46534 14815 2289 2952 14125 16842 962 10301 20860 2854 24030 1689 14891 1921 1182 2067 8651 39408 2277 7164 4792 936 765 10545 38806 36406 1418 1868 15221 16684 4101 17616 26482 6094 18977 1669 8896 42075 2662 17629 3635 1938 3375 19295 15756 19163 12170 3474 13181 5556 2267 10341 34917 2673 10737 32458 16950 18632 1892 16431

12 6 9 13 14 16 25 47 8 26 4 24 0 12 54 99 10 13 17 89 56 94 88 3 10 55 8 61 48 1 2 10 248 36 1 29 39 49 14 5 4 12 19 40 22 16 23 3 11 9 20 30 1 100 24 24 2 8 7 18 21 31 12 32 14 3 19 27 13 1 8 2 23 11 30 12 13 18 45 3 13 6 26 51 13 12 86 27 4 11 6 20 40 37 9 2 7 20 4 14 17 31 11 3 17 6 3 16 1 6 9 24 30 165 16 25 9 1 4 1 50 0 7 5 2 38 3 1 3 9 4

5480 4883 17332 1780 4017 2327 5551 2636 4032 3118 7315 1301 24765 4462 7521 2408 5691 7153 32642 1506 2293 1953 3566 28956 20232 4796 12591 1465 2676 31546 29275 21056 4537 1480 8842 5256 3125 22174 32739 28097 28479 8484 27047 6448 8498 1595 6157 7979 4529 18371 1685 3734 16078 2054 16637 1482 7128 11851 11761 6419 2938 15040 18797 7612 5711 1527 1711 13148 12706 27262 14986 27899 2736 2550 1577 15490 36135 1264 23820 23143 1713 53889 1452 14116 2133 1260 1971 7009 22207 2198 7136 2520 1377 1277 10112 39377 31031 1850 2355 14383 24003 5915 30780 27760 10215 27997 1889 7386 40329 5286 4321 5870 3411 2513 6342 16292 17851 11680 5258 11581 2398 8444 10649 28498 2687 12685 34780 20716 28825 2476 28640

31 43 393 35 52 26 119 3 7 36 3 6 4 16 3 33 30 2 28 3 21 25 128 8 5 26 16 8 55 14 2 41 1 28 5 52 26 6 3 1 9 9 7 34 9 20 35 89 49 25 43 14 9 13 11 75 1 7 3 172 19 4 54 145 14 6 197 44 15 6 40 2 63 19 2 0 0 32 1 0 18 3 3 118 13 14 43 13 70 24 6 74 23 1 2 2 11 23 5 17 46 5 5 3 25 20 31 38 0 103 34 25 88 57 0 3 43 1 27 0 19 55 12 14 12 13 1 0 0 13 7

5783 2538 7131 1190 5614 1506 3097 1768 3643 1674 10440 1302 8422 4784 7094 2353 4166 10542 17681 1155 1592 833 2214 19857 11512 3492 17252 1169 1594 21218 22079 18799 3025 845 8399 3033 3241 51597 21048 16883 22612 11692 37623 9581 10646 1412 9794 10130 7760 36777 1430 2737 13727 1070 16070 2541 38681 15758 15945 3066 1750 29072 5370 4443 7085 1246 3641 12199 25792 29507 15869 34115 17441 2386 1738 11443 16264 812 31002 46890 2693 57767 1815 16389 1970 686 1760 11479 33282 2330 10158 3905 1245 1578 8311 39802 37117 1468 1602 11718 20405 10950 13327 32026 7086 39491 1215 4774 43075 3043 23961 6930 2584 1911 17973 13301 15277 8739 31286 10407 3508 2785 10372 14946 3154 14415 39738 23135 57211 1805 58067

29 6 32 112 82 34 26 22 9 81 21 19 40 9 56 20 98 12 2 53 40 38 56 10 68 16 6 63 33 6 5 3 11 23 7 4 11 9 55 15 4 9 2 17 3 15 12 14 17 1 37 15 5 55 11 10 9 1 5 33 73 8 25 19 101 170 62 1 3 5 31 12 4 137 32 7 10 79 67 0 2 3 113 13 35 46 29 28 3 1 8 1 28 9 3 11 7 11 82 8 7 57 47 7 222 6 16 38 2 21 1 81 17 11 0 3 116 3 6 6 12 38 9 13 11 4 14 34 6 26 2

5932 4108 5211 1421 5446 1799 3056 1552 3239 1884 8564 771 23215 3089 4990 10504 1870 6166 41213 1052 1934 1239 1471 41039 24304 4908 12852 1227 1650 43157 42691 33475 9549 1048 8997 3094 2506 43373 20289 16364 37490 6181 28594 5610 8365 940 5399 6286 3329 27857 1470 12123 7218 792 9800 975 5727 11263 13820 2858 3202 22492 25204 13744 6381 1521 2497 13377 30449 29613 16100 29333 3213 8467 941 9381 32058 809 47992 38555 1800 47538 1440 15531 2100 579 1505 5463 35384 1467 5489 2254 693 655 6849 43371 41206 778 1151 10143 16106 24166 22946 35429 31009 27588 873 4262 46294 2312 4614 5992 1754 1135 5474 10284 33497 7715 29540 7428 1900 2837 6408 17939 1823 7818 32453 12322 26330 1402 25957

36 122 20 54 72 111 34 2 26 18 54 61 14 17 86 726 9 23 2 39 4 26 8 15 6 149 4 31 34 14 16 2 17 30 0 1 5 1 8 17 18 21 8 15 7 38 26 11 92 21 49 27 1 2 74 17 22 2 29 92 57 8 33 50 32 7 31 14 47 66 30 4 62 88 8 36 21 56 2 18 64 3 104 90 84 177 9 71 22 29 17 27 18 83 9 4 1 24 74 22 4 25 4 2 5 41 15 4 0 7 38 253 19 34 27 1 0 6 2 2 16 10 16 0 6 21 15 0 25 3 9

6638 2566 9186 1076 8001 1695 4604 2820 9443 1794 12023 1192 16774 10546 12584 8136 8145 10923 38395 1604 1883 1604 4025 39494 26030 6777 37091 1393 1727 39222 37348 34808 8015 1388 9367 8715 6616 25714 33261 25557 37034 18955 15453 11147 11308 1316 9405 7894 6620 31788 1569 4433 19739 1966 16598 2678 31207 25615 27502 3087 2147 21260 8456 7627 4896 1245 3486 11880 18932 30215 28362 42091 32800 3974 3315 15531 15521 1184 8870 20725 2667 24949 2213 13485 2045 1315 3139 14400 31643 2713 7204 5083 1152 1450 10431 35900 38766 2047 2244 11841 20675 14966 17932 26022 15777 36675 1431 10196 44495 3568 23053 10155 4081 4647 17551 12870 21430 14417 5913 13391 3817 3146 10001 22830 6341 14198 23163 20620 29328 3160 24034

18 27 31 26 3 2 26 31 13 19 4 6 38 10 2 33 5 0 14 49 8 32 50 7 7 26 12 5 17 1 6 1 92 69 6 8 6 25 4 3 5 19 13 21 2 94 4 2 9 10 36 58 28 8 11 40 2 13 4 24 5 10 26 111 19 60 42 22 1 2 16 12 12 5 34 9 10 36 3 12 0 1 58 6 7 25 2 16 0 9 24 25 26 1 7 7 3 54 43 14 3 37 44 22 5 11 15 72 2 2 18 47 11 47 21 8 12 10 45 17 51 50 9 11 8 51 25 7 6 34 2

12052 2407 6166 1451 3846 1943 3088 2159 8241 1299 5561 749 22602 3502 6006 1504 2926 6256 34881 1505 1782 1422 1765 38882 30122 6897 11399 1284 2082 39450 37354 29127 24918 1260 7121 3322 2563 48161 27527 27156 40651 6068 22713 3190 8119 1160 6836 5888 3169 29723 1356 8190 7837 1752 4650 1185 5978 11209 11014 5192 2201 15353 19428 12984 7026 1293 4369 10017 17996 17734 12521 23882 15630 2136 1443 9582 35520 1264 16685 24628 1621 54276 1675 11219 2253 1107 1543 5515 37692 1670 6464 4675 1189 1140 3386 35747 27554 1455 1452 7303 18602 27344 17641 24005 26793 34296 1171 7258 42940 3586 8134 6056 2091 1544 11197 10364 31040 8869 28364 8053 2183 2835 8007 16499 2754 9728 24718 20583 48237 1472 49881

67 39 53 39 54 34 1 61 159 17 0 34 30 48 18 15 13 24 2 32 12 40 36 3 1 212 10 108 4 2 7 3 444 14 4 4 24 3 12 2 8 41 2 11 2 29 5 25 21 10 31 11 185 17 24 1 6 35 9 233 25 0 174 33 31 13 51 3 49 49 14 2 90 39 18 26 6 47 26 1 11 1 2 37 14 52 9 21 21 10 20 51 41 48 2 14 10 28 34 1 6 33 17 1 37 3 20 12 2 43 15 55 43 35 47 15 7 26 13 8 26 26 11 6 4 32 4 10 1 11 2

13572 2525 7248 751 7971 943 3541 1913 5864 1747 7319 1137 14034 4965 2738 1174 3999 9450 45146 1319 1229 932 1180 49861 13285 2387 47871 1020 1522 54808 49424 46498 3993 1106 9952 4812 8833 10959 38584 35385 49151 8109 10246 5460 8898 1112 6500 6649 6448 43472 1150 2258 16907 1199 10792 2553 36369 42383 49941 2514 896 13546 4827 6630 10812 816 1077 20115 26556 52121 51163 48446 18848 2593 3190 9902 33366 715 5163 12043 1228 14492 1674 16177 1332 540 1973 12641 50417 2280 6640 3005 955 859 7983 44040 46278 1382 1582 8641 9087 10374 8144 33399 4486 25032 1544 5358 49810 2145 13156 6545 2146 1394 10250 11440 24280 8495 4972 9891 2614 2230 8000 34693 2415 12904 33373 12681 12888 1883 10994

83 134 28 36 42 53 47 59 18 44 10 0 24 117 17 33 85 2 18 15 21 20 32 9 66 15 2 15 1 5 7 3 36 6 15 63 32 2 0 8 7 22 5 2 4 30 15 6 0 11 34 29 22 39 25 1 6 16 5 14 17 12 87 3 40 68 75 10 5 4 1 13 25 15 49 8 123 26 51 3 14 5 41 135 34 66 32 4 0 18 4 13 4 5 5 1 10 34 5 21 8 97 3 1 35 50 24 38 1 6 9 43 18 62 60 2 14 9 16 4 34 18 12 10 14 40 5 21 9 10 3

5337 2067 4860 1096 2529 1662 3634 3078 3916 1916 7706 965 19230 1625 2701 2026 1939 6709 26386 547 1800 1000 2075 28525 16754 2909 12448 1721 2040 30481 27909 26577 7210 783 6613 2646 3130 37078 27403 17468 42385 5690 25553 2377 6864 1059 4194 4406 2885 14711 1138 4714 15000 1391 6201 2128 5883 9710 11139 4990 7015 18250 10524 6602 2911 4534 2038 10827 14015 16164 13759 24424 9702 2229 1538 16386 20007 1157 34731 31619 2617 64182 993 11611 970 2474 1615 4314 27063 2156 9575 3377 993 1201 8455 39388 33642 1124 1401 9733 16574 26440 20749 30395 14717 34371 1570 5460 44153 5050 4135 6959 2338 1469 6144 14291 24096 8156 7263 9982 2584 2823 9111 23873 2794 8182 44409 17943 23846 1598 20174

33 5 19 15 26 19 17 17 49 19 17 26 18 4 25 16 41 18 0 4 32 52 71 5 4 9 19 14 5 14 10 3 50 131 66 14 13 16 7 1 21 75 8 27 6 108 45 2 3 16 49 57 77 42 47 43 35 3 22 21 508 2 399 15 7 883 39 13 45 12 15 13 437 18 150 60 6 55 5 13 52 2 12 60 162091 73 11 6 42 14 0 18 25 49 5 3 6 20 4 10 4 8 17 3 29 3 3 60 6 94 138 20 15 35 31 5 19 43 54 6 23 24 8 22 41 51 29 2 13 32 9

-3 116 80 71 -64 109 20 21 -63 45 -50 58 90 -59 -22 78 -28 -38 -25 21 36 23 15 -32 35 29 -70 46 53 -21 -25 -42 -13 43 -34 34 -38 3 -6 -10 -30 -36 40 -39 -55 74 -37 -5 -46 -51 66 2 -22 41 -1 -66 -78 -71 -75 290 55 -40 310 12 13 71 -12 47 -40 -35 -68 -40 -82 11 -47 10 115 31 131 11 -40 124 -14 -5 11 7 -5 -19 -44 -3 0 -47 47 67 -4 1 -15 30 26 -6 44 44 75 5 68 48 13 -17 -4 99 -75 61 76 -26 -67 3 -7 -4 51 -12 -57 273 3 -18 1 18 7 22 55 31 74

3 12 -26 14 -50 36 -33 -19 -66 -22 -29 58 -35 -56 -26 74 -48 -9 -59 -7 -6 -47 -28 -53 -23 -6 -58 16 -9 -47 -43 -49 -42 -18 -37 -23 -36 140 -39 -46 -44 -12 95 -10 -44 54 0 21 -7 -2 40 -25 -34 -27 -5 -42 21 -62 -67 86 -8 16 17 -34 40 39 87 36 23 -29 -66 -27 18 4 -41 -19 -3 -16 201 125 -6 140 7 10 3 -42 -15 33 -16 2 42 -19 33 106 -21 3 2 4 -14 -23 22 167 -24 21 16 108 -27 -46 2 14 36 91 33 -43 -7 -16 -20 -28 801 -21 -37 23 0 -57 18 34 22 36 207 -5 253

5 82 -46 36 -52 62 -34 -29 -70 -12 -41 -6 78 -72 -48 675 -77 -46 -5 -15 14 -22 -52 -3 62 32 -69 22 -6 7 9 -8 84 1 -32 -21 -50 102 -42 -47 -8 -54 48 -47 -56 3 -45 -25 -60 -26 44 230 -65 -46 -42 -78 -82 -73 -71 74 69 -10 449 103 26 70 29 50 45 -29 -66 -37 -78 270 -68 -34 90 -16 366 85 -37 98 -15 4 9 -51 -27 -37 -10 -36 -23 -53 -26 -14 -35 12 13 -45 -38 -33 -3 489 30 34 409 45 -48 -52 10 -13 -74 65 -9 -66 -72 -35 75 -37 750 -44 -66 25 -38 -49 -32 -27 0 -27 41 -26 58

82 -6 -33 35 -52 15 -33 -23 -13 -28 -54 -37 35 -67 -52 -82 -64 -43 -9 -6 -5 -11 -56 -2 16 2 -69 -8 21 1 0 -16 211 -9 -24 -62 -61 87 -17 6 10 -68 47 -71 -28 -12 -27 -25 -52 -6 -14 85 -60 -11 -72 -56 -81 -56 -60 68 3 -28 130 70 43 4 25 -16 -5 -41 -56 -43 -52 -46 -56 -38 129 7 88 19 -39 118 -24 -17 10 -16 -51 -62 19 -38 -10 -8 3 -21 -68 0 -29 -29 -35 -38 -10 83 -2 -8 70 -6 -18 -29 -3 1 -65 -40 -49 -67 -36 -19 45 -38 380 -40 -43 -10 -20 -28 -57 -31 7 0 64 -53 108

104 -2 -21 -30 0 -44 -23 -32 -38 -3 -39 -5 -16 -53 -78 -86 -51 -13 18 -18 -35 -42 -71 26 -49 -65 29 -27 -12 40 32 34 -50 -20 6 -45 34 -57 16 38 33 -57 -34 -51 -21 -16 -31 -16 -3 37 -27 -49 -14 -39 -35 -5 17 65 82 -19 -58 -36 -43 -13 121 -34 -69 69 40 73 80 15 -43 -35 -4 -36 115 -40 -42 -42 -54 -42 -24 20 -35 -59 -37 -12 59 -16 -8 -41 -17 -41 -23 23 19 -32 -30 -27 -56 -31 -55 28 -72 -32 8 -47 12 -40 -43 -36 -47 -70 -42 -11 13 -41 -16 -26 -32 -29 -20 52 -62 -9 44 -39 -56 -40 -54

-20 -19 -47 2 -68 -2 -21 9 -59 7 -36 -19 15 -85 -79 -75 -76 -39 -31 -66 -4 -38 -48 -28 -36 -57 -66 24 18 -22 -25 -24 -10 -44 -29 -70 -53 44 -18 -32 14 -70 65 -79 -39 -20 -55 -44 -56 -54 -27 6 -24 -29 -63 -21 -81 -62 -59 62 227 -14 24 -13 -41 264 -42 -9 -26 -47 -51 -42 -70 -44 -54 6 29 -2 292 53 -2 157 -55 -14 -53 88 -49 -70 -14 -21 33 -34 -14 -17 -19 10 -13 -45 -38 -18 -20 77 16 17 -7 -6 10 -46 -1 42 -82 -31 -43 -68 -65 11 12 -43 23 -25 -32 -10 -9 5 -56 -42 92 -13 -19 -49 -16

Q00534 Q00534 Q00534 P50613 P50613 P50613 P49336 P49336 P49336 P49336 P50750 Q00532 O14757 O14757 O96017 O96017 Q13490 P48730 P49674 Q8IXA3 P78368 P68400 P01106 P23528 P23528 Q9Y281 Q60598 P41279 P41279 P35354 O15075 P16220 P16220 P16220 P02511 P02511 P02511 P02511 P02511 P02511 P41240 P41240 P78396 P14635 P24385 P24385 P24864 P51959 P99999 O75553 P53355 Q9UIK4 Q9UER7 O00273 Q13574 P78527 P78527 O60496 O60496 O94768 O00418 P00533 P00533 P00533 P00533 P00533 P00533 P05198 P05198 P06730 P06730 P06730 Q04637 P21709 P04626 P04626 P04626 P04626 P04626 P04626 P27361 P27361 P27361 P27361 P27361 P27361, P28482 P28482 P27361 P27361 P27361 Q16659 Q13164 Q13164 Q13164 Q13164 Q13164 Q13164 P30101 P13667 Q05397 Q05397 Q05397 Q05397 Q05397 Q05397 Q05397 Q05397 P25445 P48023 P07332 P11362 P21802 Q02790 O43524 P35916 P01100 P01100 P06241 P17677 Q12851 P14136 P63244 P25098 P25098 P35626 P10809 P38646 P11021 P11021 P14625 P14625

