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Variable. Total (N = 140). Median Age (Years). 35 (0.4-61). Gender. Male. 69 (49%). Female. 71 (51%). Genotype. betaS/betaS. 25 (17.8%). betaS/beta039.

Supplementary Materials: Table S1. Sickle genotype/phenotype.

Variable Median Age (Years) Gender Male Female Genotype betaS/betaS betaS/beta039 betaS/IVSnt110 betaS/IVSnt1 betaS/δβ betas/INS1nt6 betaS/IVS2nt745 betaS/-87 betaS/IVS1nt5 betaS/lepore betaS/INV2nt1 not available Sickle Phenotype HbSS HbS/β0 thal HbS/β+ thal HbS/δβ thal HbS/Lepore

Total (N = 140) 35 (0.4-61) 69 (49%) 71 (51%) 25 (17.8%) 35 (25%) 33 (23.6%) 10 (7.2%) 4 (2.8%) 16 (11.5%) 5 (3.6%) 1 (0.7%) 1 (0.7%) 1 (0.7%) 3 (2.1%) 6 (4.3%) 25 (17.9%) 54 (37.9%) 56 (40.7%) 4 (2.8%) 1 (0.7%)

Table S2. Mean hematologic and organ function parameters. First Visit

Last Visit

Variable

No HU (N = 50)

Median HU dose White blood count (K/uL) ANC (K/uL) Hemoglobin (g/dL) Hemoglobin F (%) ALT (U/L) Total bilirubin (mg/dL) Direct bilirubin (mg/dL) Ferritin (mcg/L) TRV (m/s) Creatinine (mg/dL)

-

HU