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Mar 4, 2014 - The present invention relates to an improved and novel pro- cess for ... Lapatinib of formula-(1) having chemical name N-{3-chloro- ... LAPATINIB (BASE). -1.0. Mar. 4, 2014. -1.5. -2.0. -2.5. Sheet 2 of 3 ..... ethanol, methanol, 2-propanol or a mixture thereof. ... mL of acetic acid were charged under stirring.