248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378

NK069-NK070 NK069-NK070-2 PK026-PK027-1 PK028-PK029-1 NK194-NK195-1 NK194-NK195-3 NK194-NK195-4 NK071 NN050 NN051 PN035 PN036 PN037 PN038 PN039 PN100 PN101 PN101-2 NN052 NN052-2 NN053 NK072 NN054 NN054-2 NN054-3 NN055 NN062 NN152-1 NN152 PN040-1 PN040-2 PN041 PN042-1 PN042-2 PN042-3 NN057 NN057-2 NN057-3 NN058 NN059-1 NN059-2 NN059-3 NN060 NN060-2 NN060-3 NN061 NN061-10 NN061-2 NN061-3 NN061-4 NN061-5 NN061-6 NN061-7 NN061-8 NN061-9 NN061-11 NN061-12 NN061-13 NN061-14 NN061-15 NN061-16 NN061-18 NN061-17 NN063 PN103 NN130 NN131 NK073 NK074 NN064 NN064-2 NN064-3 NN064-4 NN065 NN065-2 NK075-1 NK075-2 NK075-3 NK075-4 NK075-5 PK030-PK031 NK076-1 NK076-2 NK076-3 NN161 NK078-2 NK078-3 PN043 PN044 NK079 PK032 PK032-1 PK033 NK080 NK080-2 NK081 NK081-2 NK082 NK083-1 NK083-2 PK139 PN045 PN046-2 PN117 PN118 NK084-1 NK084-2 NK085 NK086 NK087 PK035-1 PK035-2 PK035-4 NK217 NK088-1 NK088-2 NK088-3 NK189 NK196 NK197 NN162 PN047 PN048-1 PN048-2 PN048-3 NP004 NN153 NK089 PK036 PK037 PK038

GSK3ab GSK3ab GSK3ab GSK3ab GSK3ab GSK3ab GSK3ab Haspin hHR23B Hip Histone H1 Histone H2A.X Histone H2B Histone H3 Histone H3 Histone H3 Histone H3 Histone H3 HO1 HO1 HO2 Hpk1 Hsc70 Hsc70 Hsc70 HSF4 Hsp105 Hsp27 Hsp27 Hsp27 Hsp27 Hsp27 Hsp27 Hsp27 Hsp27 Hsp40 Hsp40 Hsp40 Hsp47 Hsp60 Hsp60 Hsp60 Hsp70 Hsp70 Hsp70 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90 Hsp90a Hsp90a Hsp90a Hsp90a Hsp90a Hsp90a Hsp90a Hsp90b HspBP1 Huntingtin I1PP2A I2PP2A ICK IGF1R IkBa IkBa IkBa IkBa IkBb IkBb IKKa IKKa IKKa IKKa IKKa IKKa/b IKKb IKKb IKKb IKKg (NEMO) ILK1 ILK1 Integrin a4 Integrin b1 IR IR (INSR) IR (INSR) IR/IGF1R (INSR) IRAK1 IRAK1 IRAK2 IRAK2 IRAK3 IRAK4 IRAK4 IRb/IGF1Rb IRS1 IRS1 IRS1 IRS1 JAK1 JAK1 JAK2 JAK3 JIK (TAO3) JNK JNK JNK JNK1 JNK1/2/3 JNK1/2/3 JNK1/2/3 JNK2 JNK2/3 JNK3 Jun Jun Jun Jun Jun KAP KDEL receptor 1 KHS Kit Kit Kit

Pan-specific Pan-specific S21/S9 Y279/ Y216 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific phospho CDK1 sites S139 S14 S10 S28 T11 T3 T3 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S15 S15 S78 S82 S82 S82 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S421 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S180/S181 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S988 S785 Pan-specific Y999 Y999 Y1189/Y1190 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y1131/Y1146 Y612 Y1179 S312 S639 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T183/Y185 T183/Y185 T183+Y185 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S63 S73 S73 S73 Pan-specific Pan-specific Pan-specific Y703 Y730 Y936

Glycogen synthase-serine kinase 3 alpha/beta Glycogen synthase-serine kinase 3 alpha/beta Glycogen synthase-serine kinase 3 alpha/beta Glycogen synthase-serine kinase 3 alpha/beta Glycogen synthase-serine kinase 3 alpha/beta Glycogen synthase-serine kinase 3 alpha/beta Glycogen synthase-serine kinase 3 alpha/beta Haploid germ cell-specific nuclear protein-serine kinase UV excison repair protein RAD23 homolog B Hsp70/Hsc70 interacting protein (ST13) Histone H1 phosphorylated Histone H2A variant X Histone H2B Histone H3.3 Histone H3.3 Histone H3.3 Histone H3.3 Histone H3.3 Heme oxygenase 1 Heme oxygenase 1 Heme oxygenase 2 Hematopoetic progenitor protein-serine kinase 1 Heat shock 70 kDa protein 8 Heat shock 70 kDa protein 8 Heat shock 70 kDa protein 8 Heat shock transcription factor 4 Heat shock 105 kDa protein Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) Heat shock 27 kDa protein beta 1 (HspB1) DnaJ homolog, subfamily B member 1 DnaJ homolog, subfamily B member 1 DnaJ homolog, subfamily B member 1 Heat shock 47 kDa protein (collagen-binding protein 1, colligin 1) Heat shock 60 kDa protein 1 (chaperonin, CPN60) Heat shock 60 kDa protein 1 (chaperonin, CPN60) Heat shock 60 kDa protein 1 (chaperonin, CPN60) Heat shock 70 kDa protein 1 Heat shock 70 kDa protein 1 Heat shock 70 kDa protein 1 Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha/beta Heat shock 90 kDa protein alpha Heat shock 90 kDa protein alpha Heat shock 90 kDa protein alpha Heat shock 90 kDa protein alpha Heat shock 90 kDa protein alpha Heat shock 90 kDa protein alpha Heat shock 90 kDa protein alpha Heat shock 90 kDa protein beta Hsp70 binding protein 1 Huntington's disease protein Acidic leucine-rich nuclear phosphoprotein 32 family member A Protein SET Intestinal cell protein-serine kinase (MAK-related kinase (MRK) Insulin-like growth factor receptor protein-tyrosine kinase Inhibitor of NF-kappa-B alpha (MAD3) Inhibitor of NF-kappa-B alpha (MAD3) Inhibitor of NF-kappa-B alpha (MAD3) Inhibitor of NF-kappa-B alpha (MAD3) Inhibitor of NF-kappa-B beta (thyroid receptor interacting protein 9) Inhibitor of NF-kappa-B beta (thyroid receptor interacting protein 9) Inhibitor of NF-kappa-B protein-serine kinase alpha (CHUK) Inhibitor of NF-kappa-B protein-serine kinase alpha (CHUK) Inhibitor of NF-kappa-B protein-serine kinase alpha (CHUK) Inhibitor of NF-kappa-B protein-serine kinase alpha (CHUK) Inhibitor of NF-kappa-B protein-serine kinase alpha (CHUK) Inhibitor of NF-kappa-B protein-serine kinase alpha/beta Inhibitor of NF-kappa-B protein-serine kinase beta Inhibitor of NF-kappa-B protein-serine kinase beta Inhibitor of NF-kappa-B protein-serine kinase beta I-kappa-B kinase gamma/NF-kappa-B essential modulator Integrin-linked protein-serine kinase 1 Integrin-linked protein-serine kinase 1 Integrin alpha 4 (VLA4) Integrin beta 1 (fibronectin receptor beta subunit, CD29 antigen) Insulin receptor beta chain Insulin receptor Insulin receptor Insulin receptor / Insulin-like growth factor 1 receptor Interleukin 1 receptor-associated kinase 1 (Pelle-like protein kinase) Interleukin 1 receptor-associated kinase 1 (Pelle-like protein kinase) Interleukin 1 receptor-associated kinase 2 Interleukin 1 receptor-associated kinase 2 Interleukin 1 receptor-associated kinase 3 Interleukin 1 receptor-associated kinase 4 Interleukin 1 receptor-associated kinase 4 Insulin receptor / Insulin-like growth factor 1 receptor beta Insulin receptor substrate 1 Insulin receptor substrate 1 Insulin receptor substrate 1 Insulin receptor substrate 1 Janus protein-tyrosine kinase 1 Janus protein-tyrosine kinase 1 Janus protein-tyrosine kinase 2 Janus protein-tyrosine kinase 3 STE20-like protein-serine kinase Jun N-terminus protein-serine kinase (stress-activated protein kinase (SAPK)) Jun N-terminus protein-serine kinase (stress-activated protein kinase (SAPK)) Jun N-terminus protein-serine kinase (stress-activated protein kinase (SAPK)) Jun N-terminus protein-serine kinase (stress-activated protein kinase (SAPK)) 1 Jun N-terminus protein-serine kinases (stress-activated protein kinase (SAPK)) 1/2/3 Jun N-terminus protein-serine kinases (stress-activated protein kinase (SAPK)) 1/2/3 Jun N-terminus protein-serine kinases (stress-activated protein kinase (SAPK)) 1/2/3 Jun N-terminus protein-serine kinases (stress-activated protein kinase (SAPK)) 2 Jun N-terminus protein-serine kinase (stress-activated protein kinase (SAPKa/b)) 2/3 Jun N-terminus protein-serine kinase (stress-activated protein kinase (SAPKb)) 3 Jun proto-oncogene-encoded AP1 transcription factor Jun proto-oncogene-encoded AP1 transcription factor Jun proto-oncogene-encoded AP1 transcription factor Jun proto-oncogene-encoded AP1 transcription factor Jun proto-oncogene-encoded AP1 transcription factor Cyclin-dependent kinase associated phosphatase (CDK inhibitor 3, CIP2) ER lumen protein retaining receptor 1 Kinase homologous to SPS1/STE20 (MAP kinase kinase kinase protein-serine kinase 5 (MEKKK5) Kit/Steel factor receptor-tyrosine kinase Kit/Steel factor receptor-tyrosine kinase Kit/Steel factor receptor-tyrosine kinase

16945 4522 1526 1833 19526 1847 2132 2093 40878 17593 2680 2967 12591 1813 22170 4985 12616 10951 19670 18716 16663 12161 12114 19838 15706 38798 9746 20442 12017 552 2319 15828 30639 1327 11124 886 13257 15516 4705 7335 35250 7118 1027 7234 22605 11910 10316 8671 2305 2211 8556 7755 7500 10752 9044 9124 16027 10458 8299 13532 27904 20076 6146 37189 2288 18001 14740 2352 2330 19561 8551 10564 1042 15951 1445 8664 4871 9388 21447 7086 957 654 2692 19990 42631 5180 1538 39578 4193 43806 40906 37538 3403 27340 8329 20290 27791 4405 1016 1790 1315 31819 22661 2036 885 19713 4674 25351 17495 3264 30375 27912 29922 45365 2124 9730 1590 4232 2149 1713 39697 1018 5668 15174 36901 7601 6044 5879 42003 44549 30624

88 31 24 45 15 96 17 33 5 5 50 8 5 29 7 25 7 24 27 15 9 28 15 10 1 8 22 23 79 71 22 2 7 32 92 55 4 2 6 26 9 5 32 33 10 10 8 163 42 8 3 6 11 30 24 40 98 15 8 17 104 4 13 22 84 25 17 12 28 9 7 7 40 3 79 362 25 32 39 27 3 36 11 33 2 98 38 4 44 2 5 4 22 51 6 5 27 8 124 9 34 6 151 26 38 20 88 3 70 10 16 12 6 4 9 35 31 30 13 8 8 12 18 5 2 36 9 12 4 1 4

1711 3104 2075 2952 27078 1464 2808 2627 42440 21579 4074 4311 15149 2452 15266 6144 32527 13085 16636 13464 22450 14174 8843 18953 10681 29880 13526 19339 13232 1750 5134 25070 35262 1348 21338 1673 21799 19449 5027 3212 36435 8336 2448 2869 18232 10447 14137 4597 3927 6997 10939 13864 19090 19880 15914 21061 10437 20092 18221 17514 22348 22050 15391 40880 1780 18641 23050 2363 1917 11904 7075 14458 7396 15720 1778 1774 4578 9505 22596 3233 1220 1375 3160 24018 25912 13484 2071 15840 5271 30878 30891 32464 3826 3409 10991 19957 36569 3224 1565 1868 1608 25753 13125 2014 2274 28422 3698 27318 12358 3064 25236 27191 28443 38715 2547 8846 2174 8243 5011 2130 33514 2095 5754 28074 30938 9846 5903 6779 15274 14912 28575

20 3 28 27 5 13 10 4 2 6 16 66 14 3 8 77 6 18 16 21 37 15 17 2 27 67 18 12 31 44 54 20 29 13 3 56 114 5 29 31 5 0 12 4 4 6 377 22 46 2 13 52 11 12 43 126 141 18 29 0 24 11 45 0 71 8 10 31 3 3 1 14 92 5 24 47 32 1 55 3 37 27 65 1 33 43 54 4 5 3 14 25 8 30 0 10 8 19 8 19 26 27 2 46 11 20 9 27 27 8 18 4 1 12 31 1 1 39 178 10 4 17 13 55 9 16 32 50 3 2 25

6117 3239 1086 18656 60261 1617 2178 2344 47370 31098 4817 3172 42203 2832 11253 7057 25730 12178 34907 16938 25232 9444 6145 56425 10991 48460 7936 25455 8956 1940 2334 41756 37513 1361 14252 1613 34219 56611 6270 5222 47675 11098 1460 4229 56909 21855 18153 6605 4422 2827 17629 8879 8055 8136 7798 9186 14832 9513 10310 10280 57716 59547 3174 40484 1868 52213 52369 2898 2384 13443 7551 5214 776 14322 744 3189 3060 11853 3927 3944 1500 808 4911 17682 31142 4931 1678 31504 4854 33217 30152 36188 23658 15253 6928 16377 31893 2379 1390 1617 1409 41775 23393 1686 2975 25033 4705 31675 8223 3281 53887 34771 32399 40910 2160 8422 2391 3968 2300 1348 35083 1533 8292 16440 33756 10322 7452 3966 13829 13477 28260

54 9 4 8 1 22 1 1 1 14 54 41 3 24 4 28 69 49 4 17 15 46 34 0 61 2 2 3 2 0 10 20 11 2 42 6 230 0 3 72 1 2 40 20 2 25 66 19 56 62 49 0 34 9 45 24 41 15 5 6 2 4 22 7 41 1 3 31 19 2 17 35 63 34 5 5 27 210 5 46 53 50 106 4 6 10 44 18 63 10 19 56 79 17 4 31 98 24 15 11 36 32 93 25 96 192 24 2 12 23 8 4 20 1 11 19 21 7 5 2 8 4 52 0 17 34 106 25 1 1 5

836 2394 909 29159 37121 822 1701 1895 46943 19137 4675 2325 13672 1982 17701 3141 15753 8937 16771 10985 17663 7279 4877 40769 9934 48654 5279 17512 10852 1698 2823 33103 42295 822 33497 1774 18586 35462 2704 4160 43952 6475 1219 2107 32408 7915 12751 4667 2866 4280 17415 11546 10628 8236 8121 8796 14573 6945 6224 8362 28369 47259 21386 49348 1766 40698 41449 1429 1798 9868 4775 4875 927 12997 956 2478 1864 5495 28201 1746 894 750 3195 18314 44954 6454 927 17241 27500 46412 44800 41667 26664 3389 15948 12469 19885 2381 735 1591 1466 37575 24611 4581 2162 24864 2771 35868 8421 4790 29246 38599 38021 48025 1159 7010 1185 6722 4317 846 42077 928 3481 13376 36775 7089 7116 6960 9460 8960 36079

9 21 34 4 6 32 14 39 3 2 18 17 7 0 72 9 47 49 0 42 2 1 73 1 32 0 40 3 35 23 42 40 5 7 3 112 28 19 3 90 12 20 71 8 1 43 52 19 5 51 16 16 45 7 11 42 23 57 71 17 9 4 10 1 16 2 2 1 30 7 22 28 1 29 15 1 52 191 17 32 35 50 124 33 2 8 9 14 2 9 1 10 8 42 65 20 3 126 93 47 33 7 90 390 73 7 36 20 3 997 1 4 5 4 254187 27 26 20 224 23 6 1 45 14 7 25 12 11 15 7 1

4778 7147 1527 11433 34012 2690 5644 2776 38594 22225 2898 4323 17352 2949 16475 10853 17135 15995 23286 6896 20132 9297 12721 22922 9223 30889 10344 20242 10487 1819 2879 18344 24009 1573 14613 1485 18913 20285 5344 7880 36467 9368 1839 8344 22406 21632 28038 12122 2826 3310 8673 19303 7225 8510 8451 16365 15784 15153 9014 9704 24542 25110 13413 39243 2158 20348 19488 3304 3356 17479 11081 7932 1526 22773 1469 2551 7891 8742 23838 6445 2076 1167 3969 24092 38468 8746 2222 33711 5644 37855 35084 37183 9612 20425 10861 18973 32928 4087 1388 1586 2218 26560 24510 2612 6255 23610 6168 25447 8104 6117 26451 24809 26802 38439 2359 12204 2638 7944 2854 3017 34339 1430 5540 23535 28469 8104 10355 5264 27001 19808 22274

5 31 100 28 8 18 51 6 10 15 7 23 12 8 41 6 11 9 18 3 1 1 27 3 14 13 47 12 3 5 30 33 17 51 37 29 19 8 41 36 10 3 29 43 22 16 44 19 16 26 103 29 49 14 6 87 22 56 3 129 7 15 84 1 30 30 2 61 12 10 41 34 18 6 22 67 90 13 104 3 71 90 34 0 0 66 4 4 15 8 5 1 114 11 17 10 2 10 89 37 19 17 149 3 52 12 5 0 14 10 16 4 10 4 44 23 9 41 12 72 2 45 37 41 5 2 17 36 1 2 3

