These findings were reproduced with nicotine-containing chewing gum. In contrast, when patients with IgA glomerulo- nephritis smoked, a similar increment.
J Am Soc Nephrol
Effects
of Smoking
Volunteers
and in Patients EBERHARD
RITZ,*
MELCHIOR
SEYFARTH,
*Depc,rt,ple,zt Center,
Patients
Abstract.
on Renal
of internal
Heidelberg,
with
URS
renal
with BENCK,* and
Medicine,
Gertnany;
disease
EDUARD
have
Disease
FRANEK,*
CHRISTINE
Caro!a
University
Universir’,
min’),
a poor
Heidelberg
Munich,
and
accompanied
by
involved have the effects of
vasopressin
(from
1 .27
epinephrine
(from
37
smoking
in
smoking,
and
sham
smoking
cotinine
measurements.
of seven
patients
tis,
occasional
also
were
obtained
while
order flow
These
with
acid
or
days. using
‘311-hippurate
caused
chewing
with
a minor
sure
(MAP)
renal
but
and
plasma
increase
of MAP
mmHg)
and
Smoking
has
heart
to
effects, not
the
the
well
urinary
damage,
is highly type
tiansen was
confirmed
same
by
holds
In established renal failure
health
hazard
or
8.98 7.52
(1-3).
(4,5).
albumin mellitus,
the risk
numerous
with
diabetic nephropathy, in smokers is higher
the
gum. In contrast, smoked, a similar
changes increase
of FF were not uniform, of urinary albumin/creatinine 20 volunteers for statistical
on the
that,
true
for both
with In
that
patients
year
smoking
patients
retrospective
Chris-
II diabetes
(9-1
mented
of progression
of 2, and
this
that
Copyright
Society
U 1998 by the American
Society
of Nephrology
study
of
at the
time
(18),
to
nally,
preliminary
is
intervention
and
and
on systemic acute
changes
findings
are
of
on progres-
this
trial)
study was
to 40
on
smokers,
from
the
pack-
indicated
that
increased
day
of
this sham
issue,
renal
smoking
, less
than
five
was
an
to end-stage by differtreatment.
(multiple
Fi-
risk
the relative
risk
factor of end-
of I .7 in subjects
(5). the
deleterious
disease
we compared
glomerulonephritis.
docu-
nephritis
not explained
by a factor
per
A
patients
of
MRFIT
progression
i.e.
a greater
progression
underlying
IgA
found
nephritis
was
autosomal
er a!. (17)
counterparts.
of onset
effect
cigarettes
versus with
had
nonproteinuric lupus
information In
Chapman
mechanisms
To address
Some
disease.
or in immunosuppressive data
potential
(16).
for accelerated
failure
smoking
sional
all
(P
