Trends In Non-polio Acute Flaccid Paralysis ... - Dr. Jacob Puliyel

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Jan 17, 2014 - Puliyel J, Vashisht N, Sreenivas V.Trends In Non-polio Acute Flaccid Paralysis ..... 5. http://www.npspindia.org/bulletin.pdf accessed on. 19/3/11.
Article ID: WMCPLS0035

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Trends In Non-polio Acute Flaccid Paralysis Incidence In India Corresponding Author: Dr. V. Sreenivas, Associate Professor, Department of Biostatistics, All India Institute of Medical Sciences, New Delhi , Department of Bio-statistics, All India Institute of Medical Sciences, New Delhi 110029, 110029 - India Submitting Author: Dr. Jacob Puliyel, Head of Pediatrics, Department of Pediatrics, St Stephens Hospital, St Stephens Hospital, Tis Hazari, Delhi 110054, 110054 - India

Submitted on:17-Jan-2014, 08:58:35 AM GMT Accepted on:21-Jan-2014, 02:42:46 AM GMT Article ID: WMCPLS0035 Article Type: Research articles Article URL: http://webmedcentralplus.com/article_view/35 Subject Categories:PAEDIATRICS Keywords:Acute flaccid paralysis, surveillance, vaccination, polio How to cite the article: Puliyel J, Vashisht N, Sreenivas V.Trends In Non-polio Acute Flaccid Paralysis Incidence In India. WebmedCentral plus PAEDIATRICS 1970;-39(1):WMCPLS0035 Source(s) of Funding: JP conceived the study and planned it with NV and VS. NV collected the data, VS did the statistical analysis with NV, NV wrote the first draft of the paper that was revised by JP and VS. The final draft is approved by all the authors. VS and JP are guarantors. Competing Interests: None

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Trends In Non-polio Acute Flaccid Paralysis Incidence In India Author(s): Puliyel J, Vashisht N, Sreenivas V

Abstract Background: Although the incidence of polio acute flaccid paralysis (AFP) is coming down in India, the non-polio AFP (NPAFP) rate has increased. Nationwide, the NPAFP rate is 13.7/100,000 where the expected rate is 1-2/100,000. We examined the correlates of NPAFP, to discern explanations for the increase. Methods: National Polio Surveillance data 2000-2012 was used. Differences between states and changes over time were examined. Demographic factors and polio programme parameters were assessed. Multiple linear regression analysis adjusting for region/state, literacy rate, female literacy rate, population density and per-capita GDP was performed. Results: NPAFP increased with the OPV doses used. (R2=32.1%;P2=62.5). Per capita income of the state, female literacy and overall literacy showed negative correlation with NPAFP. This disappeared in a multivariable analysis when the number of doses of OPV was considered. On multiple regression analysis, the number of OPV doses was the only factor that showed a positive correlation with the NPAFP rate. NPAFP in UP and Bihar decreased in 2012 coinciding with a reduction in OPV administered. Conclusion: Our observation showed positive association between NPAFP and the number of OPV doses. In 1994 the National Academy of Sciences, Washington noted a causal relation between Guillain-Barre syndrome and OPV. We hope our findings will stimulate further work to bring down the NPAFP incidence and if needed, to rationalize and optimize the dose schedule of the OPV. Key words: Acute flaccid paralysis, surveillance, vaccination, polio

Introduction Acute Flaccid Paralysis (AFP) surveillance helps identify poliovirus circulation promptly and also provides certification quality evidence that wild polio transmission is not occurring. To qualify as AFP for polio surveillance, there must be acute onset of focal

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weakness or paralysis with reduced tone in the absence of other obvious cause (like trauma) in children under 15 years (1). The full list of causes of non-polio AFP were reviewed and listed by Marx and colleagues (2). Transient weakness (postictal paralysis for example) is not included (3). In the absence of wild polio transmission, the WHO estimates that there is a background annual incidence of at least 1 case of AFP per 100,000 children under 15 because of diseases like Guillain–Barré syndrome (GBS). In other words, once polio is eradicated, it is expected that the AFP rate (made up of polio and non-polio AFP) would come down to 1 to 2 per 100,000 as there would only be non polio AFP left (4). The surveillance performance of India has been excellent, and the incidence of polio AFP is coming down in the country (5). As a consequence the total AFP rate (which includes polio and non-polio causes of AFP) must come down with the non-polio AFP rate remaining steady. Inexplicably however, the non-polio AFP rate has shown a trend to increase. Nationally, the non-polio AFP rate is 13.7 per 100,000 (2012 data) where the acceptable rate is 1 to 2 per 100,000 (6). In the state of Uttar Pradesh (UP) the non-polio AFP rate is 24.6 per 100,000 and in Bihar this is 37 per 100,000 (2012 data) (5). It has been said that the increase in AFP in recent years is the result of a deliberate effort (that began in 2004) to intensify surveillance and reporting in India (7). However, a surveillance program no matter how good, can only record every case of AFP, but it cannot exaggerate the numbers or explain the 20 to 40 fold increase in the non-polio AFP rate, as seen in the state of Bihar (assuming that the natural non-polio AFP rate should lie between 1 to 2 per 100,000 as per internationally accepted norms) (6). The lowest non-polio AFP rates are seen in the states were polio was eliminated earliest. These are the states which must have had the best implementation of the polio control programme and the best surveillance. If good surveillance was the reason for the increase in non-polio AFP, it is paradoxical that the well-performing states should have the lowest non-polio AFP rates. Follow-up of these cases of non-polio AFP is not done routinely. However a fifth of these cases of non-polio AFP in the state of Uttar Pradesh were followed-up after 60 days, in 2005. 35.2% were found to have

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residual paralysis and 8.5% had died (total residual paralysis or death 43.7%). (8) This suggests that the pathology in children being registered as non-polio AFP cannot be considered as trivial. There is thus impelling reason to try and understand the underlying causes for the surge in non-polio paralysis numbers. The AFP rates are different in the various states and Union Territories of India. In this study we examined the factors that correlate with the non polio AFP rates in the states, to discern possible explanations for the increasing incidence of non-polio AFP. Data on AFP rate from the National Polio Surveillance Programme (NPSP) in India over the period 2000–2012 was used. Differences between states and changes over time with respect to non-polio AFP were examined. Association with demographic factors and polio programme parameters were assessed. States reporting more wild polio cases are targeted for increased vaccine coverage. For example it was reported that during the year 2005, children under 5 years in UPand Bihar received on average 15 doses of trivalent oral polio vaccine (tOPV), compared with 10 doses in the rest of India (9). Confounding is a possibility. On cursory examination of the NPSP data it appears that the states with the highest polio rates are also the ones with higher non-polio AFP rates. It is conceivable that the factors that result in higher polio incidence in these states, also promote non-polio AFP. Grassly and colleagues suggest that high population densities and poor sanitation explain the persistence of polio (9). We aimed to see whether various factors like population density, literacy and poverty could explain the non-polio AFP rate.