1869 3001 1225 11625 52015 1484 2136 1602 43586 26733 2623 2412 26057 2317 24869 3504 13208 3379 20178 9010 19116 6240 5156 46261 6336 43217 4685 19203 6787 2098 3558 25554 36525 1686 26033 2188 11905 40783 4740 7428 37935 6376 1473 3267 26742 9849 8626 3103 2440 17285 7907 8143 11508 9741 11814 12045 10556 9715 6686 9748 24914 49816 6168 45965 5893 32594 29882 1540 2521 9705 4350 3016 1099 14719 1031 1662 2795 6172 21526 2096 1457 820 2766 17824 40275 13436 1696 20608 13305 44344 52593 45309 14895 3401 7357 34303 27589 2366 1154 1485 1688 30714 18914 2272 7362 25652 2792 27428 3507 2582 34812 30333 28950 49224 1416 10299 1980 13056 3720 1494 39013 1156 3377 17734 37654 6600 8865 8323 14666 14152 27157

1 15 21 28 4 39 21 54 7 1 15 37 30 5 2 2 20 30 11 16 85 5 48 5 51 1 24 3 39 6 7 115 6 19 26 59 5 18 30 44 3 26 29 48 14 10 144 22 28 85 264 49 4 26 30 14 11 45 13 31 13 3 121 3 78 13 3 24 30 3 50 38 10 25 24 22 10 90 115 19 15 88 28 4 0 64 9 7 37 1 0 5 20 1 53 97 40 9 11 34 2 16 26 33 75 36 9 8 32 25 34 2 22 16 77 29 11 49 7 4 19 61 8 7 2 15 17 3 5 1 15

11844 3109 879 5171 15730 1648 1665 2443 49105 11305 2245 2808 10672 1308 12037 7981 7883 13092 12219 8978 11256 8157 6876 10454 9705 44971 6029 10006 7584 2172 2342 13202 35470 1138 20587 793 8655 9121 7468 4799 35992 9451 1578 3678 11173 9758 8243 9580 4057 2592 4947 7777 5066 4461 5641 5899 6679 5755 7779 7270 12137 14104 2836 50943 1363 9561 11044 2368 2253 19382 4724 13592 1023 14696 1396 1946 6013 3798 16528 10056 1011 927 2294 16654 54545 9177 1629 38085 4330 52976 42314 50902 7570 15399 5677 11842 34142 3782 6133 1375 622 34837 20918 1078 2585 22418 4906 32616 5818 2632 38423 27321 22953 53095 1771 4783 1398 2938 1773 1513 49568 945 5525 19567 47394 9689 11972 2189 47296 42925 32666

776 8 14 26 11 20 30 28 1 7 37 17 3 36 44 22 14 39 16 31 1 14 25 23 15 17 17 19 43 32 2 12 10 7 31 71 12 12 54 40 0 11 52 377 11 1 12 74 51 72 65 1 45 5 29 107 13 47 2 28 0 2 9 2 7 2 1 47 25 18 161 73 67 4 43 32 17 0 17 74 102 68 54 64 8 73 27 0 51 3 10 12 69 9 25 25 77 29 1655 30 121 9 138 1762 30 16 53 10 4 21 46 33 43 2 50 25 29 22 26 26 3 16 43 2 1 1 29 25 11 23 15

1768 3757 1631 7917 29398 1411 1875 2377 50714 17157 3281 2785 15255 1728 15990 6878 26764 13661 19090 14891 15180 9256 9671 17413 12252 44374 6358 16495 11239 2013 3686 21264 45684 1597 25981 2417 16690 14946 4219 5690 37773 8803 2025 2192 15641 6181 6604 3982 5292 5638 8441 5624 9343 14976 14533 8566 9742 10604 14026 13196 14713 18282 7970 49985 2313 17457 19203 1160 2387 11518 2668 7140 569 11725 1230 2538 2876 3198 26075 1618 814 857 2997 16982 35972 10367 1707 16495 8332 36864 41164 39901 14657 3391 2565 14424 29272 2952 929 1246 1415 30225 29996 2692 2592 16864 3886 30828 6053 2135 24240 34211 32136 55707 1483 3738 1712 3773 13440 3866 41634 908 4736 34250 39421 6578 3857 4872 14669 13764 26021

2 1 28 222 4 111 48 5 3 0 30 3 7 2 45 31 12 31 7 3 8 1 7 23 31 23 8 12 64 28 8 56 12 81 7 2 38 43 31 50 0 16 41 24 13 2 2 10 33 37 17 42 132 35 5 41 12 69 57 62 3 9 58 8 47 0 9 55 23 21 20 54 2 4 6 10 16 42 53 49 25 44 53 2 0 26 2 2 46 0 6 2 11 14 38 3 40 1 34 1 39 3 69 39 17 47 37 8 42 40 44 5 5 0 26 76 26 75 1124 32 15 113 86 64 10 32 8 28 21 11 56

-90 -31 36 61 39 -21 32 26 4 23 52 45 20 35 -31 23 158 19 -15 -28 35 17 -27 -4 -32 -23 39 -5 10 217 121 58 15 2 92 89 64 25 7 -56 3 17 138 -60 -19 -12 37 -47 70 216 28 79 155 85 76 131 -35 92 120 29 -20 10 150 10 -22 4 56 0 -18 -39 -17 37 610 -1 23 -80 -6 1 5 -54 28 110 17 20 -39 160 35 -60 26 -30 -24 -14 12 -88 32 -2 32 -27 54 4 22 -19 -42 -1 157 44 -21 8 -29 -6 -17 -3 -5 -15 20 -9 37 95 133 24 -16 106 2 85 -16 30 -2 15 -64 -67 -7

-64 -28 -29 918 209 -12 2 12 16 77 80 7 235 56 -49 42 104 11 77 -10 51 -22 -49 184 -30 25 -19 25 -25 252 1 164 22 3 28 82 158 265 33 -29 35 56 42 -42 152 84 76 -24 92 28 106 15 7 -24 -14 1 -7 -9 24 -24 107 197 -48 9 -18 190 255 23 2 -31 -12 -51 -26 -10 -49 -63 -37 26 -82 -44 57 24 82 -12 -27 -5 9 -20 16 -24 -26 -4 595 -44 -17 -19 15 -46 37 -10 7 31 3 -17 236 27 1 25 -53 1 77 25 8 -10 2 -13 50 -6 7 -21 -12 51 46 8 -9 36 23 -33 -67 -70 -8

-95 -47 -40 1491 90 -56 -20 -9 15 9 74 -22 9 9 -20 -37 25 -18 -15 -41 6 -40 -60 106 -37 25 -46 -14 -10 208 22 109 38 -38 201 100 40 129 -43 -43 25 -9 19 -71 43 -34 24 -46 24 94 104 49 42 -23 -10 -4 -9 -34 -25 -38 2 135 248 33 -23 126 181 -39 -23 -50 -44 -54 -11 -19 -34 -71 -62 -41 31 -75 -7 15 19 -8 5 25 -40 -56 556 6 10 11 684 -88 91 -39 -28 -46 -28 -11 11 18 9 125 144 26 -41 41 -52 47 -4 38 27 6 -45 -28 -25 59 101 -51 6 -9 -39 -12 0 -7 18 18 -77 -80 18

-61 -58 -20 2 53 -45 -62 -42 13 20 -9 -44 50 -21 51 -68 -23 -79 -13 31 -5 -33 -59 102 -31 40 -55 -5 -35 15 24 39 52 7 78 47 -37 101 -11 -6 4 -32 -20 -61 19 -54 -69 -74 -14 422 -9 -58 59 14 40 -26 -33 -36 -26 0 2 98 -54 17 173 60 53 -53 -25 -44 -61 -62 -28 -35 -30 -35 -65 -29 -10 -67 -30 -30 -30 -26 5 54 -24 -39 136 17 50 22 55 -83 -32 81 -16 -42 -17 -6 -24 16 -23 -13 18 9 -55 8 -57 -58 32 22 8 28 -40 -16 -25 64 30 -50 14 -19 -39 -25 32 -19 -14 58 -46 -29 22

148 -57 -42 -55 -54 -39 -70 -12 27 -49 -23 -35 -38 -56 -27 -26 -54 -18 -48 30 -44 -12 -46 -54 5 46 -42 -51 -28 19 -19 -28 48 -28 41 -47 -54 -55 40 -39 -1 1 -14 -56 -50 -55 -71 -21 44 -22 -43 -60 -30 -48 -33 -64 -58 -62 -14 -25 -51 -44 -79 30 -37 -53 -43 -28 -33 11 -57 71 -33 -35 -5 -24 -24 -57 -31 56 -51 -21 -42 -31 42 5 -27 13 -23 40 21 37 -21 -25 -48 -38 4 -7 342 -13 -72 31 -15 -59 -59 -5 -20 28 -28 -57 45 10 -14 38 -25 -61 -47 -63 -38 -50 44 -34 0 -17 66 20 16 -58 75 117 47

-63 -47 7 -31 -14 -48 -67 -14 31 -23 13 -36 -12 -41 -3 -37 56 -15 -18 116 -25 0 -24 -24 33 44 -39 -19 7 11 28 16 90 2 78 63 -12 -26 -21 -28 4 -6 10 -74 -30 -71 -76 -67 87 70 -3 -71 29 76 72 -48 -38 -30 56 36 -40 -27 -41 27 7 -14 -1 -65 -29 -34 -76 -10 -63 -49 -16 -1 -64 -63 9 -75 -61 -27 -24 -30 -6 19 -23 -51 48 -3 17 7 52 -83 -76 -24 -11 -28 -33 -21 -36 14 22 3 -59 -29 -37 21 -25 -65 -8 38 20 45 -37 -69 -35 -53 371 28 21 -36 -15 46 38 -19 -63 -7 -46 -31 17

P49840,P49841 P49840,P49841 P49840,P49841 P49840,P49841 P49840,P49841 P49840,P49841 P49840,P49841 Q8TF76 P54727 P50502 Q02539 P16104 P33778 P84243 P84243 P84243 P84243 P84243 P09601 P09601 P30519 Q92918 P11142 P11142 P11142 Q9ULV5 Q92598 P04792 P04792 P04792 P04792 P04792 P04792 P04792 P14602 P25685 P25685 P25685 P29043 P10809 P10809 P10809 P08107 P08107 P08107 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P07900 P08238 O95351 P42858 P39687 Q01105 Q9UPZ9 P08069 P25963 P25963 P25963 P25963 Q15653 Q15653 O15111 O15111 O15111 O15111 O15111 O15111 O14920 O14920 O14920 Q9Y6K9 Q13418 Q13418 P13612 P05556 P06213 P06213 P06213 P06213 P51617 P51617 O43187 O43187 Q9Y616 Q9NWZ3 Q9NWZ3 P35568 P35568 P35568 P35568 P23458 P23458 O60674 P52333 Q9UHG7 P45983 P45983 P45983 P45983 P45983 P45983 P45983 P45984 P45984 P53779 P05412 P05412 P05412 P05412 P05412 Q16667 P24390 Q9Y4K4 P10721 P10721 P10721

379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509

NK090 NK090-2 NP005 NK091 NK092-2 NK092-3 PK039 PK040 PK041 NK093 PK042-PK118 NK094 NK095 PK043 NK096 NK097 PK044 PN049-PN112-1 PN049-PN112-2 PN050-1 NK098 NN067 NN155 NK099-1 NK099-2 NK099-3 NK099-4 NK099-5 PK046-1 PK046-2 PK046-3 PK047-2 PK048-1 PK048-2 PK048-3 NK099-6 PK045-PN007 NK100-1 NK100-2 NK100-3 PK049-2 PK049 PK050 NK101 NK101-2 NK101-3 PK127 PK051 PK051-2 PK051-3 NK102 NK103 NK103-2 NK103-3 PK052 NK104 NK104-2 NK105-1 NK105-2 PK129 NK106-2 NK107 NK107-2 NK107-3 NK107-4 NK108 NK108-2 NK109 NK110 PK054-2 NP006 NP007 PN051-1 PN051-2 NK208 PK056 NN132 NN068 PK057 NK111 NK112 NN069 PK058 NK113-1 NK113-2 NK113-3 NK113-4 NK114 NK115 NK116 PK116 PN052 NK117-1 NK117-2 NK117-3 NK117-4 NK117-5 NK118 NK119 NN070 NN071 NK207 NK212 PN054 NN074 PN055 NN140-1 NN075 NN083 NN077 NN078 NN080 PN056 NN081-NN120 PK060-1 PK060-2 PK060-3 PK060-4 PK060-5 NK120-1 NK120-10 NK120-11 NK120-2 NK120-3 NK120-4 NK120-5 NK120-7 NK121 NK059-1 NK059-2 NN082

Ksr1 Ksr-1 LAR LATS1 Lck Lck Lck Lck Lck LIMK1 LIMK1/2 LOK Lyn Lyn MAK MAPKAPK2 MAPKAPK2 MAPKAPK2ab MAPKAPK2ab MARCKS MARK Mcl1 MEF-2 MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1 (MAP2K1) MEK1/2 MEK1/2+B23 (NPM) MEK2 (MAP2K2) MEK2 (MAP2K2) MEK2 (MAP2K2) MEK2 (MAP2K2) MEK2 (MAP2K2) MEK2 (MAP2K2) MEK3 (MAP2K3) MEK3 (MAP2K3) MEK3 (MAP2K3) MEK3 (MAP2K3) MEK3/6 (MAP2K3/6) MEK3/6 (MAP2K3/6) MEK3/6 (MAP2K3/6) MEK3b (MAP2K3) MEK4 (MAP2K4) MEK4 (MAP2K4) MEK4 (MAP2K4) MEK4 (MAP2K4) MEK5 (MAP2K5) MEK5 (MAP2K5) MEK6 (MAP2K6) MEK6 (MAP2K6) MEK6 (MAP2K6) MEK7 (MAP2K7) MEKK1 (MAP3K1) MEKK1 (MAP3K1) MEKK1 (MAP3K1) MEKK1 (MAP3K1) MEKK2 (MAP3K2) MEKK2 (MAP3K2) MEKK4 (MAP3K4) Met Met MKP1 MKP2 MLC(MLRC2) MLC(MLRC2) MLK3 MLK3 mMOB1 Mn SOD Mnk1 Mnk2 Mos MSH2 Msk1 MST1 MST1 MST1 MST1 MST2 MST3 mTOR (FRAP) mTOR (FRAP) MYPT1 Nek2 Nek2 Nek2 Nek2 Nek2 Nek4 Nek7 NFkappaB p50 NFkappaB p65 NIK Nlk NMDAR2B NME7 NR1 Nrf2 NT5E p107 p18 INK4c p21 CDKI1 p27 Kip1 p27 Kip1 p35, p25 p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38a MAPK p38d MAPK p38g MAPK (Erk6) p38g MAPK (Erk6) p53

Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S158 Y192 Y505 Pan-specific Y507+T508, Y504+T505 Pan-specific Pan-specific Y507 Pan-specific Pan-specific T222 T334 T334 S158+S162 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T291 T291 T291 S297 T385 T385 T385 Pan-specific S217+S221, S4 Pan-specific Pan-specific Pan-specific T394 T394 T394 Pan-specific Pan-specific Pan-specific S218 S218/S207 S218/S207 S218/S207 Pan-specific Pan-specific Pan-specific Pan-specific S257+T261 Pan-specific Pan-specific Pan-specific Pan-specific S207 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y1003 Pan-specific Pan-specific S19 S19 Pan-specific T277+S281 Pan-specific Pan-specific T209+T214 Pan-specific Pan-specific Pan-specific S376 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S2448 T696 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y1474 Pan-specific S896 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T187 Pan-specific T180+Y182 T180+Y182 T180+Y182 T180+Y182 T180+Y182 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific

