Jul 21, 2015 - clinical outcomes in patients with MV in a medical ICU (MICU). Methods: We retrospectively evaluated MICU data prospectively collected ...
ORIGINAL ARTICLE
http://dx.doi.org/10.4046/trd.2015.78.4.336 ISSN: 1738-3536(Print)/2005-6184(Online) • Tuberc Respir Dis 2015;78:336-340
Unplanned Extubation in Patients with Mechanical Ventilation: Experience in the Medical Intensive Care Unit of a Single Tertiary Hospital
Tae Won Lee, M.D., Jeong Woo Hong, M.D., Jung-Wan Yoo, M.D., Sunmi Ju, M.D., Seung Hun Lee, M.D., Seung Jun Lee, M.D., Ph.D., Yu Ji Cho, M.D., Ph.D., Yi Yeong Jeong, M.D., Ph.D., Jong Deog Lee, M.D., Ph.D. and Ho Cheol Kim, M.D., Ph.D. Department of Internal Medicine, Gyeongsang Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea
Background: Potentially harmful unplanned extubation (UE) may occur in patients on mechanical ventilation (MV) in an intensive care unit (ICU) setting. This study aimed to evaluate the clinical characteristics of UE and its impact on clinical outcomes in patients with MV in a medical ICU (MICU). Methods: We retrospectively evaluated MICU data prospectively collected between December 2011 and May 2014. Results: A total of 468 patients were admitted to the MICU, of whom 450 were on MV. Of the patients on MV, 30 (6.7%) experienced UE; 13 (43.3%) required reintubation after UE, whereas 17 (56.7%) did not require reintubation. Patients who required reintubation had a significantly longer MV duration and ICU stay than did those not requiring reintubation (19.4±15.1 days vs. 5.9±5.9 days days and 18.1±14.2 days vs. 7.1±6.5 days, respectively; p0.999 TB 3 (17.6) 3 (23.1) >0.999 CKD 3 (17.6) 2 (15.4) >0.999 HF 2 (11.8) 5 (38.5) 0.190 APACHE II 16.9±9.1 16.0±5.9 0.778 SOFA score 7.5±3.2 5.1±2.9 0.051 Septic shock 7 (41.2) 0 0.023 ARDS 4 (23.5) 4 (36.4) 0.671 Physiologic and laboratory parameter Systolic BP 132.4±13.1 135.3±22.6 0.685 Diastolic BP 80.3±9.1 76.0±16.1 0.400 HR, 1/min 99.5±18.9 103.7±19.1 0.557 RR, 1/min 22.2±3.5 24.7±5.9 0.195 pH 7.41±0.10 7.42±0.07 0.664 37.5±10.3 46.3±18.2 0.136 PaCO2, mm Hg 87.5±21.3 81.5±27.3 0.509 PaO2, mm Hg HCO3, mmol/L 23.2±5.1 28.5±8.4 0.064 95.8±2.2 95.7±2.3 0.853 SpO2, % FiO2 35.4±8.8 38.1±5.6 0.339 Ventilatory support ACMV 1 (5.9) 2 (15.4) 0.565 SIMV 5 (29.4) 2 (15.4) 0.427 CPAP 8 (47.1) 7 (53.8) >0.999 T-piece 3 (17.6) 2 (15.4) >0.999 Use of sedative agents 2 (11.8) 2 (15.4) >0.999 Use of inotropic agents 2 (11.8) 1 (7.7) >0.999 Duration of MV, day 5.9±5.9 19.4±15.1 0.015 LOS in ICU, day 7.1±6.5 18.1±14.2 0.009 LOS in hospital, day 25.8±23.8 41.6±34.8 0.167 Mortality 1 (5.9) 6 (54.5)* 0.007 Values are presented as mean±SD or number (%). *Two patients were not reintubated at the request of the families. Accordingly, we have excluded these patients from comparisons of mortality. Nine unplanned extubation patients died in this study. UE: unplanned extubation; ICU: intensive care unit; AECOPD: chronic obstructive pulmonary disease acute exacerbation; DM: diabetes mellitus; HTN: hypertension; TB: tuberculosis; CKD: chronic kidney disease; HF: heart failure; APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; ARDS: acute respiratory distress syndrome; BP: blood pressure; HR: heart rate; RR: respiratory rate; PaCO2: partial alveolar pressure of CO2; PaO2: partial pressure of alveolar O2; SpO2: O2 saturation; FiO2: fraction of inspired O2; ACMV: assist control mechanical ventilation; SIMV: synchronized intermittent mandatory ventilation; CPAP: continuous positive airway pressure; MV: mechanical ventilation; LOS: length of stay.
Tuberc Respir Dis 2015;78:336-340
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Unplanned extubation in the ICU
of time interval between UE and reintubation, four patients were within 6 hours after UE, two patients were from 18 to 24 hours. Two patients were from 24 to 48 hours of UE and two patients were do-not intubation due to family request. Patients who required reintubation had a significantly longer MV duration and ICU stay compared with those who did not require reintubation (16.9±14.1 days vs. 5.6±5.9 days and 6.6±6.4 days vs. 16.2±13.1 days, respectively; p