Matherials and methods The data on AFP, polio and non-polio AFP and number of polio rounds were examined in each state in each year from 2000 to 2012. Data from the National Polio Surveillance web site (5) was used. The raw data, as extracted from the web site, has been uploaded as supplementary file (and also available at http://bit.ly/npsi_data). Data on numbers of polio rounds during the years 2003 and 2012 was incomplete and so figures for these years were not included in the general analysis. However data from 2012 on polio rounds for some states were available and they were used in analysis specific for those states. When different areas within a state received different numbers of doses, the arithmetic mean of doses was taken as the representative dose for that state. Normal linear regression analysis was carried out, taking the non-polio AFP rate as the outcome

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variable and the number of OPV doses as the explanatory variable. Both these were treated as continuous variables. Multiple linear regression analysis was carried out to adjust for region/state, literacy rate, female literacy rate and per capita GDP. Pearson’s correlation coefficient of non-polio AFP rate with the per capita income (10) and population density (11) of each state and union territory were looked into. According to Rosser and colleagues, sanitation is closely linked to female literacy in a range of Asian countries. (12) We could not find authentic data on sanitation in the different states and hence we used female literacy as a surrogate for social development and also of the general level of sanitation and hygiene in each state. Data on female literacy and overall literacy was obtained from the Census of India (13). We also included overall literacy because some communities tend not send their girl children to school and we expected overall literacy may have a positive effect on the evolving social developments of the area, which may not be reflected entirely and accurately by female literacy in that area. We explored whether any correlation exists between the non-polio AFP rates and the number of doses of polio vaccine used in the state in that year. Further, we tried to look for cumulative effect by adding data on vaccine doses from previous years.

Results The non-polio AFP rate per 100,000 increased with increased number of OPV doses during 2000-2011, irrespective of time and region. Figure 1 shows the trend of non-polio AFP with doses of OPV. As can be seen, the relationship is curvilinear with a more steep increase in non-polio AFP beyond 6 doses of OPV. To demonstrate this association, the Pearson correlation was calculated. This association is statistically highly significant (R2= 32.1%; P)

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Figure 1: Trends in Non Polio AFP rate with number of OPV doses Looking at data up to 2012 from Uttar Pradesh and Bihar, where the maximum doses of OPV were used, the R2 was 51.9% (P < 0.001). Regression analysis indicated that for an increase of one dose of OPV, the non-polio AFP rate increased on the average by 3.7 per 100,000 populations under 15 (95% CI: 2.1-5.3). The relation is shown in Figure 2. To examine the trends over time we looked at the relationship of the non-polio AFP rate each year to the number of doses of OPV received in that year separately for UP and Bihar. Figure 3 shows the non-polio AFP over the years in the states of UP and Bihar alongside the 4 year cumulative OPV doses. The fall in NPAFP rate for the first time in 2012 with a decrease in the OPV doses is noted.

previous 4 years. Association (R2) of non-polio AFP rate with OPV doses received in 2011 was 52.6%. It increased to 56.9.6%, when we looked at AFP rate in 2011 related to total doses received in the years 2010 and 2011. Adding up dosesreceived in 2009 to that in 2010 and 2011 further increased the association (R2 = 54.4%) and adding up doses received between 2009 and 2011 the regression coefficient rose to 62.5. All these correlations were highly significant (P < 0.001). The association showed no further improvement with addition in OPV doses from earlier years. Per capita income of the state, female literacy and overall literacy showed negative correlation with the non-polio AFP (R2 = 4.1%, P < 0.001; R2 = 13.0%, P < 0.001; and R 2 =12, P < 0.001 respectively). Population density did not show any association with the non-polio AFP (R2 = 0.0%, P = 0.91). A multivariable model to adjust simultaneously the influence of factors like overall literacy, female literacy and per capita GDP, confirmed the significant positive association between the number of OPV doses and non-polio AFP rate. Per capita income, female literacy and overall literacy did not show significant association with non-polio AFP rate once we considered the number of doses of OPV. After adjusting for these factors, the average increase in the non-polio AFP rate was 1.30 per 100,000 (P < 0.001, 95% CI: 1.09-1.51) with each dose of OPV. The results of this multiple regression analysis are presented in Table 1.

Figure 2: Trends in Non Polio AFP rate with number of OPV doses in UP and Bihar

Table 1: Multivariate Regression Analysis

Discussion Figure 3: Yearly trend in non-polio AFP rate with 4 year cumulative polio doses in Bihar and UP The figures on the Y axis represent number of doses of polio and the non-polio AFP rate /100,000 children. When the effect of cumulative doses over the previous years was examined, the non-polio AFP rate in 2011 best correlated to the cumulative doses received in the

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Our results indicate that the incidence of non-polio AFP was strongly associated with the number of OPV doses delivered to the area. We also observed a dose response relation with cumulative doses over the years, which further strengthen the hypothetical relationship between polio vaccine and non-polio AFP. The cumulative dose received in the previous 4 years related best to the non-polio AFP rate in 2011.

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Children over 5 are not vaccinated and the vaccine naïve newborns are added to the pool each year and this is perhaps the reason cumulative doses beyond 4 years did not improve the strength of association. The fall in the NPAFP rate in Bihar and UP for the first time in 2012, with a decrease in the number of OPV doses delivered, is further corroborative evidence of a causative association between OPV doses and the NPAFP rate A regression analysis reveals an association but does not prove a causal role. Ecological fallacies must be borne in mind meaning that correlation of aggregate variables take into account cross sectional effects which are not relevant at the individual level. The likelihood of confounding also needs to be kept in mind. Poor sanitation can cause spread of entero-pathogens (like Campylobacter jejuni) which cause non polio flaccid paralysis. The same sanitation problem can result in increased polio in that area and this will trigger more frequent polio immunization rounds in the locality. Thus, a spurious relationship between OPV doses and non-polio flaccid paralysis may be inferred when poor sanitation is the real culprit - the confounding variable – causing the non-polio AFP. Data from the WHO / UNICEF Joint Monitoring Programme (JMP) for Water Supply and Sanitation, suggests that states of Delhi and Kerala, with a female literacy rate of 75% and 88% respectively have achieved millennium development goals (MDGs) on sanitation already, while Assam with 64% female literacy and Arunachal with 55% female literacy will achieve it in 10 years, and Madhya Pradesh and Orissa with 50% and 51% female literacy respectively, will achieve the MDG only in the next century. (14) This further supports the observation that sanitation is linked to female literacy in many Asian countries. (12) In the absence of hard data on the number of households with toilets for safe disposal of excreta and free running water, we tried to remove the confounding effect of poor sanitation, by using female literacy as a surrogate for social development in the state and its level of sanitation and hygiene. We did not find an association of non-polio AFP rates with female literacy in the multivariable analysis. Admittedly although female literacy is often used as a surrogate for social development, it need not be an adequate surrogate for sanitation in an area. However poor sanitation by itself cannot explain why the incidence of non-polio AFP should increase year to year in the same area, in proportion to doses of polio vaccine administered here, unless sanitation in the area is deteriorating each year, coinciding with increased vaccine doses administered.

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Another possible explanation for the apparent association could be increased surveillance of AFP in areas where the polio related AFP is high, and this may be detecting more cases of NPAFP. Though the surveillance has improved over time, there is no evidence to suggest that there are differences in the quality of surveillance between states in the same year. The difference in non-polio AFP rate between states in any particular year cannot therefore be explained on the basis of improved surveillance alone. In fact it is the states with the best health indicators and therefore presumably the best surveillance, (for example Goa and Kerala) that have some of the lowest non-polio AFP rates. The case definition of AFP has also changed over the years but the definition at any point of time has been uniform all over the country and so this cannot explain the differences in the rates of non polio AFP seen in different states in the same year. Our findings point to the need for a critical appraisal to find the factors contributing to the increase in non-polio AFP with increase in OPV doses – perhaps looking at the influence of strain shifts of enteropathogens induced by the vaccine given repatedly. The clear dose response relationship indicates that this relationship in not a spurious one. In 1994 the Institute of Medicine of the National Academy of Sciences, Washington had noted that the evidence available to them favors acceptance of a causal relation between Guillain-Barre syndrome (a major component of the non polio AFP rate) and OPV. (15) All these factors need to be examined. Further studies perhaps including a rapid epidemiological appraisal exploring the hypothesis of association between number of doses of OPV and NPAFP by case control studies, individual children with NPAFP being the cases and matched healthy children as the controls are called for.