Protein-serine kinase suppressor of Ras 1 Protein-serine kinase suppressor of Ras 1 LCA antigen-related (LAR) receptor tyrosine phosphatase Large tumor suppressor 1 protein-serine kinase (WARTS) Lymphocyte-specific protein-tyrosine kinase Lymphocyte-specific protein-tyrosine kinase Lymphocyte-specific protein-tyrosine kinase Lymphocyte-specific protein-tyrosine kinase Lymphocyte-specific protein-tyrosine kinase LIM domain kinase 1 LIM domain kinase 1/2 Lymphocyte-oriented protein-serine kinase Yes-related protein-tyrosine kinase Yes-related protein-tyrosine kinase Male germ cell-associated protein-serine kinase Mitogen-activated protein kinase-activated protein kinase 2 Mitogen-activated protein kinase-activated protein kinase 2 Mitogen-activated protein kinase-activated protein kinase 2 alpha/beta Mitogen-activated protein kinase-activated protein kinase 2 alpha/beta Myristoylated alanine-rich protein kinase C substrate MAP/microtubule affinity-regulating protein-serine kinase 1 Myeloid cell leukemia differentiation protein 1 Myelin expression factor 2 (MYEF2) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1 (MKK1) MAPK/ERK protein-serine kinase 1/2 (MKK1/2) MAPK/ERK protein-serine kinase 1/2 (MKK1/2) + B23 (nucleophosmin, numatrin, nucleolar protein NO38) MAPK/ERK protein-serine kinase 2 (MKK2) MAPK/ERK protein-serine kinase 2 (MKK2) MAPK/ERK protein-serine kinase 2 (MKK2) MAPK/ERK protein-serine kinase 2 (MKK2) (human) MAPK/ERK protein-serine kinase 2 (MKK2) MAPK/ERK protein-serine kinase 2 (MKK2) (mouse) MAPK/ERK protein-serine kinase 3 (MKK3) MAPK/ERK protein-serine kinase 3 (MKK3) MAPK/ERK protein-serine kinase 3 (MKK3) MAPK/ERK protein-serine kinase 3 (MKK3) MAPK/ERK protein-serine kinase 3/6 (MKK3/6) MAPK/ERK protein-serine kinase 3/6 (MKK3/6) MAPK/ERK protein-serine kinase 3/6 (MKK3/6) MAPK/ERK protein-serine kinase 3 beta isoform (MKK3 beta) MAPK/ERK protein-serine kinase 4 (MKK4) MAPK/ERK protein-serine kinase 4 (MKK4) MAPK/ERK protein-serine kinase 4 (MKK4) MAPK/ERK protein-serine kinase 4 (MKK4) MAPK/ERK protein-serine kinase 5 (MKK5) MAPK/ERK protein-serine kinase 5 (MKK5) MAPK/ERK protein-serine kinase 6 (MKK6) MAPK/ERK protein-serine kinase 6 (MKK6) MAPK/ERK protein-serine kinase 6 (MKK6) MAPK/ERK protein-serine kinase 7 (MKK7) MAPK/ERK kinase kinase 1 MAPK/ERK kinase kinase 1 MAPK/ERK kinase kinase 1 MAPK/ERK kinase kinase 1 MAPK/ERK kinase kinase 2 MAPK/ERK kinase kinase 2 MAPK/ERK kinase kinase 4 Hepatocyte growth factor (HGF) receptor-tyrosine kinase Hepatocyte growth factor (HGF) receptor-tyrosine kinase MAP kinase phosphatase 1 (CL100, VH1) MAP kinase phosphatase 2 (VH2) Myosin regulatory light chain 2, smooth muscle isoform Myosin regulatory light chain 2, smooth muscle isoform Mixed-lineage protein-serine kinase 3 Mixed-lineage protein-serine kinase 3 Preimplantation protein 3 Manganese superoxide dismutase (SOD2) MAP kinase-interacting protein-serine kinase 1 (calmodulin-activated) MAP kinase-interacting protein-serine kinase 2 (calmodulin-activated) Moloney sarcoma oncogene-encoded protein-serine kinase DNA mismatch repair protein mutS homolog2, colon cancer, nonpolyposis type 1 Mitogen & stress-activated protein-serine kinase 1 Mammalian STE20-like protein-serine kinase 1 (KRS2) Mammalian STE20-like protein-serine kinase 1 (KRS2) Mammalian STE20-like protein-serine kinase 1 (KRS2) Mammalian STE20-like protein-serine kinase 1 (KRS2) Mammalian STE20-like protein-serine kinase 2 (KRS1) Mammalian STE20-like protein-serine kinase 3 Mammalian target of rapamycin (FRAP) Mammalian target of rapamycin (FRAP) Myosin phosphatase target 1 NIMA (never-in-mitosis)-related protein-serine kinase 2 NIMA (never-in-mitosis)-related protein-serine kinase 2 NIMA (never-in-mitosis)-related protein-serine kinase 2 NIMA (never-in-mitosis)-related protein-serine kinase 2 NIMA (never-in-mitosis)-related protein-serine kinase 2 NIMA (never-in-mitosis)-related protein-serine kinase 4 NIMA (never-in-mitosis)-related protein-serine kinase 7 NF-kappa-B p50 nuclear transcription factor NF-kappa-B p65 nuclear transcription factor NF-kappa beta-inducing kinase Serine/threonine protein kinase NLK N-methyl-D-aspartate (NMDA) glutamate receptor 2B subunit Nucleotide diphosphate kinase 7 (nm23-H7) N-methyl-D-aspartate (NMDA) glutamate receptor 1 subunit zeta Nuclear factor erythroid 2-related factor 2 Ecto-5'-nucleotidase (CD73 antigen) Retinoblastoma (Rb) protein-related p107 (PRB1) p18 INK4c cyclin-dependent kinase inhibitor cyclin-dependent kinase inhibitor 1 (MDA6) p27 cyclin-dependent kinase inhibitor 1B p27 cyclin-dependent kinase inhibitor 1B CDK5 regulatory subunit 1, p35, p25 Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 alpha Mitogen-activated protein-serine kinase p38 delta (MAPK13) Mitogen-activated protein-serine kinase p38 gamma (MAPK12) Mitogen-activated protein-serine kinase p38 gamma (MAPK12) Tumor suppressor protein p53 (antigenNY-CO-13)

939 9316 37608 4027 10168 38218 21661 38478 30579 43500 37012 11203 8070 672 3334 12164 4420 4318 36530 4961 1730 7748 2675 42281 1420 1245 3196 1364 27874 41591 549 46480 16934 43335 869 2038 760 38825 1741 1652 35646 34409 42692 8102 5412 5691 2064 1499 46701 26170 41255 5364 11478 2850 22807 8308 947 3237 5242 5403 10171 4575 3475 1873 9658 3762 11647 2979 835 31824 9318 42297 45536 2122 9452 29674 14003 3756 10417 9269 2162 40938 1117 2184 45107 11008 1923 24787 41054 6395 7710 6986 2540 2906 9189 7791 18857 2744 3324 12435 14631 7818 5329 2941 2288 1219 17217 25106 15182 39061 22149 10632 3306 10697 2130 856 39835 1294 3134 1362 534 7426 9842 2848 6527 21029 3374 9895 7150 1517 10169

30 15 5 43 33 5 7 4 5 3 1 66 52 7 15 6 38 45 3 116 53 8 42 4 4 58 36 39 1 7 60 3 17 1 636 7 26 14 4 30 9 2 0 0 11 7 16 66 12 5 1 15 18 62 5 6 2 57 120 164 35 24 19 13 3 17 5 6 128 10 30 3 4 43 1 10 3 39 9 6 33 4 17 3 4 16 36 4 4 16 22 4 62 15 17 2 9 24 66 22 3 5 92 303 33 79 6 18 35 5 30 7 7 7 5 10 11 1 8 34 20 12 10 4 26 8 20 52 16 8 18

1374 7104 20094 3859 10602 35991 12958 16219 30609 38277 29852 10335 8610 1609 6280 10913 4196 4411 31851 6503 4527 8077 5661 30672 2000 1652 5379 2042 16183 31354 1462 31883 19556 19063 1333 2188 1486 33063 2308 2879 34624 36221 34132 8455 4746 6962 2480 2046 46377 31164 41774 8120 15895 2437 21698 12367 1458 4139 6903 3767 11231 3869 4802 2215 12280 4698 14792 4356 1205 32657 12154 38288 35309 2899 11430 32374 27117 5954 7708 9881 1964 36043 1233 5553 35129 11696 1942 15770 36145 7694 21706 8442 2356 5210 10219 8752 29086 3194 8402 13602 15284 7652 9510 3654 13432 1135 27637 19775 15108 39910 25933 12534 1437 11076 3532 1912 37367 1670 11286 5165 847 11056 15474 3390 7455 24896 3487 14626 14296 3256 12237

27 19 8 20 25 2 5 13 1 1 14 10 18 7 43 31 17 46 15 186 34 9 8 17 2 16 10 17 2 23 60 1 35 14 16 46 6 5 0 54 1 11 16 18 42 2 17 17 7 14 4 5 10 34 7 41 3 30 33 9 60 20 39 6 9 42 16 90 29 6 0 12 4 1 3 4 2 85 3 22 6 5 6 89 3 3 12 171 4 7 153 15 88 74 8 52 23 26 13 9 0 2 8 111 32 23 0 4 33 1 30 20 40 5 44 5 20 15 274 53 32 12 19 6 5 16 5 75 3 5 2

738 5124 48933 4779 7521 35510 15858 14916 35972 44953 30496 10265 7477 1021 3674 8831 5793 2852 40115 12211 1966 6939 6758 39616 1504 1429 3454 1561 12578 15507 744 14934 20526 13502 615 1501 715 51170 1832 1626 45902 43024 17821 6513 5812 9099 1552 1399 22177 27678 48977 4758 16784 2154 28646 7334 1464 3861 4858 1411 8554 6914 5227 2388 9016 4039 16785 3773 1040 16519 5679 51988 19144 2411 5993 15804 17231 7155 9909 5780 1670 43932 1003 3386 52440 11044 1956 22257 42237 8909 6808 7466 3662 3308 5760 8632 19087 2420 3144 13172 18805 6427 8152 11634 4563 1506 15201 14755 13925 16505 17315 11278 1196 13314 2236 2157 43374 2750 5939 2491 928 8709 22724 2843 7542 54339 4175 6413 10752 2873 9941

70 11 4 15 3 4 15 8 8 2 1 1 23 5 7 19 45 23 21 86 129 11 29 4 16 17 12 43 4 10 81 1 45 0 46 55 14 12 40 15 22 3 11 6 71 35 10 30 8 23 5 31 1 47 48 11 19 21 18 22 9 6 13 10 16 55 143 0 51 10 32 7 0 38 22 7 18 77 8 45 41 1 65 28 7 4 24 60 2 84 9 20 10 9 44 25 2 1 21 5 2 12 26 77 9 32 8 7 0 10 5 2 145 8 17 39 2 86 59 18 42 61 61 7 9 0 9 1 47 49 9

520 5671 41470 3205 6886 35097 18841 11171 31846 43033 31236 17890 6213 271 3557 7873 4915 3408 40484 29739 1157 5624 5562 43231 1030 1450 5201 1231 10592 13102 1008 13713 33142 11276 792 1423 1004 41920 1598 1226 41860 42196 24943 5673 1882 3834 2856 779 36578 21490 49712 4389 12536 2079 21475 3530 709 2287 6797 2598 5362 4825 4827 1385 7820 1875 12031 2480 1233 15291 5360 48260 28804 1373 5863 16689 15333 4598 12500 5431 1074 45947 986 2691 46897 7645 1119 16552 45940 4700 5222 6100 2196 2476 6531 7073 15476 2362 6737 11398 12093 3464 3622 27793 7946 704 16052 13510 11907 23502 16663 8295 510 10588 1773 1396 47060 1799 4624 4664 639 8879 10700 2840 4757 30718 3325 15383 8672 2336 7406

8 16 21 19 4 9 22 24 4 13 11 103 6 1472 36 8 23 16 7 9 0 9 7 12 46 15 147 106 27 4 83 4 26 17 67 90 25 0 18 25 8 1 21 253 16 0 0 13 18 15 2 14 24 34 2 99 16 36 61 23 4 13 133 20 4 8 5 4 39 3 4 1 26 24 37 16 6 47 32 56 55 2 23 37 5 12 53 27 9 43 204 26 8 23 25 19 41 21 25 1 20 10 25 6 7 117 26 9 15 0 41 8 40 28 8 12 1 4 34 37 72 13 8 13 1 2 80 15 17 27 4

1155 9849 30930 4860 7902 32071 19135 21627 23195 35241 32319 14824 12006 1064 3255 13171 8014 4510 28355 5198 1741 6334 2436 31779 1473 1731 2726 1301 18352 34555 1150 42381 14258 29746 1516 4550 1611 32108 1711 2384 32840 34334 26396 7266 6661 6949 3749 1669 35125 23296 39784 4254 15850 3240 23930 9617 1192 6956 10424 5427 8463 6313 5906 3177 13997 8236 15643 6697 1006 18777 8561 41574 22930 2363 12514 19435 20048 6544 11944 12537 2698 37563 1188 4426 44374 11460 1617 21148 39756 11537 10873 11722 5288 7008 16238 7709 21838 3073 6456 11770 13020 8929 6240 5453 5158 1145 19919 23155 14201 27822 21648 10395 1067 11045 5125 1502 40123 3241 12063 2428 1338 12716 13675 3501 8750 28800 6575 7809 10315 2501 7146

14 61 0 124 30 8 2 18 2 11 11 46 26 39 0 14 35 31 11 38 18 17 47 7 5 37 19 28 0 19 58 5 18 7 134 65 41 10 22 24 6 1 3 32 11 41 10 26 3 5 6 138 6 17 5 1 46 28 27 5 20 15 53 13 5 6 16 47 119 12 19 0 23 31 8 12 9 3 33 9 6 6 6 20 1 24 27 3 0 49 25 10 4 52 61 39 5 115 93 27 2 8 11 56 10 9 10 41 17 9 1 0 155 11 18 4 5 2 54 10 135 57 4 5 26 10 96 13 10 2 9

1135 5745 39555 6706 4940 41469 15205 14221 35481 45032 48313 7880 7217 1098 2663 11517 4468 2770 42081 9098 3896 6700 2701 46363 1666 1325 4901 1837 17619 36503 930 35614 27573 24207 1211 1864 1319 46710 1653 1968 33987 39492 21764 4308 2800 6226 2289 1343 29803 25673 46442 3579 6670 2050 20732 7813 1507 2802 8758 3363 9955 4008 5132 2350 18317 4861 14099 3028 1520 21008 10641 47836 27115 1911 11872 26943 13316 2900 6371 9154 1695 43194 1027 10599 48977 12699 2522 16489 47449 6128 5728 6606 2870 2704 16716 7738 19004 2358 3397 14056 14450 5369 5716 7837 6422 1344 14586 14834 16610 30490 17945 7026 1188 10926 2352 1191 43218 1605 6783 3571 914 8889 15529 2968 8220 23763 4591 14531 14874 4200 9250

10 27 8 47 81 1 11 10 5 6 10 26 2 2 47 24 32 14 6 13 47 16 6 2 114 17 12 28 3 5 36 3 11 33 56 29 19 14 3 59 9 4 26 58 24 3 73 8 2 34 10 99 16 6 5 20 11 74 2 1 32 37 36 11 51 43 75 4 116 5 19 1 12 61 2 28 16 45 55 0 8 1 8 284 0 29 68 88 2 15 51 145 6 18 108 15 36 40 53 29 9 37 24 25 20 54 20 15 30 4 14 26 65 3 8 33 2 60 44 14 33 46 54 16 68 7 44 30 2 40 14

446 4413 50793 4145 7220 49779 23389 38303 34433 55336 43807 9338 6258 976 2320 7107 2904 2505 45172 5511 981 5547 3172 52311 1260 1144 3377 1316 36497 46576 555 49099 33078 46084 490 1549 762 51795 1691 1215 43787 42570 50851 3601 2952 6028 697 1484 52692 23830 50915 5454 9543 1739 17328 4063 958 3016 2979 1484 7251 3472 3044 1686 6503 4281 8562 1950 680 26063 4628 51294 50715 1795 4498 25533 11683 4169 11314 5125 2058 49314 775 2055 53342 7610 1566 18397 49483 6257 6171 5232 3134 2493 5321 4043 18724 1813 2263 10149 15589 3692 4297 4966 3550 935 14340 10758 10011 41867 13866 7464 984 10806 1348 1044 49252 1555 3703 2257 642 9177 8523 1658 7235 15086 3148 4558 8110 1853 9336

73 32 1 40 29 3 3 1 6 2 4 35 0 13 6 2 107 11 2 4 3 10 7 1 5 20 42 4 12 23 44 0 19 12 26 47 2 9 2 11 9 1 0 10 76 26 11 30 2 6 2 19 1 38 1 58 16 16 13 59 18 16 6 37 18 1 3 18 82 8 10 0 2 42 1 5 2 69 54 3 53 1 4 14 5 10 9 7 2 38 63 8 4 35 20 138 15 50 20 27 8 14 17 20 45 36 2 22 15 8 14 12 12 2 46 11 1 18 206 52 29 4 9 18 9 1 13 25 23 26 14

863 4979 45437 3207 2919 43679 15825 17058 40770 39424 28712 9596 6668 1752 3009 5631 4516 2954 47096 6642 4096 5746 6019 42940 1068 4709 6890 1396 15261 37051 2538 30372 26350 17800 683 711 1068 46191 1462 1313 41312 40099 38217 3134 2681 6722 1884 1223 49305 21642 50261 6136 13552 21967 10434 9816 1722 3406 5202 1456 17084 2904 3852 2160 7288 2822 12730 3737 997 28799 14017 46400 35547 2597 5033 28991 13260 4022 10487 6714 1323 45858 782 3141 48175 11466 1501 20318 47948 6628 5401 4501 3282 3066 7659 6446 18879 2318 8714 14606 20079 4178 4648 7114 8282 1218 15069 15906 15354 38271 22621 10585 1327 11319 49630 17313 47555 2427 4769 4088 939 12355 8758 3313 7837 15780 3408 16333 18367 3592 13214

39 21 19 40 30 7 11 10 5 38 34 185 31 40 16 31 43 8 1 44 77 4 10 14 14 0 17 56 4 20 100 36 83 20 19 207 76 12 29 27 23 0 5 7 27 73 93 93 13 15 7 7 32 95 7 63 5 22 48 39 65 3 8 2 53 1 7 4 2 7 68 0 6 5 59 0 14 130 1 26 20 11 41 18 0 47 1 1 4 17 10 19 1 4 20 58 34 26 30 7 6 18 60 178 40 53 0 2 4 3 30 21 38 32 11 10 13 8 208 49 16 27 19 67 39 7 7 16 6 13 21

46 -24 -47 -4 4 -6 -40 -58 0 -12 -19 -8 7 139 88 -10 -5 2 -13 31 162 4 112 -27 41 33 68 50 -42 -25 166 -31 15 -56 53 7 96 -15 33 74 -3 5 -20 4 -12 22 20 37 -1 19 1 51 38 -14 -5 49 54 28 32 -30 10 -15 38 18 27 25 27 46 44 3 30 -9 -22 37 21 9 94 59 -26 7 -9 -12 10 154 -22 6 1 -36 -12 20 182 21 -7 79 11 12 54 16 153 9 4 -2 78 24 487 -7 61 -21 0 2 17 18 -57 4 66 123 -6 29 260 279 58 49 57 19 14 18 3 48 100 115 20

-21 -45 30 19 -26 -7 -27 -61 18 3 -18 -8 -7 52 10 -27 31 -34 10 146 14 -10 153 -6 6 15 8 14 -55 -63 36 -68 21 -69 -29 -26 -6 32 5 -2 29 25 -58 -20 7 60 -25 -7 -53 6 19 -11 46 -24 26 -12 55 19 -7 -74 -16 51 50 27 -7 7 44 27 25 -48 -39 23 -58 14 -37 -47 23 91 -5 -38 -23 7 -10 55 16 0 2 -10 3 39 -12 7 44 14 -37 11 1 -12 -5 6 29 -18 53 296 99 24 -12 -41 -8 -58 -22 6 -64 24 5 152 9 113 89 83 74 17 131 0 16 158 24 -35 50 89 -2

