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NUTRITION AND DIET RESEARCH PROGRESS
VITAMIN
C: NUTRITION, SIDE EFFECTS AND SUPPLEMENTS
CHRISTINA M. JACKSON EDITOR
Nova Science Publishers, Inc. New
Yo~k
Copyright© 2011 by Nova Science Publishers, Inc. All rights reserved. No part of this book may be reproduced, stored iu a retrieval system or transmitted in any form or by any means: electronic, electrostatic, magnetic, tape, mechanical
photocopyiug, recording or otherwise without the written permission of the Publisher. For permission to use material from tills book please contact us:
Telephone 631-231-7269; Fax 631-231-8175 Web Site: http://www.novapublishers.com NOTICE TO THE READER The Publisher has taken reasonable care in the preparation of this book, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of
iuformation contained iu this book. The Publisher shall not be liable for any special, consequential, or exemplary damages resulting, in whole or in part, from the readers' use of, or reliance upon, this material. Any parts of this book based on government reports are so indicated
and copyright is claimed for those parts to the extent applicable to compilations of such works. Independent verification should be sought for any data, advice or recommendations contained in
this book. In addition, no responsibility is assumed by the publisher for any i~ury and/or damage to persons or property arising from any methods, products, instructions, ideas or otherwise contained in this publication. This publication is designed to provide accurate and authoritative information with regard to the subject matter covered herein. It is sold with the clear understanding that the Publisher is not
engaged in rendering legal or any other professional services. If legal or any other expert assistance is required, the services of a competent person should be sought. FROM A DECLARATION OF PARTICIPANTS JOINTLY ADOPTED BY A COMMITTEE OF THE AMERICAN BAR ASSOCIATION AND A COMMITTEE OF PUBLISHERS. Additional color graphics may be available in the e-book~version of this book.
Library of Congress Cataloging-in-Publication Data Vitamin C : nutrition, side effects, and supplements I editor, Christina M. Jackson. p. ; em.
Includes bibliographical references and index.
ISBN 978-1-61728-754-1 (hardcover) 1. Vitamin C--Physiological effect. 2. Vitamin C--Therapeutic use. I. Jackson, Christina M., editor. [DNLM: 1. Ascorbic Acid--metabolism. 2. Ascorbic Acid--adverse effects. 3. Dietary Supplements. 4.
Nutritive Value. QU 210] QP772.A8V568 2010 612.3'99--dc22 2010044748
Published by Nova Science Publishers, Inc. f New York
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Contents vii
Preface Chapter I
Chapter II
Vitamin C: Nutritional Role, Supplementation in Pathophysiological States and Side Effects Ramon Rodrigo and Andres Miranda Vitamin C and Prevention of Premature Rupture of Fetal Membranes Mahboube Haji Foghaha, Tahere Keshavarz and Mohammad Ebrahim Parsanezhad
1
69
Chapter III
Vitamin C: Nutrition, Supplements and Biological Effects in Fish M.A. Hossain and I.S. Azad
129
Chapter IV
Does Vitamin C Act as an Antioxidant or Prooxidant? Mufide (Aydogan) Ahbab and Aslr Korkmaz
169
Chapter V
Vitamin C Supplementation in Dialysis Patients: Benefits and Risks A/pars/an Ersoy and Cum a Bulent Gul
205
Chapter VI
Metabolic Effects of Vitamin Cat Rest and During Exercise Stanislaw Poprz~cki, Adam Zajqc and J6zef Langfort
233
Chapter VII
Vitamin C in Skeletal Muscle:The Importance of Transport Marcela Low, Daniel Sandoval, Francisco Nualart and Juan Pablo Henriquez
259
Chapter VIII
Vitamin C in the Monkey Brain Rafael Covefias, Arturo Mangas, Dominique Bodet, Sebastien Duleu, Pilar Marcos and Michel Gejfard
275
Chapter IX
Vitamin C Supplementation in Cancer Cachexia and RelatedOxidative Stress C/elia Madeddu, Antonio Maccio and Giovanni Mantovani
289
Vl
Chapter X
Contents Parenteral Vitamin C Administration Increases Lymphocyte Apoptosis Rate in Septic Patients after Abdominal Surgery Ignacio Ferron-Celma, Alfonso Mansilla, Laila H assan, Carmen Olmedo, Karim Mtif.fak, Pablo Bueno and Jose-Antonio Ferron
Chapter XI
Vitamin C: Its Antioxidant Effects on Periodontitis Daisuke Ekuni, Takaaki Tomofuji, Koichiro Irie, Tetstq'i Azuma, Naofumi Tamaki, Tatsuo Yamamoto and Manabu Morita
Chapter XII
Effects of Vitamin Con Oxidative Stress-Induced Molecular Pathways in Epilepsy Mustafa Naz1roglu
299
311
321
Chapter XIII
Vitamin C in Human Platelets Isabella Savini, Luciana Avigliano and Maria Valeria Catani
335
Chapter XIV
Vitamin C: Absorption and Reabsorption Rodolfo A. Medina, Maria de los Angeles Garcia, Juan Pablo Henriquez, Pedro Cisternas and Francisco Nualart
353
Index
367
In: Vitamin C: Nutrition, Side Effects and Supplements ISBN: 978-1-61728-754-1 Editor: Christina M. Jackson, pp.205-231 ©20 II Nova Science Publishers, Inc.
Chapter V
Vitamin C Supplementation in Dialysis Patients: Benefits and Risks Alparslan Ersoy+* and Cuma Bulent Gul* Division ofNephrology, Uludag University Medical School, Bursa, Tnrkey'
Abstract Foods that are the main sources of vitamin C 3re often restricted or needed to be avoided in potassium restricted diets in dialysis patients. Inadequate intake and dialysis losses can result in ascorbate deficiency. Serious vitamin C deficiency seen in many patients may also contribute to poor oral health, chronic fatigue and some comorbidities including cardiovascular and neurological dysfunction. Therefore, a daily vitamin C supplement of 30-90 mg is reconunended a800 ng/mL than in those whose serum ferritin was