Conclusion Our observation showed positive association between the non-polio AFP rate and the number of OPV doses. Though there is a possibility that the apparent association between the increasing trend of non-polio AFP and OPV doses could be a statistical artifact due to confounding factors, the magnitude of non-polio AFP incidence and its increasing trend are public health problems in themselves and need to be looked into. We hope our findings will stimulate further work to bring down the non-polio AFP incidence and if needed, may also to rationalize and optimize the dose schedule of the OPV.

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References 1. Ahmad A Rehman A. One year surveillance data of acute flaccid paralysis at Bahwal Victoria Hospital Bahawalpur Pakistan Journal of Medical Sciences 2007;23:308-12. 2. Marx et al., Epidemiologic Reviews, 2000, Vol 22(2): 298-316. 3. Canadian Pediatric Society. Surveillance Canadian Pediatric Surveillance Programme Acute Flaccid Paralysis. http://www.cps.ca/english/Surveillance/CPSP/Studies/ acute.htm 4. Alcala H. The differential diagnosis of poliomyelitis and other flaccid paralysis. Bio Med Infant Mex 1993; 50: 136-144. 5. http://www.npspindia.org/bulletin.pdf accessed on 19/3/11 6. http://www.who.int/wer/2010/wer8525.pdf 7. Grassly NC, Wenger J, Bahl S, Sutter RW, Aylward RB. Protective efficacy of a monovalent oral type 1 poliovirus vaccine. Lancet 2007; 370: 129-130. 8. Puliyel JM, Gupta MA, Mathew JL. Polio Eradication & the future for other programmes: Situation analysis for strategic planning in India. Indian J Med Res 2007; 125: 1-4. 9. Grassly NC, Fraser C, Wenger J, Deshpande JM, Sutter RW, Heymann DL, Aylward RB. New Strategies for the Elimination of Polio from India. Science 2006; 314: 1150 – 1153. 10. Gupta S. States Performance in Per capita Income Growth ASSOCHAM ECO PULSE January 2008 www.assocham.org/arb/aep/states-per-capita-income. doc Accessed on 28/2/2011 11. Census of India. "Area and Population". Government of India (2001). http://www.censusindia.gov.in/Census_And_You/area _and_population.aspx. Quoted in Wikipedia: List of states and union territories of India by population. http://en.wikipedia.org/wiki/List_of_states_and_union_t erritories_of_India_by_population 12. Rosser JB, Rosser MV. Comparative Economics in a Transforming World Economy, 2nd Edition Massachusetts MIT Press ISBN 0-262-18234-3 (2004) Page 476 13. Census of India 2001-- State wise population totals file:///C:/Documents%20and%20Settings/Admin/Deskt op/AFP%20Polio/Literacy.htm 14. WHO / UNICEF Joint Monitoring Programme (JMP) for Water Supply and Sanitation. http://www.wssinfo.org/data-estimates/introduction/

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Accessed on 15/5/12 15. Stratton KR, Howe CJ, Johnston RB. Adverse events associated with childhood vaccines other than pertussis and rubella. Summary of a report from the Institute of Medicine. JAMA. 1994;271:1602-5.

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Illustrations Illustration 1 Supplementary Data

National Polio Surveillance India updated data 2000 - 2012 NPSP Polio surveillance data on Acute Flaccid Paralysis (AFP) and non-polio AFP and Demographic data State

state year

Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andaman & Nicobar Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh

1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2

1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004

poli o

afp rate

afp

npaf p

npafp rate

0 0 0 0 0 0 0 0 0 0 0 0 0

2 1 0 2 0 0 3 5 3 0 3 0 1

1.44 0.73 0 1.46 0 0 2.52 4.1 2.42 0 2.29 0 2.7

2 0 0 2 0 0 2 5 3 0 3 0 1

1.44 0 0 1.46 0 0 1.68 4.1 2.42 0 2.29 0 2.7

0 0 0 19 1

373 342 371 474 468

1.38 1.17 1.27 1.58 1.55

365 332 369 401 462

1.35 1.14 1.27 1.34 1.53

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GDP 1567 1567 1567 1567 1567 1567 1567 1567 1567 1567 1567 1567 1567 1567 236094 236094 236094 236094 236094 236094

Percap gdp (Rs 10,000) 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00439981 0.00309715 0.00309715 0.00309715 0.00309715 0.00309715 0.00309715

Populatio n 356152 356152 356152 356152 356152 356152 356152 356152 356152 356152 356152 356152 356152 356152 76210007 76210007 76210007 76210007 76210007 76210007

Densit y 43 43 43 43 43 43 43 43 43 43 43 43 43 43 277 277 277 277 277 277

Female Literacy literacy 81 81 81 81 81 81 81 81 81 81 81 81 81 81 61 61 61 61 61 61

Number of dose

75 75 75 75 75 75 75 75 75 75 75 75 75 75 51 51 51 51 51 51 Page 7 of 24

4 2 2 2 5 2 2 2 3.5 1.5 2 2 2 4.5 2 2 2 2.33 6

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Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Andhra Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh

2 2 2 2 2 2 2 2 3 3 3 3

2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002

0 0 5 1 0 0 0 0

740 566 777 756 855 857 1110 1309

2.74 2.09 2.84 2.62 3.08 3.04 3.88 5.22

738 507 767 753 851 794 1048 1270

2.73 1.87 2.8 2.61 3.07 2.82 3.66 5.06

0 0 0

8 6 3

1.86 1.34 0.68

6 6 2

1.39 1.34 0.46

Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Arunachal Pradesh Assam Assam Assam Assam Assam Assam

3 3 3 3 3 3 3 3 3 4 4 4 4 4 4

2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004

0 0 0 0 0 0 0 0 0

6 7 12 39 48 24 15 37 36

1.23 1.41 2.42 7.85 9.38 4.55 2.75 6.57 6.47

6 7 7 39 48 24 12 34 35

1.23 1.41 1.41 7.85 9.38 4.55 2.2 6.04 6.29

0 1 0 1 0

156 149 145 145 190

1.46 1.43 1.29 1.36 1.8

151 144 144 125 196

1.42 1.39 1.28 1.17 1.8

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236094 236094 236094 236094 236094 236094 236094 236094 2987 2987 2987 2987

0.00309715 0.00309715 0.00309715 0.00309715 0.00309715 0.003097 0.003097 0.003097 0.00272048 0.00272048 0.00272048 0.00272048

76210007 76210007 76210007 76210007 76210007 76210007 76210007 76210007 1097968 1097968 1097968 1097968

277 277 277 277 277 277 277 277 13 13 13 13

61 61 61 61 61 61 61 61 55 55 55 55

51 51 51 51 51 51 51 51 44 44 44 44

2 2 5.5 4 1.5 2 2 2 4 2 2 2

2987 2987 2987 2987 2987 2987 2987 2987 2987 57543 57543 57543 57543 57543 57543

0.00272048 0.00272048 0.00272048 0.00272048 0.00272048 0.00272048 0.00272 0.00272 0.00272 0.00215876 0.00215876 0.00215876 0.00215876 0.00215876 0.00215876

1097968 1097968 1097968 1097968 1097968 1097968 1097968 1097968 1097968 26655528 26655528 26655528 26655528 26655528 26655528