-45 -39 10 -20 -32 -8 -13 -71 4 -1 -16 60 -23 -60 7 -35 11 -21 11 499 -33 -27 108 2 -28 16 63 -10 -62 -68 84 -70 96 -74 -9 -30 32 8 -8 -26 17 23 -42 -30 -65 -33 38 -48 -22 -18 21 -18 9 -27 -6 -58 -25 -29 30 -52 -47 5 39 -26 -19 -50 3 -17 48 -52 -42 14 -37 -35 -38 -44 9 22 20 -41 -50 12 -12 23 4 -31 -42 -33 12 -27 -32 -13 -14 -15 -29 -9 -18 -14 103 -8 -17 -56 -32 845 247 -42 -7 -46 -22 -40 -25 -22 -85 -1 -17 63 18 39 48 243 20 20 9 0 -27 46 -1 55 21 54 -27

-2 -42 28 38 -37 29 -21 -34 53 28 49 -47 -40 3 -18 -13 -44 -39 48 75 124 6 11 46 13 -23 80 41 -4 6 -19 -16 93 -19 -20 -59 -18 45 -3 -17 3 15 -18 -41 -58 -10 -39 -20 -15 10 17 -16 -58 -37 -13 -19 26 -60 -16 -38 18 -37 -13 -26 31 -41 -10 -55 51 12 24 15 18 -19 -5 39 -34 -56 -47 -27 -37 15 -14 139 10 11 56 -22 19 -47 -47 -44 -46 -61 3 0 -13 -23 -47 19 11 -40 -8 44 25 17 -27 -36 17 10 -17 -32 11 -1 -54 -21 8 -50 -44 47 -32 -30 14 -15 -6 -17 -30 86 44 68 29

-61 -55 64 -15 -9 55 22 77 48 57 36 -37 -48 -8 -29 -46 -64 -44 59 6 -44 -12 30 65 -14 -34 24 1 99 35 -52 16 132 55 -68 -66 -53 61 -1 -49 33 24 93 -50 -56 -13 -81 -11 50 2 28 28 -40 -46 -28 -58 -20 -57 -71 -73 -14 -45 -48 -47 -54 -48 -45 -71 -32 39 -46 23 121 -24 -64 31 -42 -36 -5 -59 -24 31 -35 -54 20 -34 -3 -13 24 -46 -43 -55 -41 -64 -67 -48 -14 -41 -65 -14 20 -59 -31 -9 -31 -18 -28 -54 -30 50 -36 -28 -8 -2 -74 -31 23 -52 -69 -7 -52 -28 -38 -53 -17 -48 -52 -42 -21 -26 31

-25 -49 47 -34 -63 36 -17 -21 76 12 -11 -35 -44 65 -8 -57 -44 -35 66 28 135 -9 147 35 -28 172 153 7 -17 7 121 -28 85 -40 -55 -84 -34 44 -15 -45 26 17 45 -57 -60 -3 -50 -27 40 -7 26 44 -14 578 -56 2 45 -51 -50 -73 102 -54 -35 -32 -48 -66 -19 -44 -1 53 64 12 55 10 -60 49 -34 -39 -12 -46 -51 22 -34 -29 9 0 -7 -4 21 -43 -50 -62 -38 -56 -53 -16 -14 -25 35 24 54 -53 -26 30 61 6 -24 -31 8 38 4 2 24 2 868 1052 19 -25 -60 68 -30 -3 -36 -5 -10 -45 -48 109 78 44 85

Q8IVT5 Q8IVT5 P10586 O95835 P06239 P06239 P06239 P06239 P06239 P53667 P53667 O94804 P07948 P07948 P20794 P49137 P49137 P49137 P49137 P29966 Q9P0L2 Q07820 Q9P2K5 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 Q02750 P36507 P36507 P36507 P36507 P36507 P36507 P46734 P46734 P46734 P46734 P46734 P46734 P46734 P46734 P45985 P45985 P45985 P45985 Q13163 Q13163 P52564 P52564 P52564 O14733 Q13233 Q13233 Q13233 Q13233 Q9Y2U5 Q9Y2U5 Q9Y6R4 P08581 P08581 P28562 Q13115 P19105 P19105 Q16584 Q16584 Q9Y3A3 P04179 Q9BUB5 Q9HBH9 P00540 P43246 O75582 Q13043 Q13043 Q13043 Q13043 Q13188 Q9Y6E0 P42345 P42345 O14974 P51955 P51955 P51955 P51955 P51955 P51957 Q8TDX7 P19838 Q04206 Q99558 Q9UBE8 Q13224 Q9Y5B8 Q05586 Q16236 P21589 P28749 P42773 P38936 P46527 P46527 Q15078 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 Q16539 O15264 P53778 P53778 P04637

510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640

PN057-1 PN057-2 PN057-3 NN123 NP008 NN084 NK122 NK122-2 NK122-4 PK061 PK131 NK200 NK200-2 NK123 NK190 NK124 NN085-1 NN085-2 PN058 NN086 PN059 PN060-1 PN060-2 NN087 NK125 PK063 PK064-2 PK065 NN141-1 NK126-1 NK126-2 PK066 PN061 NN088 NN089 NK191 PN127 NN114 NK192 NK209 NK213 NK127-1 NK127-2 PK067 PK068 NN116 NK128 PK069 NK129 NK129-2 PK071-1 PK071-2 PK072-1 PK072-3 NK130-1 NK130-2 NK130-3 NK130-5 NK130-6 NK130-7 NK131-1 NK131-2 NK201 NK218 NK132 PK073 PK074 NK133 NK133-2 PK075-2 NK134 NK134-2 PK076-2 NK135 PK077-1 PK077-2 PK078 PK080 NK136 NK136-2 PK081-1 NK137 PK082-1 PK082-2 PK083 PK084 PK086-2 NK138 PK087 NK142 PK092 PK093-1 PK093-2 NK139 NK140 PK088 NK141 PK091 NK143 NK202 NK203 NN115 NK144-1 NK144-3 PK094-2 PK132 NN156 NK145 PK117 NK146 NK146-2 NK147 NP009 NP009-2 PP001 NP010 NP010-2 NP011 NP033 NP012 NP012-2 NP035 NP032 NP013 NP015 NP016 NP018 NP019 NP020 NP020-2 NP021

p53 p53 p53 p73 PAC1 PACSIN1 PAK1 PAK1 PAK1 PAK1/2/3 PAK1/2/3 PAK2 PAK2 PAK3 PAK5 PAK6 PARP1 PARP1 Pax2 Paxillin Paxillin 1 Paxillin 1 Paxillin 1 PCNA PCTK1 (PCTAIRE1) PDGFRa PDGFRa/b PDGFRb PDI PDK1 PDK1 PDK1 PED15 (PEA15) PERP PI3K PI3K p110 delta PI3K p85/p55 PI3KR4 PI4KCB PIP5K2a PITSLRE PKA Ca/b PKA Ca/b PKA Ca/b PKA Cb PKA R1a PKA R2a PKA R2a PKBa (Akt1) PKBa (Akt1) PKBa (Akt1) PKBa (Akt1) PKBa (Akt1) PKBa (Akt1) PKBb (Akt2) PKBb (Akt2) PKBb (Akt2) PKBb (Akt2) PKBb (Akt2) PKBb (Akt2) PKBg (Akt3) PKBg (Akt3) PKC PKC h PKCa PKCa PKCa/b2 PKCb1 PKCb1 PKCb1/2 PKCb2 PKCb2 PKCb2 PKCd PKCd PKCd PKCd PKCd PKCe PKCe PKCe PKCg PKCg PKCg PKCg PKCg PKCh PKCl/i PKCl/i PKCm (PKD) PKCm (PKD) PKCm (PKD) PKCm (PKD) PKN3 PKCq PKCq PKCz PKCz/l PKG1 PKG1a PKG1b PKM2 PKR1 PKR1 PKR1 PKR1 PLC R(PLCg2) Plk1 Plk1 Plk2 Plk2 Plk3 PP1/Ca PP1/Ca PP1/Ca PP1/Cb PP1/Cb PP1/Cg PP2A B' (B56) PP2A/Aa/b PP2A/Aa/b PP2A/Bb PP2A/Bg2 PP2A/Ca PP2B/Aa PP2Ca PP2Cd PP4/A’2 PP4C PP4C PP5C

S392 S392 S392 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S144/S141/S154 T423/402/421 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S394 Pan-specific Y31 Y118 Y118 Pan-specific Pan-specific Y754 Y572+Y574/Y579+Y581 Y716 Pan-specific Pan-specific Pan-specific S244 S116 Pan-specific Pan-specific Pan-specific Y467/Y199 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T197 S338 Pan-specific Pan-specific S98 Pan-specific Pan-specific T308 T308 S473 S473 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S657 T638/T641 Pan-specific Pan-specific T500 Pan-specific Pan-specific T641 Pan-specific Y313 Y313 T507 S664 Pan-specific Pan-specific S729 Pan-specific T514 T514 T655 T674 S674 Pan-specific T555 Pan-specific S738+S742 S910 S910 Pan-specific Pan-specific T538 Pan-specific T410/T403 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T451 T446 Pan-specific Pan-specific T210 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T320 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific

Tumor suppressor protein p53 (antigenNY-CO-13) Tumor suppressor protein p53 (antigenNY-CO-13) Tumor suppressor protein p53 (antigenNY-CO-13) Tumor suppressor protein p73 Dual specificity MAP kinase protein phosphatase Protein kinase C + casein kinase substrate in neurons protein 1 p21-activated kinase 1 (alpha) (serine/threonine-protein kinase PAK 1) p21-activated kinase 1 (alpha) (serine/threonine-protein kinase PAK 1) p21-activated kinase 1 (alpha) (serine/threonine-protein kinase PAK 1) p21-activated kinase 1/2/3 (serine/threonine-protein kinase PAK 1/2/3) p21-activated kinase 1/2/3 (serine/threonine-protein kinase PAK 1/2/3) p21-activated kinase 2 (gamma) (serine/threonine-protein kinase PAK 2) p21-activated kinase 2(gamma) (serine/threonine-protein kinase PAK 2) p21-activated kinase 3 (beta) (serine/threonine-protein kinase PAK 3) p21-activated kinase 5 (serine/threonine-protein kinase PAK 7) p21-activated kinase 6 (serine/threonine-protein kinase PAK 6) Poly [ADP-ribose] polymerase 1 (ADPRT) Poly [ADP-ribose] polymerase 1 (ADPRT) Paired box protein 2 Paxillin 1 Paxillin 1 Paxillin 1 Paxillin 1 Proliferating cell nuclear antigen PCTAIRE-1 protein-serine kinase Platelet-derived growth factor receptor kinase alpha Platelet-derived growth factor receptor kinase alpha/beta Platelet-derived growth factor receptor kinase beta Protein disulfide-isomerase 3-phosphoinositide-dependent protein-serine kinase 1 3-phosphoinositide-dependent protein-serine kinase 1 3-Phosphoinositide-dependent protein-serine kinase 1 Phosphoprotein-enriched in diabetes/astrocytes 15 p53-induced protein PIGPC1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase, regulatory subunit 4 phosphatidylinositol 4-kinase, catalytic, beta polypeptide Phosphatidylinositol 4-phosphatase 5-kinase type 2 alpha PITSLRE serine/threonine-protein kinase CDC2L1 cAMP-dependent protein-serine kinase catalytic subunit alpha/beta cAMP-dependent protein-serine kinase catalytic subunit alpha/beta cAMP-dependent protein-serine kinase catalytic subunit alpha/beta cAMP-dependent protein-serine kinase catalytic subunit beta cAMP-dependent protein-serine kinase type I-alpha regulatory chain cAMP-dependent protein-serine kinase regulatory type 2 subunit alpha cAMP-dependent protein-serine kinase regulatory type 2 subunit alpha Protein-serine kinase B alpha Protein-serine kinase B alpha Protein-serine kinase B alpha Protein-serine kinase B alpha Protein-serine kinase B alpha Protein-serine kinase B alpha Protein-serine kinase B beta Protein-serine kinase B beta Protein-serine kinase B beta Protein-serine kinase B beta Protein-serine kinase B beta Protein-serine kinase B beta Protein-serine kinase B gamma Protein-serine kinase B gamma Protein-serine kinase C alpha Protein kinase C eta type Protein-serine kinase C alpha Protein-serine kinase C alpha Protein-serine kinase C alpha, beta 2 Protein-serine kinase C beta 1 Protein-serine kinase C beta 1 Protein-serine kinase C beta 1/2 Protein-serine kinase C beta 2 Protein-serine kinase C beta 2 Protein-serine kinase C beta 2 Protein-serine kinase C delta Protein-serine kinase C delta Protein-serine kinase C delta Protein-serine kinase C delta Protein-serine kinase C delta Protein-serine kinase C epsilon Protein-serine kinase C epsilon Protein-serine kinase C epsilon Protein-serine kinase C gamma Protein-serine kinase C gamma Protein-serine kinase C gamma Protein-serine kinase C gamma Protein-serine kinase C gamma Protein-serine kinase C eta Protein-serine kinase C lambda/iota Protein-serine kinase C lambda/iota Protein-serine kinase C mu (Protein kinase D) Protein-serine kinase C mu (Protein kinase D) Protein-serine kinase C mu (Protein kinase D) Protein-serine kinase C mu (Protein kinase D) Protein-serine kinase C nu Protein-serine kinase C theta Protein-serine kinase C theta Protein-serine kinase C zeta Protein-serine kinase C zeta/lambda Protein-serine kinase G1 (cGMP-dependent protein kinase) cGMP-dependent protein kinase 1, alpha isozyme cGMP-dependent protein kinase 1, beta isozyme Pyruvate kinase, isozymes M1/M2 Double stranded RNA dependent protein-serine kinase Double stranded RNA dependent protein-serine kinase Double-stranded RNA-dependent protein-serine kinase Double-stranded RNA-dependent protein-serine kinase 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 Polo-like protein-serine kinase 1 Polo-like protein-serine kinase 1 Polo-like protein kinase 2 (serum -inducible kinase (SNK)) Polo-like protein kinase 2 (serum -inducible kinase (SNK)) Polo-like protein kinase 3 (cytokine- inducible kinase (CNK)) Protein-serine phosphatase 1 - catalytic subunit - alpha isoform Protein-serine phosphatase 1 - catalytic subunit - alpha isoform Protein-serine phosphatase 1 - catalytic subunit - alpha isoform Protein-serine phosphatase 1 - catalytic subunit - beta isoform Protein-serine phosphatase 1 - catalytic subunit - beta isoform Protein-serine phosphatase 1 - catalytic subunit - gamma isoform Protein-serine phosphatase 2A - B regulatory subunit - B56 alpha isofrom Protein-serine phosphatase 2A - A regulatory subunit - alpha and beta isoforms Protein-serine phosphatase 2A - A regulatory subunit - alpha and beta isoforms Protein-serine phosphatase 2A - B regulatory subunit - beta isoform Protein-serine phosphatase 2A - B regulatory subunit - gamma isoform Protein-serine phosphatase 2A - catalytic subunit alpha isoform Protein-serine phosphatase 2B - catalytic subunit - alpha isoform Protein-serine phosphatase 2C - catalytic subunit - alpha/beta Protein-serine phosphatase 2C - catalytic subunit - delta isoform Protein-serine phosphatase 4 - regulatory subunit (PPX/A'2) Protein-serine phosphatase X - catalytic subunit (PPX/C) Protein-serine phosphatase X - catalytic subunit (PPX/C) Protein-serine phosphatase 5 - catalytic subunit (PPT)

4129 20234 992 32746 9653 13505 13036 880 7488 4561 1784 3383 10272 8427 14396 23704 4252 19002 1790 32931 27141 28154 12615 18258 6430 44633 19782 11427 18563 1533 7835 1171 27586 38241 45723 16816 794 3893 1485 6943 6687 44232 18581 45270 8284 13370 4030 5633 30942 2854 44855 7426 7413 6330 2935 1118 3085 1499 7042 8459 3995 8026 1081 5725 46732 9132 5592 9176 6629 38323 4379 10725 5543 11379 38653 31786 1030 27561 12344 8411 2800 6802 33321 27571 30578 22402 16145 6919 5454 8101 4513 5074 916 10525 42017 933 10196 1832 14490 1468 1139 2039 7740 45315 30717 1055 3307 1506 1009 1700 11041 3466 8118 7826 904 5070 1509 7915 14845 7568 8595 17255 7700 41905 18283 13599 39866 4700 1864 7967 42176

18 49 23 7 8 2 13 54 18 27 1 100 27 5 96 28 26 13 31 12 5 44 33 19 102 4 22 8 16 29 28 38 40 6 2 15 75 34 11 15 5 8 34 11 5 27 27 38 5 189 6 7 4 141 15 2 36 37 52 42 14 398 102 62 6 27 865 117 26 13 19 34 47 7 5 8 11 8 28 36 28 19 21 74 9 59 60 63 16 8 16 195 6 69 9 25 64 27 7 26 150 24 59 9 1 5 59 12 38 22 1 98 39 5 19 11 59 44 4 8 16 62 93 4 13 10 5 8 10 5 0

7779 17576 1459 34100 11859 17715 14563 1171 6192 5683 3378 1050 11871 9150 26521 32552 5661 10566 2169 19226 22703 17572 10772 16647 7216 38096 10391 6429 22945 2149 34012 2011 10290 17096 43700 40847 2784 3400 3221 4859 9407 39136 13688 48323 8567 20405 12673 6398 31592 18106 44950 11466 8485 1697 21774 1268 3237 1970 13177 18213 6721 4372 1572 7530 46058 8607 1004 12618 10326 36556 3616 14746 15992 10474 35225 26838 1329 31794 10307 13139 3616 14334 24869 28211 17797 25599 15158 8161 13621 5457 11326 11973 1609 18175 41078 1591 10068 2965 20154 2126 1990 13839 27026 36841 24583 3190 8628 3511 1738 6673 11804 6866 23164 14790 2385 12717 2880 16524 20681 11751 9639 15673 15963 36861 21080 25669 41699 9545 9072 9222 40300

9 56 29 21 16 23 66 11 23 20 63 21 5 7 55 24 31 5 11 70 74 64 10 8 30 25 37 47 18 51 6 42 105 15 21 36 70 5 11 34 24 30 50 1 19 943 1 11 5 82 32 16 78 109 81 15 19 28 299 36 74 82 12 386 25 55 26 25 33 5 17 3 0 7 9 24 2 15 6 11 6 29 39 42 10 20 37 16 10 51 37 5 1 61 2 43 35 37 31 13 1 19 25 27 122 7 7 68 35 14 27 2 0 2 43 153 31 26 31 3 47 41 5 12 9 13 2 36 4 11 2

