Treating paracetamol overdose by charcoal

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D. TABERNER\ M.C. VENNING and P. ACKRILL. From the ..... next morning are shown. patients ..... Lyon IM, Williams R. Histopathological changes in the liver.
Q J Med 1996; 89:297-306

Treating paracetamol overdose by charcoal haemoperfusion and long-hours high-flux dialysis R.M. HIGGINS, DJ.A. GOLDSMITH, A. MacDIARMID-GORDON, D. TABERNER\ M.C. VENNING and P. ACKRILL From the Departments of Renal Medicine and ^ Haematology, Withington Hospital, Manchester, UK Received 22 August 1995 and in revised form 7 November 1995

Summary with serious paracetamol overdose were seen, of whom 51 received charcoal haemoperfusion and/or high-flux dialysis. Patients who were admitted within the first 42 h after overdose and who received haemoperfusion and/or dialysis had significantly lower peak levels of prothrombin time, bilirubin and creatinine than those who were admitted after 42 h. Mortality was also lower amongst patients admitted before 42 h, at 2/18 (11%) vs. 15/33 (45%), p