13 13 13 13 13 13 13 13 13 340 340 340 340 340 340

55 55 55 55 55 55 55 55 55 64 64 64 64 64 64

44 44 44 44 44 44 44 44 44 56 56 56 56 56 56

5 2 2 2 3.5 1.5 2 2 2 6 2 2 2 2 6

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Assam Assam Assam Assam Assam Assam Assam Assam Bihar Bihar Bihar Bihar Bihar Bihar Bihar Bihar

4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5

2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006

0 2 0 1 0 0 0 0

285 360 536 475 542 429 470 586

2.57 3.1 4.5 3.9 4.41 3.45 3.72 4.74

283 315 535 470 539 404 462 580

2.55 2.71 4.49 3.87 4.39 3.25 3.65 4.69

50 27 121 17 39 30 57

3.46 2.14 2.57 2.3 6.15 14.39 18.99

1279 646 659 644 2059 5110 6075

Bihar

5

2007

503

27.18

Bihar

5

2008

233

Bihar

5

2009

117

Bihar

5

2010

9

Bihar

5

2011

0

Bihar Chandigarh Chandigarh Chandigarh

5 6 6 6

2012 1999 2000 2001

0

1444 711 874 800 2183 5246 7087 1038 7 1165 9 1351 0 1558 5 1761 6 1587 4

1 0

8 12

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3.07 1.95 1.94 1.85 5.78 14.02 16.28

57543 57543 57543 57543 57543 57543 57543 57543 79682 79682 79682 79682 79682 79682 79682 79682

0.00215876 0.00215876 0.00215876 0.00215876 0.00215876 0.002159 0.002159 0.002159 0.00096004 0.00096004 0.00096004 0.00096004 0.00096004 0.00096004 0.00096004 0.00096004

26655528 26655528 26655528 26655528 26655528 26655528 26655528 26655528 82998509 82998509 82998509 82998509 82998509 82998509 82998509 82998509

340 340 340 340 340 340 340 340 881 881 881 881 881 881 881 881

64 64 64 64 64 64 64 64 48 48 48 48 48 48 48 48

56 56 56 56 56 56 56 56 34 34 34 34 34 34 34 34

2 4 3.5 5.5 2.5 2 2 2 6 4 3 4

9723

25.44

79682

0.00096004

82998509

881

48

34

10.5

29.67

11201

28.51

79682

0.00096004

82998509

881

48

34

10.5

33.45

13206

32.7

79682

0.00096004

82998509

881

48

34

9.3

37.53

14548

35.27

79682

0.00096

82998509

881

48

34

8

41.27

17175

40.23

79682

0.00096

82998509

881

48

34

8

37.42

15559

36.68

2.49 3.36

7 12

2.18 3.36

79682 9872 9872 9872

0.00096 0.0109611 0.0109611 0.0109611

82998509 900635 900635 900635

881 7900 7900 7900

48 82 82 82

34 77 77 77

7 4 3 2

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6 8 7.5

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Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chandigarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Chhattisgarh Dadra & Nagar Haveli Dadra & Nagar Haveli

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6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 7 7 7

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

8

1999

8

2000

1 0 0 0 1 0 0 0 0 0 0

14 3 12 9 19 14 15 24 21 38 58

3.77 0.78 3 2.17 4.43 3.16 3.28 4.52 3.19 6.48 13.65

12 3 12 9 16 14 15 24 20 37 58

3.23 0.78 3 2.17 3.73 3.16 3.28 4.52 3.03 6.31 13.65

0 0 1 0 0 0 0 0 0 0 0 0 0

0 127 165 213 234 507 331 482 497 519 374 319 618

0 1.43 1.95 2.47 2.67 5.67 3.64 5.2 5.27 5.41 3.08 3.38 6.22

0 124 161 176 228 497 294 480 493 518 302 279 557

0 1.4 1.9 2.04 2.6 5.56 3.23 5.18 5.2 5.4 3.08 2.95 5.61

0

WebmedCentral plus > Research articles

1

1.44

1

1.44

9872 9872 9872 9872 9872 9872 9872 9872 9872 9872 9872 51921 51921 51921 51921 51921 51921 51921 51921 51921 51921 51921 51921 51921 51921

0.0109611 0.0109611 0.0109611 0.0109611 0.0109611 0.0109611 0.0109611 0.0109611 0.010961 0.010961 0.010961 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492 0.002492

900635 900635 900635 900635 900635 900635 900635 900635 900635 900635 900635 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803 20833803

7900 7900 7900 7900 7900 7900 7900 7900 7900 7900 7900 154 154 154 154 154 154 154 154 154 154 154 154 154 154

82 82 82 82 82 82 82 82 82 82 82 65 65 65 65 65 65 65 65 65 65 65 65 65 65

77 77 77 77 77 77 77 77

220490

449

60

43

6

220490

449

60

43

3

77 52 52 52 52 52 52 52 52 52 52 52 52 52 52

Page 10 of 24

2 5 3 4 3.5 5.5 5.5 2 2 2 6 3 2 2 5 2 2 3.5 4.5 1.5 2 3 2

WMCPLS0035

Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Dadra & Nagar Haveli Daman & Diu Daman & Diu Daman & Diu Daman & Diu Daman & Diu Daman & Diu

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

8

2001

0

1

1.14

1

1.14

220490

449

60

43

2

8

2002

0

1

1.11

1

1.11

220490

449

60

43

2

8

2003

0

0

0

0

0

220490

449

60

43

8

2004

0

1

0.95

1

0.95

220490

449

60

43

6

8

2005

0

1

0.91

1

0.91

220490

449

60

43

4

8

2006

0

3

2.61

3

2.61

220490

449

60

43

4

8

2007

0

3

2.61

3

2.61

220490

449

60

43

3.5

8

2008

0

1

0.87

1

0.87

220490

449

60

43

3.5

8

2009

0

5

4.31

5

4.31

220490

449

60

43

1.5

8

2010

0

7

5.88

7

5.88

220490

449

60

43

2

8

2011

0

4

2.82

4

2.82

220490

449

60

43

2

8 9 9 9 9 9 9

2012 1999 2000 2001 2002 2003 2004

0

9

13.04

9

13.04

0 0 0 0 0

1 2 1 3 0

1.99 3.13 1.54 4.41 0

1 2 1 3 0

1.99 3.13 1.54 4.41 0

220490 158204 158204 158204 158204 158204 158204

449 1413 1413 1413 1413 1413 1413

60 81 81 81 81 81 81

43 70 70 70 70 70 70

2 6 3 2 2

WebmedCentral plus > Research articles

Page 11 of 24

6

WMCPLS0035

Daman & Diu Daman & Diu Daman & Diu Daman & Diu Daman & Diu Daman & Diu Daman & Diu Daman & Diu Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Delhi Goa Goa Goa Goa Goa Goa Goa Goa

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

9 9 9 9 9 9 9 9 10 10 10 10 10 10 10 10 10 10 10 10 10 10 11 11 11 11 11 11 11 11

2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006

0 0 0 0 0 0 0 0

1 2 4 1 3 5 6 2

1.25 2.33 4.4 1.03 2.91 4.59 5.35 5.88

1 1 4 1 3 5 6 2

1.25 1.16 4.4 1.03 2.91 4.59 5.35 5.88

3 3 24 3 2 1 6 2 5 4 0 0 0

110 104 121 97 114 167 219 265 264 311 430 707 771

2.17 1.89 2.1 1.61 1.81 2.53 3.17 3.66 3.49 4.42 5.99 8.57 11.28

98 94 88 84 112 165 177 261 257 305 359 675 771

1.93 1.71 1.53 1.39 1.77 2.5 2.56 3.61 3.4 4.33 5.14 8.18 10.65

0 0 0 0 0 0 0

19 7 5 7 10 15 8

3.29 1.58 1.12 1.55 2.16 3.21 1.68

18 7 5 7 10 15 7

3.12 1.58 1.12 1.55 2.16 3.21 1.47

WebmedCentral plus > Research articles

105385 105385 105385 105385 105385 105385 105385 105385 105385 105385 105385 105385 105385 105385 12400 12400 12400 12400 12400 12400 12400 12400