3716 27406 765 45885 11994 9270 15903 1427 10311 7016 1753 1594 8688 8207 17038 19651 5573 12076 1475 16516 29066 31137 12652 12492 6273 17550 22135 10292 53648 1463 7388 1098 31541 36371 43386 19264 951 3327 2227 9646 6627 45689 12730 20021 3081 20021 11172 8198 43392 3549 43150 14279 10490 32427 6609 1719 3943 1774 9004 6936 20699 3443 940 6600 50625 10816 767 8160 5004 35360 2615 11260 6538 10035 15923 14681 1216 30592 8170 9730 2688 9454 18783 30577 20297 2837 2154 11902 2282 9844 2773 7340 1028 16127 56490 1699 11071 1931 12702 1419 2055 2730 19069 45371 29277 1372 2764 1410 1776 2194 8065 2756 9384 3394 1331 7210 1827 7710 34309 22443 9067 12205 12379 45439 18307 27434 37243 5461 2784 10565 49528

17 59 1 4 11 144 59 20 13 6 41 37 12 7 3 7 106 24 4 17 3 48 147 28 30 1 63 4 3 24 61 21 0 104 2 18 19 12 44 42 18 37 1 7 38 17 25 60 3 7 3 13 11 8 6 15 158 30 44 13 744 18 73 30 2 14 76 40 1 3 15 27 18 3 7 3 104 2 44 15 28 2 734 59 95 8 75 26 296 9 31 28 81 24 2 11 5 18 38 13 108 1 16 6 11 45 26 26 8 60 0 9 17 38 97 10 1 30 8 27 13 29 17 22 19 73 3 16 6 34 16

4382 30573 914 27961 7954 15563 8404 634 7636 3770 1224 739 6130 5651 23916 14735 2637 28111 1265 32838 41219 9083 11255 14089 10417 21680 38885 6480 16685 1172 12166 9443 32687 15554 47605 24527 1432 2201 3111 15543 7700 45439 16128 33664 22151 21937 14229 3020 36448 10158 48736 17773 8318 29247 17428 583 1888 1605 5496 6450 4128 3355 635 5107 46507 18410 2226 9109 6568 45887 2813 10771 34614 9160 13932 12584 890 37782 8179 7078 3262 9864 33723 35923 33840 11527 27383 7511 31174 9482 21268 20845 967 19385 43439 1079 11839 2736 22113 1634 1235 11770 13550 38481 36273 3695 5058 1356 625 2456 14058 4930 14468 5350 3601 13679 1709 10199 11147 12234 10409 9624 9774 41181 13509 13088 43071 7691 5104 9421 40358

50 10 13 2 3 98 3 83 14 54 8 30 9 6 6 25 13 27 33 99 8 201 50 12 915 17 4 27 18 52 33 1515 2 46 5 33 14 2 98 666 6 11 16 8 150 53 78 6 2 1107 2 92 26 16 497 34 0 46 15 6 82 2 56 49 11 310 59 3 167 15 29 1 7 8 7 3 51 13 11 12 47 32 1 2 15 28 49 14 16 38 19 16 74 43 4 42 38 26 16 3 91 7 10 8 27 579 75 9 86 92 24 59 11 28 6 40 2 25 1 18 18 40 12 2 43 30 6 95 11 41 5

6510 21661 1656 36725 9861 11347 12892 974 11158 5622 3287 2326 16486 8704 18477 24715 7393 10569 1746 23978 24616 30264 12056 16483 13463 39498 19894 17501 20115 1651 11378 955 22591 26562 37011 23500 1093 3192 1569 12787 10648 36451 16226 41723 9750 17268 7662 7644 34619 4055 38347 7874 11917 6084 4807 1297 6382 1879 13534 11594 6837 4586 1145 11070 43763 12415 940 12131 6166 32009 2079 15002 6773 11524 22304 20646 1095 24157 10281 12451 5673 10168 13289 23939 19462 21623 3291 7837 11930 9408 8161 10505 1197 8687 35609 2242 9038 5532 19508 1720 2295 4145 17481 34068 26705 4922 8704 1951 1781 2644 12981 5859 12800 6557 1712 9036 1757 10022 27915 13198 8883 12691 7999 41591 19489 31550 38442 7765 4417 10565 34537

24 19 20 8 12 6 21 16 5 19 50 70 22 8 5 16 12 32 0 9 10 15 32 7 210 18 44 7 8 34 14 4 3 70 7 14 11 9 4 39 20 10 27 2 40 28 25 42 2 51 6 27 5 31 35 1 9 49 10 31 29 200 40 2 2 25 75 39 37 1 48 12 16 5 8 8 29 5 11 17 45 8 6 49 325 34 58 0 141 7 83 23 18 15 2 595 1 561 17 60 62 32 48 0 5 75 25 3 31 7 5 19 35 13 13 25 4 3 12 51 64 29 24 15 4 2 0 2 35 11 1

5785 20537 1061 32254 9108 7296 8673 1175 6779 5075 1657 1240 11004 6665 19447 15965 5201 6582 2134 23399 27301 26623 7800 27784 6748 27136 26329 6269 14943 4140 5232 1637 16244 16659 47037 25722 2938 4000 1804 5401 16347 49403 13105 48038 8351 21831 1139 5887 33386 1021 48216 6249 7949 6336 5077 2143 5983 1727 10020 12238 6941 6614 942 9216 25018 7949 745 9069 6538 44522 2877 12699 21448 8886 22723 33320 1355 38334 5910 6978 4087 8298 30651 28949 28192 29093 17289 8524 13156 7101 10317 11417 1150 10368 49355 1048 15078 2257 17237 1796 2091 10773 18333 44365 37959 2800 6831 1964 1852 4612 8568 5314 17010 14890 1769 16610 2832 12943 19500 12561 11314 15082 17002 48474 17389 10390 46531 16295 5050 9588 44864

34 15 20 7 14 44 29 16 26 18 271 43 6 17 4 3 69 51 52 7 5 28 21 104 311 49 24 51 6 403 78 3 30 2 6 225 72 18 5 109 413 6 15 3 55 71 30 11 7 75 2 4 37 99 47 11 1071 1 18 16 14 41 10 21 10 64 97 5 48 16 3 6 6 58 35 8 31 1 57 2 52 8 52 44 86 23 10 21 35 3 17 17 30 34 18 42 65 35 33 31 30 14 33 16 22 20 76 2 18 2 34 51 11 19 5 54 40 67 16 57 680 16 334 6 34 20 18 155 109 75 30

3621 24656 876 25318 7969 7737 7849 832 6140 5380 1555 1459 9082 8339 29109 17999 6141 17246 1018 18750 30311 36693 6084 36895 3965 46530 23822 5040 13196 2014 7142 573 21860 40907 49402 14100 787 2342 6303 6322 4677 49556 9775 53619 7159 8955 5958 4347 34980 1933 50875 5569 6881 5372 5672 1354 2566 2273 7438 3400 2700 2959 920 5204 52911 13777 734 6176 15200 46195 2242 6499 8600 9606 40283 42742 588 35654 10085 11594 2593 8944 18727 28871 10605 14291 20686 7480 12709 11048 5235 6082 808 13166 52076 734 7595 1103 8013 794 1718 1999 14646 50304 43425 1044 2404 1566 1323 569 6851 2805 13664 4012 1217 5367 2282 9488 13439 8419 6513 9137 5982 50993 12996 11104 47590 5876 2463 5427 49470

23 9 39 8 8 24 15 33 5 5 22 212 25 26 26 10 18 65 100 76 6 41 172 36 32 2 51 51 5 381702 28 32 21 23 3 3 18 32 83 61 6 10 3 3 78 80 46 18 9 25 5 39 38 88 30 51 0 22 17 11 12 15 30 67 1 15 22 27 77 2 29 8 10 20 10 11 166 2 45 142 9 3 6 47 79 124 68 17 71 31 45 26 3 8 2 49 15 16 46 78 69 34 80 7 6 167 5 29 63 187 13 6 15 12 54 60 117 24 9 13 23 48 7 3 20 8 0 61 8 26 1

10601 28053 745 31198 10298 19682 8644 1352 9318 3447 3594 1469 6881 6801 16582 18784 4388 12006 1874 17953 36251 17925 7640 34284 7912 37629 15499 7651 16372 962 13556 637 14607 20232 55263 21805 938 3140 13519 5631 3369 45798 12616 57841 9910 12456 3341 7213 38388 1794 50611 6708 9618 5220 6877 1770 2967 1836 7894 6924 5685 3497 1108 6204 44626 8820 988 8567 7487 41382 11375 8394 16593 9297 28055 30877 1029 31983 7997 7861 3363 6628 47032 44309 35944 37299 21869 9239 14749 6654 18775 16025 1601 15496 50126 885 6763 1567 17184 1087 1438 10478 16128 46086 37843 1908 2440 2865 1902 3575 3883 4757 11638 12192 1646 11632 2529 13238 11086 9305 12723 11970 11764 49138 16321 12433 47096 7717 8349 10172 44820

37 27 69 1 10 17 7 21 47 19 4 2 33 1 16 16 41 21 2 0 7 55 54 57 88 26 43 169 49 33 2 71 49 12 18 34 11 8 709 207 55 13 67 1 21 14 34 9 8 22 27 41 10 74 1 41 42 73 18 39 61 32 22 17 36 47 30 2 6 10 197 60 4 15 12 97 39 39 5 16 24 14 12 6 116 18 14 42 19 21 59 6 62 3 8 3 92 45 18 2 173 33 141 3 6 41 20 38 18 19 4 4 38 7 60 2 29 29 14 26 21 31 0 2 61 29 0 4 17 35 1

88 -13 47 4 23 31 12 33 -17 25 89 -69 16 9 84 37 33 -44 21 -42 -16 -38 -15 -9 12 -15 -47 -44 24 40 334 72 -63 -55 -4 143 251 -13 117 -30 41 -12 -26 7 3 53 214 14 2 534 0 54 14 -73 642 13 5 31 87 115 68 -46 45 32 -1 -6 -82 38 56 -5 -17 37 189 -8 -9 -16 29 15 -17 56 29 111 -25 2 -42 14 -6 18 150 -33 151 136 76 73 -2 70 -1 62 39 45 75 579 249 -19 -20 202 161 133 72 293 7 98 185 89 164 151 91 109 39 55 12 -9 107 -12 15 89 5 103 387 16 -4

-10 35 -23 40 24 -31 22 62 38 54 -2 -53 -15 -3 18 -17 31 -36 -18 -50 7 11 0 -32 -2 -61 12 -10 189 -5 -6 -6 14 -5 -5 15 20 -15 50 39 -1 3 -31 -56 -63 50 177 46 40 24 -4 92 42 412 125 54 28 18 28 -18 418 -57 -13 15 8 18 -86 -11 -25 -8 -40 5 18 -12 -59 -54 18 11 -34 16 -4 39 -44 11 -34 -87 -87 72 -58 22 -39 45 12 53 34 82 9 5 -12 -3 80 34 146 0 -5 30 -16 -6 76 29 -27 -20 16 -57 47 42 21 -3 131 197 5 -29 61 8 0 102 -7 16 49 33 17

6 51 -8 -15 -18 15 -36 -28 2 -17 -31 -78 -40 -33 66 -38 -38 48 -29 0 52 -68 -11 -23 62 -51 97 -43 -10 -24 55 706 18 -59 4 46 80 -43 110 124 15 3 -13 -26 167 64 253 -46 18 256 9 139 12 362 494 -48 -39 7 -22 -24 3 -58 -41 -11 0 102 -60 -1 -1 20 -36 0 525 -19 -64 -60 -14 37 -34 -16 17 45 1 30 11 -49 70 9 472 17 371 311 6 84 3 16 16 49 53 11 8 477 75 -15 18 250 53 -10 -38 44 27 42 78 -32 298 170 13 29 -25 62 21 -44 27 -2 -26 -4 8 64 174 18 -4

-11 -5 -36 -12 -8 -36 -33 21 -39 -10 -50 -47 -33 -23 5 -35 -30 -38 22 -2 11 -12 -35 69 -50 -31 32 -64 -26 151 -54 71 -28 -37 27 9 169 25 15 -58 54 36 -19 15 -14 26 -85 -23 -4 -75 26 -21 -33 4 6 65 -6 -8 -26 6 2 44 -18 -17 -43 -36 -21 -25 6 39 38 -15 217 -23 2 61 24 59 -43 -44 -28 -18 131 21 45 35 425 9 10 -25 26 9 -4 19 39 -53 67 -59 -12 4 -9 160 5 30 42 -43 -22 1 4 74 -34 -9 33 127 3 84 61 29 -30 -5 27 19 113 17 -11 -67 21 110 14 -9 30

-44 14 -47 -31 -19 -32 -39 -15 -45 -4 -53 -37 -45 -4 58 -27 -17 63 -42 -22 23 21 -50 124 -71 18 20 -71 -34 22 -37 -40 -3 54 33 -40 -28 -27 302 -51 -56 36 -40 29 -27 -48 -22 -43 1 -52 33 -29 -42 -12 18 4 -60 21 -45 -71 -61 -35 -20 -53 21 11 -22 -49 147 44 8 -57 27 -17 81 107 -46 48 -2 -7 -54 -12 41 21 -46 -34 529 -5 7 17 -36 -42 -33 52 46 -67 -16 -80 -59 -54 -25 -52 -16 48 63 -79 -72 -20 -26 -78 -47 -52 7 -39 -29 -41 30 -5 -52 -36 -27 -28 -25 23 -33 -65 24 -24 -44 -49 43

63 30 -55 -15 4 73 -33 39 -16 -39 9 -37 -58 -22 -10 -24 -41 14 7 -25 47 -41 -37 108 -41 -5 -22 -56 -19 -42 19 -33 -35 -24 49 -7 -14 -2 762 -56 -68 26 -22 39 2 -28 -56 -6 11 -56 32 -15 -19 -14 43 36 -54 -2 -42 -40 -17 -24 -3 -44 2 -29 5 -29 21 29 447 -44 145 -19 26 50 -6 32 -22 -37 -41 -35 254 85 85 72 565 18 24 -29 130 53 34 78 41 -61 -25 -72 -12 -37 -37 153 -8 35 42 -61 -72 47 7 35 -70 -19 -9 86 -4 29 44 32 -60 -30 43 -6 47 18 -16 -61 23 -1 89 -4 30

P04637 P04637 P04637 O15350 Q05923 Q9BY11 Q13153 Q13153 Q13153 Q13153 Q13153 Q13177 Q13177 O75914 Q9P286 Q9NQU5 P09874 P09874 Q02962 P49023 P49023 P49023 P49023 P12004 Q00536 P16234 P16234 P09619 P07237 O15530 O15530 O15530 Q15121 Q9H230 P27986 O00329 P27986 Q99570 Q5VWC1 P48426 P21127 P17612 P17612 P17612 P22694 P10644 P13861 P13861 P31749 P31749 P31749 P31749 P31749 P31749 P31751 P31751 P31751 P31751 P31751 P31751 Q9Y243 Q9Y243 P17252 P24723 P17252 P17252 P17252 P05771 P05771 P05771 P05771-2 P05771-2 P05771 Q05655 Q05655 Q05655 Q05655 Q05655 Q02156 Q02156 Q02156 P05129 P05129 P05129 P05129 P05129 P24723 P41743 P41743 Q15139 Q15139 Q15139 Q15139 O94806 Q04759 Q04759 Q05513 Q05513 Q13976 Q13976 P14619 P14618 P19525 P19525 P19525 P19525 P16885 P53350 P53350 Q9NYY3 Q9NYY3 Q9H4B4 P62136 P62136 P62136 P62140 P62140 P36873 Q15172 P30153 P30153 Q00005 Q9Y2T4 P67775 Q08209 P35813 O15297 Q8TF05 P60510 P60510 P53041

641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736 737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 764 765 766 767 768 769 770 771

NP021-2 NP022 NP022-2 PN062 NK148 PK095-PK096 NK149 NK149-2 NK150 NK151 PN104 NK152 NN142 NK204 NP023 NP023-2 PP003 NP024 NP025 NP026 NP026-2 NP036 NK153 NK154 NK154-2 PK097-2 NN150 NN150-2 NN092-1 PN063-2 PN064 NK155-2 NK155-3 NK155-4 PK098 NK205 NK205-2 NK156 NK156-2 NN093 PN065 PN066 PN067 PN068 PN069 PN070 PN071 PN113 PN131 NK157 NK158 NK159-1 NK159-2 NK160 NK161 NK162 NK163 NK164 NK164-2 PK137 PK099 PK100-2 PK101-1 PK101-2 PK102 PK103 NK165 NK166 NK167 PN073 NK168-NK169-1 NK168-NK169-3 NK168-NK169-2 PK104-PK140 PK105-PK141 PK106-PK142 NK169 NN133 NK170 PN074-2 PN074 PP004 NK171 NN095 PN075 PN076 NN096 PN125 NN145 NN097 NN098 NN151 NN099 PN077 NN100 NN101 NK172 NK172-2 NK172-3 NK172-4 PK107 PK108 PN078-PN135 PN079-PN136-1 NN102-NN124 NN102-NN124-2 NN139 NN103 PN080 NN104 NN104-2 PN081-2 PN082 NN117 NN105 PN083 NN106 NN107 NN108 NK173 NN134 NK174 PN084 PN111 NK175-1 NK175-2 NK175-3 NK175-4 NK175-5 PN085 PN086

