Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp
Heart Failure
Trend of Clinical Outcome and Surrogate Markers During Titration of β-Blocker in Heart Failure Patients With Reduced Ejection Fraction – Relevance of Achieved Heart Rate and β-Blocker Dose – Naoko Kato, PhD; Koichiro Kinugawa, MD, PhD; Teruhiko Imamura, MD; Hironori Muraoka, MD; Shun Minatsuki, MD; Toshiro Inaba, MD; Hisataka Maki, MD; Taro Shiga, MD, PhD; Masaru Hatano, MD; Atsushi Yao, MD, PhD; Issei Komuro, MD, PhD; Ryozo Nagai, MD, PhD
Background: The aim of this study was to examine trends of clinical outcome and to clarify surrogate markers when titrating β-blocker in heart failure patients with reduced left ventricular ejection fraction (HFrEF, LVEF