0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.0076087 0.007609 0.007609 0.007609 0.009201 0.009201 0.009201 0.009201 0.009201 0.009201 0.009201 0.009201

158204 158204 158204 158204 158204 158204 158204 158204 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 13850507 1347668 1347668 1347668 1347668 1347668 1347668 1347668 1347668

1413 1413 1413 1413 1413 1413 1413 1413 9340 9340 9340 9340 9340 9340 9340 9340 9340 9340 9340 9340 9340 9340 364 364 364 364 364 364 364 364

81 81 81 81 81 81 81 81 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82

70 70 70 70 70 70 70 70 75 75 75 75 75 75 75 75 75 75 75 75 75 75 76 76 76 76 76 76 76 76 Page 12 of 24

4 4 3.5 3.5 1.5 2 2 2 3 3 2 6 8 6.5 9.5 9.5 9.5 8 10 7 4 2 2 2 5 2 2

WMCPLS0035

Goa Goa Goa Goa Goa Goa Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Gujarat Haryana Haryana Haryana Haryana Haryana Haryana Haryana Haryana Haryana Haryana

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

11 11 11 11 11 11 12 12 12 12 12 12 12 12 12 12 12 12 12 12 13 13 13 13 13 13 13 13 13 13

2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

0 0 0 0 0 0

32 23 13 25 26 18

6.67 4.74 2.63 5.01 6.65 4.58

32 23 13 23 24 17

6.67 4.74 2.63 4.51 6.14 4.33

2 1 24 3 0 1 4 1 0 0 0 0 0

313 306 348 378 432 565 563 844 699 793 908 1031 938

1.83 1.51 1.7 1.8 1.97 2.53 2.49 4.2 3.4 3.78 4.23 4.71 4.36

286 298 310 323 431 557 513 838 698 792 849 1013 910

1.67 1.47 1.51 1.54 1.97 2.49 2.27 4.17 3.4 3.77 3.96 4.63 4.23

4 5 37 3 2 1 18 6 2

194 220 273 247 315 423 439 554 568

2.46 2.64 3.18 2.8 3.43 4.55 4.57 5.61 5.59

176 206 218 223 309 417 362 538 559

2.23 2.47 2.54 2.53 3.41 4.49 3.76 5.44 5.5

WebmedCentral plus > Research articles

12400 12400 12400 12400 12400 12400 216651 216651 216651 216651 216651 216651 216651 216651 216651 216651 216651 216651 216651 216651 106385 106385 106385 106385 106385 106385 106385 106385 106385 106385

0.009201 0.009201 0.009201 0.009201 0.009201 0.009201 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.0042756 0.004276 0.004276 0.004276 0.005031 0.005031 0.005031 0.005031 0.005031 0.005031 0.005031 0.005031 0.005031 0.005031

1347668 1347668 1347668 1347668 1347668 1347668 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 50671017 21144564 21144564 21144564 21144564 21144564 21144564 21144564 21144564 21144564 21144564

364 364 364 364 364 364 258 258 258 258 258 258 258 258 258 258 258 258 258 258 478 478 478 478 478 478 478 478 478 478

82 82 82 82 82 82 70 70 70 70 70 70 70 70 70 70 70 70 70 70 69 69 69 69 69 69 69 69 69 69

76 76 76 76 76 76 59 59 59 59 59 59 59 59 59 59 59 59 59 59 56 56 56 56 56 56 56 56 56 56 Page 13 of 24

2 3.5 1.5 2 2 2 6 3 2.5 2 6 3 4 4.5 3.5 1.5 2 2 4 3 2 2 6 5 5.25 5.5 7.25

WMCPLS0035

Haryana Haryana Haryana Haryana Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Himachal Pradesh Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir Jammu & Kashmir

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

13 13 13 13 14 14 14 14 14 14 14 14 14 14 14 14 14 14 15 15 15 15 15 15 15 15 15 15 15 15

2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010

4 1 0 0

680 661 996 1379

6.91 6.61 9.79 13.48

669 591 929 1335

6.8 5.91 9.14 13.05

0 0 0 0 0 0 1 0 0 1 0 0 0

59 44 37 30 48 48 61 95 91 103 142 141 178

2.44 1.86 1.52 1.22 1.92 1.89 2.36 3.6 3.4 4.77 6.47 6.32 8.37

58 44 37 27 48 46 51 95 90 102 135 134 175

2.4 1.86 1.52 1.1 1.92 1.8 1.97 3.61 3.36 4.72 6.15 6 8.23

0 0 1 0 0 0 1 0 0 0 1

80 109 77 84 90 107 146 174 140 178 191

2.21 2.88 1.85 1.99 2.09 2.39 3.2 3.73 2.93 3.59 3.72

79 107 76 82 90 107 140 174 140 178 189

2.18 2.82 1.82 1.95 2.09 2.39 3.07 3.73 2.93 3.59 3.68

WebmedCentral plus > Research articles

106385 106385 106385 106385 25435 25435 25435 25435 25435 25435 25435 25435 25435 25435 25435 25435 25435 25435 24265 24265 24265 24265 24265 24265 24265 24265 24265 24265 24265 24265

0.005031 0.005031 0.005031 0.005031 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.004184 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.00239212 0.002392

21144564 21144564 21144564 21144564 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 6077900 10143700 10143700 10143700 10143700 10143700 10143700 10143700 10143700 10143700 10143700 10143700 10143700

478 478 478 478 109 109 109 109 109 109 109 109 109 109 109 109 109 109 46 46 46 46 46 46 46 46 46 46 46 46

69 69 69 69 77 77 77 77 77 77 77 77 77 77 77 77 77 77 54 54 54 54 54 54 54 54 54 54 54 54

56 56 56 56 68 68 68 68 68 68 68 68 68 68 68 68 68 68 41 41 41 41 41 41 41 41 41 41 41 41 Page 14 of 24

5.5 4 4.6 4 2 2 2 5 2 3 2 3.5 1.5 3 2 2 4 2 2 2 5 2 2 2 3.5 1.5 4

WMCPLS0035

Jammu & Kashmir Jammu & Kashmir Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Jharkhand Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka Karnataka

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

15 15 16 16 16 16 16 16 16 16 16 16 16 16 16 16 17 17 17 17 17 17 17 17 17 17 17 17 17

2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

0 0

239 268

4.53 5.34

237 267

4.49 5.32

0 2 12 0 0 2 1 0 0 2 8 0 0

0 241 281 214 395 917 912 1368 1532 1493 1324 1529 1497

0 1.99 2.62 1.86 2.48 7.77 7.55 11.1 12.07 11.38 10.36 11.37 10.96

0 221 252 189 386 893 835 1357 1522 1485 1170 1465 1418

0 1.82 2.35 1.64 3.4 7.56 6.92 11.1 12 11.32 9.15 10.9 10.4

8 0 0 34 1 0 0 1 0 0 0 0 0

317 339 318 426 503 742 595 811 751 773 841 912 995

1.7 1.65 1.52 2.03 2.32 3.36 2.62 3.56 4.01 4.27 4.41 4.7 5.27

283 331 315 343 497 736 536 810 750 773 749 872 954

1.52 1.61 1.5 1.63 2.29 3.33 2.36 3.55 4.01 4.27 3.93 4.49 5.05

WebmedCentral plus > Research articles

24265 24265 62950 62950 62950 62950 62950 62950 62950 62950 62950 62950 62950 62950 62950 62950 170741 170741 170741 170741 170741 170741 170741 170741 170741 170741 170741 170741 170741 170741