PP5C PP6C PP6C PRAS40 PRK1 (PKN1) PRK1/2 (PKN1/2) PRK2 (PKN2) PRK2 (PKN2) PRKAB1 PRKWNK4 Progesterone Receptor PRP4K PSD-95 PSTAIRE PTEN PTEN PTEN PTP1B PTP1C PTP1D PTP1D PTPD1 PyDK2 (PDHK2) Pyk2 Pyk2 Pyk2 Rab5 Rab5 Rac1 Rac1 Rad17 Raf1 Raf1 Raf1 Raf1 RafA (Araf) RafA (Araf) RafB (Braf) RafB (Braf) Rb Rb Rb Rb Rb Rb Rb Rb Rb Rb RIP2/RICK RIPK1 ROKa (ROCK2) ROKa (ROCK2) ROKb (ROCK1) RONa ROR2 ROS RSK1 RSK1 RSK1 RSK1/2 RSK1/2 RSK1/2 RSK1/2 RSK1/2/3 RSK1/3 RSK2 RSK4 RYK S6 S6Ka (p70 S6Ka, p85 S6Ka) S6Ka (p70 S6Ka, p85 S6Ka) S6Ka (p70 S6Ka, p85 S6Ka) S6Ka (p70 S6Ka, p85 S6Ka) S6Ka (p70 S6Ka, p85 S6Ka) S6Ka (p70 S6Ka, p85 S6Ka) S6Kb (p70 S6Kb) SG2NA SGK3 Shc1 Shc1 SHP2 SLK Smac/DIABLO Smad1/5/9 Smad2 Smad2/3 SMC1 SOCS2 SOCS4 SOD (Cu/Zn) SOD (Mn) SODD SOX9 SPHK1 SPHK2 Src Src Src Src Src Src STAT1a/b STAT1a/b STAT1a/b STAT1a/b STAT1a STAT2 STAT2 STAT3 STAT3 STAT3 STAT3 STAT4 STAT5A STAT5A STAT5B STAT6 STI1 STK33 Striatin Syk Synapsin 1 Synapsin 1 TAK1 TAK1 TAK1 TAK1 TAK1 Tau Tau

Pan-specific Pan-specific Pan-specific T246 Pan-specific T774, T816 Pan-specific Pan-specific Pan-specific Pan-specific S294 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S380+T382+S385 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y579 Pan-specific Pan-specific Pan-specific S71 S645 Pan-specific Pan-specific Pan-specific S259 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific T356 S612 S780 S807 S807+S811 T821 T826 S608 S795 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S363 S221/S227 S363/S369 S380/S386 S380/S386 T573/T577/T570 T359+S363/T356+S360 Pan-specific Pan-specific Pan-specific S235 Pan-specific Pan-specific Pan-specific T229, T252 T444+S447, T421+S424 T412, T389 Pan-specific Pan-specific Pan-specific Y349+Y350 Y349+Y350 S576 Pan-specific Pan-specific S463+S465/S463+S465/S465+S467 S465+S467 Pan-specific S957 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S181 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y418 Y529 S727 Y701 Pan-specific Pan-specific Pan-specific Pan-specific Y690 Pan-specific Pan-specific S727 Y705 Pan-specific Pan-specific Y694 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S9 S603 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S515 S515+S518

Protein-serine phosphatase 5 - catalytic subunit (PPT) Protein-serine phosphatase 6 - catalytic subunit (PPVC) Protein-serine phosphatase 6 - catalytic subunit (PPVC) Proline-rich Akt substrate 40 kDa (Akt1S1) Protein kinase C-related protein-serine kinase 1 Protein kinase C-related protein-serine kinase 1/2 Protein kinase C-related protein-serine kinase 2 Protein kinase C-related protein-serine kinase 2 5'-AMP-activated protein kinase (AMPK), beta-1 regulatory subunit Putative protein-serine kinase WNK4 Progesterone receptor Protein-serine kinase PRP4 homolog Disks large homolog 4 PSTAIRE Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and protein phosphatase and tensin homolog deleted on chromosome 10 Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and protein phosphatase and tensin homolog deleted on chromosome 10 Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and protein phosphatase and tensin homolog deleted on chromosome 10 Protein-tyrosine phosphatase 1B Protein-tyrosine phosphatase 1C (SHP1, SHPTP1) Protein-tyrosine phosphatase 1D (SHP2, SHPTP2, Syp, PTP2C) Protein-tyrosine phosphatase 1D (SHP2, SHPTP2, Syp, PTP2C) Protein-tyrosine phosphatase non-receptor type 21 Pyruvate dehydrogenase kinase isoform 2 Protein-tyrosine kinase 2 Protein-tyrosine kinase 2 Protein-tyrosine kinase 2 Ras-related protein Rab-5A Ras-related protein Rab-5A Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Rad17 homolog Raf1 proto-oncogene-encoded protein-serine kinase Raf1 proto-oncogene-encoded protein-serine kinase Raf1 proto-oncogene-encoded protein-serine kinase Raf1 proto-oncogene-encoded protein-serine kinase A-Raf proto-oncogene serine/threonine-protein kinase A-Raf proto-oncogene serine/threonine-protein kinase RafB proto-oncogene-encoded protein-serine kinase RafB proto-oncogene-encoded protein-serine kinase Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Retinoblastoma-associated protein 1 Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) Receptor-interacting protein-serine kinase 1 RhoA protein-serine kinase alpha RhoA protein-serine kinase alpha RhoA protein-serine kinase beta Macrophage-stimulating protein receptor alpha chain ROR2 neurotrophic receptor-tyrosine kinase Orosomucoid 1 receptor-tyrosine kinase Ribosomal S6 protein-serine kinase 1 Ribosomal S6 protein-serine kinase 1 Ribosomal S6 protein-serine kinase 1 Ribosomal S6 protein-serine kinase 1/2 Ribosomal S6 protein-serine kinase 1/2 Ribosomal S6 protein-serine kinase 1/2 Ribosomal S6 protein-serine kinase 1/2 Ribosomal S6 protein-serine kinase 1/2/3 Ribosomal S6 protein-serine kinase 1/3 Ribosomal S6 protein-serine kinase 2 Ribosomal S6 protein-serine kinase 4 (alpha 6) RYK tyrosine-protein kinase 40S ribosomal protein S6 p70/p85 ribosomal protein-serine S6 kinase alpha p70/p85 ribosomal protein-serine S6 kinase alpha p70/p85 ribosomal protein-serine S6 kinase alpha p70/p85 ribosomal protein-serine S6 kinase alpha p70/p85 ribosomal protein-serine S6 kinase alpha p70/p85 ribosomal protein-serine S6 kinase alpha p70 ribosomal protein-serine S6 kinase beta Striatin-3 Serum/glucocorticoid regulated kinase 3 SH2 domain-containing transforming protein 1 SH2 domain-containing transforming protein 1 Protein-tyrosine phosphatase 1D (SHPTP2, Syp, PTP2C) STE20-like protein-serine kinase Second mitochondria-derived activator of caspase Mothers against decapentaplegic homologs 1/5/9 Mothers against decapentaplegic homolog 2 SMA- and mothers against decapentaplegic homolog 2/3 Structural maintenance of chromosomes protein 1A Suppressor of cytokine signaling 2 Suppressor of cytokine signalling 4 (SOCS7) Superoxide dismutase 1 Superoxide dismutase [Mn], mitochondrial [Precursor] Silencer of death domains (Bcl2 associated athanogene 4 (BAG4)) SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) Sphingosine kinase 1 Sphingosine kinase 2 Src proto-oncogene-encoded protein-tyrosine kinase Src proto-oncogene-encoded protein-tyrosine kinase Src proto-oncogene-encoded protein-tyrosine kinase Src proto-oncogene-encoded protein-tyrosine kinase Src proto-oncogene-encoded protein-tyrosine kinase Src proto-oncogene-encoded protein-tyrosine kinase Signal transducer and activator of transcription 1 alpha/beta Signal transducer and activator of transcription 1 alpha/beta Signal transducer and activator of transcription 1 alpha/beta Signal transducer and activator of transcription 1 alpha/beta Signal transducer and activator of transcription 1 alpha Signal transducer and activator of transcription 2 Signal transducer and activator of transcription 2 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Signal transducer and activator of transcription 6 Stress induced phosphoprotein 1 (Hsc70/Hsp90 organizing protein (Hop)) FLJ35932 protein-serine kinase Striatin Spleen protein-tyrosine kinase Synapsin 1 isoform Ia Synapsin 1 isoform Ia TGF-beta-activated protein-serine kinase 1 TGF-beta-activated protein-serine kinase 1 TGF-beta-activated protein-serine kinase 1 TGF-beta-activated protein-serine kinase 1 TGF-beta-activated protein-serine kinase 1 Microtubule-associated protein tau Microtubule-associated protein tau

2382 7755 4486 33340 5251 2061 6549 7743 2903 6025 12125 2596 2129 1382 14885 1515 33943 36261 45285 41300 18054 19682 4529 12936 40671 30016 2626 13628 43764 27630 7833 985 9313 6963 1402 2860 10440 8027 1141 45035 29325 46474 1715 9122 2471 11450 29474 5827 1667 42677 40655 45672 6210 40564 43621 1988 2480 9612 10301 16701 37682 11299 795 35452 1688 1740 1796 4730 1834 7363 13438 1189 1568 27474 2444 2574 2156 17964 3397 20130 9434 24196 3067 5722 7765 24910 43579 3643 18694 6420 2932 25572 8682 45158 8241 9880 926 4914 7884 7875 8705 18818 40380 1592 19290 995 2759 21272 21295 14043 689 41420 1242 12681 13004 1334 11440 10879 46445 5366 16880 10712 11313 881 20009 811 1532 1406 14241 39694 38797

39 27 33 4 38 0 21 17 0 93 52 50 7 1 2 15 1 4 2 1 2 26 25 8 7 1 11 31 1 5 31 2 43 16 40 33 6 16 10 4 20 9 11 34 23 8 8 129 20 3 26 2 21 14 1 62 26 1 17 30 26 13 66 23 9 2 28 6 7 5 52 7 37 17 12 92 9 3 2 13 83 2 12 21 72 7 5 28 12 21 76 6 18 5 29 19 15 24 32 7 91 53 1 59 10 50 12 61 24 22 75 0 19 6 2 171 11 46 6 64 6 6 34 181 26 173898 482 8 24 2 11

7152 16746 17755 33194 7736 4990 22989 8443 4898 12965 5749 9295 4930 1792 21897 1384 29358 27662 44024 43694 19360 26076 6854 12827 38032 30603 6010 25983 42377 26274 17650 1727 15003 8308 4159 4582 10992 9704 2122 33981 36790 48100 3781 16461 6935 28292 37224 3107 2088 32367 42081 38218 12078 35465 31484 3666 2612 12100 15300 19281 39143 19162 1011 32777 2196 2068 2464 6276 3009 11660 23067 1266 2325 13163 7794 1421 2974 19511 23881 35536 39825 14397 4530 7305 20641 9650 40338 4694 34001 13531 6353 8735 8580 43867 20957 22498 3322 14471 9569 10231 6431 9303 33794 3152 19389 1269 6883 28534 20546 19846 1197 38789 5201 22645 20940 1348 18797 21470 35639 26402 29508 20086 8136 1113 31624 1929 2348 2147 21190 45386 33224

87 45 102 7 3 18 25 1 26 19 40 18 48 29 62 29 4 14 11 4 13 0 57 12 5 11 9 3 5 16 26 13 35 19 23 52 21 6 16 23 20 5 50 43 19 18 2 79 27 35 5 13 22 1 66 1 16 2 24 186 7 3 57 8 58 30 4 13 1 13 8 2 6 8 6 31 10 62 5 31 23 17 18 23 26 60 4 12 2 18 42 21 275 7 35 40 45 71 17 0 55 34 49 70 36 7 1 42 13 14 23 0 13 7 0 7 20 11 0 4 24 42 195 4 21 2 491 23 13 12 0

2914 13418 7001 36636 13641 2790 15660 7927 3068 4555 19890 3223 3482 1761 17565 1080 28212 48285 45770 46542 30390 17930 3221 9746 42883 27561 3347 60334 44809 28961 7710 1256 11829 4860 2800 3221 8958 13880 1738 37848 28204 18119 2624 14881 4472 35681 18577 3096 1659 38886 50666 42056 10003 40652 44775 1949 2674 9474 9960 12103 45476 13795 903 38978 2313 2330 1893 5538 1893 9012 14721 915 1863 12405 4230 996 3466 32514 5896 15726 16916 13464 3798 6784 12106 11906 36238 2963 15434 7911 2650 55145 9747 18269 13793 16309 1300 6228 5344 4013 23461 4748 20625 1043 13446 703 2915 13924 13645 11400 1045 45744 1823 16262 9201 792 10736 13834 55791 3698 57987 8586 6959 901 17495 1708 2032 1096 11790 47639 53820

40 41 43 3 296 8 434 20 28 18 72 8 1 6 39 32 33 31 30 27 149 8 18 16 30 131 23 1 3 25 23 56 13 2 33 46 7 6 61 1 52 2 37 35 13 4 1 27 16 2 7 4 24 0 26 7 6 2 17 59 31 20 54 0 8 16 27 43 15 1 54 8 16 61 6 1 15 6 36 12 13 37 7 14 29 96 6 1 2 2 74 3 21 2 18 20 78 57 5 58 79 34 2 47 13 77 30 20 35 22 95 25 34 13 13 16 23 5 2 18 1 13 151 75 22 19 11 5 28 2 7

8313 10163 8232 40090 5487 3710 14344 4249 2427 11059 22598 3081 3039 1414 19427 766 37167 44972 46527 43353 28348 17498 2425 6662 46059 36566 2675 13676 45241 33849 20667 855 7654 4623 3636 6597 5506 11505 1848 41131 20227 31524 2132 19220 10601 37664 17139 2260 1197 38504 38212 42338 10897 40589 40639 2544 2772 7653 9009 26716 40227 25803 686 43290 3450 1041 1289 3715 2338 7075 10162 804 1342 10013 5772 848 2063 13454 16216 16576 14753 33645 6733 2668 20412 22872 44365 2442 20530 6339 7840 34215 6911 38865 17142 6861 1246 15790 12230 3948 29431 25036 23688 187 29511 646 10474 10967 16430 16626 744 37536 4083 15928 8139 1165 14025 21124 48677 18683 15332 8973 5282 1203 18167 1507 1584 3567 10829 40291 40161

156 6 2 5 8 186 68 20 59 19 149 1 21 20 87 40 8 7 4 4 49 3 16 4 1 2 3 1 2 1 75 0 5 22 66 40 20 16 20 7 30 5 37 13 54 1 3 65 18 5 2 10 4 1 4 32 38 6 23 28 2 3 22 2 46 0 17 7 11 46 1 78 56 52 18 33 4 31 3 5 18 8 73 6 8 25 5 11 6 13 39 4 26 6 25 25 73 22 70 11 3 55 57 13 21 41 88 144 45 15 23 20 644 32 9 43 56 31 0 29 6 27 17 221 4 80 250 29 20 1 0

3366 10271 8146 29226 5749 2512 16135 11849 4022 6117 12398 5496 5817 2256 18137 1303 32971 40092 39579 37745 21008 18678 2955 11211 32510 29043 9719 12692 38011 24808 10916 2417 12928 6422 3121 6282 6251 9441 2166 36603 21127 31087 2412 18078 2702 31093 26882 5776 1439 36562 44461 39839 13925 36197 36828 2657 3130 9305 14105 22255 28878 20912 1442 32857 2948 1444 1526 4431 2188 17046 17903 1061 2103 20791 4390 1364 5264 22712 4626 15797 17376 19471 3422 10564 8091 15364 39390 2939 19297 9781 3802 37836 14866 34548 6692 13861 1541 5465 8201 9999 7731 10462 25739 1286 19920 1202 3194 16526 14387 14323 901 32885 1739 20629 12706 1446 15158 17586 39573 3078 18568 7901 4964 2123 23181 2774 2277 1366 10050 33434 36180

24 18 13 1 69 42 307 21 71 44 24 33 31 0 17 83 5 19 4 4 33 12 41 4 12 20 169 29 9 2 8 270 20 83 31 10 36 0 18 7 1 7 20 26 7 5 11 220 4 2 1 4 11 2 0 32 22 4 6 7 4 16 3 2 51 47 25 38 21 110 22 7 36 40 56 52 12 5 39 1 2 2 8 48 3 7 5 14 7 20 207 1 13 24 10 15 17 139 14 18 1 71 13 21 9 39 31 18 21 0 6 26 66 5 11 21 20 1 2 136 9 138 42 66 16 5 40 15 44 3 1

6591 10039 11917 36744 1823 2227 20898 8887 4306 2320 5529 7265 7099 2238 6548 2957 36073 41910 50464 31637 10135 27457 3240 12247 29645 32006 3975 17963 47339 22744 22893 1444 9852 5374 2874 6329 7510 11083 3003 46454 32182 48069 3105 31321 16220 30739 35098 8439 3416 39459 40904 48529 15503 46942 36012 1294 3403 10108 19870 7658 43414 26897 1091 45753 1347 2874 2170 7700 3077 8925 7976 1519 1705 25540 4452 1284 3366 18333 22074 24412 45604 18633 4809 7932 6032 21140 49520 2963 33389 2168 8211 17949 16867 48492 15724 7359 1836 10775 7432 6944 6904 12766 44794 1284 16205 1767 6506 24090 21166 18914 1698 46950 1582 13132 12402 2068 15790 16159 46851 18858 11174 14253 5430 4241 28064 1960 1805 963 15919 42657 41023

24 214 55 13 1 140 53 4 59 16 284 87 77 27 79 83 8 7 1 52 151 14 19 16 54 18 30 52 7 74 18 31 7 119 68 59 34 0 36 4 0 1 18 5 28 4 4 120 66 4 40 3 1 3 17 37 17 9 11 5 52 17 20 10 94 418 23 19 13 80 77 42 34 6 79 46 10 19 8 55 19 6 82 1 8 17 3 13 1 26 37 19 134 2 20 6 31 41 100 29 15 13 0 15 12 22 50 17 19 10 33 2 5 41 7 4 3 4 0 6 41 1 105 224 15 1 22 41 95 22 31

1915 8417 4728 37257 4133 1115 6201 5547 2359 2748 18618 2646 3000 1314 9501 693 39322 47527 52351 48414 13215 14982 2931 7354 48057 24004 2031 12582 48952 27902 7205 1205 14358 3506 1559 2363 6012 8213 1127 50774 27628 50732 1693 26183 2304 32967 32320 12502 926 50506 54199 51352 10554 50601 48419 1787 1483 6968 9339 29645 34393 24805 883 45716 1182 1049 1636 2147 1364 7203 11197 1378 1022 16071 2055 771 1933 15695 2615 18079 17258 27861 2455 6355 6774 31281 48148 2107 18039 5984 2614 17495 10533 51167 7947 10608 2046 7152 3468 3563 13116 25658 43663 788 12345 552 1695 10794 21173 8593 1009 43932 1122 10555 9192 1070 7442 11566 50621 2283 14228 6717 5049 573 19116 1971 2515 1396 5080 48201 49757

15 19 41 17 38 88 37 1 19 9 35 24 22 27 22 33 1 1 2 6 4 1 24 20 3 95 62 8 1 6 24 35 13 17 56 23 22 7 48 4 7 5 46 26 30 11 30 75 6 2 2 2 27 2 4 1 59 4 8 11 3 13 7 5 24 26 2 47 26 49 0 59 22 200 48 4 4 0 1 5 1 1 3 50 54 6 2 3 2 204 0 12 58 6 55 51 8 354 125 5 19 69 16 29 0 318 7 4 92 3 50 28 10 17 0 79 39 18 6 23 19 264 85 39 40 37 1060 31 49 7 11

3078 11329 15686 39268 3673 1684 20857 5311 3422 7660 7784 6892 3554 1852 13525 870 40023 39092 50303 45935 16701 25760 6043 8240 44516 32745 3476 16815 46325 30848 15587 1073 11450 7508 1911 3474 8281 14559 3458 60142 40552 46425 6135 41042 14728 30637 41330 5725 4110 56955 54113 47245 12267 54388 53010 6331 2583 9289 25888 21025 49807 29694 812 48010 3941 3900 2551 5356 13204 15554 10639 231 5823 19496 15843 934 2694 21665 33587 49283 32631 10806 3993 8145 8739 6477 46836 3475 42112 25073 13114 15248 3343 57440 16962 13733 1069 9176 4752 3000 6464 8389 47148 1965 13531 1235 5183 23884 9533 17451 1181 34986 1227 11009 13187 872 14933 21583 41168 21595 10573 18803 6305 1248 28032 2393 1488 622 7643 43446 36806

25 25 4 3 2 1 6 13 61 53 1 25 20 13 25 17 3 24 2 3 6 50 51 4 10 29 14 24 11 6 3 34 23 26 55 1 8 38 82 5 0 1 386 25 8 37 2 7 219 2 10 15 41 23 7 65 6 1 138 9 3 37 23 31 62 88 1 37 204 116 36 201 124 46 279 225 1 45 20 20 10 34 14 175 2 43 3 6 13 54 7 18 2609 15 69 49 4 36 269 17 21 6 14 223 42 24 225 71 81 31 33 1 269 14 12 33 9 12 34 24 33 41 39 51 26 110 10 365 146 5 78

200 116 296 0 47 142 251 9 69 115 -53 258 132 30 47 -9 -14 -24 -3 6 7 32 51 -1 -6 2 129 91 -3 -5 125 75 61 19 197 60 5 21 86 -25 25 3 120 80 181 147 26 -47 25 -24 4 -16 94 -13 -28 84 5 26 49 15 4 70 27 -8 30 19 37 33 64 58 72 7 48 -52 219 -45 38 9 603 77 322 -40 48 28 166 -61 -7 29 82 111 117 -66 -1 -3 154 128 259 195 21 30 -26 -51 -16 98 1 27 149 34 -4 41 74 -6 319 79 61 1 64 97 -23 392 75 88 -28 26 58 138 53 53 49 14 -14

22 73 56 10 160 35 139 2 6 -24 64 24 64 27 18 -29 -17 33 1 13 68 -9 -29 -25 5 -8 27 343 2 5 -2 28 27 -30 100 13 -14 73 52 -16 -4 -61 53 63 81 212 -37 -47 0 -9 25 -8 61 0 3 -2 8 -1 -3 -28 21 22 14 10 37 34 5 17 3 22 10 -23 19 -55 73 -61 61 81 74 -22 79 -44 24 19 56 -52 -17 -19 -17 23 -10 116 12 -60 67 65 40 27 -32 -49 170 -75 -49 -34 -30 -29 6 -35 -36 -19 52 10 47 28 -29 -41 -6 27 20 -31 244 -20 -38 2 -13 111 33 -22 -17 20 39

249 31 84 20 5 80 119 -45 -16 84 86 19 43 2 31 -49 10 24 3 5 57 -11 -46 -49 13 22 2 0 3 23 164 -13 -18 -34 159 131 -47 43 62 -9 -31 -32 24 111 329 229 -42 -61 -28 -10 -6 -7 75 0 -7 28 12 -20 -13 60 7 128 -14 22 104 -40 -28 -21 27 -4 -24 -32 -14 -64 136 -67 -4 -25 377 -18 56 39 120 -53 163 -8 2 -33 10 -1 167 34 -20 -14 108 -31 35 221 55 -50 238 33 -41 -88 53 -35 280 -48 -23 18 8 -9 229 26 -37 -13 23 94 5 248 -9 -16 -53 37 -9 86 3 154 -24 2 4

96 -2 46 26 -68 -11 30 -25 7 -62 -55 32 22 -1 -64 127 9 5 28 -16 -52 47 10 9 -9 10 -59 42 25 -8 110 -40 -24 -16 -8 1 20 17 39 27 52 55 29 73 500 -1 31 46 137 8 -8 22 11 30 -2 -51 9 9 41 -66 50 29 -24 39 -54 99 42 74 41 -48 -55 43 -19 23 1 -6 -36 -19 377 55 162 -4 41 -25 -25 38 26 1 73 -78 116 -53 13 40 135 -47 19 97 -9 -31 -11 22 74 0 -19 47 104 46 47 32 88 43 -9 -36 -2 43 4 -8 18 513 -40 80 9 100 21 -29 -21 -29 58 28 13

-43 -18 -42 27 -28 -56 -62 -53 -41 -55 50 -52 -48 -42 -48 -47 19 19 32 28 -37 -20 -1 -34 48 -17 -79 -1 29 12 -34 -50 11 -45 -50 -62 -4 -13 -48 39 31 63 -30 45 -15 6 20 116 -36 38 22 29 -24 40 31 -33 -53 -25 -34 33 19 19 -39 39 -60 -27 7 -52 -38 -58 -37 30 -51 -23 -53 -43 -63 -31 -43 14 -1 43 -28 -40 -16 104 22 -28 -7 -39 -31 -54 -29 48 19 -23 33 31 -58 -64 70 145 70 -39 -38 -54 -47 -35 47 -40 12 34 -35 -49 -28 -26 -51 -34 28 -26 -23 -15 2 -73 -18 -29 10 2 -49 44 38

-9 10 93 34 -36 -33 29 -55 -15 25 -37 25 -39 -18 -25 -33 21 -2 27 22 -21 38 104 -26 37 13 -64 32 22 24 43 -56 -11 17 -39 -45 32 54 60 64 92 49 154 127 445 -1 54 -1 185 56 22 19 -12 50 44 138 -17 0 84 -6 72 42 -44 46 34 170 67 21 503 -9 -41 -78 177 -6 261 -32 -49 -5 626 212 88 -45 17 -23 8 -58 19 18 118 156 245 -60 -78 66 153 -1 -31 68 -42 -70 -16 -20 83 53 -32 3 62 45 -34 22 31 6 -29 -47 4 -40 -1 23 4 602 -43 138 27 -41 21 -14 -35 -54 -24 30 2

P53041 O00743 O00743 Q96B36 Q16512 Q16512 Q16513 Q16513 Q9Y478 Q96J92 P06401 Q13523 P78352 NA P60484 P60484 P60484 P18031 P29350 Q06124 Q06124 Q16825 Q15119 Q14289 Q14289 Q14289 P20339 P20339 P60953 P60953 O75943 P04049 P04049 P04049 P04049 P10398 P10398 P15056 P15056 P06400 P06400 P06400 P06400 P06400 P06400 P06400 P06400 P06400 P06400 O43353 Q13546 O75116 O75116 Q13464 Q04912 Q01974 P08922 Q15418 Q15418 Q15418 Q15418 Q15418 Q15418 Q15418 Q15418 Q15418 P51812 Q9UK32 P34925 P62753 P23443 P23443 P23443 P23443 P23443 P23443 Q9UBS0 Q13033 Q96BR1 P29353 P29353 Q06124 Q9H2G2 Q9NR28 Q15797 Q15796 Q15796 Q14683 O14508 Q8WXH5 Q6ND84 P04179 O95429 P48436 Q9NYA1 Q9NRA0 P12931 P12931 P12931 P12931 P12931 P12931 P42224 P42224 P42224 P42224 P42224 P52630 P52630 P40763 P40763 P40763 P40763 Q14765 P42229 P42229 P51692 P42226 P31948 Q8NEF5 O43815 P43405 P17600 P17600 O43318 O43318 O43318 O43318 O43318 P10636 P10636

772 773 774 775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 790 791 792 793 794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812

PN090 PN090-2 PN091 PN092 PN106 PN107 PN122 NK220-1 NK220-2 NK176 NK177 NP034 NN110 NN111 NK178 NK179 NK180 NK181 NK181-2 NK183-1 NK183-2 PN093 PN109 NN154 PK110 PK133 NP030 PN094 NK184 NK185 NP037 NK186 NK186-2 NK214 NK187 NK187-2 PK112 PK113 PK109 NK188-1 NK188-2

Tau Tau Tau Tau Tau Tau Tau TBK1 TBK1 TEK (TIE2) Tlk1 TPIPb TRADD Trail TrkA TrkB TTK Tyk2 Tyk2 Tyro10 (DDR2) Tyro10 (DDR2) Tyrosine Hydroxylase Tyrosine Hydroxylase Ubiquitin VEGFR2 (KDR) VEGFR2 (KDR) VHR Vimentin Vrk1 Wee1 WIP1 Yes Yes YSK1 ZAP70 ZAP70 ZAP70 ZAP70 ZAP70/Syk ZIPK ZIPK

S712 S712 S716 S720 S518 S738 T547 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific S71 S19 Pan-specific Y1054 Y1214 Pan-specific S33 Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Pan-specific Y292 Y315+Y319 Y319/Y352 Pan-specific Pan-specific

Microtubule-associated protein tau Microtubule-associated protein tau Microtubule-associated protein tau Microtubule-associated protein tau Microtubule-associated protein tau Microtubule-associated protein tau Microtubule-associated protein tau Serine/threonine-protein kinase TBK1 Serine/threonine-protein kinase TBK1 Angiopoietin-1 receptor-tyrosine kinase Tousled-like protein-serine kinase 1 Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 Tumor necrosis factor receptor type 1 associated DEATH domain protein Tumor necrosis factor-related apoptosis-inducing ligand Nerve growth factor (NGF) receptor-tyrosine kinase BNDF/NT3/4/5 receptor- tyrosine kinase Dual specificity protein kinase Protein-tyrosine kinase 2 (Jak-related) Protein-tyrosine kinase 2 (Jak-related) Neurotrophic receptor-tyrosine kinase of discoidin domain receptor family, member 2 precursor Neurotrophic receptor-tyrosine kinase of discoidin domain receptor family, member 2 precursor Tyrosine hydroxylase isoform a Tyrosine hydroxylase isoform a Ubiquitin Vascular endothelial growth factor receptor-tyrosine kinase 2 (Flk1) Vascular endothelial growth factor receptor-tyrosine kinase 2 (Flk1) Dual specificity protein phosphatase 3 Vimentin Vaccinia related protein-serine kinase 1 Wee1 protein-tyrosine kinase Protein phosphatase 1D Yamaguchi sarcoma proto-oncogene-encoded tyrosine kinase Yamaguchi sarcoma proto-oncogene-encoded tyrosine kinase Serine/threonine-protein kinase 25 Zeta-chain (TCR) associated protein-tyrosine kinase, 70 kDa Zeta-chain (TCR) associated protein-tyrosine kinase, 70 kDa Zeta-chain (TCR) associated protein-tyrosine kinase, 70 kDa Zeta-chain (TCR) associated protein-tyrosine kinase, 70 kDa Zeta-chain (TCR) associated protein-tyrosine kinase, 70 kDa/Spleen protein-tyrosine kinase ZIP kinase (death associated protein-serine kinase 3 (DAPK3)) ZIP kinase (death associated protein-serine kinase 3 (DAPK3))

22689 17087 15869 41918 2896 41324 1954 3697 8402 6174 4712 1779 44026 14914 3778 16131 10059 7930 7447 5343 6864 974 2820 9007 23525 1113 44548 3526 6355 4360 9653 17386 39509 15142 45469 7061 31653 38040 1111 22724 23082

34 81 70 3 63 12 1 6 11 148 23 52 14 23 48 15 13 86 15 43 152 101 76 7 9 42 7 34 27 27 11 194 1 50 4 26 11 8 23 51 5

8851 21074 11300 38926 2762 23857 2516 14617 13665 4880 5265 3279 42364 17944 2328 14013 12767 16377 9027 4947 6932 1984 3834 20711 48070 1825 43131 8616 17450 3794 6950 21364 40225 11388 40319 11615 30497 36552 1129 17219 26931

66 24 7 21 5 82 3 119 46 67 51 43 5 9 9 36 24 15 4 18 21 21 54 29 6 53 5 12 9 51 28 24 1 42 8 61 13 2 37 11 42

32915 22134 6670 46528 1373 42803 2128 3668 8479 2599 4019 2729 50608 13087 4776 15674 9677 7314 3199 3340 10955 1380 4999 9113 14475 1458 54477 4732 4031 4877 8451 12806 48491 15029 46507 6765 27141 44037 1403 19449 19653

17 29 27 0 8 13 31 15 44 63 16 28 9 6 67 19 40 33 50 7 39 11 113 7 4 41 2 18 117 28 2 30 2 91 12 11 32 13 20 2 22

31448 28459 26038 41508 1971 40573 10122 5246 6595 4086 3812 2418 40152 11488 2052 16654 6068 4713 5183 2555 5788 860 1962 15272 11732 1168 30596 5906 14239 3140 8007 13636 37355 7582 39962 4598 20841 36628 795 10016 17613

13 24 26 9 34 9 569 45 5 59 92 279 15 14 26 13 74 25 47 1 189 19 70 65 1 85 32 62 45 68 47 152 39 12 21 20 51 19 78 7 29

16726 21233 14538 31771 2009 33115 4504 7688 9887 8716 3650 2835 35601 11776 6249 11835 11974 10056 7825 7655 5112 1026 3399 7506 15922 4414 38827 6145 9421 4521 12208 12988 35085 15166 35940 9411 26036 30868 945 19356 24975

45 15 41 16 24 8 20 44 32 49 35 18 1 5 31 5 28 39 8 11 21 22 19 12 8 104 2 7 77 27 5 0 7 58 4 9 10 1 34 3 17

8416 23007 15257 45480 2743 31962 3917 8568 12808 4889 2727 2172 45919 10426 2198 16820 7344 7966 6390 3190 3958 1635 3501 12108 37633 1833 46900 4251 7734 3925 11875 29147 42910 9999 45845 8047 36026 38183 1014 16438 23675

34 30 38 10 17 15 40 91 136 37 11 32 1 33 9 44 24 7 4 18 15 32 8 26 24 39 2 51 14 33 10 16 5 72 0 17 11 2 17 1 10

32153 22979 15205 45676 1135 41400 3276 3246 2821 3106 2960 1630 52917 10930 2431 14251 18018 5827 4217 3091 9373 1464 2623 8062 16223 1212 54556 4628 7789 2066 8656 11315 48402 5012 53987 2666 27094 46748 1119 8084 16873

38 15 4 2 21 7 227 2 16 13 21 56 7 1 96 28 37 30 23 22 10 31 12 16 26 47 1 2 173 29 1 86 1 82 5 14 61 2 61 8 9

25979 7846 6815 51947 2721 33307 2491 7556 8101 4475 2521 2120 47234 14202 1723 21473 7027 7402 5252 2877 7107 2199 3355 10550 43539 1244 47898 8086 7619 3715 9627 15224 43958 5841 50665 2005 31061 35358 1259 15788 25183

25 84 38 7 49 6 28 26 19 31 50 42 8 14 42 16 30 26 7 9 53 42 17 64 18 38 16 56 17 62 30 81 5 23 27 36 3 27 10 47 0

-61 23 -29 -7 -5 -42 29 295 63 -21 12 84 -4 20 -38 -13 27 107 21 -7 1 104 36 130 104 64 -3 144 175 -13 -28 23 2 -25 -11 64 -4 -4 2 -24 17

45 30 -58 11 -53 4 9 -1 1 -58 -15 53 15 -12 26 -3 -4 -8 -57 -37 60 42 77 1 -38 31 22 34 -37 12 -12 -26 23 -1 2 -4 -14 16 26 -14 -15

39 67 64 -1 -32 -2 418 42 -21 -34 -19 36 -9 -23 -46 3 -40 -41 -30 -52 -16 -12 -30 70 -50 5 -31 68 124 -28 -17 -22 -5 -50 -12 -35 -34 -4 -28 -56 -24

-50 8 5 43 37 -3 -13 11 30 -44 -25 -23 29 -11 -65 42 -39 -21 -18 -58 -23 59 3 61 136 -58 21 -31 -18 -13 -3 124 22 -34 28 -14 38 24 7 -15 -5

92 8 5 44 -44 25 -27 -58 -71 -64 -19 -43 49 -7 -61 20 50 -42 -46 -60 83 43 -23 7 2 -73 41 -25 -17 -54 -29 -13 38 -67 50 -72 4 51 18 -58 -32

55 -63 -53 64 35 1 -45 -2 -18 -49 -31 -25 33 21 -72 81 -41 -26 -33 -62 39 114 -1 41 173 -72 23 32 -19 -18 -21 17 25 -61 41 -79 19 15 33 -18 1

P10636 P10636 P10636 P10636 P10636 P10636 P10636 Q9UHD2 Q9UHD2 Q02763 Q9UKI8 Q6XPS3 Q15628 P50591 P04629 Q16620 P33981 P29597 P29597 Q16832 Q16832 P07101 P07101 P62988 P35968 P35968 P51452 P08670 Q99986 P30291 O15297 P07947 P07947 O00506 P43403 P43403 P43403 P43403 P43403 O43293 O43293