0.002392 0.002392 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.0023361 0.002336 0.002336 0.002336 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323 0.00323

10143700 10143700 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 26945829 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562 52850562

46 46 338 338 338 338 338 338 338 338 338 338 338 338 338 338 276 276 276 276 276 276 276 276 276 276 276 276 276 276

54 54 54 54 54 54 54 54 54 54 54 54 54 54 54 54 67 67 67 67 67 67 67 67 67 67 67 67 67 67

41 41 39 39 39 39 39 39 39 39 39 39 39 39 39 39 57 57 57 57 57 57 57 57 57 57 57 57 57 57 Page 15 of 24

2 2 4 2.5 2 6 4 4 4.5 3.5 1.5 5.33 6 4 2 2.5 2 3 6 2 3 2.75 3.5 1.5 2 2 2

WMCPLS0035

Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Kerala Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Lakshadweep Madhya Pradesh Madhya Pradesh

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

18 18 18 18 18 18 18 18 18 18 18 18 18 18 19 19 19 19 19 19 19 19 19 19 19 19 19 19 20 20

1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000

1 0 0 0 0 0 0 0 0 0 0 0 0

96 123 142 117 206 218 226 229 292 326 350 395 328

1.02 1.29 1.55 1.28 2.26 2.3 2.36 2.28 2.88 3.83 3.87 4.25 3.93

93 118 142 111 206 217 206 229 292 326 320 377 323

0.99 1.24 1.55 1.22 2.26 2.29 2.15 2.28 2.88 3.83 3.54 4.01 3.87

0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 1 0 1 1 0 1 0 0 0 0 1

0 0 4.55 0 4.55 4.17 0 4.17 0 0 0 0 5.56

0 0 1 0 1 1 0 1 0 0 0 0 1

0 0 4.55 0 4.55 4.17 0 4.17 0 0 0 0 5.56

2

634

2.01

608

1.93

WebmedCentral plus > Research articles

118998 118998 118998 118998 118998 118998 118998 118998 118998 118998 118998 118998 118998 118998

116322 116322

0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737 0.003737

0.001927 0.001927

31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 31841374 60650 60650 60650 60650 60650 60650 60650 60650 60650 60650 60650 60650 60650 60650 60348023 60348023

819 819 819 819 819 819 819 819 819 819 819 819 819 819 1895 1895 1895 1895 1895 1895 1895 1895 1895 1895 1895 1895 1895 1895 196 196

91 91 91 91 91 91 91 91 91 91 91 91 91 91 88 88 88 88 88 88 88 88 88 88 88 88 88 88 64 64

88 88 88 88 88 88 88 88 88 88 88 88 88 88 82 82 82 82 82 82 82 82 82 82 82 82 82 82 50 50 Page 16 of 24

4 2 2 2 5 2 2 2 3.5 1.5 2 2 2 4 2 2 2 5 2 2 2 3.5 1.5 2 2 2 6 3

WMCPLS0035

Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Madhya Pradesh Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Maharashtra Manipur Manipur Manipur Manipur

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

20 20 20 20 20 20 20 20 20 20 20 20 21 21 21 21 21 21 21 21 21 21 21 21 21 21 22 22 22 22

2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002

0 21 11 0 0 3 0 1 0 0 0 0

383 497 532 772 1141 1273 2145 2284 2722 2737 2814 2933

1.59 2.02 2.1 2.98 4.3 4.69 7.74 7.9 9.41 9.27 9.33 9.9

365 452 436 747 1127 1071 2135 2274 2719 2477 2741 2835

1.51 1.84 1.72 2.88 4.25 3.95 7.7 7.86 9.4 8.39 9.09 9.57

7 4 6 3 3 0 5 2 2 0 5 0 0

598 601 592 710 818 1205 1294 1881 1915 2255 2499 2791 3065

1.84 1.8 1.73 2.04 2.3 3.34 3.53 5.05 5.05 5.86 6.52 7.18 7.78

562 579 571 634 808 1200 1119 1873 1908 2255 2318 2711 2980

1.73 1.73 1.67 1.82 2.28 3.33 3.05 5.03 5.05 5.86 6.05 6.97 7.56

0 0 0

WebmedCentral plus > Research articles

16 14 9

1.76 1.37 0.95

14 14 9

1.54 1.37 0.95

116322 116322 116322 116322 116322 116322 116322 116322 116322 116322 116322 116322 432413 432413 432413 432413 432413 432413 432413 432413 432413 432413 432413 432413 432413 432413 5714 5714 5714 5714

0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.001927 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.004463 0.002637 0.002637 0.002637 0.002637

60348023 60348023 60348023 60348023 60348023 60348023 60348023 60348023 60348023 60348023 60348023 60348023 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 96878627 2166788 2166788 2166788 2166788

196 196 196 196 196 196 196 196 196 196 196 196 315 315 315 315 315 315 315 315 315 315 315 315 315 315 97 97 97 97

64 64 64 64 64 64 64 64 64 64 64 64 77 77 77 77 77 77 77 77 77 77 77 77 77 77 69 69 69 69

50 50 50 50 50 50 50 50 50 50 50 50 68 68 68 68 68 68 68 68 68 68 68 68 68 68 60 60 60 60

2.5 2 2 6 4.66 6.33 5.125 6.5 3.5 4 4

Page 17 of 24

4 2 2.5 3 2.5 5 4.66 5.25 5 5.5 5.5 6 5 4 2 2 2

WMCPLS0035

Manipur Manipur Manipur Manipur Manipur Manipur Manipur Manipur Manipur Manipur Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Meghalaya Mizoram Mizoram Mizoram Mizoram Mizoram Mizoram

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

22 22 22 22 22 22 22 22 22 22 23 23 23 23 23 23 23 23 23 23 23 23 23 23 24 24 24 24 24 24

2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004

0 0 0 0 0 0 0 0 0 0

8 12 19 14 22 24 21 18 19 33

0.84 1.22 1.97 1.42 2.21 2.39 2.05 1.73 1.79 3.06

7 12 19 12 22 24 21 17 19 33

0.74 1.22 1.97 1.22 2.21 2.39 2.05 1.63 1.79 3.06

0 0 0 0 0 0 0 0 0 0 0 0 0

9 18 14 11 17 24 21 42 38 33 28 29 42

1.02 1.97 1.48 1.07 1.69 2.09 2.03 3.94 3.51 2.96 2.39 2.41 3.47

7 18 14 10 17 24 20 42 38 33 27 29 41

0.79 1.97 1.48 0.97 1.69 2.09 1.93 3.94 3.51 2.96 2.3 2.41 3.39

0 0 0 0 0

11 4 4 2 0

3.19 1.14 1.2 0.59 0

11 4 4 2 0

3.19 1.14 1.2 0.59 0

WebmedCentral plus > Research articles

5714 5714 5714 5714 5714 5714 5714 5714 5714 5714 6470 6470 6470 6470 6470 6470 6470 6470 6470 6470 6470 6470 6470 6470 2697 2697 2697 2697 2697 2697

0.002637 0.002637 0.002637 0.002637 0.002637 0.002637 0.002637 0.002637 0.002637 0.002637 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.00279 0.003035 0.003035 0.003035 0.003035 0.003035 0.003035

2166788 2166788 2166788 2166788 2166788 2166788 2166788 2166788 2166788 2166788 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 2318822 888573 888573 888573 888573 888573 888573

97 97 97 97 97 97 97 97 97 97 103 103 103 103 103 103 103 103 103 103 103 103 103 103 42 42 42 42 42 42

69 69 69 69 69 69 69 69 69 69 63 63 63 63 63 63 63 63 63 63 63 63 63 63 88 88 88 88 88 88

60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 86 86 86 86 86 86 Page 18 of 24

5 2 2 2 3.5 1.5 2 2 2 4 2 2 2 2 5 2 2 2 3.5 1.5 2 2 2 2 2 2 5

WMCPLS0035

Mizoram Mizoram Mizoram Mizoram Mizoram Mizoram Mizoram Mizoram Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Nagaland Orissa Orissa Orissa Orissa Orissa Orissa Orissa Orissa

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

24 24 24 24 24 24 24 24 25 25 25 25 25 25 25 25 25 25 25 25 25 25 26 26 26 26 26 26 26 26

2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006

0 0 0 0 0 0 0 0

6 8 14 7 8 4 5 16

1.74 2.28 3.8 1.74 1.94 0.95 1.17 3.69

6 6 14 7 8 4 5 15

1.74 1.71 3.8 1.74 1.94 0.95 1.17 3.46

0 0 0 0 0 0 0 0 0 0 0 0 0

8 6 2 1 3 11 4 23 18 27 31 34 29

1.31 0.75 0.26 0.12 0.34 1.23 0.4 2.21 1.64 2.33 2.56 4.18 4.07

8 6 2 1 3 11 4 23 18 27 31 33 29

1.31 0.75 0.26 0.12 0.34 1.23 0.4 2.21 1.64 2.33 2.56 4.05 4.07

0 0 4 2 0 0 0

273 312 267 265 284 679 850

2.1 2.14 1.83 1.82 1.9 4.34 5.35

259 304 262 240 278 677 730

1.99 2.09 1.8 1.65 1.85 4.33 4.59

WebmedCentral plus > Research articles

2697 2697 2697 2697 2697 2697 2697 2697 5346 5346 5346 5346 5346 5346 5346 5346 5346 5346 5346 5346 5346 5346 78536 78536 78536 78536 78536 78536 78536 78536

0.003035 0.003035 0.003035 0.003035 0.003035 0.003035 0.003035 0.003035 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.00268638 0.002686 0.002686 0.002686 0.00213386 0.00213386 0.00213386 0.00213386 0.00213386 0.00213386 0.00213386 0.00213386

888573 888573 888573 888573 888573 888573 888573 888573 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 1990036 36804660 36804660 36804660 36804660 36804660 36804660 36804660 36804660

42 42 42 42 42 42 42 42 120 120 120 120 120 120 120 120 120 120 120 120 120 120 236 236 236 236 236 236 236 236

88 88 88 88 88 88 88 88 67 67 67 67 67 67 67 67 67 67 67 67 67 67 64 64 64 64 64 64 64 64

86 86 86 86 86 86 86 86 62 62 62 62 62 62 62 62 62 62 62 62 62 62 51 51 51 51 51 51 51 51 Page 19 of 24

2 2 2 3.5 1.5 2 2 2 2 2 2 5 2 2 2 3.5 1.5 2 2 2 3 2 2 2 2 5 2 2

WMCPLS0035

Orissa Orissa Orissa Orissa Orissa Orissa Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Pondicherry Punjab Punjab Punjab Punjab Punjab Punjab Punjab Punjab Punjab Punjab

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26 26 26 26 26 26 27 27 27 27 27 27 27 27 27 27 27 27 27 27 28 28 28 28 28 28 28 28 28 28

2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

1 2 0 0 0 0

1023 1227 1481 1506 1157 1996

6.41 7.59 10.91 10.96 8.32 14.18

1017 1216 1473 1342 1125 1925

6.37 7.52 10.85 9.7 8.09 13.67

0 0 0 0 0 0 0 0 0 0 0 0 0

5 6 7 5 6 18 6 11 19 16 14 13 15

1.24 1.58 2.37 1.68 1.98 5.84 1.92 3.44 5.81 4.8 4.13 3.77 4.26

5 6 7 4 6 18 6 10 19 16 14 13 15

1.24 1.58 2.37 1.35 1.98 5.84 1.92 3.13 5.81 4.8 4.13 3.77 4.26

0 5 2 1 0 1 8 1 2

214 197 175 154 215 263 238 371 389

2.59 2.33 2.03 1.75 2.4 2.88 2.55 3.89 4

203 185 169 141 213 260 208 368 383

2.46 2.19 1.96 1.6 2.38 2.84 2.23 3.86 3.94

WebmedCentral plus > Research articles

78536 78536 78536 78536 78536 78536 5700 5700 5700 5700 5700 5700 5700 5700 5700 5700 5700 5700 5700 5700 109735 109735 109735 109735 109735 109735 109735 109735 109735 109735

0.00213386 0.00213386 0.00213386 0.002134 0.002134 0.002134 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00585 0.00450491 0.00450491 0.00450491 0.00450491 0.00450491 0.00450491 0.00450491 0.00450491 0.00450491 0.00450491

36804660 36804660 36804660 36804660 36804660 36804660 974345 974345 974345 974345 974345 974345 974345 974345 974345 974345 974345 974345 974345 974345 24358999 24358999 24358999 24358999 24358999 24358999 24358999 24358999 24358999 24358999

236 236 236 236 236 236 2034 2034 2034 2034 2034 2034 2034 2034 2034 2034 2034 2034 2034 2034 484 484 484 484 484 484 484 484 484 484

64 64 64 64 64 64 81 81 81 81 81 81 81 81 81 81 81 81 81 81 70 70 70 70 70 70 70 70 70 70

51 51 51 51 51 51 74 74 74 74 74 74 74 74 74 74 74 74 74 74 64 64 64 64 64 64 64 64 64 64 Page 20 of 24

4.5 4.5 1.5 2 2 2 2 2 2 2 5 2 2 2 3.5 1.5 2 2 2 2 2 2 5 2.5 5.25 4.5 4.5

WMCPLS0035

Punjab Punjab Punjab Punjab Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Rajasthan Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim Sikkim

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28 28 28 28 29 29 29 29 29 29 29 29 29 29 29 29 29 29 30 30 30 30 30 30 30 30 30 30 30 30

2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010

4 0 0 0

457 357 576 730

4.61 4.32 6.74 9.45

450 329 547 703

4.53 3.98 6.4 9.1

0 0 41 4 0 0 1 3 2 3

536 451 466 440 624 931 1003 1336 1353 1439

2.42 1.9 2.01 1.85 2.59 3.76 3.95 5.19 5.08 5.34

504 435 402 383 613 919 834 1323 1342 1430

2.27 1.83 1.73 1.61 2.54 3.71 3.29 5.14 5.04 5.3

0 0

1823 2053

6.47 7.36

1753 1949

6.22 6.99

0 0 0 0 0 0 0 0 0 0 0

WebmedCentral plus > Research articles

12 4 1 3 2 2 2 6 5 3 7

5.95 1.84 0.45 1.32 0.85 0.82 0.79 2.31 2.08 1.22 2.76

12 4 1 3 2 2 1 6 5 3 6

5.95 1.84 0.45 1.32 0.85 0.82 0.4 2.31 2.08 1.22 2.36

109735 109735 109735 109735 124224 124224 124224 124224 124224 124224 124224 124224 124224 124224 124224 124224 124224 124224 1803 1803 1803 1803 1803 1803 1803 1803 1803 1803 1803 1803

0.00450491 0.004505 0.004505 0.004505 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.00219837 0.002198 0.002198 0.002198 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.00333363 0.003334

24358999 24358999 24358999 24358999 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 56507188 540851 540851 540851 540851 540851 540851 540851 540851 540851 540851 540851 540851

484 484 484 484 165 165 165 165 165 165 165 165 165 165 165 165 165 165 76 76 76 76 76 76 76 76 76 76 76 76

70 70 70 70 61 61 61 61 61 61 61 61 61 61 61 61 61 61 70 70 70 70 70 70 70 70 70 70 70 70

64 64 64 64 44 44 44 44 44 44 44 44 44 44 44 44 44 44 61 61 61 61 61 61 61 61 61 61 61 61 Page 21 of 24

3.5 3 2 3 2 2 2 6 4 5.25 4.6 6.5 5.5 4 4.6 2 2 2 2 5 2 2 2 3.5 1.5 2

WMCPLS0035

Sikkim Sikkim Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tamil Nadu Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura Tripura

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30 30 31 31 31 31 31 31 31 31 31 31 31 31 31 31 32 32 32 32 32 32 32 32 32 32 32 32 32 32

2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

0 0

8 7

3.05 3.26

8 7

3.05 3.26

0 0 0 2 1 0 0 0 0 0 0 0 0

292 302 287 310 398 539 423 545 557 604 602 622 655

1.55 1.57 1.55 1.66 2.1 3.05 2.37 3.02 3.06 3.28 3.55 3.76 3.72

275 294 286 267 395 537 376 544 557 604 570 607 630

1.46 1.53 1.54 1.43 2.09 3.04 2.11 3.02 3.06 3.28 3.45 3.67 3.58

0 0 0 0 0 2 0 0 0 0 0 0 0

19 20 15 8 21 54 53 79 60 60 87 58 91

1.39 1.57 1.16 0.61 1.58 5.01 4.85 5.84 4.37 4.22 5.95 3.91 6.28

18 20 15 6 52 52 41 79 60 60 82 58 90

1.31 1.57 1.16 0.46 4.83 4.83 3.75 5.84 4.37 4.22 5.61 3.91 6.21

WebmedCentral plus > Research articles

1803 1803 223528 223528 223528 223528 223528 223528 223528 223528 223528 223528 223528 223528 223528 223528 9124 9124 9124 9124 9124 9124 9124 9124 9124 9124 9124 9124 9124 9124

0.003334 0.003334 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.00358185 0.003582 0.003582 0.003582 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.00285196 0.002852 0.002852 0.002852

540851 540851 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 62405679 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203 3199203

76 76 480 480 480 480 480 480 480 480 480 480 480 480 480 480 305 305 305 305 305 305 305 305 305 305 305 305 305 305

70 70 73 73 73 73 73 73 73 73 73 73 73 73 73 73 74 74 74 74 74 74 74 74 74 74 74 74 74 74

61 61 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 65 Page 22 of 24

2 2 2 2 2 2 5 2 2 2 3.5 1.5 2 2 2 2 2 2 2 5 2 4 2 3.5 1.5 2 2 2

WMCPLS0035

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

Uttar Pradesh Uttar Pradesh Uttar Pradesh Uttar Pradesh Uttar Pradesh Uttar Pradesh

33 33 33 33 33 33

1999 2000 2001 2002 2003 2004

178 216 1242 83 82

Uttar Pradesh

33

2005

29

Uttar Pradesh

33

2006

519

Uttar Pradesh

33

2007

341

Uttar Pradesh

33

2008

305

Uttar Pradesh

33

2009

602

Uttar Pradesh

33

2010

10

Uttar Pradesh

33

2011

0

Uttar Pradesh Uttarakhand Uttarakhand Uttarakhand Uttarakhand Uttarakhand Uttarakhand Uttarakhand Uttarakhand Uttarakhand

33 34 34 34 34 34 34 34 34 34

2012 1999 2000 2001 2002 2003 2004 2005 2006 2007

0

1847 1871 3515 1971 4058 1026 4 1219 2 1488 5 1764 9 1878 5 2142 3 2237 4 2096 8

0 3 14 0 1 1 13 6

0 68 98 87 114 266 246 268

WebmedCentral plus > Research articles

2.64 2.82 5.18 2.84 5.72

1461 1478 1845 1562 3789

2.09 2.23 2.72 2.25 5.34

279762 279762 279762 279762 279762 279762

0.00168331 0.00168331 0.00168331 0.00168331 0.00168331 0.00168331

166197921 166197921 166197921 166197921 166197921 166197921

690 690 690 690 690 690

57 57 57 57 57 57

43 43 43 43 43 43

4 3 4 4

14.14

10055

13.83

279762

0.00168331

166197921

690

57

43

9

16.42

10271

13.83

279762

0.00168331

166197921

690

57

43

7.5

19.59

14343

18.88

279762

0.00168331

166197921

690

57

43

10.5

22.71

17108

22.01

279762

0.00168331

166197921

690

57

43

10.5

23.63

17931

22.56

279762

0.00168331

166197921

690

57

43

8.4

26.26

19453

23.85

279762

0.001683

166197921

690

57

43

8

26.82

21635

25.93

279762

0.001683

166197921

690

57

43

8

25.79

20560

25.29

0 2 2.84 2.59 3.21 7.42 6.75 7.18

0 60 81 67 110 260 203 260

0 1.77 2.34 1.99 3.1 7.25 5.576 6.97

279762 25776 25776 25776 25776 25776 25776 25776 25776 25776

0.001683 0.00303627 0.00303627 0.00303627 0.00303627 0.00303627 0.00303627 0.00303627 0.00303627 0.00303627

166197921 8489349 8489349 8489349 8489349 8489349 8489349 8489349 8489349 8489349

690 159 159 159 159 159 159 159 159 159

57 72 72 72 72 72 72 72 72 72

43 60 60 60 60 60 60 60 60 60

7 4 2 2 4

Page 23 of 24

6

5.5 5 5.25 4.7

WMCPLS0035

Uttarakhand Uttarakhand Uttarakhand Uttarakhand Uttarakhand West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal West Bengal

Downloaded from http://www.webmedcentralplus.com on 22-Jan-2014, 08:59:08 AM

34 34 34 34 34 35 35 35 35 35 35 35 35 35 35 35 35 35 35

2008 2009 2010 2011 2012 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

1 4 0 0 0 8 1 49 28 2 0 1 2 2 0 8 1 0

WebmedCentral plus > Research articles

372 347 352 365 423 451 409 579 511 711 1628 1895 2253 1853 1995 2084 2515 3147

9.79 8.98 9.03 9.19 10.27 1.55 1.41 1.94 1.83 2.5 5.7 6.48 7.53 6.07 6.42 6.31 7.47 9.95

368 339 331 361 410 410 393 506 423 697 1619 1756 2239 1844 1988 1942 2446 3095

9.68 8.77 8.49 9.09 9.95 1.41 1.35 1.7 1.51 2.45 5.66 6 7.47 6.04 6.4 5.88 7.24 9.79

25776 25776 25776 25776 25776 236044 236044 236044 236044 236044 236044 236044 236044 236044 236044 236044 236044 236044 236044

0.00303627 0.00303627 0.003036 0.003036 0.003036 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.00294407 0.002944 0.002944 0.002944

8489349 8489349 8489349 8489349 8489349 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197 80176197

159 159 159 159 159 903 903 903 903 903 903 903 903 903 903 903 903 903 903

72 72 72 72 72 69 69 69 69 69 69 69 69 69 69 69 69 69 69

60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60

Page 24 of 24

6.5 5.5 4 4 4 3 3 3 6 5.5 6.33 2.75 6.5 1.5 6 6